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Prolotherapy in Musculoskeletal Disorders, Guideline for Orthopedic Application

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Open Journal of Regenerative Medicine 2023年第2期12卷 64-84页

作者： Asma Mafhoumi mohammad hossein nabian Saeed Reza Mehrpour School of Medicine Tehran University of Medical Sciences Tehran Iran Center for Orthopedic Trans-Disciplinary Applied Research (COTAR) Tehran University of Medical Sciences (TUMS) Tehran Iran Department of Orthopedic and Trauma Surgery Shariati Hospital Tehran University of Medical Sciences Tehran Iran

Purpose: Prolotherapy is a therapeutic method that involves injecting an irritant substance into injured areas of tendons, ligaments, and articular spaces. It has a wide application in orthopedic fields, including arthritis, tendinopathies, and back pain. Protocol of injection varies extensively based on the pathological condition. This review aims to discuss orthopedic applications of prolotherapy and its related outcomes, intending to introduce more specific injection protocols in each field. Methods: In a narrative review of literature, various musculoskeletal indications and contraindications of prolotherapy, as well as the method and location of injection, solution type, procedure intervals and frequencies, outcomes and side effects are investigated to reveal all aspects of the current knowledge about this new approach. Results: Chronic back pain, osteoarthritis, and tendinopathies are considered the most common indications for prolotherapy. Protocol of injection varies from one condition to another. The actual concentration of administered dextrose ranges from 12.5% to 25%. Results of the different studies indicate that prolotherapy could have a pleasing effect on improving patient’s pain and functional outcomes. No severe complication has been mentioned in previous investigations. Conclusion: Prolotherapy is a new therapeutic option that can be suggested as an effective method in recalcitrant musculoskeletal conditions.

关键词： Prolotherapy Hyperosmolar Dextrose Low Back Pain Osteoarthritis Tendinopathy

An Orthopedic Approach to a Child with a Limp: A Step-by-Step Review Article

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Open Journal of Orthopedics 2023年第11期13卷 457-476页

作者： Kamran Shirbache Brice Ilharreborde Ali Shirbacheh Ehsan Hedayat mohammad hossein nabian Center of Orthopedic Trans-Disciplinary Applied Research Tehran University of Medical Sciences Tehran Iran Robert Debré Hospital AP-HP University Paris Cité Paris France Hospital Centre of Niort Niort France Shariati Hospital Tehran University of Medical Sciences Tehran Iran

This article explains the orthopedic approach to limping in children. This is a review article including a selected collection of new articles extracted from PubMed and Google Scholar searched for clinical points and beneficial approaches to limping children. In this paper, limping is divided into two categories, painful and painless. After stating the important points in the patient’s medical history and explaining specific examinations in this area, different gait types in children are explained and the best evaluation method for them is presented. Then, paraclinical examinations and imaging are described in a practical evaluation, high-risk etiologies of limping such as infections, tumors, and fractures are explained in detail and red flags are considered at each step. The algorithms and the list of differential diagnoses for each age group are included, which can provide physicians with a more comprehensive approach to limping in children.

关键词： Limping Child Abnormal Gait Claudication Approach

Regenerative Medicine in Orthopaedics: Microsurgery Achievements for Translational Animal Model

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Open Journal of Regenerative Medicine 2023年第2期12卷 21-35页

作者： hossein Nematian Kamran Shirbache Zahra Vahdati Nesa Milan Leila Oryadi Zanjani Masoumeh Firouzi Kimiya Shirbacheh mohammad hossein nabian Center for Orthopedic Trans-Disciplinary Applied Research (COTAR) Tehran University of Medical Sciences Tehran Iran Iranian Tissue Bank and Research Center Imam Khomeini Medical Complex Hospital Tehran University of Medical Sciences Tehran Iran Research Center for Neural Repair (RCNR) University of Tehran Tehran Iran Material Sciences and Engineering Najafabad Branch Islamic Azad University Isfahan Iran

