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Targeting miRNA by CRISPR/Cas in cancer:advantages and challenges

Military Medical Research 2024年第3期11卷 345-373页

作者： Bashdar Mahmud Hussen Mohammed Fatih Rasul Snur Rasool Abdullah Hazha Jamal Hidayat Goran Sedeeq Hama Faraj Fattma Abodi ali abbas Salihi Aria Baniahmad Soudeh Ghafouri-Fard Milladur Rahman Mark C.Glassy Wojciech Branicki mohammad Taheri Department of Biomedical Sciences Cihan University-ErbilErbilKurdistan Region 44001Iraq Department of Clinical Analysis College of PharmacyHawler Medical UniversityErbilKurdistan Region 44001Iraq Department of Pharmaceutical Basic Science Faculty of PharmacyTishk International UniversityErbilKurdistan Region 44001Iraq Medical Laboratory Science Lebanese French UniversityErbilKurdistan Region 44001Iraq Department of Biology College of EducationSalahaddin University-ErbilErbilKurdistan Region 44001Iraq Department of Medical Laboratory Science Komar University of Science and TechnologySulaymaniyah 46001Iraq Department of Medical Microbiology College of Health SciencesHawler Medical UniversityErbilKurdistan Region 44001Iraq Department of Biology College of ScienceSalahaddin University-ErbilErbilKurdistan Region 44001Iraq Center of Research and Strategic Studies Lebanese French UniversityErbil 44001Iraq Institute of Human Genetics Jena University Hospital07747 JenaGermany Department of Medical Genetics School of MedicineShahid Beheshti University of Medical SciencesTehran 374-37515Iran Department of Clinical Sciences MalmöSection for SurgeryLund University22100 MalmöSweden Translational Neuro-Oncology Laboratory San Diego(UCSD)Moores Cancer CenterUniversity of CaliforniaSan DiegoCA 94720USA Faculty of Biology Institute of Zoology and Biomedical ResearchJagiellonian University31-007 KrakówPoland Urology and Nephrology Research Center Shahid Beheshti University of Medical SciencesTehran 374-37515Iran

Clustered regulatory interspaced short palindromic repeats(CRISPR)has changed biomedical research and provided entirely new models to analyze every aspect of biomedical sciences during the last *** the study of cancer,the CRISPR/CRISPR-associated protein(Cas)system opens new avenues into issues that were once unknown in our knowledge of the non-coding genome,tumor heterogeneity,and precision ***/Cas-based geneediting technology now allows for the precise and permanent targeting of mutations and provides an opportunity to target small non-coding RNAs such as microRNAs(miRNAs).However,the development of effective and safe cancer gene editing therapy is highly dependent on proper design to be innocuous to normal cells and prevent introducing other *** study aims to highlight the cutting-edge approaches in cancer-gene editing therapy based on the CRISPR/Cas technology to target miRNAs in cancer ***,we highlight the potential challenges in CRISPR/Cas-mediated miRNA gene editing and offer advanced strategies to overcome them.

关键词： CRISPR CRISPR/Cas9 CRISPR/Cas12 Gene editing miRNAs Cancer therapy

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Exploring the meaning of care among lived experiences of patients with blindness:an interpretive phenomenological study

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Frontiers of Nursing 2024年第3期11卷 319-326页

作者： mohammad ali mohammadi Mehdi Heidarzadeh Saeed Mehri Mahmood Shamshiri Department of Medical-Surgical Nursing School of Nursing and MidwiferyArdabil University of Medical SciencesArdabil ***Iran Department of Emergency Nursing School of Nursing and MidwiferyArdabil University of Medical SciencesArdabil ***Iran Department of Critical Care Nursing School of Nursing and MidwiferyArdabil University of Medical SciencesArdabil ***Iran

Objective:To explore the meaning of care experienced by people with blindness in ***:Interpretive phenomenology along with the 6-step method of van Manen was used to conduct the *** purposeful sampling,15 people with legal blindness were *** analysis was used to isolate the meaning of ***:Five themes emerged:(a)nurses in the eyes of patients with blindness;(b)negligence in the caring moments;(c)being cared for in ambiguity;(d)Uncoordinated care;and(e)Psychological discomfor *** sub-themes were condensed into an overarching theme titled as“marginalized patients inside the stereotypical healthcare system.”Conclusions:Lived experiences of patients with blindness revealed that hospitals provide stereotypic or inappropriate care for this minority group in *** professionals par ticularly nurses should be skilled to provide person-centered and coordinated care for patients with blindness.

