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Amelioration of paracetamol hepatotoxicity and oxidative stress on mice liver with silymarin and Nigella sativa extract supplements

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Asian Pacific Journal of Tropical Biomedicine 2015年第7期5卷 515-524页

作者： Reham Zakaria Hamza mohammad salem al-harbi Zoology Department Faculty of Science Zagazig University Biology Department Faculty of Science Taif University

Objective: To evaluate the ameliorator property of silymarin or/and Nigella sativa(N. sativa) extract against N-acetyl-p-aminophenol(APAP)-induced injury in male mice at the biochemical, histological and ultrastructural ***: The mice were divided into seven groups(10/group). The first group was served as control. While, the second group was treated with dose of APAP. The third and fourth groups were treated with silymarin alone and N. sativa extract alone respectively. The fifth and sixth groups were treated with combination of APAP with silymarin and APAP with N. sativa extract respectively. The seventh group was treated with combination of both ameliorative compounds(silymarin and N. sativa extract) with APAP and all animals were treated for a period of 30 days. Results: Exposure to APAP at the treated dose to mice led to an alteration of liver functions, increased the alanine transaminase, aspartate aminotransferase and lactate dehydrogenase levels, decreased total protein level as well as the increasing the superoxide dismutase and malondialdehyde while decreased catalase, glutathione peroxidase and glutathione reduced activities. The effects of APAP on the biochemical parameters of mice were dose-dependent. Administration of silymarin or/and N. sativa extract to APAP-treated mice attenuates the toxicity of this compound, objectified by biochemical, histological and ultrastructural improvement of liver. But the alleviation was more pronounced with the both antioxidants. Conclusions: The synergistic effect of silymarin and N. sativa extract is the most powerful in reducing the toxicity induced by APAP and improving the liver functions and antioxidant capacities of mice.

关键词： Paracetamol Silymarin Nigella sativa extract Liver function

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Occupational health risks among healthcare workers during the COVID-19 pandemic in Saudi Arabia: preparing for the future pandemics

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Nursing Communications 2024年第2期8卷 1-5页

作者： Reham Suliman al Kharyef Aisha ali al harbi Mohammed Abdelhamied Genedy Mohamed K.M.Khalil Suliman Mohamed al Eidi Ministry of Health Riyadh 13352Saudi Arabia Consultant Public Health and Research Development.Cairo 11728 Egypt

Background:This study aimed to assess the occupational risks encountered by Healthcare Workers(HCWs)in Saudi Arabia during the COVID-19 ***:A cross-sectional survey was carried out from May to October *** a multi-stage stratified random sampling technique,an online questionnaire was sent to the recruited HCWs,across Saudi ***:Of the 768 HCWs recruited,702 participated in the survey.A significant majority(over 80%)reported working beyond 8 hours ***-19 infection,confirmed via PCR,was identified in 25%of the ***,infection was significantly correlated with direct or close contact(p=0.0007).Psychological distress was reported by 81%,with anxiety being the most prevalent(33%),followed by stress(19%),depression(17%),and insomnia(12%).Around 20%experienced headaches post-PPE use,while 14%reported adverse skin reactions,predominantly allergy and dermatitis.A concerning one-third of respondents reported exposure to ***:High infection rate,physical and psychological risks among HCWs especially those in direct contact with patients,reflect the need for enhancing the entirety of outbreak preparedness and response,specifically *** surveillance system,is crucial to adequately monitor and support HCWs during pandemic scenarios.

关键词： COVID-19 pandemic healthcare worker risk Saudi Arabia

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Chaotic Krill Herd with Deep Transfer Learning-Based Biometric Iris Recognition System

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Computers, Materials & Continua 2022年第12期73卷 5703-5715页

作者： harbi al-Mahafzah Tamer AbuKhalil Bassam A.Y.alqaralleh Department of Computer Science Faculty of Information TechnologyAl-Hussein Bin Talal University Ma’an71111Jordan MIS Department College of Business AdministrationUniversity of Business and TechnologyJeddah21448Saudi Arabia

Biometric verification has become essential to authenticate the individuals in public and private *** several biometrics,iris has peculiar features and its working mechanism is complex in *** recent developments in Machine Learning and Deep Learning approaches enable the development of effective iris recognition *** this motivation,the current study introduces a novel Chaotic Krill Herd with Deep Transfer Learning Based Biometric Iris Recognition System(CKHDTL-BIRS).The presented CKHDTL-BIRS model intends to recognize and classify iris images as a part of biometric *** achieve this,CKHDTL-BIRS model initially performs Median Filtering(MF)-based preprocessing and segmentation for iris *** addition,MobileNetmodel is also utilized to generate a set of useful feature ***,Stacked Sparse Autoencoder(SSAE)approach is applied for *** last,CKH algorithm is exploited for optimization of the parameters involved in SSAE *** proposed CKHDTL-BIRS model was experimentally validated using benchmark dataset and the outcomes were examined under several *** comparison study results established the enhanced performance of CKHDTL-BIRS technique over recent approaches.

