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Assessment of circulating levels of microRNA-326,microRNA-424,and microRNA-511 as biomarkers for hepatocellular carcinoma in Egyptians

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World Journal of Hepatology 2022年第8期14卷 1562-1575页

作者： Samar Samir Youssef Asmaa Elfiky Mohamed M Nabeel Hend Ibrahim Shousha Tamer Elbaz Dalia Omran mohammad saeed marie mohammad A Elzahry Amr Abul-Fotouh Ahmed Hashem Mohamed F Guda Ashraf O Abdelaziz Department of Microbial Biotechnology National Research CentreCairo 1211Egypt Department of Environmental and Occupational Medicine National Research CentreCairo 1211Egypt Department of Endemic Medicine and Hepatogastroenterology Faculty of MedicineCairo UniversityCairo 11562 Egypt Department of Endemic Medicine Faculty of MedicineCairo UniversityCairo 1256Egypt Theodor Bilharz Research Institute Cairo 1256Egypt

BACKGROUND Hepatocellular carcinoma(HCC)is the fifth most common *** expression of microRNAs(miRNAs)-326,miRNA-424,and miRNA-511 has been associated with the diagnosis and prognosis of HCC in different ***,limited information is available regarding their expression in Egyptian HCC *** To assess the role of circulating miRNAs-326,miRNA-424,and miRNA-511 in Egyptian HCC *** This prospective observational study included 70 HCC patients and 25 healthy *** circulating levels of these three miRNAs were evaluated by real-time *** operating characteristic curve analysis was used to test the diagnostic accuracy of micro RNA expression *** All miRNAs were differentially expressed in HCC patients;miRNAs326 and miRNA-424 were upregulated,while miRNA-511 was *** miRNA-326 and miRNA-424 showed sensitivity and specificity of 97%,71.4%,and 52%,60%,respectively,to differentiate HCC from ***,miRNA-326 was associated with survival and could differentiate between Child grades(A vs B);miRNA-424 significantly differentiated early vs intermediate stages of HCC;while miRNA-511 was significantly correlated with response to modified Response Evaluation Criteria in Solid Tumors(m RECIST).CONCLUSION We conclude that miRNA-326,miRNA-424,and miRNA-511 have diagnostic and prognostic roles in Egyptian patients with hepatitis C virus-related HCC and should be considered for better disease management.

关键词： Hepatocellular carcinoma miRNAs-326 miRNA-424 miRNA-511 Modified response evaluation criteria in solid tumors

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A Unified Optimization-Based Framework to Adjust Consensus Convergence Rate and Optimize the Network Topology in Uncertain Multi-Agent Systems

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IEEE/CAA Journal of Automatica Sinica 2021年第9期8卷 1539-1548页

作者： mohammad saeed Sarafraz mohammad Saleh Tavazoei Department of Electrical Engineering Sharif University of TechnologyTehran 11365-9363Iran

This paper deals with the consensus problem in an uncertain multi-agent system whose agents communicate with each other through a weighted undirected(primary)*** considered multi-agent system is described by an uncertain state-space model in which the involved matrices belong to some matrix *** the main contribution of the paper,a unified optimization-based framework is proposed for simultaneously reducing the weights of the edges of the primary communication graph(optimizing the network topology)and synthesizing a controller such that the consensus in the considered uncertain multi-agent system is ensured with an adjustable convergence *** the NP-hardness nature of the optimization problem related to the aforementioned framework,this problem is relaxed such that it can be solved by regular LMI ***/practical-based examples are presented to verify the usefulness of the obtained results.

