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Can Campylobacter jejuni play a role in development of celiac disease? A hypothesis

World Journal of Gastroenterology 2007年第35期13卷 4784-4785页

作者： Behnam Sabayan Farzaneh Foroughinia mohammad hadi imanieh Student Research Center of Shiraz University of Medical Sciences ShirazIran Gastrohepatology Research Center Department of PediatricsShiraz University of Medical SciencesShirazIran

Celiac disease （CD） is an entropathy with malabsortive condition in which an allergic reaction to the cereal grain-protein （gluten） causes small intestine rnucosal injury. CD is a multifactorial disorder in which both genetic and environmental factors contribute to the disease development. Mechanisms have been described to explain the pathology of CD. T cells specific for multiple gluten peptides are found in virtually all patients. Generation of such a broad T cell response may be a prerequisite for disease development. CD is associated with multiple extraintestinal presentations, including neurological deficits. Recent studies have shown a significant correlation between anti-ganglioside antibodies and neurological disorders in patients with underlying CD. Gangliosides are glycosphingolipids which are abundant in nervous system and in other tissues including gastrointestinal tract. It is not known what triggers the release of anti-ganglioside antibodies in people with gluten sensitivity. But, the mechanism is likely to involve the intestinal immune system response to ingested gliadin, a component of wheat gluten. Studies showed that mechanisms different from gluten exposure may be implicated in antibody formation, and other environmental factors may also exist. In addition, considering the fact that genetic predisposition dysregulating mucosal immune responses in the presence of certain environmental triggers like gastrointestinal infections may be strong etiological factors for developing chronic intestinal inflammation including CD, the hypothesis raised in our mind that antiganglioside antibody formation in CD may play a role not only in development of neurological complications in celiac patients, but also in development of CD itself. As presence of Campylobacter jejuni in other diseases with antigangliosides antibody formation has been established, we propose the possible role of Campylobacter jejuni in development of CD in association with other genetic and

关键词： Celiac disease Gangliosides Campylobacter jejuni Molecular mimicry

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Comparison of different diagnostic methods in infants with Cholestasis

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World Journal of Gastroenterology 2006年第36期12卷 5893-5896页

作者： Seyed Mohsen Dehghani Mahmood Haghighat mohammad hadi imanieh Bita Geramizadeh Department of Pediatric Gastroenterology Gastroenterohepatology Research Center of Nemazee Hospital Shiraz University of Medical Sciences Shiraz Iran Department of Pathology Nemazee Hospital Shiraz University of Medical Sciences Shiraz Iran

AIM: To evaluate different methods in differentiating idiopathic neonatal hepatitis from biliary atresia. METHODS: Sixty-five infants with cholestatic jaundice and final diagnosis of idiopathic neonatal hepatitis and biliary atresia were studied prospectively from September 2003 to March 2006. A thorough history and physical examination were undertaken and the liver enzymes were examined. All cases underwent abdominal ultrasonography, hepatobiliary scintigraphy, and percutaneous liver biopsy. The accuracy, sensitivity, specificity and predictive values of these various methods were compared. RESULTS: There were 34 girls and 31 boys, among them 46 subjects had idiopathic neonatal hepatitis (age, 61 ± 17 d) and 19 had biliary atresia (age, 64 ± 18 d). The mean age at onset of jaundice was significantly lower in cases of biliary atresia when compared to idiopathic neonatal hepatitis cases (9 ± 13 d vs 20 ± 21 d; P = 0.032). The diagnostic accuracy of different methods was as follows: liver biopsy, 96.9%; clinical evaluation, 70.8%; ultrasonography, 69.2%; hepatobiliary scintigraphy, 58.5%; and liver enzymes, 50.8%.CONCLUSION: Our results indicate that clinical evaluation by an experienced pediatric hepatologist and a biopsy of the liver are considered as the most reliable methods to differentiate idiopathic neonatal hepatitis and biliary atresia.

