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Cellulose-based composite scaffolds for bone tissue engineering and localized drug delivery

Bioactive Materials 2023年第2期20卷 137-163页

作者： Mahsa Janmohammadi Zahra Nazemi Amin Orash Mahmoud Salehi Amir Seyfoori Johnson V.John mohammad sadegh nourbakhsh Mohsen Akbari Faculty of New Sciences and Technologies Semnan UniversitySemnanP.O.Box:19111-35131Iran Laboratory for Innovations in Micro Engineering(LiME) Department of Mechanical EngineeringUniversity of Victori1Victori1BCV8P 5C2Canada Terasaki Institute for Biomedical Innovations Los AngelesCA90050USA Biotechnology Center Silesian University of TechnologyAkademicka 2A44-100GliwicePoland Faculty of Materials and Metallurgical Engineering Semnan UniversitySemnanP.O.Box:19111-35131Iran

Natural bone constitutes a complex and organized structure of organic and inorganic components with limited ability to regenerate and restore injured tissues,especially in large bone *** improve the reconstruction of the damaged bones,tissue engineering has been introduced as a promising alternative approach to the conventional therapeutic methods including surgical interventions using allograft and autograft *** composite scaffolds consisting of multifunctional biomaterials in combination with the cells and bioactive therapeutic agents have great promise for bone repair and *** and its derivatives are renewable and biodegradable natural polymers that have shown promising potential in bone tissue engineering ***-based scaffolds possess numerous advantages attributed to their excellent properties of non-toxicity,biocompatibility,biodegradability,availability through renewable resources,and the low cost of preparation and ***,cellulose and its derivatives have been extensively used for delivering growth factors and antibiotics directly to the site of the impaired bone tissue to promote tissue *** review focuses on the various classifications of cellulose-based composite scaffolds utilized in localized bone drug delivery systems and bone regeneration,including cellulose-organic composites,cellulose-inorganic composites,cellulose-organic/inorganic *** will also highlight the physicochemical,mechanical,and biological properties of the different cellulose-based scaffolds for bone tissue engineering applications.

关键词： Cellulose Cellulose derivatives Bone tissue engineering Drug delivery system

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Synthesis and Biomedical Application of SiO<sub>2</sub>/Au Nanofluid Based on Laser-Induced Surface Plasmon Resonance Thermal Effect

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Journal of Modern Physics 2011年第9期2卷 944-953页

作者： mohammad E. Khosroshahi mohammad sadegh nourbakhsh Lida Ghazanfari 不详

We described the synthesis of Au coated SiO2 nanoshells linked with NH2 biomolecular ligands using a simple wet chemical method with a particular application for laser tissue soldering. Tunable nanoshells were prepared by using different gold colloidal concentrations. The nanoshells are characterized by UV-vis spectroscopy, FTIR, XRD and AFM. The FTIR results confirmed the functionalized surfaces of silica nanoparticles with NH2 terminal groups. A broad absorption was observed between 470 - 600 nm with a maximum range between 530 - 560 nm. Based on the XRD results three main peaks of Au (111), (200) and (220) were identified. In addition, AFM results showed that the diameter of silica core was between 90 - 110 nm with gold shell thickness between 10 - 30 nm. A possible tissue soldering using gold nanoshells and laser-induced thermal effect based on surface plasmon resonance is demonstrated. In our case this corresponds to 90?C (i.e. below vaporization) using the higher gold concentration (2 ml) at 60 W·cm–2.

关键词： Gold Nanoshells Synthesis UV-vis Spectroscopy XRD AFM Tissue Soldering PACS 44.40 + a 78.20.-n 78.20.nb

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Risk factors for congenital nasolacrimal duct obstruction in children under two years of age

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国际眼科杂志 2025年第1期25卷 17-23页

作者： Rozhin Kasiri Gholamreza Khataminia Ali Kasiri mohammad sadegh Mirdehghan mohammad Armin Kasiri Infectious Ophthalmologic Research Center Ahvaz Jundishapur University of Medical SciencesAhvaz ***Iran Islamic Azad University Tehran Medical Sciences Tehran ***Iran

·AIM:To identify various risk factors that may play a significant role in the development of congenital nasolacrimal duct obstruction(CNLDO).·METHODS:This observational case-control study included a case group of 122 children less than two years of age with CNLDO who underwent probing and irrigation treatment at the ophthalmology department of Imam Khomeini Hospital in Ahvaz,Iran,from June 2022 to June2024.A control group of 122 age-matched children without CNLDO was also included for *** was collected from the children's medical records.·RESULTS:The study found a significant correlation between the occurrence of CNLDO and several maternal factors,such as preeclampsia,the use of levothyroxine,hypothyroidism,having more than three pregnancies(gravidity>3),natural pregnancy,and gestational diabetes ***,in children,factors,such as oxygen therapy,anemia,reflux,jaundice,and a family history of CNLDO in first-degree relatives were associated with CNLDO,and maternal preeclampsia and hypothyroidism were found to significantly increase the risk of developing CNLDO in children.·CONCLUSION:Given that CNLDO affects both premature and full-term children,the present findings may potentially facilitate the early identification of children and infants at risk of nasolacrimal duct obstruction,thereby preventing the onset of chronic dacryocystitis.