Purpose: Despite many scientific advances, Regenerative Medicine is still in the preclinical stages in many areas. In this article, we intend to discuss the role of microsurgery in the bench-to-bedside transition of such primary findings. Method: By searching the papers related to the history of Regenerative Medicine (RM) and the news of Tissue Engineering (TE) in orthopedics in Pubmed, Scopus, and Google Scholar databases, we accessed a complete archive of various topics related to this field. Result: We first assessed the history and achievements of regenerative medicine, then we realized the importance of translational medical sciences and the role of animal models in this incipient phenomenon. Finally, after mastering the capabilities of microsurgery and the useful contribution of this technique to the advancement of clinical applications of regenerative medicine in various branches such as skin, skeletal system, nerves, and blood vessels, we decided to express the gist of our studies through this article. Conclusion: Considering the widespread use of small animals in regenerative medicine projects and the inevitable role of microsurgery in performing the best intervention on these animal models, the significant progress of regenerative medicine clinical application requires special attention to microsurgery in associated research.

关键词： Regenerative Medicine Tissue Engineering Translational Animal Models Microsurgery Achievement

Regenerative Medicine: A Review of Solutions in the Treatment of Skin Defects

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Open Journal of Regenerative Medicine 2023年第2期12卷 97-113页

作者： Melika Heidarzadeh Kaveh Same Fatemeh Baghaie Nia Fatemeh Khavari Sina Shahabi mohammad hossein nabian Saied Reza Mehrpour mohammadabadi Center for Orthopedic Trans-Disciplinary Applied Research Tehran University of Medical Sciences Tehran Iran

The issue of skin defects is a major concern of almost every trauma surgeon after surgery. Despite numerous conventional methods and introduction of the reconstruction ladder, managing skin defects is still a challenge for the trauma surgeons. In recent years, parallel to the advances in the more conventional methods of skin repair, regenerative medicine has offered new and novel treatments. This article aims to explore these contemporary regenerative solutions as well as to review the conventional methods of treating skin defects.

关键词： Regenerative Medicine Skin Wound Defect

Comparison of a new single-donor human fibrin adhesive with suture for posterior tibial nerve repair in rat： biomechanical resistance and functional analysis

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Chinese Journal of Traumatology 2014年第3期17卷 146-152页

作者： Reza Erfanian Masoumeh Firouzi mohammad hossein nabian Masoud Darvishzadeh Leila Oryadi Zanjani Shayan Abdollah Zadegan Reza Shahryar Kamrani Tissue Repair Lab Institute of Biochemistry andBiophysics University of Tehran Tehran 13145-1384 Iran Cellular and Molecular Biology Tissue Repair LabInstitute of Biochemistry and Biophysics University ofTehran Tehran 13145-1384 Iran Research Center for Neural Repair University ofTehran Tehran Iran Department of Orthopedic and Trauma Surgery Shariati Hospital Tehran University of Medical SciencesTehran Iran

血纤维蛋白粘合剂的 ObjectiveThe 使用在神经修理有一个宽广背景。当前，单个施主的血纤维蛋白粘合剂的非最优的物理性质限制了他们的用法。表演和修改血纤维蛋白胶水的物理特征在 *** Wistar 老鼠的以后的胫骨的神经的修理从单个施主... 详细信息

血纤维蛋白粘合剂的 ObjectiveThe 使用在神经修理有一个宽广背景。当前，单个施主的血纤维蛋白粘合剂的非最优的物理性质限制了他们的用法。表演和修改血纤维蛋白胶水的物理特征在 *** Wistar 老鼠的以后的胫骨的神经的修理从单个施主的人的血浆准备了的现在的实验研究被划分成 5 个组；在控制组，胫骨的神经是，完全， transected 和没有处理在四个试验性的组被做神经树桩被一缝术，三缝术，有血纤维蛋白胶水的一缝术和血纤维蛋白胶水分别地独自重新连接。在 8 星期后续期间，胫骨的函数索引每周被测量，粘合剂力量，发炎和疤形成在 *** 树桩裂开率的结束被估计，粘合剂力量在所有试验性的组是类似的并且显著地不同于控制组(P ； < ； 0.05 ) 。在第八个后续星期末，一和三个缝术组的功能的恢复比血纤维蛋白胶水在被用于修理的组显著地高(P ； < ； 0.05 ) 。发炎和疤织物形成的数量在准备单个施主的血纤维蛋白粘合剂举办的所有 *** 学习结果表演之中是类似的能从长远的观点看提供要求的粘着性和抓住神经树桩的可接受的机械性质；然而，我们承认更多的研究被需要改进单个施主血纤维蛋白粘合剂修理的功能的结果。

