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Non-alcoholic steatohepatitis and influence of age and gender on histopathologic findings

World Journal of Gastroenterology 2010年第33期16卷 4169-4175页

作者： Nargess Ebrahimi Daryani Nasser Ebrahimi Daryani Seyed Moayed Alavian Ali Zare Seyed-mohammad Fereshtehnejad mohammad reza Keramati mohammad reza pashaei Peiman Habibollahi Department of Gastroenterology and Hepatology Tehran University of Medical Sciences Center for Gastroenterology and Liver Disease Baqiatallah University of Medicine and Tehran Hepatitis Center Department of Pathology Firouzgar HospitalIran Uni- versity of Medical Sciences Gastrointestinal & Liver Disease Research Center(GILDRC) Iran University of Medical Sciences Department of Surgery Iran University of Medical Sciences

AIM:To characterize the histopathologic specifications of non-alcoholic steatohepatitis(NASH)according to age and ***:An analytical cross-sectional study was conducted in two private gastroenterology clinics on biopsy proven patients suffering from *** histopathologic findings as well as demographic and laboratory data of the patients at the time of biopsy were gathered retrospectively from clinical *** grading and staging of histopathologic findings were performed according to the Brunt method after reevaluation of the slides by a *** were divided into two groups according to age(belowand above 55 years).Mean quantitative grade of all pathologic findings were also calculated according to Brunt scoring ***:A total number of 77 NASH patients,consisting of 58 males(75.3%)and 19(24.7%)females with a mean age of 41.99±11.80 years(range,18-70 years),were *** mean age(48.72±13.99 years vs 39.74±10.16 years,P=0.004)and aspartate aminotransferase level(75.11±29.68 U/L vs 52.78± 25.00 U/L,P=0.002)was significantly higher in female *** quantitative grade of hepatosteatosis was significantly higher in females(2.00±0.82 vs 1.59 ±0.68,P=0.031)compared to *** four percent(34/65)of young patients had mild hepatosteatosis (GradeⅠ)while only one patient(11.2%)in the older group had gradeⅠ*** aged≥55 had significantly more severe hepatosteatosis(GradeⅢ) (44.4%vs 9.5%,P=0.007)and the mean quantitative grade of hepatosteatosis was significantly higher among them(2.33±0.71 vs 1.56±0.67,P=0.002).Multivariate analysis after omitting the confounding role of age revealed a higher grade of hepatosteatosis in female patients(P=0.010).CONCLUSION:These findings point toward the possible influence of age in the severity of steatohepatitis,portal and lobar inflammation in patients suffering from NASH while gender independently might contribute to the level of steatohepatitis.

关键词： Non-alcoholic steatohepatitis Age Gender Histopathologic findings

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