关键词： Convergence-rate element-wise uncertainty robust controller topology design

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Vulnerability of ordinary moment resistant concrete frames

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Earthquake Engineering and Engineering Vibration 2011年第4期10卷 519-533页

作者： mohammad Barkhordary saeed Tariverdilo Department of Civil Eng. Faculty of Eng.Urmia University

The effects of structural modeling （bar slip in lap splice）, ground motion selection process （epsilon effect） and size of a structure （number of bays and stories） on the fragility of reinforced concrete ordinary moment resisting frames are investigated. An analytical model is developed to account for bar slip in lap splice, which exhibits good correlation with existing experimental data. Then, incremental dynamic analysis is used to derive the fragility curves for four model structures. The model structures simulate frames with a different number of bays and stories. Finally, the fragility curves are corrected for the epsilon effect. The results show that slip in the lap splice can significantly increase the failure probability, especially for the collapse prevention limit state. At the same time, it is found that spectral shape has a significant impact on the fragility curves. It is also found that accounting for or ignoring bar slip or epsilon effects increases the probability of failure for larger structures. This indicates an unconservative bias in the safety of larger structures.

关键词： lap-splice slip incremental dynamic analysis fragility curve epsilon effect

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RAPID AND FACILE SYNTHESIS OF ACYL AZIDES FROM ACYL HALIDES USING A POLYMER-SUPPORTED AZIDE ION UNDER HETEROGENEOUS CONDITIONS

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Chinese Journal of Polymer Science 2013年第7期31卷 1002-1010页

作者： mohammad Ali Karimi Zarchi saeed Barani Department of Chemistry College of SciencesYazd University

In this article a rapid and facile method for synthesis of acyl azide is described. The cross-linked poly（N-methyl-4- vinylpyridinium） azide ion, [Pa-VP]N3 is prepared and used as an efficient polymeric reagent for synthesis of acyl azides from acyl halides at room temperature under heterogeneous conditions. Various benzoyl halides, with electron-withdrawing groups as well as electron-donating groups, were transformed into the corresponding benzoyl azides in high to excellent yields in short reaction times. The acyl azide products were characterized by FT-IR, and some of them were also characterized by IH- and/or 13C-NMR spectroscopy, and physical properties were compared to literature values of known compounds. The spent polymeric reagents can be regenerated and reused for several times without losing their activity. Relative to the reported methods, the present method has the advantages of operational simplicity, mild reaction conditions, fast reaction rates, simple reaction work-up and lower hazardous and potentially explosive nature. Also the present method is the first procedure for the synthesis of acyl azides from acyl halides by using a polymer-supported azide ion under heterogeneous conditions.

关键词： Acyl azide Acyl halide Polymeric reagent Heterogeneous condition.

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Hydrothermal synthesis and physicochemical characterization of CuO/ZnO/Al_2O_3 *** I:Effect of crystallization time

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Particuology 2012年第6期10卷 729-736页

作者： saeed Saedy mohammad Haghighi Mahsa Amirkhosrow Chemical Engineering Department Sahand University of TechnologyP.O.Box 51335-1996Sahand New TownTabrizIran Reactor and Catalysis Research Center Sahand University of TechnologyP.O.Box 51335-1996Sahand New TownTabrizIran

A hydrothermal method was successfully used for synthesis of CuO/ZnO/AI203 （CZA） nanopowder with atomic ratio of 6：3：1. The effect of crystallization time （3, 6, 9, and 12 h） on physicochemical properties of nanopowder was investigated. Nanopowders were characterized using XRD, FESEM, EDX, FTIR, TG, and BET techniques. The XRD patterns confirmed metal oxides formation and their good crystallinity with average crystallite size of 20nm as obtained by the Scherrer equation. Relative crystallinity was shown to increase with increasing crystallization time. In agreement with XRD results, FESEM images also illustrated nanosized particles. EDX mapping indicated homogenous dispersion of elements. BET specific surface area analysis showed acceptable surface area for CZA nanopowder, FTIR spectroscopy confirmed metal oxides formation during hydrothermal and calcination processing. TG results illustrated high thermal stability of the synthesized nanopowders. TG-DTG and FTIR analyses were used to propose a reaction mechanism for nanopowder formation during processing. Physicochemical characterization showed optimal crystallization time to be 6 h.

