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中国医疗器械信息 2008年第9期14卷 29-30,44页

作者： karim D. Kalache Katja Eder Tilman Esser Hans Proquitt’e Gisela Stoltenburg-Didinger John P.Hartung Christian Bamberg 李雪莲张珏华复旦大学附属妇产医院超声科

目的:评价三维超声的平面重切和非平面重切技术。方法:前瞻性研究经二维超声诊断为严重脑部畸形的胎儿。每一病例都获得高质量的胎儿脑部三维容积,并利用三维扩展成像的ObliqueView和动态MR技术对其进行分析。结果:检查8例胎儿(20-30孕... 详细信息

目的:评价三维超声的平面重切和非平面重切技术。方法:前瞻性研究经二维超声诊断为严重脑部畸形的胎儿。每一病例都获得高质量的胎儿脑部三维容积,并利用三维扩展成像的ObliqueView和动态MR技术对其进行分析。结果:检查8例胎儿(20-30孕周,平均23孕周)伴有下列中枢神经系统畸形:半叶全前脑、透明隔缺失、双胎输血综合征中的孔洞脑畸形、胼胝体部分缺失、Dandy-Walker畸形、脑穿通畸形、Galen静脉瘤及cavumvergae扩张。结论:对任何重建水平的三维容积进行平面和非平面的重切都能提供有价值的图像,但有一个重要的先决条件是获取资料的过程中没有声影。

关键词：中枢神经系统 Oblique View 产前诊断三维超声

Clinico-Pathological Profile of Malignant Abdominal Tumors in Children: Experience of the Pediatric Oncology Unit in Bamako

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Open Journal of Pediatrics 2021年第4期11卷 608-617页

作者： Abdoul karim Doumbia Adama Dembele Pierre Togo Oumar Coulibaly Arsene Dackono Mohamed Elmouloud Cissé Fousseyni Traoré Hawa Diall Boubacar Togo Abdoul Aziz Diakité Yakaria Coulibaly Cheick Bougadary Traore Lala N’drainy Sidibe Belco Maiga Diakite Fatoumata Léonie Francois Karamoko Sacko Djeneba Konaté Guediouma Dembele Hacimi Poma Adama Bah Djibril Kassogue Oumar Keita Ibrahim Ahamadou Department of Pediatrics at CHU Gabriel Touré Bamako Mali Pediatric Surgery Department of the Gabriel Touré CHU Bamako Mali Pathological Anatomy and Cytology Department of the “Point G” CHU Bamako Mali

Introduction: the objective was to describe the epidemiological and histological aspects of malignant abdominal tumors in children. Methodology: This was a descriptive, cross-sectional study conducted from January 1, 2017 to December 31, 2018. We included all patients aged 0 to 15 years with histologically confirmed abdominal malignancies. Results: We collected 46 files of malignant tumors of the abdomen (35% of pediatric cancers). The majority of patients were under 5 years old (65%). The sex ratio was 1.7. They were generally from disadvantaged socio-economic backgrounds (67%). The average consultation time was 50 days. The main reasons for consultation were abdominal mass (48%), pain (17%) or distension (9%). The mass was large, hard (89%), immobile (71%) and painful (46%). Malnutrition was found in 80% of patients. The mass was retro-peritoneal in 63% of cases and renal in 54%. It was solid in 94% of cases and heterogeneous in 76% of cases. The assay for tumor markers was not performed. Anemia was present in all patients. Fine needle aspiration was performed in 43%, biopsy in 37% and myelogram in 15% of cases. spinal cord involvement was observed in 28% of Burkitt’s cases. The main cancers diagnosed were nephroblastoma (52%), Burkitt’s lymphoma (26%) and neuroblastoma (13%). Stage 1 and stage 2 were frequent in 20% and 22% of cases, respectively;36% of cases were not staged. The average duration of chemotherapy was 11 weeks. Total resection was performed in 30% of cases. The outcome of the patients was marked by total remission in 65%. Conclusion: Abdominal malignancies are very common in children. The diagnosis of certainty is late in our context.