关键词： Biometric verification iris recognition deep learning parameter tuning machine learning

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Development of PCCNN-Based Network Intrusion Detection System for EDGE Computing

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Computers, Materials & Continua 2022年第4期71卷 1769-1788页

作者： Mohd Anul Haq Mohd Abdul Rahim Khan Talal al-harbi Department of Computer Science College of Computer and Information SciencesMajmaah UniversityAl-Majmaah 11952Saudi Arabia

Intrusion Detection System(IDS)plays a crucial role in detecting and identifying the DoS and DDoS type of attacks on IoT ***,anomaly-based techniques do not provide acceptable accuracy for efficacious intrusion ***,we found many difficulty levels when applying IDS to IoT devices for identifying attempted *** this background,we designed a solution to detect intrusions using the Convolutional Neural Network(CNN)for Enhanced Data rates for GSM Evolution(EDGE)*** created two separate categories to handle the attack and non-attack events in the *** findings of this study indicate that this approach was significantly *** attempted both multiclass and binary *** the case of binary,we clustered all malicious traffic data in a single ***,we developed 13 layers of Sequential 1-D CNN for IDS detection and assessed them on the public dataset *** Component Analysis(PCA)was implemented to decrease the size of the feature vector based on feature extraction and *** approach proposed in the current investigation obtained accuracies of 99.34%and 99.13%for binary and multiclass classification,respectively,for the NSL-KDD *** experimental outcomes showed that the proposed Principal Component-based Convolution Neural Network(PCCNN)approach achieved greater precision based on deep learning and has potential use in modern intrusion detection for IoT systems.

关键词： IDS edge computing machine learning NSL-KDD IoT

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Conocarpus Biochar Induces Changes in Soil Nutrient Availability and Tomato Growth Under Saline Irrigation

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Pedosphere 2016年第1期26卷 27-38页

作者： Adel Rabie A.USMAN mohammad I.al-WABEL Yong S.OK Abdulaziz al-harbi Mahmoud WAHB-alLAH Ahmed Hamdy EL-NAGGAR Mahtab AHMAD Abdulelah al-FARAJ Abdulrasoul al-OMRAN Soil Sciences Department College of Food Agricultural SciencesKing Saud UniversityP.O.Box 2460Riyadh 11451(SaudiArabia) Department of Soils and Water Faculty of AgricultureAssiut UniversityAssiut 71526(Egypt) Korea Biochar Research Center Kangwon National UniversityChunehon 200-701(Korea) lant Production Department College of Food and Agricultural SciencesKing Saud UniversityP.O.Box 2460Riyadh 11451(Saudi Arabia) Vegetable Crops Department Faculty of AgricultureAlexandria UniversityAlexandria 21321(Egypt) Department of Soil Science Faculty of AgricultureAin Shams University68 HadayekShobraP.O.Box 11241Cairo 11241(Egypt) Agricultral Engineering Department College of Food&Agricultural SciencesKing Saud UniversityP.O.Box 2460Riyadh 11451(Saudi Arabia)

Thermally modified organic materials commonly known as biochar have gained popularity of being used as a soil *** information, however, is available on the role of biochar in alleviating the negative impacts of saline water on soil productivity and plant growth. This study, therefore, was conducted to investigate the effects of Conocarpus biochar(BC) and organic farm residues(FR) at different application rates of 0.0%(control), 4.0% and 8.0%(weight/weight) on yield and quality of tomatoes grown on a sandy soil under drip irrigation with saline or non-saline water. The availability of P, K, Fe, Mn, Zn and Cu to plants was also investigated. The results demonstrated clearly that addition of BC or FR increased the vegetative growth, yield and quality parameters in all irrigation treatments. It was found that salt stress adversely affected soil productivity, as indicated by the lower vegetative growth and yield components of tomato plants. However, this suppressing effect on the vegetative growth and yield tended to decline with application of FR or BC, especially at the high application rate and in the presence of biochar. Under saline irrigation system, for instance, the total tomato yield increased over the control by 14.0%–43.3% with BC and by 3.9%–35.6% with FR. These could be attributed to enhancement effects of FR or BC on soil properties, as indicated by increases in soil organic matter content and nutrient availability. Therefore, biochar may be effectively used as a soil amendment for enhancing the productivity of salt-affected sandy soils under arid conditions.