关键词： ZnO CuO Al2O3 Mixed oxides Nanopowder Hydrorhermal

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Particle agglomeration and interphase interactions affect Young’s modulus of nanobiocomposites:eyes at mathematical modeling

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Acta Mechanica Sinica 2024年第9期40卷 10-21页

作者： Pooriya Sarrami mohammad Rafienia saeed Karbasi Student Research Committee School of Advanced Technologies in MedicineIsfahan University of Medical SciencesIsfahan 81746-73461Iran Biosensor Research Center Isfahan University of Medical SciencesIsfahan 81746-73461Iran Department of Biomaterials Nanotechnology and Tissue EngineeringSchool of Advanced Technologies in MedicineIsfahan University of Medical SciencesIsfahan 81746-73461Iran

Computational modeling is a new approach to optimize Young’s modulus of scaffolds by performing a minimal number of ***,presenting a modeling algorithm to predict Young’s modulus and characterize the governing parameters is a challenging ***,a novel modeling approach has been proposed to estimate Young’s modulus of scaffolds,considering particle agglomeration and interphase *** the characteristic parameters of these two phenomena,we modified the Maxwell model using a simple three-step algorithm to determine the optimal value of these parameters and predict Young’s ***,the model provides a precision of more than 95%for all the studied cases and presents a remarkably better performance compared to the two other *** instance,the proposed model has reduced the average absolute relative error of Young’s modulus of poly(3-hydroxybutyrate)-keratin/hydroxyapatite nanorods from 25.1%to 0.08%,demonstrating the high efficiency of this model in predicting Young’s modulus of *** results of this study could lighten the way of fabricating nanobiocomposites with optimal mechanical properties,spending lower cost and energy.

关键词： Predictive models Mechanical properties Polymer nanocomposites Particle agglomeration Bone tissue engineering

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Effect of chemical activation process on adsorption of As(V) ion from aqueous solution by mechano-thermally synthesized zinc ferrite nanopowder

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International Journal of Minerals,Metallurgy and Materials 2020年第4期27卷 526-537页

作者： mohammad Sefidmooy Azar Shahram Raygan saeed Sheibani School of Metallurgy and Materials Engineering College of EngineeringUniversity of TehranTehranIran

Nanostructured ZnFe2O4 was synthesized by the heat treatment of a mechanically activated mixture of ZnO/α-Fe2O3.X-ray diffraction(XRD)and differential thermal analysis(DTA)results demonstrated that,after 5 h of the mechanical activation of the mixture,ZnFe2O4 was formed by heat treatment at 750°C for 2 *** improve the characteristics of ZnFe2O4 for adsorption applications,the chemical activation process was *** 2 h chemical activation with 1 mol·L?1 HNO3 and co-precipitation of 52%?57%dissolved ZnFe2O4 led to an increase in the saturated magnetization from 2.0 to 7.5 emu·g?1 and in the specific surface area from 5 to 198 m2·g?*** addition,the observed particle size reduction of chemically activated ZnFe2O4 in field emission scanning electron microscopy(FESEM)micrographs was in agreement with the specific surface area *** improvements in ZnFe2O4 characteristics considerably affected the adsorption performance of this *** results revealed that mechano-thermally synthesized ZnFe2O4 had the maximum arsenic adsorption of 38%with the adsorption capacity of 0.995 mg·g?1 in a 130 mg·L?1 solution of As(V)after 30 min of ***,chemically activated ZnFe2O4 showed the maximum arsenic adsorption of approximately 99%with the adsorption capacity of 21.460 mg·g?1 under the same *** results showed that the weak adsorption performance of mechano-thermally synthesized ZnFe2O4 was improved by the chemical activation process.