关键词： Cancer Abdomen Child Sub-Saharan Africa

Study of Cerebral Vascular Accidents in Children with Sickle Cell from 6 Months to 15 Years of Age at the Gabriel Toure University Hospital Center

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Open Journal of Pediatrics 2023年第6期13卷 852-861页

作者： Mohamed Elmouloud Cissé Abdoul Aziz Diakité Adama Dembélé Belco Maiga Moussa Diallo Abdoul karim Doumbia Oumar Coulibaly Pierre Togo Hawa Gouro Diall Abdoulaye Barry Karamoko Sacko Amadou Touré Issa Sanou Fousseyny Traore Djeneba Konaté Kalirou Traoré Lala N’Drainy Sidibé Bory Traoré Ibrahim Ahamadou Yacouba Aba Coulibaly Hawa Konaré Aminata Doumbia Department of Pediatrics Gabriel Toure University Hospital Bamako Mali

Sickle cell disease is a hereditary disease that remains a public health problem in Mali. Our objective was to study strokes in children with sickle cell disease aged from 6 months to 15 years in the pediatrics department of the Gabriel Toure university hospital center. This was a retrospective descriptive study from April 1, 2019 to March 31, 2021 and prospective from April 1, 2021 to April 30, 2022, i.e. 3 years, which took place in the Pediatrics department of the Gabriel Toure university hospital center. During this study, we identified 22 cases of stroke among 714 children with sickle cell disease. The frequency of stroke in this population is 3.08%. The age group from1 to 5 years was the most affected with 40.9%. The average age of the patients was 7 years with extremes ranging from 1 year to 15 years and a median of 5 years. The male gender was predominant with 54.5%, for a sex ratio of 1.2. Headaches were the most common neurological antecedents (63.5%). Half of the patients were diagnosed with sickle cell disease after the onset of the stroke. The installation of the deficit was progressive in 54.5% of cases. Consciousness disorders were the most frequent reason of consultation (27.2%), followed by convulsions (18.1%). The most common neurological signs were impaired consciousness and hemiparesis with 45.5% each. The stroke was ischemic in 100% of cases. There were 95.5% of SS forms and 4.5% of Sβ0thalassemia forms. Our patients had a hemoglobin level less than 7 g/dl in 57.1% of cases and between 7 and 9 g/dl in 42.8% of cases and hyperleukocytosis (leukocytes > 10,000/mm3) in 95.4% of cases. The Sylvian artery was the most affected (45.5%). The fatality rate was 22.7%.

关键词： Sickle Cell Anemia Vessels Brain Children

配方施肥对库尔勒香梨果实及土壤矿质营养含量的影响

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北方园艺 2015年第16期 166-170页

作者：李经洽克热木.伊力艾克拜尔.伊拉洪顾祝禹新疆农业大学林学与园艺学院新疆乌鲁木齐830052 新疆农业大学草业与环境学院新疆乌鲁木齐830052

以16年生库尔勒香梨树为试材,分析连续2年配方施肥对香梨果实及土壤矿质营养含量变化的影响。结果表明:香梨果实中矿质营养的含量,在配方施肥1年有不同程度的增加;相同施肥年限下,配方施肥2的果实中矿质营养的含量,N、K、Ca、Zn含量最... 详细信息

以16年生库尔勒香梨树为试材,分析连续2年配方施肥对香梨果实及土壤矿质营养含量变化的影响。结果表明:香梨果实中矿质营养的含量,在配方施肥1年有不同程度的增加;相同施肥年限下,配方施肥2的果实中矿质营养的含量,N、K、Ca、Zn含量最高,P含量配方施肥2与配方施肥3差异不显著;配方施肥1年,各配方处理后土壤中碱解N、速效P、速效K、交换Ca、Mg的含量有不同程度增加;连续2年配方施肥处理,土壤中矿质营养含量有普遍增加趋势。配方施肥处理能提高果实、土壤营养元素的含量,其中配方施肥2年效果明显。各处理之间有着显著差异,施肥效应表现为:配方施肥2>配方施肥3>配方施肥1>CK,配方施肥2年效果最好。

关键词：库尔勒香梨配方施肥果实矿质营养土壤矿质营养

Tuberculosis in Children: Epidemio-Clinical Aspects in the Paediatric Department of the Gabriel TouréUniversity Hospital Center

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Open Journal of Pediatrics 2022年第2期12卷 376-388页

作者： Adama Dembélé Abdoul Aziz Diakité Mohamed Elmouloud Cissé Bassirou Diarra Belco Maïga Issa Sanou Pierre Togo Abdoul karim Doumbia Oumar Coulibaly Karamoko Sacko Djéneba Konaté Hawa Diall Lala Ndrainy Sidibé Bréhima Dégoga Fatoumata Léonie Diakité Guédiouma Dembélé Fatoumata Dicko Mariam Sylla Boubacar Togo Department of Paediatrics University Teaching Hospital of Gabriel Touré Bamako Mali University Clinical Research Center University of Sciences Techniques and Technologies of Bamako Bamako Mali Department of Pediatrics CHU Gabriel Touré Bamako Mali

