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Autologous hematopoietic stem cell transplantation conditioning regimens and chimeric antigen receptor T cell therapy in various diseases

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World Journal of Transplantation 2024年第1期14卷 32-41页

作者： Shahzaib Maqbool Maryam Farhan Baloch Muhammad abdul Khaliq Khan Azeem Khalid Kiran Naimat Department of Medicine Holy Family HospitalRawalpindi 46000Pakistan Department of Community Medicine Allama Iqbal Medical CollegeLahore 45000Pakistan Department of Community Dentistry Baqai Medical UniversityKarachi 43000Pakistan Department of Medicine Allama lqbal Medical CollegeLahore 45000Pakistan Department of MedicineLiaquat University of Medical and Health Sciences Karachi 43000Pakistan

Conditioning regimens employed in autologous stem cell transplantation have been proven useful in various hematological disorders and underlying malignancies;however,despite being efficacious in various instances,negative consequences have also been *** conditioning regimens were extracted from various literature searches from databases like PubMed,Google scholar,EMBASE,and *** regimens for each disease were compared by using various end points such as overall survival(OS),progression free survival(PFS),and leukemia free survival(LFS).Variables were presented on graphs and analyzed to conclude a more efficacious conditioning *** multiple myeloma,the most effective regimen was high dose melphalan(MEL)given at a dose of 200/mg/*** comparative results of acute myeloid leukemia were presented and the regimens that proved to be at an admirable position were busulfan(BU)+MEL regarding OS and BU+VP16 regarding *** case of acute lymphoblastic leukemia(ALL),BU,fludarabine,and etoposide(BuFluVP)conferred good disease control not only with a paramount improvement in survival rate but also low risk of ***,for ALL,chimeric antigen receptor(CAR)T cell therapy was preferred in the context of better OS and *** respect to Hodgkin’s lymphoma,mitoxantrone(MITO)/MEL overtook carmustine,VP16,cytarabine,and MEL in view of PFS and vice versa regarding ***-Hodgkin’s lymphoma patients were administered MITO(60 mg/m2)and MEL(180 mg/m2)which showed promising ***,amyloidosis was considered,and the regimen that proved to be competent was MEL 200(200 mg/m2).This review article demonstrates a comparison between various conditioning regimens employed in different diseases.

关键词： Conditioning regimens Multiple myeloma Lymphoma Hodgkin Non-Hodgkin Acute leukemia

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A review of salivary composition changes induced by fasting and its impact on health

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Food Science and Human Wellness 2024年第1期13卷 50-64页

作者： Nurul Fadhilah Kamalul Aripin NIdayu Zahid Mohd Aizat abdul Rahim Hashim Yaacob Parvez I.Haris Zubaidah Haji AbdRahim Rauzah Hashim School of Chemical Engineering College of EngineeringUniversiti Teknologi MARAShah Alam 40450Malaysia Centre for Fundamental and Frontier Sciences in Nanostructure Self-Assembly Department of ChemistryFaculty of ScienceUniversiti MalayaKuala Lumpur 50603Malaysia Department of Oral and Craniofacial Sciences Faculty of DentistryUniversiti MalayaKuala Lumpur 50603Malaysia UMSC Dental Specialist Clinic UM Dentistry TowerUniversiti MalayaMedical CentreKuala Lumpur 50603Malaysia Leicester School of Allied Health Sciences De Montfort UniversityLeicester LE19BHUnited Kingdom Chancellery(Research and Innovation) Universiti MalayaKuala Lumpur 50603Malaysia

Human saliva is an indispensable fluid that maintains a healthy oral cavity which otherwise can lead to oral diseases(dental caries and periodontitis).In addition,salivary metabolites and microbiome profile provide early detection of systemic diseases such as cancer and *** diagnostic has gained popularity due to its non-invasive sampling ***(abstinence from food or drink or both)research for weight loss and improve health is common,but studies using fasting saliva are *** metabolites in fasting saliva have been reported with interesting results,which can be enhanced by considering different confounding *** example,fasting saliva contains higher salivary nitrite,which is related to nitric oxide(NO).NO is a vasodilator supporting the healthy function of endothelial cells and its deficiency is connected to many *** timely supply of NO through exogenous and endogenous means is highlighted and the potential advantage of fasting salivary composition changes in relation to COVID-19 infection is *** review aims to provide a general discussion on the salivary composition,properties,and functions of the whole saliva,including the health benefits of fasting.