关键词： risk factors congenital nasolacrimal duct obstruction children

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Analysis of Spray Evaporation in a Model Evaporating Chamber:Effect of Air Swirl

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Journal of Thermal Science 2023年第2期32卷 837-853页

作者： mohammad sadegh ABEDINEJAD Department of Mechanical Engineering Faculty of EngineeringAlzahra UniversityTehranIran

Spray evaporation of liquid fuels in a turbulent flow is a common process in various engineering applications such as *** between fuel droplets(discrete phase)and fluid flow(continuous phase)have a considerable effect on liquid fuel *** this paper,both the single-and two-phase modeling of liquid fuel injection into a model evaporating chamber are *** influences of important issues such as turbulence models,coupling between gas phase and droplets,secondary break-up and air swirling on the current spray simulation are ***,the shear stress transport turbulence model,Taylor analogy break-up and two-way coupling models are applied to simulate the two-phase *** and spray of fuel droplets in hot air are modeled employing an Eulerian-Lagrangian *** current results show an acceptable agreement with the *** the fuel atomizer,bigger droplets are detected near the spray edge and minor droplets are situated in the *** increasing the droplets axial position,the droplets diameter decreases with a finite *** smaller droplets have a deeper penetration,but their lifetime is smaller and they evaporate sooner.A linear relation between penetration and lifetime of smaller droplets is *** droplet penetration and mean axial velocity of gas phase are observed for no air swirling *** effect of variation of swirl number on the lifetime of droplets is almost *** enhancing the swirl number,the uniformity of droplet size distribution is reduced and some large droplets are formed up in the domain.

关键词： secondary break-up droplet evaporation air swirling fuel spray gas-droplets coupling

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Production of ultra-transparent glass-ceramics via controlled crystallization of nanocrystals in the glassy matrix of LAST

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International Journal of Minerals,Metallurgy and Materials 2014年第1期21卷 71-76页

作者： mohammad sadegh Shakeri Materials and Energy Research Center(MERC)

Microstructural variation in glass-ceramics encompasses the range from nanocrystalline transparent materials to microcrystalline tough materials. In this investigation, the crystallization process was controlled for the development of ultra transparent LiEO-A1203-SiO2 glass-ceramics containing TiO2 as a nucleating agent （LAST）. Results of UV-Vis absorption spectra were compared with the expected theo- retical values calculated by the Rayleigh scattering method for the determination of ultra transparency. Results of the investigation illustrate that the control of crystallization increases the range of ultra transparency by the reduction of crystal size and their uniformity in the glassy matrix. Last but not the least, the optimized samples are ultra transparent approximately in the whole light wavelengths.

关键词： glass-ceramics transparency nanocrystals crystallization

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Fabrication,microstructure,and optical properties of nanocrystalline transparent LAST glass ceramics containing CeO_2

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International Journal of Minerals,Metallurgy and Materials 2014年第4期21卷 401-407页

作者： mohammad sadegh Shakeri Materials and Energy Research Center (MERC)

In the present research, the effect of CeO2 dopant on the fabrication of transparent lithium aluminosilicate titanate （LAST） glass ceramics was investigated. Nanocrystallineβ-quartz solid solution （s.s.） was observed to be the main phase crystallized in this system. Com-parable refractive indices of the glassy matrix andβ-quartz s.s., as well as the incorporation of very fine grains size were determined as the main reasons for retaining the transparency of the glass ceramics. CeO2 was introduced as a suitable optical agent, playing a role as a network modifier in the glass ceramics, because it does not accelerate the growth process and retards the extended growth of crystals. Optical investi-gations indicate that the Fermi energy level, direct and indirect band gaps, and Urbach energy decrease with increasing nanocrystal content in the glassy matrix of specimens, which can be related to the expansion of conduction band, the enhancement of ionic bonds in the crystal lat-tice, and the enhancement of structural arrangement degree, respectively.