关键词： Idiopathic neonatal hepatitis Biliary atresia Clinical evaluation Liver biopsy

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Organisms causing spontaneous bacterial peritonitis in children with liver disease and ascites in Southern Iran

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World Journal of Gastroenterology 2006年第36期12卷 5890-5892页

作者： Mahmood Haghighat Seyed Mohsen Dehghani Abdolvahab Alborzi mohammad hadi imanieh Bahman Pourabbas Mehdi Kalani Department of Pediatric Gastroenterology Shiraz University of Medical Science Shiraz Iran Department of Professor Alborzi Clinical Microbiology Research Center Shiraz University of Medical Science Shiraz Iran

AIM： To determine the causative agents of spontaneous bacterial peritonitis （SBP） in children with liver disease and ascites in our center. METHODS： During a 2.5 year period, from September 2003 to March 2006, 12 patients with 13 episodes of SBP were studied. In all cases at the time of admission serum albumin and glucose, urinalysis and urine culture was performed. Analysis [white blood cell （WBC） count with differential, albumin, glucose], gram stain, culture by BACTEC method and antibiogram was done on ascitic fluids. Abdominal paracentesis was repeated after 48 h of antibiotic therapy for bacteriologic assay. The patients were followed for at least three months in a gastroenterology clinic. RESULTS： There were 7 girls （58%） and 5 boys （42%） with a median age of 5.2 years （range, 6 mo to 16 years）. All cases had positive ascitic fluid culture. Gram stain was positive in 5 （38.5%） of them. The isolated organisms were S. pneumoniae in 5 （38.5%）, E. coli in 2 （15.3%）, S. viridans in 2 （15.3%）, and K. pneumoniae, H. influenza, Enterococci, and nontypable Streptococcus each in one （7.7%）. All of them except Enterococci were sensitive to ciprofloxacin and ceftriaxone. All ascitic fluid cultures were negative after 48 h of antibiotic therapy. CONCLUSION： S. pneumoniae is the most common cause of SBP in the pediatric age group and we recommend a third generation cephalosporine （e.g., Ceftriaxlone or Cefotaxime） for empirical therapy in children with SBP.

关键词： Spontaneous bacterial peritonitis Children Cirrhosis Causes Empirical therapy

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Post-transplant lymphoproliferative disorder after liver transplantation: Incidence, long-term survival and impact of serum tacrolimus level

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World Journal of Gastroenterology 2017年第7期23卷 1224-1232页

作者： Ahad Eshraghian mohammad hadi imanieh Seyed Mohsen Dehghani Saman Nikeghbalian Alireza Shamsaeefar Frouzan Barshans Kourosh Kazemi Bita Geramizadeh Seyed Ali Malek-Hosseini Transplant Research Center Shiraz University of Medical Sciences Gastroenterohepatology Research Center Namazi Hospital

To investigate incidence and survival of post-transplant lymphoproliferative disorder (PTLD) patients after liver *** cross-sectional survey was conducted among patients who underwent liver transplantation at Shiraz Transplant Center (Shiraz, Iran) between August 2004 and March 2015. Clinical and laboratory data of patients were collected using a data gathering *** were 40 cases of PTLD in the pediatric age group and 13 cases in the adult group. The incidence of PTLD was 6.25% in pediatric patients and 1.18% in adult liver transplant recipients. The post-PTLD survival of patients at 6 mo was 75.1% ± 6%, at 1 year was 68.9% ± 6.5% and at 5 years was 39.2% ± 14.2%. Higher serum tacrolimus level was associated with lower post-PTLD survival in pediatric patients (OR = 1.07, 95%CI: 1.006-1.15, P = 0.032). A serum tacrolimus level over 11.1 ng/mL was predictive of post PTLD survival (sensitivity = 90%, specificity = 52%, area under the curve = 0.738, P = 0.035).CONCLUSIONIncidence of PTLD in our liver transplant patients is comparable to other centers. Transplant physicians may consider adjustment of tacrolimus dose to maintain its serum level below this cutoff point.

关键词： Post-transplant lymphoproliferative disorder Liver transplantation Survival Tacrolimus Epstein-Barr virus

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Behavior Analysis of Biomimetic Soft Bending Actuators in Free Motion and Contact

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Journal of Bionic Engineering 2023年第3期20卷 967-981页

作者： mohammad hadi Namdar Ghalati Sepideh Akbari Hamed Ghafarirad mohammad Zareinejad Department of Mechanical Engineering Amirkabir University of TechnologyTehran***Iran New Technologies Research Center(NTRC) Amirkabir University of TechnologyTehran***Iran

