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Topography versus non-topography-guided photorefractive keratectomy with corneal cross-linking variations in keratoconus

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International Journal of Ophthalmology(English edition) 2022年第5期15卷 721-727页

作者： Sana Niazi Jorge Alio del Barrio Azad Sanginabadi Farideh Doroodgar Cyrus Alinia Alireza Baradaran-Rafii Feaizollah Niazi Hossein mohammad-Rabei mohammad mehdi sadoughi Jorge L.Alio Department of Ophthalmology Shahid Beheshti University of Medical SciencesTehran 3113Iran Vissum Alicante 03016Spain Division of Ophthalmology Universidad Miguel HernándezAlicante 03016Spain Department of Optometry Iran University of Medical SciencesTehran 4599Iran Negah Specialty Ophthalmic Research Center Shahid Beheshti University of Medical ScienceTehran 4599Iran Department of Public Health School of Public HealthUrmia University of Medical SciencesUrmiaWest Azerbaijan 3734Iran Department of ophthalmology University of South FloridaTampaFlorida 33617USA

AIM:To compare the visual results of non-topographyguided and topography-guided photorefractive keratectomy(PRK)applying sequential and simultaneous corneal crosslinking(CXL)treatment for ***:Interventional and comparative prospective ***-nine eyes(36 patients)suffering from keratoconus(stages 1 Amsler-Krumeich classification)were divided into four groups:sequential topography-guided photorefractive keratectomy with CXL,simultaneous topography-guided photorefractive keratectomy with CXL,simultaneous nontopography guided photorefractive keratectomy with CXL,and sequential non-topography guided photorefractive keratectomy with *** main outcome measures were pre-and postoperative uncorrected distance visual acuity(UDVA),best corrected distance visual acuity(CDVA),manifest refraction,contrast sensitivity,and ***:All analyzed visual,contrast sensitivity,and refractive parameters showed a significant improvement in the four groups(all P<0.05).A noticeable improvement was seen in keratometry in all the groups,and a remarkable difference was observed between topography-guided groups in comparison to non-topography-guided groups(P<0.05).Interestingly,the improvement in all parameters showed a degree of stability to the end of the ***:The treatment priorities in all four groups are safety,efficacy,and predictability in the correction of the sphero-cylindrical errors in mild and moderate *** significant differences among groups in the recorded objective outcomes were found.

关键词： photorefractive keratectomy corneal collagen cross-linking keratoconus

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Novel Point Mutations in 3'-Untranslated Region of GATA4 Gene Are Associated with Sporadic Non-syndromic Atrial and Ventricular Septal Defects

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Current Medical Science 2022年第1期42卷 129-143页

作者： Mehri KHATAMI Sajedeh GHORBANI Mojgan Rezaii ADRIANI Sahar BAHALOO Mehri Azami NAEINI mohammad mehdi HEIDARI mehdi HADADZADEH Department of Biology Faculty of ScienceYazd UniversityYazd ***Iran Department of Cardiac Surgery Afshar HospitalShahid Sadoughi University of Medical SciencesYazd ***Iran

Objective:Transcription factor GATA4 has significant roles in embryonic heart *** of GATA4 appear to be responsible for a wide variety of congenital heart defects(CHD).Despite the high prevalence of GATA4 mutations in CHD phenotypes,extensive studies have not been *** 3'-untranslated region(3'-UTR)of tho GATA4 gene comprises regulatory motifs and microRNA binding sites that are critical for the appropriate gene expression,nuclear transportation,and regulation of translation,and stability of *** study aimed to evaluate the association between mutations in the 3'-UTR of the GATA4 gene and CHD risk among Iranian patients.