关键词： Saliva Fasting Nitrate Nitrite Nitric oxide

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Navigating Biomedical Ethical Challenges of Artificial Intelligence in Healthcare

IJLAI Transactions on Science and Engineering

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IJLAI Transactions on Science and Engineering 2024年第2期2卷 29-35页

作者： Mirza abdul Aleem Baig Center for Biomedical Engineering School of Electronic Engineering and Information Science University of Science and Technology of China(USTC) HefeiAnhuiP.R.China

Biomedical ethics,commonly known as bioethics,constitutes a dynamic and interdisciplinary field that confronts the intricate ethical challenges and moral quandaries inherent at the convergence of medicine,healthcare,and the life *** foundation lies in the core principles of respect for autonomy,beneficence,non-maleficence,and justice,which collectively establish a robust framework for guiding ethical decisionmaking in the realm of clinical practice,research endeavors,and the formulation of healthcare *** principle of autonomy underscores the importance of respecting individuals’rights to make informed decisions about their own healthcare,while beneficence and non-maleficence emphasize the ethical obligation to promote well-being and prevent ***,in the context of biomedical ethics,demands the equitable distribution of resources and fair treatment for all *** ethics serves as an indispensable compass for healthcare professionals,researchers,policymakers,and society at large,providing ethical guidance to navigate the intricate landscape of advancements in medicine and the life sciences.

关键词： Biomedical ethics Autonomy underscores Non-maleficence

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Solving the Generalized Traveling Salesman Problem Using Sequential Constructive Crossover Operator in Genetic Algorithm

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Computer Systems Science & Engineering 2024年第5期48卷 1113-1131页

作者： Zakir Hussain Ahmed Maha Ata Al-Furhood abdul Khader Jilani Saudagar Shakir Khan Department of Mathematics and Statistics College of ScienceImam Mohammad Ibn Saud Islamic University(IMSIU)Riyadh11432Saudi Arabia Department of Computer Science College of Computer and Information SciencesJouf UniversitySakakah42421Saudi Arabia Information Systems Department Imam Mohammad Ibn Saud Islamic University(IMSIU)Riyadh11432Saudi Arabia College of Computer and Information Sciences Imam Mohammad Ibn Saud Islamic University(IMSIU)Riyadh11432Saudi Arabia

The generalized travelling salesman problem(GTSP),a generalization of the well-known travelling salesman problem(TSP),is considered for our *** the GTSP is NP-hard and very complex,finding exact solutions is highly expensive,we will develop genetic algorithms(GAs)to obtain heuristic solutions to the *** GAs,as the crossover is a very important process,the crossovermethods proposed for the traditional TSP could be adapted for the *** sequential constructive crossover(SCX)and three other operators are adapted to use in GAs to solve the *** effectiveness of GA using SCX is verified on some GTSP Library(GTSPLIB)instances first and then compared against GAs using the other crossover *** computational results show the success of the GA using SCX for this *** proposed GA using SCX,and swap mutation could find average solutions whose average percentage of excesses fromthe best-known solutions is between 0.00 and 14.07 for our investigated instances.

关键词： Generalized travelling salesman problem NP-hard genetic algorithms sequential constructive crossover swap mutation

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Development of a Novel Noise Reduction Algorithm for Smart Checkout RFID System in Retail Stores

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Computers, Materials & Continua 2024年第7期80卷 1277-1304页

作者： Shazielya Shamsul Mohammed A.H.Ali Salwa Hanim abdul-Rashid Atef M.Ghaleb Fahad M.Alqahtani Department of Mechanical Engineering Faculty of EngineeringUniversiti MalayaKuala Lumpur50603Malaysia Centre for Sustainable and Smart Manufacturing(CSSM) Faculty of EngineeringUniversiti MalayaKuala Lumpur50603Malaysia Department of Industrial Engineering College of EngineeringAlfaisal UniversityRiyadh11533Saudi Arabia Department of Industrial Engineering College of EngineeringKing Saud UniversityP.O.Box 800Riyadh11421Saudi Arabia

This paper presents a smart checkout system designed to mitigate the issues of noise and errors present in the existing barcode and RFID-based systems used at retail stores’checkout *** is achieved by integrating a novel AI algorithm,called Improved Laser Simulator Logic(ILSL)into the RFID *** enhanced RFID system was able to improve the accuracy of item identification,reduce noise interference,and streamline the overall checkout *** potential of the systemfor noise detection and elimination was initially investigated through a simulation study usingMATLAB and ILSL ***,it was deployed in a small-scale environment to validate its real-world *** show that RFID with the proposed new algorithm ILSL and AI basket is capable of accurately detecting the related itemswhile eliminating noise originating fromunrelated objects,achieving an accuracy rate of 88%.