关键词： hospitalization lived experience meaning of care people with blindness phenomenology

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Surface Morphology and Thermo-Electrical Energy Analysis of Polyaniline (PANI) Incorporated Cotton Fabric

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Energy Engineering 2024年第1期121卷 1-12页

作者： Md.Shohan Parvez Md.Mustafizur Rahman Mahendran Samykano mohammad Yeakub ali Automotive Engineering Research Group Faculty of Mechanical and Automotive Engineering TechnologyUniversiti Malaysia Pahang Al-Sultan AbdullahPekanMalaysia Department of Textile Engineering Khulna University of Engineering&Technology(KUET)KhulnaBangladesh Centre for Research in Advanced Fluid and Processes(CARIFF) Universiti Malaysia Pahang Al-Sultan AbdullahLebuhraya Tun RazakGambangMalaysia Mechanical Engineering Programme Area Faculty of EngineeringUniversiti Teknologi BruneiBruneiDarussalam

With the exponential development in wearable electronics,a significant paradigm shift is observed from rigid electronics to flexible wearable ***(PANI)is considered as a dominant material in this sector,as it is endowed with the optical properties of both metal and ***,its widespread application got delineated because of its irregular rigid form,level of conductivity,and precise choice of *** PANI in textile materials can generate promising functionality for wearable *** research work employed a straightforward in-situ chemical oxidative polymerization to synthesize PANI on Cotton fabric surfaces with varying dopant(HCl)***-treatment using NaOH is implemented to improve the conductivity of the fabric surface by increasing the monomer *** research explores the morphological and structural analysis employing SEM,FTIR and *** surface resistivity was measured using a digital multimeter,and thermal stability is measured using *** successful polymerization,a homogenous coating layer is *** is revealed that the simple pre-treatment technique significantly reduces the surface resistivity of Cotton fabric to 1.27 kΩ/cm with increasing acid concentration and thermal *** electro-thermal energy can also reach up to 38.2°C within 50 s with a deployed voltage of 15 *** modified fabric is anticipated to be used in thermal regulation,supercapacitor,sensor,UV shielding,antimicrobial and other prospective functional applications.

关键词： Polyaniline cotton in-situ polymerization SEM TGA heating fabric

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Socio-environmental factors associated with small mammal assemblage and Leptospira prevalence in Suburban Areas of Terengganu,Malaysia

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Asian Pacific Journal of Tropical Medicine 2024年第9期17卷 400-407,I0002,I0003页

作者： mohammad Izuan Mohd Zamri Nur Juliani Shafie mohammad Ridhuan Mohd ali Adedayo Michael Awoniyi Hernan Dario Argibay Federico Costa Faculty of Science and Marine Environment Universiti Malaysia TerengganuKuala NerusTerengganuMalaysia Bacteriology Unit Institute for Medical Research(IMR)Kuala LumpurMalaysia Institute of Collective Health Federal University of BahiaSalvadorBrazil Gonçalo Moniz Research Center Oswaldo Cruz FoundationBrazilian Ministry of HealthSalvadorBahiaBrazil Department of Epidemiology of Microbial Diseases Yale School of Public HealthNew HavenCT06511USA Lancaster Medical School Lancaster UniversityLancasterLA14YWUK