关键词： drip irrigation organic farm residues organic matter content salt stress sandy soils soil amendment soil productivity

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Preliminary Comparative Physiological and Biochemical Study of Five Different Goat Breeds Inhabiting Saudi Arabia

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Natural Resources 2012年第4期3卷 206-212页

作者： Mohammed salem al-harbi Sayed Amin Mohamed Amer Department of Biology Faculty of Science Taif University Taif Saudi Arabia Department of Biology Faculty of Science Taif University Taif Saudi Arabia Department of Zoology Faculty of Science Cairo University Giza Egypt

Three arbitrary chosen enzymes were examined by native-polyacrylamide gel electrophoresis to investigate physiological and genetic variations among five different goat breeds inhabiting Saudi Arabia. The goat breeds were Pakistani, Tihami, Syrian, Masri and Aardi while the investigated enzymes were alkaline phosphatase (alP), malate dehydrogenase (Mdh) and malic enzyme (ME). Six polymorphic loci with six monomeric alleles have been recorded in all studied breeds. The second locus of ME was characteristic of Syrian breed where it showed dimeric alleles. The similarity matrix that has been calculated according to the number of sharing bands indicated that these breeds have been divided into two groups: Pakistani and Tihami as one group while the other three breeds clustered in another group. The activity of the metabolic enzymes (Mdh and ME) showed concordance with the constructed relationship where the percentage amounts of these enzymes showed significant variations between the two groups more than that occurred within each group. Mdh was expressed in the second group more than in the first while ME showed, nearly, equal expression in the different breeds. Both genetic and physiological results agreed in clustering the studied breeds into Pakistani and Tihami in one group and the other three breeds in another group. This division was based on a few gene loci and a few sampling size and it needs to be supported by collecting more genetic data and more sampling size in a further molecular study.

关键词： Goat Breeds Electrophoresis Isoenzymes Physiology Saudi Arabia

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Blood Consumption in Placental Abnormalities

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Open Journal of Obstetrics and Gynecology 2022年第10期12卷 1092-1101页

作者： Mufareh Asiri salem al Suwaidan Nawal al harbi Abuobeida Ahmed Reem alanazi Razan al harbi Najla al Ajmi Maternity Hospital King Saud Medical City Riyadh KSA Research Center King Saud Medical City Riyadh KSA

Introduction: Hemorrhage is one of the most common causes of maternal morbidity and mortality. This study was conducted to investigate how much abnormal placentation can affect blood bank capacity and to measure the burden on the blood bank caused by excessive use of blood and blood products. Methodology: This is a retrospective study conducted at King Saud Medical City Maternity Hospital in Riyadh, Kingdom of Saudi Arabia, from January 2019-September 2020. It includes 170 cases diagnosed with abnormal placentation (low-lying placenta or placenta previa, accreta, increta, or percreta). The primary purpose was to measure consumption of blood and blood products in cases of placental abnormalities and to investigate how much this affects blood bank capacity. A secondary aim was to report rates of admission to the ICU and maternal mortality. Results: This study included 170 women with placental abnormalities. Placental previa had occurred in 96 cases, followed by placenta accreta in 46 cases, placenta increta in 13 cases, placenta percreta in 8 cases, and low-lying placenta in 7 cases. Most patients (93) were treated with a Bakri balloon to prevent hemorrhage, but 38 patients had a hysterectomy. The average estimation of blood loss was 2210 ml, with no maternal mortality. An average of 3.39 units of packed red blood cells (PRBC) with a maximum of 20 units, 2.12 units of fresh frozen plasma (FFP) with a maximum of 20 units, and 0.7 units of packed platelets (PP) with maximum of 12 units consumed per patient. Eighty-seven patients (51.2%) were admitted to the ICU and 83 others (48.8%) were admitted to the high dependency unit. Conclusion: Blood and blood product volumes had a linear relationship with the severity of placental abnormalities and estimated blood loss. Therefore, blood bank services should be available to save mothers’ life.