关键词： Smart checkout system RFID technology improved laser simulator logic(ILSL) reduce noise checkout process

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Losartan Induced Angioedema, a Rare Case Report and the Dilemma of Using Angiotensin II Receptor Blockers in Patients with Previous Angioedema with Angiotensin Converting Enzyme Inhibitors

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Open Journal of Emergency Medicine 2024年第3期12卷 69-76页

作者： Sayani Banerjee abdul Sajjad Pathan Department of Emergency Medicine Weston General Hospital University of Bristol & Weston NHS Foundation Trust Weston Super Mare UK Department of Emergency Medicine Royal Surrey NHS Foundation Trust Guilford UK

Angiotensin Receptor Blockers (ARB) are used as an alternative of Angiotensin Converting Enzyme Inhibitors (ACEI) in patients where ACEIs cannot be used because of their known adverse effects, cough and angioedema. Thus ARB induced angioedema is considered to be a rare phenomenon and it is continued to be used as an alternatives of ACEIs. In this case report, we reported a case of 78-year-old gentleman who presented to emergency department with losartan, an ARB induced angioedema, who did not have history of any previous use of ACEIs. He was given steroids and antihistamine as a treatment. His angioedema resolved rapidly and he was discharged after six hours of emergency department (ED) observation with stable hemodynamically. We, the authors by reporting this case, wants to make clinicians aware ARB, however rarely, can cause angioedema, which can be life threatening if clinicians are not aware of it and diagnose and stop the offending drug promptly and treat it early.

关键词： Angioedema Airway Emergency Acute Presentation

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Comprehensive Review:Diagnosis,Classification,and Risk Factors of Peritoneal Dialysis-Associated Peritonitis

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Journal of Clinical and Nursing Research 2024年第7期8卷 1-9页

作者： Lingling Guo Sairah abdul Karim Post Graduate Centre Management&Science University40100 Shah AlamSelangorMalaysia School of Nursing Jiangsu Medical College224005 YanchengJiangsu ProvinceChina Faculty of Health and Life Sciences Management&Science University40100 Shah AlamSelangorMalaysia

Peritoneal dialysis(PD)is a predominant modality of renal replacement therapy(RRT)for individuals suffering from end-stage renal disease(ESRD).Peritoneal dialysis-associated peritonitis(PDAP)represents a frequent complication among patients undergoing PD,significantly contributing to adverse clinical *** review comprehensively examines the diagnosis,classification,and risk factors associated with PDAP,aiming to offer clinical practitioners essential guidance and a foundational framework for effective clinical management.

关键词： Research progress Risk factors Peritoneal dialysis-associated peritonitis

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Focus on current and emerging treatment options for glioma:A comprehensive review

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World Journal of Clinical Oncology 2024年第4期15卷 482-495页

作者： Brandon Lucke-Wold Burhanuddin Sohail Rangwala Muhammad Ashir Shafique mohammad Arham Siddiq Muhammad Saqlain Mustafa Fnu Danish Rana Muhammad Umer Nasrullah Noor Zainab abdul Haseeb Department of Neurosurgery University of FloridaGainesvilleFL 32608United States Department of Neurosurgery Jinnah Sindh Medical UniversityKarachi 75510Pakistan Department of Neurosurgery Army Medical CollegeRawalpindi 46000Pakistan

This comprehensive review delves into the current updates and challenges associated with the management of low-grade gliomas(LGG),the predominant primary tumors in the central nervous *** a general incidence rate of 5.81 per 100000,gliomas pose a significant global concern,necessitating advancements in treatment techniques to reduce mortality and *** review places a particular focus on immunotherapies,discussing promising agents such as Zotiraciclib and ***,a CDK9 inhibitor,has demonstrated efficacy in glioblastoma treatment in preclinical and clinical studies,showing its potential as a therapeutic ***,a viral immunotherapy,induces inflammation in glioblastoma and displays positive outcomes in both adult and pediatric *** of immunotherapy extends to Pembrolizumab,Nivolumab,and Entrectinib,revealing the challenges and variabilities in patient *** promising preclinical data,the monoclonal antibody Depatuxizumab has proven ineffective in glioblastoma treatment,emphasizing the critical need to understand resistance *** review also covers the success of radiation therapy in pediatric LGG,with evolving techniques,such as proton therapy,showing potential improvements in patient quality of *** treatment is discussed in the context of achieving a balance between preserving the patient’s quality of life and attaining gross total resection,with the extent of surgical resection significantly influencing the survival *** addition to advancements in cancer vaccine development,this review highlights the evolving landscape of LGG treatment,emphasizing a shift toward personalized and targeted *** research is essential for refining strategies and enhancing outcomes in the management of LGG.