Bioinspired Soft Bending Actuators (SBA) are increasingly being used in rehabilitation, assistant robots, and grippers. Despite many investigations on free motion modeling, understanding how these actuators interact with the environment requires more detailed research. It is caused by high compliance and nonlinearity of bioinspired soft material, which leads to serious challenges in contact conditions. In this paper, a continuous deformation analysis is presented to describe the free motion nonlinear behavior of the actuator. Based on the achieved result, this study proposes static modeling of SBA affected by a concentrated external force. For this purpose, the finite rigid element method is utilized, which is based on discretizing the actuator into smaller parts and assuming these parts as rigid serial links connected by nonlinear torsional springs. To verify the proposed model, two kinds of forces are considered to be acting on the actuator, i.e. following force and constant direction force. In addition, the effect of gravity on the actuator configuration is also investigated. The validity of the model has been demonstrated through experiments in free motion, contact conditions and the presence of gravity. It generally shows that the prediction error of robot configuration is lower than 7.5%.

关键词： Biomimetic soft bending actuator Static modeling Contact Force constraints Rigid finite element

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Improvement in IBC-silicon solar cell performance by insertion of highly doped crystalline layer at heterojunction interfaces

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Chinese Physics B 2017年第10期26卷 508-514页

作者： hadi Bashiri mohammad Azim Karami Shahramm mohammadnejad School of Electrical Engineering Iran University of Science &Technology (IUST)

By inserting a thin highly doped crystalline silicon layer between the base region and amorphous silicon layer in an interdigitated back-contact （IBC） silicon solar cell, a new passivation layer is investigated. The passivation layer performance is characterized by numerical simulations. Moreover, the dependence of the output parameters of the solar cell on the additional layer parameters （doping concentration and thickness） is studied. By optimizing the additional passivation layer in terms of doping concentration and thickness, the power conversion efficiency could be improved by a factor of 2.5%, open circuit voltage is increased by 30 mV and the fill factor of the solar cell by 7.4%. The performance enhancement is achieved due to the decrease of recombination rate, a decrease in solar cell resistivity and improvement of field effect passivation at heterojunction interface. The above-mentioned results are compared with reported results of the same conventional interdigitated back-contact silicon solar cell structure. Furthermore, the effect of a-Si：H/c-Si interface defect density on IBC silicon solar cell parameters with a new passivation layer is studied. The additional passivation layer also reduces the sensitivity of output parameter of solar cell to interface defect density.

关键词： IBC silicon solar cells interface layer recombination interface defect density

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Fracture analyses of different pre-holed concrete specimens under compression

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Acta Mechanica Sinica 2015年第6期31卷 855-870页

作者： hadi Haeri Alireza Khaloo mohammad Fatehi Marji Department of Civil Engineering Sharif University of Technology Member of National Elites Foundation Center of Excellence in Structure and Earthquake Engineering Sharif University of Technology Mine Exploitation Engineering Department Faculty of Mining and Metallurgy Yazd University

Crack propagation processes in specially prepared concrete discs and rectangular specimens containing a single cylindrical hole or multiple holes of varying diameters have been studied both experimentally and numerically. In this research, the cracks coalescence paths in Brazilian disc and rectangular specimens made from rock-like material containing multi-holes are investigated. These concrete specimens are specially prepared from an appropriate mixture of Portland Pozzolana Cement （PPC）, fine sands, and water. The pre-holed Brazilian discs and rectangular specimens are experimentally tested under compression. The breakage load in the ring type disc specimens containing an axial hole with varying diameters is measured and the distribution of the induced lateral stress is obtained. The mechanism of cracks propagation in the wall of the ring type specimens is also stud- ied. In the case of multi-hole Brazilian disc and rectangular specimens, the cracks propagation and cracks coalescence are also investigated. These experiments are numerically modeled by a modified higher order displacement discontinuity method. It has been shown that the corresponding experimental and numerical results are in good agreement with each other. The results presented in this research vali date the accuracy and applicability of these crack analyses procedures.