关键词： zinc ferrite mechano-thermal chemical activation adsorption arsenic(V)

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An optimization model for synchronous road geometric and pavement enhancements

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Journal of Traffic and Transportation Engineering(English Edition) 2021年第3期8卷 421-438页

作者： mohammad Mahanpoor saeed Monajjem Vahid Balali Department of Civil Engineering K.N.Toosi University of TechnologyTehranIran Department of Civil Engineering and Construction Engineering Management California State UniversityLong BeachCA 90840USA

A synchronous optimization model for rehabilitation of existing two-way two-lane(TWTL)highways is proposed in this paper considering geometric modification and existing pavement rehabilitation. The rehabilitation process of existing roadways is categorized into geometric design modifications and pavement repairs. These two types of modification apply separately in roadway life-cycle because of the difference in nature of these repairs, which impose an extra cost and time of closure to road users and owners. This paper aims to address the modification of existing highways by a new approach linking the existing pavement condition and geometric configuration changes of the developed roadway to provide the optimum vertical alignment. The proposed procedure depends on various parameters of existing pavement condition, cross-section configuration, traffic volume and composition, and current alignment composure. In the first step, all these dependencies are explained and quantified with separate cost models. For each solution,the overall cost is calculated with a life-cycle cost analysis approach. Finally, a particle swarm optimization(PSO) based model is developed to find the optimum solution. The developed model was applied in two case studies with good and adverse geometric conditions. The results show that there is a critical condition in the roadway segments which have all these conditions:(1) the grade is more than three percent,(2) the grade is following with reverse grade, and(3) decommissioning of the asphalt concrete(or extended to lower layers) exist. The optimum solution in these critical conditions suggests the modification of the geometric configuration before the pavement rehabilitation in order to reduce the overall cost. In the absence of these conditions, the optimum alignment is more analogous with the existing alignment of the highway.

关键词： Transportation engineering Geometric modification Pavement rehabilitation Optimization Sustainability Safety

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Optimal PD/PID control of smart base isolated buildings equipped with piezoelectric friction dampers

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Earthquake Engineering and Engineering Vibration 2013年第1期12卷 39-54页

作者： Sadegh Etedali mohammad Reza Sohrabi saeed Tavakoli .Department of Civil Engineering Faculty of EngineeringUniversity of Sistan and Baluchestan Department of Civil Engineering Faculty of EngineeringUniversity of Sistan and Baluchestan Faculty of Electrical and Computer Engineering University of Sistan and Baluchestan

Long-period pulses in near-field earthquakes lead to large displacements in the base of isolated *** dissipate energy in isolated structures using semi-active control,piezoelectric friction dampers（PFD） can be *** performance of a PFD is highly dependent on the strategy applied to adjust its contact *** this paper,the seismic control of a benchmark isolated building equipped with PFD using PD/PID controllers is *** genetic algorithms,these controllers are optimized to create a balance between the performance and robustness of the closed-loop structural *** advantage of this technique is that the controller forces can easily be *** addition,the structure is equipped with only a single sensor at the base floor to measure the base *** seven pairs of earthquakes and nine performance indices,the performance of the closed-loop system is ***,the results are compared with those given by two well-known methods：the maximum possive operation of piezoelectric friction dampers and LQG *** simulation results show that the proposed controllers perform better than the others in terms of simultaneous reduction of floor acceleration and maximum displacement of the ***,they are able to reduce the displacement of the isolator systems for different earthquakes without losing the advantages of isolation.

关键词： seismic isolation semi-active control piezoelectric friction dampers PD/PID controllers

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Characterization of porous Ti-bioglass composite produced by mechanical milling and space holder sintering

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Rare Metals 2015年第9期34卷 638-644页

作者： saeed Riahi mohammad Rajabi Sayed Mahmood Rabiee Department of Mechanical Engineering Babol Noshirvani University of Technology

In this study, porous titanium-10 wt% bioglass(BG) composites were fabricated by the process of combining mechanical alloying with space holder sintering. The pore morphology and phase constituents of the milled powders and porous compacts were characterized by scanning electron microscopy(SEM), X-ray diffractometry(XRD), and Fourier transform infrared spectroscopy(FT-IR). The mechanical properties were determined by running compression test. The porosity of the sintered samples shows a downward trend with the increase of milling time. As the porosity increases, both the compressive strength and elastic modulus decrease. The results illustrate that the fabricated porous compacts with high porosity and suitable mechanical properties have the potential application in bone tissue engineering.

关键词： Titanium Bioglass Porous material Mechanical milli

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