关键词： Wistar大鼠纤维蛋白粘合剂修复功能力学性能缝合线神经纤维蛋白胶粘接强度

Multidisciplinary design optimization of a dual-spin guided vehicle

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Defence Technology（防务技术） 2024年第7期37卷 133-148页

作者： Jalal Karimi mohammad Reza Rajabi Seyed hossein Sadati Seyed Mahid hosseini Department of Aerospace Engineering Malek Ashtar University of TechnologyTehranIran

In this research,a Multidisciplinary Design Optimization approach is proposed for the dual-spin guided flying projectile design considering external and internal parts of the body as design *** this way,a parametric formulation is *** related disciplines,including structure,aerodynamics,guidance,and control are *** total mass,maximum aerodynamic control effectiveness,minimum miss distance,maximum yield stress in all subsystems,controllability and gyroscopic stability constraints are some of objectives/constraints taken into *** problem is formulated in All-At-Ones Multidisciplinary Design Optimization approach structure and solved by Simulated Annealing and minimax *** optimal configurations are evaluated in various *** resulted optimal configurations have met all design objectives and constraints.

关键词： Flying projectile optimal design All-at-ones multidisciplinary optimization Structure discipline Guidance and control discipline Aerodynamic discipline

Improvement of Surface Mechanical and Tribological Characteristics of L-PBF Processed Commercially Pure Titanium through Ultrasonic Impact Treatment

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Acta Metallurgica Sinica(English Letters) 2024年第6期37卷 1034-1046页

作者： Iman Ansarian Reza Taghiabadi Saeid Amini mohammad hossein Mosallanejad Luca Iuliano Abdollah Saboori Department of Materials Science and Metallurgy Imam Khomeini International University(IKIU)QazvinIran Department of Mechanical Engineering University of KashanKashanIran Integrated Additive Manufacturing Center Department of Management and Production EngineeringPolitecnico di TorinoCorso Duca Degli Abruzzi 2410129TurinItaly

Multi-pass ultrasonic impact treatment(UIT)was applied to modify the microstructure and improve the mechanical and tribological characteristics at the near-surface region of commercially pure Ti(CP-Ti)specimens produced by the laser powder bed fusion(L-PBF)*** considerably refined the L-PBF process-related acicular martensites(α′-M)and produced a well-homogenized and dense surface microstructure,where the porosity content of 1-,3-,and 5-pass UITed samples was reduced by 43,60,and 67%,*** UITed samples showed an enhancement in their near-surface mechanical properties up to a depth of about 300μ*** nanoindentation results for the 3-pass UITed sample revealed an increase of about 53,45,and 220%in its nanohardness,H/E_(r),and H_(3)/E_(r)^(2)indices,*** stylus profilometry results showed that performing the UIT removed the L-PBF-related features/defects and offered a smooth *** roughness average(R_(a))and the skewness(R_(sk))of the 3-pass UITed sample were found to be lower than those of the L-PBFed sample by 95 and 223%,*** the UIT also enhanced the material ratio,where the maximum load-bearing capacity(~100%)in as-L-PBFed(as-built)and 3-pass UITed samples was obtained at 60-and 10-µm depths,*** tribological investigations showed that applying the UIT resulted in a significant reduction of wear rate and average coefficient of friction(COF)of *** instance,under the normal pressures of 0.05 and 0.2 MPa,the wear rate and COF of the 3-pass UITed sample were lower than those of the L-PBFed sample by 65 and 58%,and 20 and 17%,respectively.