关键词： congenital heart disease GATA4 S'-untranslated region mutation in-silico analysis

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Analgesic effect of paracetamol combined with low- dose morphine versus morphine alone on patients with biliary colic： a double blind, randomized controlled trial

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World Journal of Emergency Medicine 2016年第1期7卷 25-29页

作者： mohammad Reza Farnia Rasoul Babaei Farzaneh Shirani mehdi Momeni Majid Hajimaghsoudi Elnaz Vahidi Morteza Saeedi Emergency Medicine Department Imam Reza Hospital Kermanshah University of Medical Sciences Kermanshah Iran Emergency Medicine Department Shariati Hospital Tehran University of Medical Sciences Tehran Iran Emergency Medicine Research Center Emergency Medicine Department Shariati Hospital Tehran University of Medical Sciences Tehran Iran Emergency Medicine Department Shahid Dr Rahnemoon Hospital Shahid Sadoughi University of Medical Sciences Yazd Iran

BACKGROUND:Numerous drugs have been proposed to alleviate pain in patients with biliary colic,especially opioids,but still there is a tendency to use less narcotics because of their side effects and the unwillingness of some *** present study aimed to compare the analgesic effect of paracetamol combined with low-dose morphine versus morphine alone in patients with biliary ***:A randomized double-blind controlled trial was performed in 98 patients with biliary colic,recruited from two emergency departments from August 2012 to August *** patients were excluded and the remaining were randomized into two groups:group A received 0.05mg/kg morphine+1 000 mg paracetamol in 100 m L normal saline and group B received 0.1 mg/kg morphine+normal saline(100 m L)as *** scores were recorded using visual analogue scale(VAS)at baseline and 15 and 30 minutes after drug *** effects and the need for rescue medication(0.75 g/kg intravenous fentanyl)were also reported within 60 minutes of drug ***:Before the infusion,the mean±SD VAS scores were 8.73±1.57 in group A and8.53±1.99 in group *** 15 minutes after drug administration,the mean±SD VAS scores were2.16±1.90 in group A vs.2.51±1.86 in group B;mean difference was–0.35,and 95%CI–1.15 to 0.45(P=0.38).At 30 minutes the mean±SD VAS scores were 1.66±1.59 in group A vs.2.14±1.79 in group B;mean difference was–0.48,and 95%CI–1.20 to 0.24(P=0.19).The mean pain scores in the two groups at 15 and 30 minutes demonstrated no significant ***:Paracetamol combined with low-dose morphine may be effective for pain management in patients with biliary colic.

关键词： Biliary colic Morphine Paracetamol Visual analogue scale

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Graphene oxide based carbon composite as adsorbent for Hg removal:Preparation, characterization, kinetics and isotherm studies

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Chinese Journal of Chemical Engineering 2017年第9期25卷 1170-1175页

作者： Tayebeh Esfandiyari Navid Nasirizadeh mohammad Dehghani mohammad Hassan Ehrampoosh Department of Environmental Health Engineering Shaheed Sadoughi University of Medical Sciences Young Researchers and Elite Club Yazd Branch Islamic Azad University

The presence of Hg in the aqueous media is known to cause severe health issues in both humans and *** technologies and especially adsorbents have been applied for its removal. In this study, a graphene oxide–carbon composite(GO–CC) as a new adsorbent was prepared by sol gel procedure and characterized using field emission scanning electron microscopy, BET and EDX. The effects of different variables including solution p H, contact time, adsorbent dose and GO ratio in adsorbent matrix on the removal capacity of Hg were studied. The isotherm data correlated well with the Langmuir isotherm model. Further analysis recommended that the Hg^(2+) adsorption process is governed by the intra-particle and external mass transfer, in which the film diffusion was the rate restrictive step. The presented composite has maximum absorption capacity, q_(max) of 68.8 mg·g^(-1), which is comparable with carbon based adsorbent reported in the previous publications.

关键词： Adsorbent Mercury removal Sol gel Carbon composite

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Climate change and potential distribution of zoonotic cutaneous leishmaniasis in Central Iran: Horizon 2030 and 2050

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Asian Pacific Journal of Tropical Medicine 2019年第5期12卷 204-215页

作者： Babak Shiravand Ahmad Ali Hanafi-Bojd Abbas Ali Dehghani Tafti mohammad Reza Abai Ali Almodarresi Masoud Mirzaei Department of Health in Disasters and Emergencies,School of Public Health,Shahid sadoughi University of Medical Sciences Department of Medical Entomology&Vector Control,School of Public Health,Tehran University of Medical Sciences Engineering College,GIS&RS Department Yazd Branch,Islamic Azad University Department of Epidemiology&Biostatistics,School of Public Health,Shahid sadoughi University of Medical Sciences Department of Health in Disasters and Emergencies School of Public Health Shahid Sadoughi University of Medical Sciences Department of Medical Entomology&Vector Control School of Public Health Tehran University of Medical Sciences Engineering College GIS&RS Department Yazd Branch Islamic Azad University Department of Epidemiology&Biostatistics School of Public Health Shahid Sadoughi University of Medical Sciences