关键词： Placenta Previa Placenta Accreta Spectrum (PAS) Hemorrhage Maternal Mortality Hysterectomy

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Tissue-Specific Isoenzyme Variations in Tilapia Fish, <i>Oreochromis niloticus</i>

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Natural Resources 2012年第4期3卷 201-205页

Native polyacrylamide gel electrophoresis have been used to analyze malate dehydrogenase (MDH), acid phosphatase (Acph) and peroxidase (Px) isoenzymes in different tissues (liver, kidney, muscle and heart) of the tilapia fish, Oreo- chromis niloticus in order to study the tissue specificity of these isoenzymes. Three, two and one fractions have been recorded respectively for the three isoenzymes in different studied tissues. The MDH-1 and MDH-2 have been ex- pressed only in muscle and heart while MDH-3 has been expressed in all studied tissues. The percentage amount of MDH in general varied significantly between muscle and different studied tissues. With respect to acid phosphatase, the percentage amount of the total enzyme showed significant difference between liver and muscle and that this variation may be due to higher gene activity in liver. Peroxidase isoenzyme was recorded in liver and heart only with significant increase in liver. The kidney was the least among the studied tissues in showing gene expression for the studied isoenzymes and therefore, liver, heart and muscle tissues are better applicable in studying the isoenzymatic profiles for fish physiology and systematics.

关键词： Oreochromis niloticus Malate Dehydrogenase Acid Phosphatase Peroxidase Isoenzymes

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Direct Power Control Based on Dead-beat Function and Extended Kalman Filter for PV Systems

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Journal of Modern Power Systems and Clean Energy 2023年第3期11卷 863-872页

作者： Mostafa Ahmed Ibrahim harbi Ralph Kennel Mohamed Abdelrahem Chair of High-Power Converter Systems(HLU) Technical University of Munich(TUM)80333 MunichGermany Department of Electrical Engineering Faculty of EngineeringAssiut UniversityAssiut 71515Egypt Department of Electrical Engineering Faculty of EngineeringMenoufia UniversityShebin El-Koum 32511Egypt IEEE

In this paper,a new proposal for the implementation of the well-known direct power control(DPC)technique in grid-connected photovoltaic(PV)systems is ***,the DPC is executed using a look-up table procedure based on the error between the actual and reference values of the active and reactive ***,the structure of the DPC is simple and results in a fast transient behavior of the inner current loop(injected currents).Therefore,in the current study,the DPC is reformulated using a dead-beat *** this formulation,the reference voltage vector(RVV)is obtained in theα-βreference ***,the switching states for the inverter can be obtained based on the sign of the components of the *** suggested DPC is compared with the conventional one and other switching tables,which are intended for performance ***,an extended Kalman filter(EKF)is utilized to eliminate all grid-voltage ***,the switching frequency of the proposed technique is minimized without any need for weighting factors or cost function *** overall control technique is validated using a hardware-in-the-loop(HIL)experimental set-up and compared with other schemes under different operating conditions.

关键词： Photovoltaic(PV)system direct power control(DPC) sensorless control switching frequency minimization weighting factor

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Selenium Nanoparticles Ameliorative Effect on Acetaminophen Hepatotoxicity in Male Mice

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Natural Science 2017年第7期9卷 207-215页

作者： mohammad S. al-harbi Sayed A. M. Amer Department of Biology Faculty of Science Taif University Taif Saudi Arabia College of Forensic Sciences Naif Arab University for Security Sciences Riyadh Saudi Arabia Zoology Department Faculty of Science Cairo University Giza Egypt

Selenium nanoparticles (SeNPs) have been widely used as anti-inflammatory and anti-toxic agent. The present study used Bacillus tequilensis for biosynthesizing SeNPs from sodium selenite (Na2SeO3) and investigated its ameliorative effects on acetaminophen (APAP) hepatotoxicity in male mice. The results indicated that alanine transaminase (alT), aspartate aminotransferase (AST) and alkaline phosphatase (alP) significantly elevated in mice treated with APAP, while other liver markers (total proteins and albumin) did not change. SeNPs either alone or in combination with APAP showed ameliorative effects on liver enzymes to some extents where their activities decreased to be insignificant with those of normal group. A slight variation was shown in total antioxidant capacity (TAC). Histopathologically, the hepatocytes of the mice treated with APAP showed cloudy swelling and vacuolar degeneration, while those treated with SeNPs or both SeNPs and APAP appeared more or less histologically normal. In conclusion, SeNPs can be used to improve or replace today’s therapies of APAP hepatotoxicity.

关键词： SeNPs Mice APAP Hepatotoxicity Antioxidant

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