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Comparative Evaluation of Different Treatment for Purulent Wounds in Dogs

Open Journal of Veterinary Medicine 2016年第7期6卷 119-126页

作者： Ahmad Massoud Niazi mohammad monir tawfeeq Amanullah Aziz Jahid Zabuli Shahpoor Rahmati Abdul Razaq Irshad Clinic Department Faculty of Veterinary Science Kabul University Kabul Afghanistan

To compare the healing of purulent wounds with Shilajit dressing vs. Vishnevsky dressing in dogs with purulent wounds of >2 weeks of duration, eight dogs were chosen from same ages in two groups i.e., Shilajit and Vishnevsky dressing group. Dressing was done on every day basis for more than two weeks of follow up period. Main outcome of healing measure was completed at three weeks. Wound healing status was assessed at three days intervals till end of three weeks. Shilajit treated achieved complete decrease in the wound surface area, effect of healing score in Shilajit dressing group in comparison to the Vishnevsky dressing group at p > 0.05 level of significance. Shilajit is highly effective in achieving a characteristic feature of regenerative and granulation healing of purulent wounds as compared to Vishnevsky dressing group in dogs.

关键词： Shilajit Wound Dressing Purulent Wound of Dog Granulation Tissue

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Inhibitory Effects of Several Fluoroquinolones on Feline CYP1A and 3A in Hepatic Microsomes

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Open Journal of Veterinary Medicine 2020年第12期10卷 219-237页

作者： Syed Sher Shah Sadaat Nasrin Stankzi mohammad monir tawfeeq Farid Ahmad Tanin Amanullah Aziz Kazuki Sasaki Department of Clinic Faculty of Veterinary Science Kabul University Kabul Afghanistan Department of Pre Clinic Faculty of Veterinary Science Kabul University Kabul Afghanistan Department of Veterinary Medicine Faculty of Agriculture Tokyo University of Agriculture and Technology Tokyo Japan

In this study, the effects of several fluoroquinolones (FQs), such as Ciprofloxacin (CPFX);Orbifloxacin (OBFX);Norfloxacin (NFX);Ofloxacin (OFX);and Enerofloxacin (EFX) on activities of both Cytochrome P450 1A (CYP1A) and Cytochrome P450 3A (CYP3A) of feline microsomes by in vitro tests were studied. Ethoxyresorufin O-deethylation (EROD) and Midazolam 1' hydroxylation and 4-hydroxylation (MDZ1'H and MDZ4H) were analyzed by High Performance Liquid Chromatography (HPLC). All the FQs inhibited the reactions by a competitive or noncompetitive and irreversible manner. The inhibitory constants (Ki) were as followings: CYP1A;ranged from 0.12 to 1.23 mM for NFX, OBFX, EFX, CPFX, OFX and CYP3A, for MDZ1'H;ranged from 5.8 to 35 and MDZ4H;9 to 29 mM, respectively. As these values are higher by 24 to 200-times of given single clinical dose of serum levels after application of FQs. It indicates that if co-administrated with these FQs by reversible inhibitory manner, the inhibition of CYP1A and CYP3A effect on CYP1A and 3A actions is not very significant to cause drug interaction with above mentioned enzyme substrates. Out of the FQs tested, CPFX and NFX for CYP1A, and CPFX for CYP3A showed irreversible inhibitory effects (time-dependent), so it has been concluded that these drugs may cause drug-drug interaction by accumulation, when they are repeatedly administrated. Since EFX is biotransformed to CPFX by the liver, it could have the identical risk too.

关键词： Several Fluoroquinolones CYP Inhibitors EROD Midazolam Microsomes

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Inhibitory Effects of Several Fluoroquinolones on Feline CYP1A and 3A in Hepatic Microsomes

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Open Journal of Veterinary Medicine（兽医学） 2020年第12期

作者： Syed Sher Shah Sadaat Nasrin Stankzi mohammad monir tawfeeq Farid Ahmad Tanin Amanullah Aziz Kazuki Sasaki

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Time of surgery and surgeon level in supracondylar humerus fractures in pediatric patients:A retrospective study

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World Journal of Orthopedics 2023年第11期14卷 791-799页

作者： Ibrahim A Albrahim Ammar K AlOmran Dalal A Bubshait Yaser tawfeeq Arwa Alumran Jaffar Alsayigh Ammar Abusultan Abdulraheem Altalib Zaid A Alzaid Shayma S Alsubaie mohammad M Alzahrani Department of Orthopedic College of MedicineImam Abdulrahman Bin Faisal UniversityDammam 34212Saudi Arabia Health Information Management and Technology College of Public HealthImam Abdulrahman Bin Faisal UniversityDammam 34212Saudi Arabia

BACKGROUND Supracondylar humerus fractures account for more than 60%of all elbow fractures and about 1/5 of all pediatric ***,these fractures can be associated with risk of complications including neurovascular injuries,malunions and limb *** exists regarding the effect of time of surgical intervention and/or level of surgeon performing the surgery on outcome of these *** To determine whether time of surgical intervention and/or surgeon level influence the outcomes of surgically managed pediatric supracondylar humerus *** We retrospectively studied 155 pediatric patients presenting with a supracondylar humerus fracture in a level 1 trauma center from January 2006 to December *** data extracted included demographic data,fracture characteristics,surgical data,and follow-up *** collected data was analyzed and P values of<0.05 were considered statistically *** Of the cohort,11%of patients had documented post-operative complications,of which the majority occurred in surgeries performed after day time working hours and in fractures requiring open *** the lowest complication rate was found in surgeries performed by pediatric orthopaedic surgeons,this did not reach statistical *** In pediatric patients undergoing surgery for supracondylar fractures,we found a higher complication rate when surgeries were not performed during working *** level and training had no significant effect on the risk of post-operative complications.

关键词： Supracondylar humerus Fracture Time of surgery Level Complications

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