Objective: To investigate and predict the effects of climate change on the potential distribution of the main vector and reservoir hosts of the disease in Yazd province in the ***: Distribution data for vector and reservoir hosts of zoonotic cutaneous leishmaniasis in Yazd province were obtained from earlier studies conducted in the *** ecological niche modeling was used to predict environmental ***-CSM1-1(m) model and two climate change scenarios, RCP 4.5 and RCP 8.5 were used for horizons 2030 and 2050 climate *** projections were based on data of a regional climate change ***: With both scenarios in 2030 and 2050, the results of jackknife test indicated that the mean temperature of wettest quarter and temperature annual range had the greatest effect on the model for the vector and the reservoir hosts, ***: The climate conditions are the major determinants of zoonotic cutaneous leishmaniasis incidence rate in Yazd *** climate conditions provide favorable habitats for ease transmission of zoonotic cutaneous leishmaniasis in this endemic *** suitability for the vector and reservoir will be expanding in the coming years compared with the current conditions, such that, in horizon 2030 & 2050, the probability of the presence of the vector and reservoir within 38 580 and 37 949 km^2, respectively, from Yazd province is above 60%.Moreover, an increase is predicted in the presence of the vector in the western parts and the reservoir in the northern and central parts of the province in the *** the role of environmental and bioclimatic factors in zoonotic cutaneous leishmaniasis occurrence can provide a guide for policy-makers in the creation and implementation of more effective policies for prevention and control.

关键词： Cutaneous leishmaniasis Climate change RCP scenario Phlebotomus papatasi Rhombomys opimus

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Effects of rhubarb(Rheum ribes L.)syrup on dysenteric diarrhea in children:a randomized,double-blind,placebo-controlled trial

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Journal of Integrative Medicine 2017年第5期15卷 365-372页

作者： Ali Khiveh mohammad Hashem Hashempur Mehrdad Shakiba mohammad Hassan Lotfi Afsaneh Shakeri Seid Kazem Kazemeini Zohre Mousavi Marzie Jabbari mohammad Kamalinejad Majid Emtiazy Department of Traditional Medicine Faculty of Iranian Traditional MedicineShahid Sadoughi University of Medical SciencesArdakanYazd ***Iran Noncommunicable Diseases Research Center Fasa University of Medical SciencesFasa ***Iran Department of Pediatrics Shahid Sadoughi University of Medical SciencesYazd ***Iran Department of Biostatistics and Epidemiology Faculty of HealthShahid Sadoughi University of Medical SciencesYazd ***Iran Department of Traditional Medicine School of Iranian Traditional MedicineTehran University of Medical SciencesTehran ***Iran Department of Pharmacognosy Faculty of PharmacyShahid Beheshti University of Medical SciencesTehran ***Iran Research Center of the Iranian Traditional Medicine Shahid Sadoughi University of Medical SciencesYazd ***Iran

BACKGROUND：Rheum ribes *** a plant native to China,Iran,Turkey,India,and a few other *** activity is considered to be one of its important properties according to various systems of traditional *** increasing rate of bacterial resistance to antibiotics has led to treatment failure in some cases of shigellosis in children,and underlines a need for safe,efficient and valid ***：The purpose of this study is to evaluate the efficacy of *** syrup as a complementary medicine for treatment of shigellosis in ***,SETTING,PARTICIPANTS AND INTERVENTIONS：This randomized,doubleblind,placebocontrolled trial started with a group of 150 children aged between 12–72 months with suspected Shigella *** syrup or placebo syrup was administered to the intervention and control groups,respectively for 5 *** addition,the standard antibiotic treatment（ceftriaxone for the first 3 days and cefixime syrup for 2 further days）was administered to both *** OUTCOME MEASURES：Body temperature,abdominal pain,need for antipyretics,defecation frequency,stool volume and consistency and microscopic stool examination were recorded as outcome *** observed adverse effects were also ***：Mean duration of fever and diarrhea in the *** group was significantly lower than that in the placebo group（P=0.016 and 0.001,respectively）.In addition,patients in the *** group showed shorter duration of need for antipyretics and shorter duration of abdominal pain（P=0.012 and 0.001,respectively）.However,there were no significant differences between the two groups regarding the microscopic stool ***,no adverse effect was ***：*** syrup can be recommended as a complementary treatment for children with Shigella dysentery.