关键词： Low-grade gliomas Monoclonal antibody Lerapolturev Glioblastoma CDK9 inhibitor

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The effects of selenium on the translation efficiency of selenoproteins Gpx1， Gpx4， and Txnrd1 in oxLDL-induced ***926 cells

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Food Science and Human Wellness 2024年

作者： Jiaqi Lu Jing Meng Yanzhi Lang abdul Rehman Yamei Yan Linwu Ran School of Public Health， Ningxia Medical University Key Laboratory of Environmental Factors and Chronic Disease Control Yinchuan School of Clinical Medicine， Ningxia Medical University Goji Berry Research Institute， Ningxia Academy of Agriculture and Forestry Sciences

Selenium is a crucial trace element that contributes to physiological processes in the body as selenoproteins. Selenoproteins serve as an integral role in the body in controlling the redox state of cells and protecting against damage induced by oxidative stress. This study aimed to investigate the effects and possible mechanism of selenium on selenoproteins expression in ***926 cells induced by oxLDL. The impact of selenium on the viability of ***926 cells was detected by the MTT method， and intracellular ROS level and mitochondrial membrane potential were assessed by fluorescent probe DCFH-DA and JC-1， respectively. RNA-seq， quantitative real-time PCR (RT-qPCR)， and western blot were used to investigate the selenoprotein expression. Selenoprotein mRNA translation efficiency was analyzed by ribosome profiling (Ribo-Seq) coupled with transcriptomics. Our data showed that selenium supplementation (0.5 μmol/L) significantly decreased ROS production， reduced mitochondrial inner membrane potential and increased the proliferative activity of ***926 cells induced by oxLDL. Moreover， The protective effects of selenium against oxLDL-induced ***926 cell injury were associated with the upregulation of the expressions of selenoproteins GPX1， GPX4， and TXNRD1. Furthermore， the expressions of selenoproteins GPX1 and GPX4 were hierarchically controlled， but the expressions of selenoproteins TXNRD1 were mainly regulated by oxLDL. Finally， Ribo-Seq coupled with transcriptomics results demonstrated that the expressions of selenoproteins GPX1， GPX4， and TXNRD1 were regulated at the translation process level. These findings suggested that selenium could have preventive effects in oxLDL induced ***926 cell injury by regulating the selenoprotein expression， and the selenoproteins expressions at the translation level in vascular endothelial cells need further study.

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A Comprehensive Classification and Analysis of Geomagnetic Storms Over Solar Cycle 24

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Research in Astronomy and Astrophysics 2024年第8期24卷 75-84页

作者： Raja Adibah Raja Halim Shah Nurul Shazana abdul Hamid Mardina abdullah Adlyka Annuar Idahwati Sarudin Zahira Mohd Radzi Akimasa Yoshikawa Department of Applied Physics Faculty of Science and TechnologyUniversiti Kebangsaan Malaysia43600 BangiMalaysia Space Science Centre(ANGKASA) Institute of Climate ChangeUniversiti Kebangsaan Malaysia43600 BangiMalaysia Department of Electrical Electronic and Systems EngineeringFaculty of Engineering and Built EnvironmentUniversiti Kebangsaan Malaysia43600 BangiMalaysia School of Physics Universiti Sains Malaysia11800 USMPulau PinangMalaysia Malaysian Space Agency(MYSA) Kuala Lumpur50480Malaysia International Research Center for Space and Planetary Environmental Science(i-SPES) Kyushu University819-0395 FukuokaJapan

A geomagnetic storm is a global disturbance of Earth?s magnetosphere,occurring as a result of the interaction with magnetic plasma ejected from the *** considerable research,a comprehensive classification of storms for a complete solar cycle has not yet been fully developed,as most previous studies have been limited to specific storm *** study,therefore,attempted to present complete statistics for solar cycle 24,detailing the occurrence of geomagnetic storm events and classifying them by type of intensity(moderate,intense,and severe),type of complete interval(normal or complex),duration of the recovery phase(rapid or long),and the number of steps in the storm?s *** analysis was applied to data from ground-based magnetometers,which measured the Dst index as provided by the World Data Center for Geomagnetism,Kyoto,*** study identified 211 storm events,comprising moderate(177 events),intense(33 events),and severe(1 event)*** 36%of ICMEs and 23%of CIRs are found to be geoeffective,which caused geomagnetic *** to four-step development of geomagnetic storms was exhibited during the main phase for this solar *** showed the geomagnetic storms developed one or more steps in the main phase,which were probably related to the driver that triggered the geomagnetic storms.A case study was additionally conducted to observe the variations of the ionospheric disturbance dynamo(Ddyn)phenomenon that resulted from the geomagnetic storm event of 2015July *** attenuation of the Ddyn in the equatorial region was analyzed using the H component of geomagnetic field data from stations in the Asian sector(Malaysia and India).The variations in the Ddyn signatures were observed at both stations,with the TIR station(India)showing higher intensity than the LKW station(Malaysia).

关键词： (Sun)sunspots-Sun activity-(Sun)solar-terrestrial relations-Sun coronal mass ejections(CMEs)

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