Objective:To examine the socio-environmental factors associated with the assemblage of small mammals and the prevalence of Leptospira pathogen in poor suburban communities of Terengganu,***:We trapped small mammals from 119 trapping points scattered around three suburban communities of Terengganu using sausage-baited live *** the average,we set up five traps for three nights at each sampling point during the trapping *** of captured animals were harvested and processed for Leptospira ***,environmental survey was conducted at each trapping point to obtain information about possible variables supporting small mammal *** used a generalized linear model to evaluate the effect of different socio-environmental variables on small mammals’***:A total of 89 small mammals,specifically,Rattus norvegicus(n=39),Rattus rattus(n=27),Rattus exulans(n=10),Suncus murinus(n=11),and Tupaia glis(n=2)were captured from 1385 trap *** individuals(15.7%)of the captured animals tested positive for Leptospira bacteria using PCR *** of our generalized linear model showed only residences bordering vacant lots as the variable positively associated with small mammal occurrence in the three study ***:Small mammal community,especially the often neglected species,could harbour and potentially contribute towards pathogenic Leptospira maintenance in the study *** adequately control small mammals’population and subsequent human zoonoses transmission,it is critical to advocate and promote appropriate infrastructure and suburban services,together with good hygiene practices that can reduce the animals’access to food and harborage.

关键词： Leptospirosis Rodents Small mammals control Suburban community Zoonotic diseases

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Outcomes of surgical correction of Peyronie’s disease with plaque excision and grafting: Comparison of testicular tunica vaginalis graft versus bovine pericardium graft

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Asian Journal of Urology 2024年第3期11卷 497-503页

作者： ali Eslahi Faisal Ahmed mohammad Reza Askarpour Hossein-ali Nikbakht Iman Shamohammadi Payam Ghasemi Hanieh alimardani Bahareh Ebrahimi Department of Urology School of MedicineShiraz University of Medical SciencesShirazIran Shiraz Geriatric Research Center Shiraz University of Medical SciencesShirazIran Urology Research Center Al-Thora General HospitalDepartment of UrologySchool of MedicineIbb University of Medical SciencesIbbYemen Social Determinants of Health Research Center Health Research InstituteBabol University of Medical SciencesBabolIran

Objective:Peyronie’s disease(PD)is an abnormal wound healing in the penile tunica *** fibrotic plaque excision,different graft materials have been used to repair the defects,but the optimal graft remains *** study aimed to compare the functional outcomes of testicular tunica vaginalis grafts and bovine pericardium grafts in patients with severe ***:A retrospective comparative study was conducted on 33 PD patients undergoing partial plaque excision and grafting from September 2015 to May *** patients were divided into two groups depending on the type of graft *** 15 patients in Group B,testicular tunica vaginalis grafts were used to repair the defect,while for 18 patients in Group A,bovine pericardium grafts were *** of the patient’s age,comorbidities,sexual function,penile curvature,postoperative complications,need for further treatment,change in penile length,and satisfaction were gathered and compared between the *** function was evaluated using the 5-item version of the International Index of Erectile Function(IIEF-5),and a functional less than 20-degree penile curvature after surgery was considered a successful ***:There was no difference in age,comorbidities,degree of curvature,perioperative IIEF-5,operative time,plaque size,or complication *** surgery,a statistically significant improvement in curvature degree(palis or bovine pericard

关键词： Peyronie's disease Plaqueexcision Testiculartunica vaginalis graft Bovinepericardium graft

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Geometric investigation of entrance proportions of houses from the Qajar to the beginning of the early Pahlavi in Dezful City(1789—1979)

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Frontiers of Architectural Research 2024年第1期13卷 57-78页

作者： Raziyeh Rezadoost Dezfuli mohammad Mehrakizadeh Behnaz Safar ali Najar Hassan Bazazzadeh mohammadjavad Mahdavinejad Department of Architecture Poznan University of Technology61-131 PoznanPoland Department of Architecture and Urban Planning Jundi Shapur University of TechnologyDezfulIran College of Engineering and Architecture University of Nizwa616 Birkat Al MawzOman Department of Architecture Faculty of Art and ArchitectureTarbiat Modares UniversityTehranIran