关键词： Concrete rings Pre-holed Brazilian disc ·Rectangular specimens Crack analyses Coalescence ·Induced lateral stress

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A robust subband adaptive filter algorithm for sparse and block-sparse systems identification

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Journal of Systems Engineering and Electronics 2021年第2期32卷 487-497页

作者： ZAHRA Habibi hadi Zayyani mohammad Shams Esfand Abadi Research Institute for Information and Communications Technologies Academic Center for EducationCulture and ResearchTehran ***Iran Department of Electrical and Computer Engineering Qom University of TechnologyQom 371951519Iran Faculty of Electrical Engineering Shahid Rajaee Teacher Training UniversityTehran ***Iran

This paper presents a new subband adaptive filter(SAF)algorithm for system identification scenario under impulsive interference,named generalized continuous mixed p-norm SAF(GCMPN-SAF)*** proposed algorithm uses a GCMPN cost function to combat the impul-sive *** further accelerate the convergence rate in the sparse and the block-sparse system identification processes,the proportionate versions of the proposed algorithm,the L0-norm GCMPN-SAF(L0-GCMPN-SAF)and the block-sparse GCMPN-SAF(BSGCMPN-SAF)algorithms are also ***,the convergence analysis of the proposed algorithm is *** results show that the proposed algorithms have a better performance than some other state-of-the-art algorithms in the literature with respect to the convergence rate and the tracking capability.

关键词： subband adaptive filter(SAF) generalized continuous mixed p-norm(GCMPN) sparse system block-sparse system impulsive interference

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Experimental investigation of density current patterns using dynamic fractal analysis

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International Journal of Sediment Research 2021年第2期36卷 165-176页

作者： mohammad Hosseini mohammad hadi Fattahi Saeid Eslamian Department of Civil Engineering Najafabad Branch Islamic Azad University Department of Civil Engineering Marvdasht Branch Islamic Azad University Department of Water Engineering Isfahan University of Technology

Density currents are caused by a difference in density, though low, of an entering fluid with the ambient fluid. This type of current is two-phased and found on riverbeds or in reservoirs behind dams, and is nonlinear in nature, complex, and sensitive to initial conditions. Fractal geometry is used as a powerful tool for studying complex natural phenomena. Using experimental studies and changes in inlet current conditions, the fractal and multi-fractal analyses of the interface between the density current and the ambient fluid were done. In addition, a search was made to find a possible connection between the nonlinear patterns. According to the results, with an increase in the inlet discharge and inlet density of the current the fractal dimension decreased. Further, the smaller the range of the singularity spectrum diagram was, i.e., the more it was less than 0.34, the lower the system’s tendency was to be multi-fractal,and the system sensitive to large local changes. In the interface between the density current and the ambient fluid, using the fractal dimension-based Richardson number could improve experimental data by 12.4%. Moreover, with an increase in the Richardson number, the Reynolds number of the current decreased. Further, upon considering the fractal dimension, the Reynolds number improved by 23% and a good correlation with a coefficient of determination of 0.76.

关键词： Density current Fractal geometry Richardson number Multi-fractal analysis Fluid interface

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Investigation of the stability and hydrodynamics of Tetrosomus gibbosus carapace in different pitchangles

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Journal of Hydrodynamics 2019年第2期31卷 368-378页

作者： Mahyar Malekidelarestaqi Alireza Riasi hadi Moradi mohammad Samadpour School of Mechanical Engineering University of TehranTehranIran Intelligent Systems Research Institute Sungkyunkwan UniversitySeoulKorea School of Electrics and Computer Engineering University of TehranTehranIran School of Mechanical Engineering Amirkabir University of TechnologyTehranIran

In this paper,stability properties of Tetrosomus gibbosus have been experimentally and numerically studied in pitching *** fish lives in southern offshores of *** usually live in extremely turbulent parts of seas and oceans,with high stability and maneuverability that has caught the attention of *** body shape let them swim with a quite rapid *** on Boxfishes have had influences on automotive and marine *** CAD file of the boxfish was created using optical *** a model was built and tested in a subsonic wind tunnel and a numerical study was conducted in virtual wind *** experimental results are consistent with the numerical ones and also support the findings of other studies on similar *** results show that the flow around the fish,which is a consequence of its body shape,tries to maintain the stable position of the fish by resisting against the external force tilting the fish from its stable horizontal *** ventral and dorsal keels of the boxfish generate column-like vortices in horizontal direction which play an imperative role in maintaining the stability of the fish.

关键词： Boxfish Tetrosomus gibbosus humpback turretfish hydrodynamic stability experimental fluid mechanics bio-inspired engineering

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