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Clinical, virologic and phylogenetic features of hepatitis B infection in Iranian patients

World Journal of Gastroenterology 2008年第35期14卷 5448-5453页

作者： Golnaz Bahramali Majid Sadeghizadeh Samad Amini-Bavil-Olyaee Seyed-Moayed Alavian Abbas Behzad-Behbahani Ahmad Adeli mohammad-reza aghasadeghi Safieh Amini Fereidoun Mahboudi Department of Genetics Faculty of Basic SciencesTarbiat Modares UniversityTehran 14115-175Iran Biotechnology Department Pasteur Institute of IranTehran 13164IranMohammad-Reza AghasadeghiSafieh AminiHepatitis and HIV DepartmentPasteur Institute of IranTehran 13164Iran Baqiyatallah Research Center for Gastroenterology and Liver Diseases Tehran Hepatitis CenterTehran 14155-3651Iran Medical Technology Research Center School of Paramedical SciencesShiraz University of Medical SciencesShiraz ***Iran Biotechnology Department Pasteur Institute of IranTehran 13164Iran Hepatitis and HIV Department Pasteur Institute of IranTehran 13164Iran

AIM： To characterize the clinical, serologic and virologic features of hepatitis B virus （HBV） infection in Iranian patients with different stages of liver disease.METHODS： Sixty two patients comprising of 12 inactive carriers, 30 chronic hepatitis patients, 13 patients with liver cirrhosis and 7 patients with hepatocellular carcinoma （HCC） were enrolled in the study. The HBV S, C and basal core promoter （BCP） regions were amplified and sequenced, and the clinical, serologic, phylogenetic and virologic characteristics were investigated.RESULTS： The study group consisted of 16 HBeAgpositive and 46 HBeAg-negative patients. Anti-HBepositive patients were older and had higher levels of ALT, ASL and bilirubin compared to HBeAg-positive patients. Phylogenetic analysis revealed that all patients were infected with genotype D （mostly ayw2）. The G1896A precore （PC） mutant was detected in 58.1% patients. HBeAg-negative patients showed a higher rate of PC mutant compared to HBeAg-positive patients （2,2 = 9.682, P = 0.003）. The majority of patients with HCC were HBeAg-negative and were infected with PC mutant variants. There was no significant difference in the occurrence of BCP mutation between the two groups, while the rate of BCP plus PC mutants was higher in HBeAg-negative patients （2,2 = 4.308, P = 0.04）. In the HBV S region, the genetic variability was low, and the marked substitution was P120T/S, with a rate of 9.7% （n = 6）.CONCLUSION： In conclusion, HBV/D is the predominant genotype in Iran, and the nucleotide variability in the BCP and PC regions may play a role in HBV disease outcome in HBeAg-negative patients.

关键词： Hepatitis B virus Clinical and virologic features Genetic variability Phylogenetic analysis

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Molecular Detection and Association of QnrA, QnrB, QnrSand BlaCMYResistance Genes among Clinical Isolates of Salmonellaspp. in Iran

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Advances in Microbiology 2014年第1期4卷 63-68页

作者： Raheleh Saboohi Bahareh Rajaei Nahid Sepehri Rad Mohamad reza Razavi mohammad reza aghasadeghi Arfa Moshiri Ahmad reza Bahremand Keivan Kave Peiman Kave Mehrangiz Zangeneh mohammad Rahbar Sara Khorami Sarvestani Seyed Davar Siadat Department of Infectious Diseases Islamic Azad University Tehran Medical Branch Tehran Iran Department of Microbiology Iranian References Laboratory Research Center Ministry of Health and Medical Education Tehran Iran Department of Microbiology Pasteur Institute of Iran Tehran Iran Department of Microbiology Pasteur Institute of Iran Tehran Iran Department of Mycobacteriology & Lung Research Pasteur Institute of Iran Tehran Iran Department of Microbiology Pasteur Institute of Iran Tehran Iran Department of Stem Cells Division of Nanobiomaterials and Tissue Engineering National Institute of Genetic Engineering and Biotechnology Tehran Iran Department of Microbiology Pasteur Institute of Iran Tehran Iran Research Institute for Endocrine Sciences Shahid Beheshti University of Medical Sciences Tehran Iran Department of Mycobacteriology & Lung Research Pasteur Institute of Iran Tehran Iran Department of Veterinary Medicine Kermanshah University of Medical Sciences Kermanshah Iran Hope Generation Foundation Tehran Iran School of Management and Medical Informatics Isfahan University of Medical Sciences Isfahan Iran

Prevalence of three plasmid-mediated quinolone resistance determinant qnrA, qnrB, qnrS and extended spectrum Cephalosporins determinant blaCMY, among eighty-five isolates of Salmonella spp. collected in the community between 2008 and 2010 was determined by PCR. Not only qnr genes but also bla genes were positive in twenty-four different isolates. PCR assay detected that 22 of 85 (25.8%) Salmonella spp. carried the qnrA, 1 (1.17%) of 85 isolates harbored the qnrB, 1 (1.17%) of them contained the qnrS, 1 (1.17%) isolate carried all the three qnrA, qnrB, qnrS genes, 24 of 85 (28.2%) Salmonella carried blaCMY and 5 (5.88%) isolates carried qnrA and blaCMY. Antimicrobial susceptibility patterns of isolates were as follows: 49 (57.6%) exhibited resistance to Nalidixic acid and none of them to Ciprofloxacin. 33 (38.82%) isolates exhibited resistance to Cephalosporins and 2 (2.35%) of them exhibited ESBL phenotype and 12 (14.1%) isolates resistance to Ampicilin. These results were confirmed by MIC determination test as well. Having detected qnr and bla genes suggested that these genes spread antibiotic resistance among pathogenic bacteria.

关键词： QnrA QnrB QnrS ESBL (Extended-Spectrum Beta-Lactamase) BlaCMY

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特殊医学状态的伊朗患者肌肉注射纯化Vero细胞狂犬病疫苗（PVRV）后的中和抗体反应

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中华实验和临床病毒学杂志 2018年第5期32卷 532-532页

作者： Pooneh Rahimi RouhAllah Vahabpour mohammad reza aghasadeghi 吕新军(编译)

使用WHO批准的的疫苗之一进行暴露后预防处置是预防狂犬病可以选择的方法。某些特殊医学状态（诸如怀孕、慢性乙型肝炎病毒感染、淋巴瘤等不同类型的癌症、Ⅰ型和Ⅱ型糖尿病、类风湿性关节炎和红斑狼疮患者使用皮质类固醇激素）患者不... 详细信息

使用WHO批准的的疫苗之一进行暴露后预防处置是预防狂犬病可以选择的方法。某些特殊医学状态（诸如怀孕、慢性乙型肝炎病毒感染、淋巴瘤等不同类型的癌症、Ⅰ型和Ⅱ型糖尿病、类风湿性关节炎和红斑狼疮患者使用皮质类固醇激素）患者不正常的免疫学功能会损害各种疫苗的免疫应答。处于上述医学状态的患者接种狂犬病疫苗后的免疫学反应从未被检测过。

关键词： Vero细胞狂犬病疫苗红斑狼疮患者医学状态抗体反应肌肉注射慢性乙型肝炎病毒感染皮质类固醇激素类风湿性关节炎

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