关键词： glass ceramics nanocrystals alurninosilicates titanates transparency optical properties

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Effect of Y_2O_3 on the crystallization kinetics of TiO_2 nucleated LAS glass for the production of nanocrystalline transparent glass ceramics

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International Journal of Minerals,Metallurgy and Materials 2013年第5期20卷 450-455页

作者： mohammad sadegh Shakeri Materials and Energy Research Center (MERC) P.O. Box 31779-83634KarajIran

Crystallization kinetics of metastable B-quartz solid solution as a desirable phase for the production of trans- parent lithium aluminosilicate （LAS） glass ceramics was investigated in the presence of Y203. Accordingly, differential thermal analysis scans were performed thoroughly to study the mechanism of crystallization kinetics. The aim of this investigation is to discover the complicated mechanism of crystallization process in the presence of co-additives and ac- cordingly find a way for increasing the transparency of glass ceramics. It is shown that the bulk （3D） growth is intensively increased by the enhancement of Y203. Then again, reducing nucleation and increasing growth mechanisms were recog- nized for the LAS system in the presence of Y2O3. Results of the investigation illustrate that when co-additives are added to glasses, it is necessary to nucleate the optical component separately before the growth process.

关键词： glass ceramics lithium aluminosilicate yttria crystallization kinetics nanocrystals transparency

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Impact of modified electrodes on boosting power density of microbial fuel cell for effective domestic wastewater treatment:A case study of Tehran

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燃料化学学报 2017年第7期45卷 871-879页

作者： Fatemeh nourbakhsh mohammad Pazouki Mohsen Mohsennia Department of Chemistry University of Kashan Department of Energy Institute of Materials and Energy (MERC) Nanoscience and Nanotechnology Institution University of Kashan

Utilizing microbial fuel cells( MFCs) is a promising technology for energy-efficient domestic wastewater treatment,but it still faces practical barriers such as low power generation. In this study,the LaMnO_3 perovskite-type oxide nanoparticles and nickel oxide/carbon nanotube/polyaniline( NCP) nanocomposite( the cathode and anode catalysts,respectively) have been prepared and used to enhance power density of MFC. The prepared La-based perovskite oxide catalysts were characterized by X-ray diffraction( XRD) and scanning electron microscopies( SEM). The electrocatalytic properties of the prepared catalysts were investigated through cyclic voltammetry( CV) and electrochemical impedance spectroscopy( EIS) and Tafel plot at ambient temperature. Results show the exchange current densities of LaMnO_3/carbon cloth cathode and NCP nanocomposite/carbon cloth anode were 1.68 and 7 times more compared to carbon cloth cathode,respectively. In comparison to the bare carbon cloth anode,the MFC with the modified electrodes shows 11 times more enhancement in power density output which according to electrochemical results,it can be due to the enhancement of the electron transfer capability. These cathodic and anodic catalysts were examined in batch and semicontinuous modes to provide conditions close to industrial conditions. This study suggests that utilizing these low cost catalysts has promising potential for wastewater treatment in MFC with high power generation and good COD removal efficiency.

关键词： carbon nanotube nickle oxide La-based perovskite oxide semi-continuous mode

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ON THE STABILITY OF FUSION FRAMES (FRAMES OF SUBSPACES)

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Acta Mathematica Scientia 2011年第4期31卷 1633-1642页

作者： mohammad sadegh Asgari Department of Mathematics Faculty of Science Islamic Azad University Central Tehran Branch Central Tehran Branch

A frame is an orthonormal basis-like collection of vectors in a Hilbert space, but need not be a basis or orthonormal. A fusion frame （frame of subspaces） is a frame-like collection of subspaces in a Hilbert space, thereby constructing a frame for the whole space by joining sequences of frames for subspaces. Moreover the notion of fusion frames provide a framework for applications and providing efficient and robust information processing *** this paper we study the conditions under which removing an element from a fusion frame, again we obtain another fusion frame. We give another proof of [5, Corollary 3.3（iii）] with extra information about the bounds.

关键词： fusion frames (frames of subspaces) exact fusion frame dual fusion frames

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Nonlinear finite time attitude control of flexible spacecraft based on a novel output redefinition method

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Chinese Journal of Aeronautics 2023年第11期36卷 373-385页

作者： Seyed Majid ESMAEILZADEH mohammad sadegh ZEYGHAMI Department of Electrical Engineering Iran University of Science and TechnologyNarmakTehran 16846-13114Iran

A finite time attitude controller is designed for a flexible spacecraft based on a novel output redefinition method, in this paper. To make the flexible appendages vibration suppression effective, the appendage tip-point is selected as the output. First, a novel output redefinition method is proposed to overcome the non-minimum phase property of the dynamic model. The proposed method not only makes the system model minimum phase but also improves the attitude control system performance. Consequently, the precise attitude pointing and stabilization are ***, a nonlinear finite time H∞controller is designed based on the backstepping approach. For the situation where the modal variables measurements are not available, a modal observer is also designed. The simulation results show the effectiveness of the proposed method in the presence of the model uncertainties and environmental disturbances.

关键词： Finite time Output redefinition H1 control Attitude control Flexible spacecraft Backstepping Robust

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