关键词： traditional Persian medicine herbal medicine Rheum ribes L rhubarb dysentery shigellosis diarrhea

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Lymphomatoid Granulomatosis with Splenomegaly and Pancytopenia

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中国肺癌杂志 2010年第1期13卷 84-86页

作者： Abolhasan HALVANI mohammad Bagher OWLIA Ramin SAMI Department of Internal Medicine Shaheed Sadoughi hospital Shaheed Sadoughi University of Medical Sciencesj Safaeieh Yazd Iran Shaheed sadoughi Hospital Shaheed Sadoughi University of Medical Sciences Safaeieh Yazd Iran Shaheed Beheshty university Tehran Iran

Lymphomatoid granulomatosis (LG) is an angiocentric lymphoproliferative disease. It usually involves lung, skin, and central nervous system, but splenomegaly and pancytopenia are the rare manifestations of the disease. We report a 15-year-old boy presented with fever, dry cough and dyspnea from two months ago, after admission patient had nodular lesions on the left leg and hepatosplenomegaly. Then he manifested neurologic signs such as seizure, aphasia and right-sided hemiplegia. Chest X-ray and CT scan revealed bilateral pulmonary nodules predominantly in lower lobes and peripheral lung fields. Laboratory exams showed pancytopenia. Skin biopsy was done, and histopathological examination and immunohistochemistry evaluation confirmed lymphomatoid granulomatosis. He was treated with steroid and cyclophosphamide but succumbed by neurologic involvement.

关键词：淋巴瘤肉芽肿病全血细胞减少症临床分析

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From Entry to Evasion:A Comprehensive Analysis of Host-Virus Interactions for Monkeypox

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Infectious Microbes & Diseases 2024年第2期6卷 56-64页

作者： Vahideh Hamidi Sofiani mohammad Rezaei Zadeh Rukerd Javad Charostad mohammad Pardeshenas Reza Ghazi Nasir Arefinia Sara Shafieipour Faranak Salajegheh Mohsen Nakhaie Department of Microbiology Golestan University of Medical SciencesGorganIran Gastroenterology and Hepatology Research Center Institute of Basic and Clinical Physiology SciencesKerman University of Medical SciencesKermanIran Universal Scientific Education and Research Network(USERN) TehranIran Department of Microbiology Faculty of MedicineShahid Sadoughi University of Medical SciencesYazdIran Department of Microbiology School of MedicineKerman University of Medical SciencesKermanIran Department of Biotechnology Golestan University of Medical SciencesGorganIran Student Research Committee Jiroft University of Medical SciencesJiroftIran Physiology Research Center Institute of NeuropharmacologyKerman University of Medical SciencesKermanIran Clinical Research Development Unit School of MedicineAfzalipour HospitalKerman University of Medical SciencesKermanIran

Monkeypox(Mpox)has posed a novel challenge and emerged as a threat to global public health since the onset of its outbreak in *** is spreading throughout the world in both endemic and non-endemic countries,indicating that its behavior is *** prevalence of Mpox and the risk of a global pandemic necessitate a better understanding of Mpox virus replications and interactions with the ***,we attempted to provide a detailed comprehensive review of Mpox virus behavior at the molecular level from the entry level to the establishment of a successful infection,including attachment and entry,DNA replication,protein expression and viron assembly and *** review also describes its strategies to evade host immune responses and inhibit apoptosis,and uncovers underlying molecular mechanisms such as subverted signaling pathways and cellular factors behind host-viral interactions.

关键词： monkeypox immunity apoptosis virus-host interaction

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What do Iranian general practitioners expect from family physician contracts?