关键词： Laser powder bed fusion Ultrasonic impact treatment Commercially pure Ti(CP-Ti) Surface mechanical properties Tribological properties

Er_(2)TiO_(5)@Ag nanocomposites:Enhanced photocatalysis and bacteria inactivation,and cytotoxicity

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Journal of Rare Earths 2024年第5期42卷 851-858,I0002页

作者： Mehdi Nazeri hossein Sedaghat Reza Rafiei mohammad Amin Farzin Seyed Mostafa hosseinpour Mashkani Department of Parasitology and Mycology Kashan University of Medical SciencesKashanIran Department of Microbiology Kashan University of Medical SciencesKashanIran General Medicine Student School of MedicineKashan University of Medical SciencesKashanIran Student Research Committee Kashan University of Medical SciencesKashanIran Institute for Biomedical Materials and Devices School of Mathematical and Physical SciencesFaculty of ScienceUniversity of Technology SydneyNSW2007Australia

In this study,we successfully synthesized Er_(2)TiO_(5)@Ag nanocomposites(NCPs) using the ultrasonicmediated sol-gel technique to create a multifunctional material with enhanced photocatalytic and antibacterial *** visible light photocatalytic activities of Er_(2)TiO_(5) nanoparticles(NPs) and Er_(2)TiO_(5)@Ag NCPs were systematically evaluated under various conditions,including different concentrations of Basic Blue 41(BB 41) dye and *** results reveal a remarkable improvement in the photocatalytic degradation efficiency of Er_(2)TiO_(5)@Ag NCPs(95%) compared to Er_(2)TiO_(5) NPs(80%).Furthermore,the antibacterial efficacy of Er_(2)TiO_(5) NPs and Er2TiO_5@Ag NCPs were extensively examined against Gram-positive and Gram-negative ***,Er_(2)TiO_(5)@Ag NCPs exhibit significantly higher minimum bactericidal concentration(MBC) values compared to Er_(2)TiO_(5) *** antibacterial effect of Er_(2)TiO_(5)@Ag NCPs is particularly pronounced against *** and Pseudomonas aeruginosa,while demonstrating moderate effects on Escherichia coli and Enterococcus *** assess the biocompatibility of the synthesized materials,we investigated their internalization by MCF-7 ***,both Er_(2)TiO_(5) NPs and Er_(2)TiO_(5)@Ag NCPs are found to be effectively internalized by the cells,suggesting their potential application in biomedical ***,our study unveils the exceptional potential of Er_(2)TiO_(5)@Ag NCPs as a dual-action solution,simultaneously possessing enhanced photocatalytic efficiency and potent antibacterial *** multifunctional nanocomposite not only outperforms Er_(2)TiO_(5) and Ag but also paves the way for innovative applications in sustainable environmental remediation and advanced biomedical technologies,promising a brighter and cleaner future.

关键词： Rare earth catalysis Nanocomposite Er_(2)TiO_(5)@Ag Antibacterial activity Photocatalysis Cytotoxicity

Insight into small eyes: a practical description from phenotypes presentations to the management

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International Journal of Ophthalmology(English edition) 2024年第2期17卷 380-391页

作者： Sana Niazi Sorcha NíDhubhghaill Farideh Doroodgar Zisis Gatzioufas mohammad hossein Dehghan Translational Ophthalmology Research Center Tehran University of Medical SciencesTehran ***Iran Antwerp University Hospital Edegem 2650Belgium Faculty of Health Sciences Antwerp UniversityAntwerpen 2000EdegemBelgium Negah Aref Ophthalmic Research Center Shahid Beheshti University of Medical SciencesTehran 16666Iran University Eye Hospital Basel Basel 4031Switzerland

This narrative review aimed to have an algorithmic approach to microphthalmos by a systematic *** definition can be related to a number of special *** the more challenging cases of complex microphthalmos,relative anterior microphthalmos,and nanophthalmos,the surgeon can approach these cases more safely if they have a deep understanding of the anatomical variations and ideal formulae for intraocular lens computation and knows how to avoid intra-and post-operative *** this article,we review the criteria by which we recognize and describe pre-,intra-,and post-operative considerations,as well as discuss the ideal intraocular lenses for microphthalmos,given the intricate varieties of small eye phenotypes.

关键词： microphthalmos nanophthalmos lenses intraocular anterior chamber axial length eye cataract microcornea syndrome