Due to the importance of the historical context of Dezful City,investigating historic buildings is *** unfortunately,a large part of it is being *** this reason,it is essential to discover the guidelines and logic behind the architectural design of these buildings to help their reconstruction or ***,there is no logical information about the components of this context and the reconstructions are usually done according to taste and based on architecture tested or personal ***,it is necessary to find a logic behind these critical components that support the whole plan or parts of it in a particular *** purpose of this research is to discover and find the logic behind the design of this building in the historical context of *** geometrical proportions can significantly help to reconstruct buildings better and more *** this purpose,30 historical houses of Dezful were randomly selected,and their input information was drawn in 2D form in ***,the length,width,and height proportions were measured,and the obtained ratios were compared with the golden proportions and dynamic *** paper studies entrance based on ratios of√2,√3,√4,√4,√1.25 andφ(the golden section).The results show that golden proportions and proportions derived from dynamic rectangles are present in the wording of all ***,the range of ratios in the plan is from 1.34 to 2,and the content of changes in the section is from 1.22 to *** results can help architects,and particularly building owners,to reconstruct based on existing logic by discovering the proportions of the entrances of the *** is possible to administer a part of the damaged tissue and estimate its dimensions and sizes because the proportions’completeness can help revive half-destroyed historical buildings.

关键词： Proportions Historical houses House entrance Dezful city Qajar period to early Pahlavi

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Accurate 3D Thermal Network Development for Direct-drive Outer-rotor Hybrid-PM Flux-switching Generator

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Chinese Journal of Electrical Engineering 2024年第2期10卷 80-92页

作者： ali Zarghani mohammad Farahzadi Aghil Ghaheri Karim abbaszadeh Faculty of Electrical Engineering Shahid Beheshti UniversityTehran ***Iran Faculty of Electrical Engineering University of Science and CultureTehran ***Iran Department of Electrical Engineering K.N.Toosi University of TechnologyTehran ***Iran

Heat and thermal problems are major obstacles to achieving high power density in compact permanent magnet(PM)***,a comprehensive,accurate,and rapid temperature rise estimation method is required for novel electric machines to ensure safe and reliable operations.A unique three-dimensional(3D)lumped parameter thermal network(LPTN)is presented for accurate thermal modeling of a newly developed outer-rotor hybrid-PM flux switching generator(OR-HPMFSG)for direct-drive ***,the losses of the OR-HPMFSG are calculated using 3D finite element analysis(FEA).Subsequently,all machine components considering the thermal contact resistance,anisotropic thermal conductivity of materials,and various heat flow paths are comprehensively modeled based on the thermal *** the proposed 3-D LPTN,internal nodes are considered to predict the average temperature as well as the hot spots of all active and passive *** measurements are performed on a prototype OR-HPMFSG to validate the efficiency of the 3-D LPTN.A comparison of the results at various operating points between the developed 3-D LPTN,experimental test,and FEA indicates that the 3-D LPTN quickly approximates the hotspot and mean temperature of all components under both transient and steady states with high accuracy.

关键词： Direct-drive wind turbine hybrid-PM flux switching generator lumped parameter thermal network temperature estimation 3D thermal modeling

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Time-dependent effects in transient liquid phase bonding of 304L and Cp-Ti using an Ag-Cu interlayer

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Journal of Central South University 2024年第7期31卷 2237-2255页

作者： Saeed VAZIRIAN mohammad MOSHKBAR BAKHSHAYESH ali FARZADI Department of Materials and Metallurgical Engineering Amirkabir University of Technology(Tehran Polytechnic)Tehran 15916-34311Iran

One of the challenges for bimetal manufacturing is the joining ***,transient liquid phase(TLP)bonding was performed between 304L stainless steel and Cp-Ti using an Ag-Cu interlayer with a thickness of 75μm for bonding time of 20,40,60,and 90 *** bonding temperature of 860℃ was considered,which is under the β transus temperature of *** TLP bonding,various intermetallic compounds(IMCs),including Ti_(5)Cr_(7)Fe_(17),(Cr,Fe)_(2)Ti,Ti(Cu,Fe),Ti_(2)(Cu,Ag),and Ti_(2)Cu from 304L toward Cp-Ti formed in the ***,on the one side,with the increase in time,further diffusion of elements decreases the blocky IMCs such as Ti_(5)Cr_(7)Fe_(17),(Cr,Fe)_(2)Ti,Ti(Cu,Fe)in the 304L diffusion-affected zone(DAZ)and reaction zone,and on the other side,Ti_(2)(Cu,Ag)IMC transformed into fine morphology toward Cp-Ti *** microhardness test also demonstrated that the(Cr,Fe)_(2)Ti+Ti_(5)Cr_(7)Fe_(17) IMCs in the DAZ on the side of 304L have a hardness value of HV 564,making it the hardest *** maximum and minimum shear strength values are equal to 78.84 and 29.0 MPa,*** cleavage pattern dominated fracture surfaces due to the formation of brittle phases in dissimilar joints.