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Family Medicine and Community Health 2019年第3期7卷 7-12页

作者： Rafat Mohebbifar Fatemeh Akbarirad mohammad Ranjbar Sima Rafiei Department of Healthcare Management Qazvin University of Medical SciencesQazvin School of Public HealthQazvinIran Student Research Center Qazvin School of Public HealthQazvin University of Medical SciencesQazvinIran School of Public Health Shahid Sadoughi University of Medical Sciences and Health ServicesYazdIran Social Determinants of Health Research Center Qazvin University of Medical SciencesQazvinIran

background Family medicine has become a main prerequisite of providing primary healthcare and a main reforming strategy to ensure the delivery of efficient and high-quality health *** This study aimed to investigate general practitioners’(GP)preferences regarding family physician *** and setting Cross-sectional study was conducted among GPs who registered in Ministry of Health and Medical Education(MoHME)family physician plan and were working in the health network of moderately developed regions in *** sample size was calculated to be 150 GPs who were randomly selected from MoHME *** Developed questionnaire was distributed to *** were analysed by ordinal regression *** Study results confirmed that‘type of employer’had the most significant effect on GPs’preferences(β=0.86).Then attributes including‘allocating quota for being accepted in medical specialty’(β=0.78),‘increased length of contract’(β=0.00.42)and‘capitation payment+15%bonus’had respectively the great effects on participants’*** also revealed that a scenario of contracting with medical council was 2.4 times more likely to be chosen by GPs compared with a scenario of contracting with a medical ***,a scenario that allocated a quota for admission to medical specialty courses was 2.18 times more probable to be preferred by them(p<0.001).Conclusion Successful implementation of family medicine requires development of suitable solutions for attracting and attaining GPs in the *** seems that using a variety of incentives and applying them in physicians’work contract would be helpful in this regard.

关键词： reforming attracting locating

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Probiotic microorganisms affect the reproductive and nervous systems of male rats treated with acrylamide

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Asian pacific Journal of Reproduction 2024年第4期13卷 178-186页

作者： Seyedhossein Hekmatimoghaddam Maryam Yadegari Fateme Zare Fatemeh Zakizadeh Seyed mohammad Seifati Hematology and Oncology Research Center Shahid Sadoughi University of Medical SciencesYazdIran Department of Laboratory Sciences School of ParamedicineShahid Sadoughi University of Medical SciencesYazdIran Neuroendocrine Research Center Shahid Sadoughi University of Medical SciencesYazdIran Department of Anatomy and Cell Biology Faculty of MedicineShahid Sadoughi University of Medical SciencesYazdIran Reproductive Immunology Research Center Shahid Sadoughi University of Medical SciencesYazdIran

Objective:To evaluate the protective effects of probiotic microorganisms on the reproductive and nervous systems of male rats treated with ***:Thirty-two rats were randomly divided into 4 groups and received normal saline through gavage(control),acrylamide 20 mg/kg body weight,acrylamide plus probiotic microorganisms(Lactobacillus acidophilus,Lactobacillus casei,Lactobacillus bulgaricus,Lactobacillus rhamnosus,Bifidobacterium breve,Bifidobacterium infantis,Streptococcus thermophilus and fructooligosaccharides,all mixed in sachets)20 or 200 mg/kg body weight,*** 30 days,the testis,prostate,seminal vesicle and cerebellum were removed,fixed and stained with hematoxylin-eosin(H&E).The Johnsen score was used to classify ***'s principle method was used to evaluate the total volume(in mm3)of the *** number of each intratubular cell type as well as intertubular Leydig cells in whole samples was measured using the physical dissector counting *** analysis and the grids were used to determine the volume of cerebellar layers as well as the Purkinje cell ***:The testis weight decreased significantly in the acrylamide-treated group compared to the other groups(P<0.001).The number of spermatogonia,spermatocytes,spermatids and Leydig cells in the acrylamide-treated group were significantly less compared to the control group(P<0.05),while they were increased significantly in the acrylamide+200 mg/kg probiotic group(P<0.05;P<0.01).The mean Johnsen score in the acrylamide-treated group was lower than in the control group(P<0.001).Acrylamide-induced changes including congestion,vacuolization in the secretory epithelial cells,and epithelial rupture were observed in the prostate and seminal *** volumes of cerebellar layers were decreased in the acrylamide group compared to the control group while recovered in both probiotic treated ***:Probiotic microorganisms alleviate acryl

关键词： Acrylamide Cerebellum Microorganisms Probiotics Prostate Rats Testis

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