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How to manage rheumatoid arthritis according to classic biomarkers and polymorphisms？

Frontiers in Biology 2017年第3期12卷 183-191页

作者： Karim Mowla mohammad Amin Saki mohammad taha jalali Zeinab Deris Zayeri Golestan Hospital Clinical Research Development Unit Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran Sana Institute of Higher Education Mazandaran Sari Iran Department of Laboratory Sciences School of Para-medical science Jundishapur University of Medical Science Ahvaz Iran

OBJECTIVES： Single nucleotide polymorphisms （SNPs）, genetic background, and epigenetics play important roles in rheumatoid arthritis （RA）. These factors can be useful in RA diagnosis, prognosis, and treatment response evaluation, particularly with the growing trends in personalized medicine. Therefore, categorizing classic genes and SNPs in RA can present an appropriate guideline for RA management. DISCUSSION： Prognostic and diagnostic biomarkers play important roles in RA diagnosis and treatment. Categorizing SNPs is not an easy process yet, but selecting classic SNPs can be useful worldwide, according to basic similarities that exist in genomes. In this review, we compiled some of these RA-associated SNPs and biomarkers in a table, according to newly identified factors. The role of epigenetics in RA is undeniable; using epigenetic biomarkers like histone deacetylase （HDACs） can be useful in RA diagnosis and treatment, miRs such as miR-146a, miR-155, and miR-222 are useful in diagnosis and can be used in treatment by interfering with other factors＇ functions. Interleukins （ILs） seem to be good prognostic and diagnostic markers and can be targeted in RA treatment. CONCLUSION： Using multiple types of biomarkers, such as useful in RA management and treatment. PTPN22, HLA-DR genes, SNPs, and epigenetic biomarkers like HDACs can be polymorphisms, miRs, and HDACs are considerable in RA susceptibility; hence, they can be valuable biomarkers in future studies. This article gathered separate information from approximately 100 articles to present useful biomarkers and polymorphisms in one review.

关键词： polymorphism rheumatoid arthritis miRs HLA-DR epigenetics

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Threatening biomarkers in lupus pregnancy： Biochemistry and genetic challenges

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Frontiers in Biology 2018年第1期13卷 28-35页

作者： Karim Mowla Elham Rajaei mohammad taha jalali Zeinab Deris Zayeri Golestan Hospital Clinical Research Development Unit Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran Hyperlipidemia Research Center Diabetes Research Center Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran

OBJECTIVES： Using genetic markers and miRs work strongly beside other sensitive biomarkers in lupus management during sensitive period of pregnancy. METHOD： PubMed and Google Scholar databases were searched from 2000 to 2017 using the terms ＂lupus,＂＂lupus pregnancy, biomarkers,＂＂micro-RNA,＂＂polymorphisms,＂＂anti-phospholipid antibodies,＂ and ＂cluster differentiation markers,＂ DISCUSSION： Complement is a valuable biomarker in lupus pregnancy. However, the complement profile has ambiguous meaning because decreased levels of C3 and C4 reflect inflammation and because they are also prognostic biomarkers for abortion. Furthermore, increased C3 and C4 levels indicate hepatic protein synthesis in hepatocytes. Anti-phospholipid （APL） antibodies are present in 25% to 50% of lupus patients, and can lead to thrombotic and obstetric complications in some pregnancies and increase the risk of abortion, especially in a pregnant woman in the active phase of lupus. Several studies have associated APL with HELLP syndrome. However, other pregnancy complications have not been associated with APL. Autoantibodies against the major vault protein and anti-double strand DNA antibodies are valuable biomarkers in evaluating lupus activity. The expression pattern ofmicro-RNAs （miRs） differs in various diseases. Current studies have demonstrated the potential of miRs as diagnostic and prognostic biomarkers in various diseases; for example, the level of miR-126 is higher in lupus. CONCLUSION： miR-223-3p and miR-451 are informative biomarkers in estimating disease activity. TWEAK, BAFF, and APOL1 genes, and their polymorphisms are informative in estimating disease activity, especially renal effects, and in monitoring higher-risk pregnant women. Further studies of these genes and their relevant polymorphisms are needed.