关键词： diffusion brazing transient liquid phase bonding dissimilar material joints microstructural evolution mechanical properties grade 2 titanium

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Auto-tuning PVT data using multi-objective optimization:Application of NSGA-II algorithm

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Petroleum 2024年第1期10卷 135-149页

作者： Abdolhadi Zarifi mohammad Madani mohammad Jafarzadegan Reservoir Engineering Systems Petroleum Engineering DepartmentMain Office Building of National Iranian South Oil Company(NISOC)AhvazIran Reservoir Engineering Division Petroleum Engineering DepartmentPetroleum Engineering and Development Company(PEDEC)TehranIran Combined Planning Management National Iranian Oil Company(NIOC)TehranIran

Reservoir simulation is known as perhaps the most widely used,accurate,and reliable method for field development in the petroleum *** integral part of a reliable reservoir simulation process is to consider robust and rigorous tuned EOS ***,EOS models are tuned iteratively through arduous workflows against experimental PVT ***,this comes with a number of drawbacks such as forcingly using weight factors,which upon alteration adversely affects the optimization *** objective of the current work is thus to introduce an auto-tune PVT matching tool using NSGA-II multi-objective *** order to illustrate the robustness of the presented technique,three different PVT samples are used,including two black-oil and one gas condensate *** utilize PengRobinson EOS during all the manual and auto-tuning *** of auto-tuned EOS-generated results with those of experimental and computed statistical error values for these samples clearly show that the proposed method is *** addition,the proposed method,contrary to the manual matching process,provides the engineer with several matched solutions,which allows them to select a match based on the engineering background to be best amenable to the problem at *** addition,the proposed technique is fast,and can output several solutions within less time compared to the traditional manual matching method.

关键词： Auto-tuning PVT Equation of state NSGA-II Multi-objective optimization

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Isoimperatorin alleviates acetic acid-induced colitis in rats

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Asian Pacific Journal of Tropical Biomedicine 2024年第4期14卷 147-153页

作者： Saied Goodarzi Amir Hossein Abdolghaffari Behnaz Najafi Mostafa Pirali Hamedani Saeed Tavakoli Mahshad Marvi Maryam Baeeri Narguess Yassa abbas Hadjiakhoondi mohammad Abdollahi Zahra Tofighi Medicinal Plants Research Center Faculty of PharmacyTehran University of Medical SciencesTehranIran Department of Toxicology and Pharmacology Faculty of PharmacyTehran Medical SciencesIslamic Azad UniversityTehranIran Department of Pharmacognosy Faculty of PharmacyTehran University of Medical SciencesTehranIran Medicinal Plants Research Center Institute of Medicinal PlantsACECRKarajIran International Campus School of Pharmacy Tehran University of Medical SciencesTehranIran Toxicology and Diseases group The Pharmaceutical Sciences Research CenterTehran University of Medical SciencesTehranIran Department of Toxicology and Pharmacology Faculty of PharmacyTehran University of Medical SciencesTehranIran

Objective:To investigate the effect of isoimperatorin on histopathological and biochemical changes in acetic acid-induced colitis ***:Colitis was induced by intracolonic administration of acetic acid solution(4%v/v)in *** were divided into six groups including the sham group,the negative control group,the dexamethasone-treated group,and the groups treated with isoimperatorin(0.1,1,and 10 mg/kg/d by gavage).The treatments were administered for three days and then colonic status was assessed by macroscopic,histopathological,and biochemical ***:Isoimperatorin significantly alleviated colonic damage in a dose-dependent manner and improved histological changes in rats with acetic acid-induced *** also significantly reduced myeloperoxidase,TNF-α,IL-1β,and malodialdehyde ***:Isoimperatorin alleviates acetic acid-induced colitis in rats and may be a potential therapeutic agent for the treatment of colitis.

关键词： Isoimperatorin Inflammatory bowel disease Acetic acid Colitis TNF-α IL-1β

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