关键词： lupus biomarker genetic micro-RNA anti-phospholipid antibodies

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Evaluation of protein Z plasma level in beta-thalassemia major patients in Ahvaz city in Iran

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Frontiers in Biology 2017年第6期12卷 442-447页

作者： mohammad taha jalali Abdorrahim Absalan Alireza Mohseni Gholam Abbas Kaydani Zeinab Deris Zayeri Department of Laboratory Sciences Hyperlipidemia Research Center Diabetes Research Center Jundishapur University of MedicalSciences Ahvaz Iran Shefa Neuroscience Research Center KhatamAlanbia Hospital Tehran Iran Blood Transfusion Research Center High Institute for Research and Education in Transfusion Medicine Tehran Iran Golestan Hospital Clinical Research Development Unit Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran

Thrombotic episodes occurred frequently in beta-thalassemia major (BTM) patients, leading to hypercoagulability of plasma. Protein Z (PZ) is a vitamin-K-dependent anti-coagulation factor that plays a role in the human homeostatic process. The objective of the current study is to investigate the distribution pattern of PZ plasma concentrations between BTM patients and the normal population in Ahvaz city, the center of Khuzestan province, southwest of Iran. Forty confirmed BTM patients and 40 healthy volunteers were evaluated for complete blood count (CBC) indices and PZ plasma levels. CBC samples were measured using an automated cell counter, and PZ was assayed with an immunoassay method. Statistical analysis was conducted using SPSS software. The ROC curve and binary logistic regression estimated the sensitivity, specificity, and Odd’s ratio for PZ measurement. The mean±SD of the PZ plasma level in normal individuals was 1.68±0.63 μg/mL, and in BTM patients, it was 1.10±0.52 μg/mL. This shows a significant reduction of PZ in BTM patients statistically (CI = 0.99; p<0.001). Further, the mean±SD of the PZ plasma levels in BTM patients who received washed red blood cells was not significantly different from that of patients undergoing packed red blood cell therapy (CI = 0.95; p = 0.320). The area under the curve (AUC) for PZ was 0.759 (p = 0.00). The cut-off value = 1.4 μg/mL of the PZ plasma level had at least 70% sensitivity and specificity in BTM patients. Several epidemiologic studies have shown thromboembolism episodes in BTM patients. In the current study, PZ was reduced significantly in BTMs. We noticed that BTMs have lower plasma PZ concentration might be predisposed to BTM.

关键词： major beta-thalassemia protein Z thrombosis immunoassay anti-coagulation factor

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Flavonoid-rich beverage effects on lipid profile and blood pressure in diabetic patients

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World Journal of Diabetes 2014年第6期5卷 962-968页

作者： Reza Amani Sara Moazen Hajieh Shahbazian Kambiz Ahmadi mohammad taha jalali Department of Nutrition School of ParamedicineDiabetes Research CenterJundishapour Univer-sity of Medical Sciences Diabetes Research Center Jundishapour University of Medical Sciences Department of Medical Statistics School of Public HealthJundishapour University of Medical Sciences Department of Laboratory Sciences School of ParamedicineJundishapour University of Medical Sciences

AIM: To compare freeze-dried strawberry(FDS) beverage and strawberry-flavored drink effects on lipid profile and blood pressure in type 2 diabetic(T2D) ***: In a randomized, double-blind, controlled trial, 36 subjects with T2D(23 females; mean ± SE age: 51.57 ± 10 years) were randomly divided into two groups. Participants consumed two cups of either pure FDS beverage(each cup containing 25 g freeze-dried strawberry powder equivalent to one serving of fresh strawberries; intervention group) or an iso-caloric drinkwith strawberry flavoring(similar to the FDS drink in fiber content and color; placebo group) daily for 6 wk. Anthropometric measurements, 3 d, 24 h dietary recall, and fasting blood samples were collected at baseline and at weeks 6 intervention. After lying down and relaxing for approximately 10 min, each participant's blood pressure was recorded in triplicate with 5 min intervals; recordings were made at baseline and the trial end-point. Each participant's lipid profile was assessed before and after ***: Assessment at the weeks 6 intervention showed a significant reduction from baseline in total cholesterol levels and total cholesterol to high-density lipoprotein cholesterol(HDL-C) ratio in the intervention group(179.01 ± 31.86 to 165.9 ± 32.4 mg/L; P = 0.00 and 3.9 ± 0.88 to 3.6 ± 0.082 mg/L; P = 0.00 respectively), but the change was not significantly different between the two groups(P = 0.07, P = 0.29 respectively). Systolic blood pressure levels were significantly reduced from baseline in both the FDS and placebo drink groups(129.95 ± 14.9 to 114.3 ± 27.5 mm Hg; P = 0.02 and 127.6 ± 15.6 to 122.9 ± 14.47 mm Hg; P = 0.00 respectively), but the reduction was not significantly different between the two groups. Diastolic blood pressure was significantly reduced post-intervention in the FDS drink group compared to placebo group(78.7 ± 7.2 vs 84.4 ± 5.8; P = 0.01), the reduction was also significant within the FDS drink group(84

关键词： placebo lipid baseline fasting drink dietary assessed participant serving cardiovascular

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