Introduction: Globally, tuberculosis is the leading cause of death from a single infectious agent ahead of HIV/AIDS. Approximately 10 million people contracted TB in 2017, 10% of whom were children aged 0 - 15 years, or about 1 million with 250,000 deaths in 2016 (including children with HIV-associated TB). The signs of TB in children are not always specific and diagnosis remains difficult unlike in adults. According to a study conducted in 2011 in the paediatric department of the CHU-Gabriel Touré, only seventeen cases of all forms of tuberculosis were found, or approximately 0.2% of hospitalised children. The objective of our study was to investigate the epidemiological and clinical aspects of tuberculosis in children. Materials and Method: This was a prospective, cross-sectional and descriptive study that took place from 24 October 2017 to 23 October 2018, or 12 months in children aged 0-15 years. Data were collected from an individual medical record opened for each patient and an individual survey form established for each child. Results: During the study period, 40,434 children were consulted. Tuberculosis was suspected in 91 children, with a frequency of 0.22%. The age range of 1 to 4 years was 36.3% with a median age of 72 months. The sex ratio was 1.8. Chronic cough with 84.6% and malnutrition with 24.17% were the most frequent symptoms. Chest X-ray revealed bilateral pulmonary lesions in 52.7% and mediastinal adenopathy in 12.1%. TST was positive in 10.9% of patients, microscopy in 26.4%, Gene Xpert in 18.7%, and culture in 16.5%. The biological diagnosis of tuberculosis was retained in 48.4% of the patients, the pulmonary form represented 93.2%. The therapeutic regime (2RHZE/4RH) was used in 81.6% of cases and the evolution was favourable in 65.9% of patients. Conclusion: The diagnosis of tuberculosis in children remains difficult in our context. The clinical signs are not always specific, and further studies are needed to further elucidate this disease.

关键词： Child Clinic Epidemiology Gabriel Touré University Hospital Center Tuberculosis

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外源赤霉素GA3对库尔勒香梨抗寒性的影响

农业科学 2014年第6期4卷 123-131页

作者：王一静克热木·伊力肖坤新疆农业大学林学与园艺学院乌鲁木齐

以树势健壮、结果正常的库尔勒香梨单株为试验材料,在展叶期(2013年5月6日)第一次喷施不同浓度的外源GA3 (50, 75, 100 mg/L),每隔20天喷施一次,共喷施三次。在休眠期枝条取样,在人工低温胁迫条件下测定膜透性、丙二醛、脯氨酸、可溶... 详细信息

以树势健壮、结果正常的库尔勒香梨单株为试验材料,在展叶期(2013年5月6日)第一次喷施不同浓度的外源GA3 (50, 75, 100 mg/L),每隔20天喷施一次,共喷施三次。在休眠期枝条取样,在人工低温胁迫条件下测定膜透性、丙二醛、脯氨酸、可溶性蛋白质、可溶性糖和淀粉含量等抗寒性指标,并计算各综合指标的隶属度。试验结果表明:100 mg/L GA3一次处理的平均隶属度大于0.7,为高抗;50 mg/L GA3 一次处理、75 mg/L GA3一次处理、50 mg/L GA3二次处理、75 mg/L GA3二次处理、100 mg/L GA3二次处理、100 mg/L GA3三次处理的平均隶属度均大于0.4,因此以上处理均为中抗;50 mg/L GA3三次处理、75 mg/L GA3三次处理的平均隶属度大于0.3,因此这两种处理为低抗。可初步认为,最佳GA3喷施浓度为100 mg/L,处理一次,能够抵抗?24℃的低温,但确定最佳喷施时间和外源激素浓度需进一步深入研究。

关键词：库尔勒香梨外源GA3 枝条抗寒性

抗HIV药物：结核病治疗期间最佳给药时机分析

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中国处方药 2010年第3期9卷 62-62页

作者： karim SS Naidoo K Grobler A

结核杆菌与人类免疫缺陷病毒（HIV）共感染的患者死亡率高。结核病患者何时开始抗病毒治疗能获得最佳疗效，这一问题目前仍有争议。本次开放随机安慰剂对照试验仅抗酸杆菌痰涂片阳性的结核病患者，伴HIV感染且CD4^＋细胞计数〈500／mm^... 详细信息

结核杆菌与人类免疫缺陷病毒（HIV）共感染的患者死亡率高。结核病患者何时开始抗病毒治疗能获得最佳疗效，这一问题目前仍有争议。本次开放随机安慰剂对照试验仅抗酸杆菌痰涂片阳性的结核病患者，伴HIV感染且CD4^＋细胞计数〈500／mm^3才能入组。最终有642例患者入选，选择结核病治疗期间开始抗病毒治疗（综合治疗组）或者在结核病治疗完成后开始抗病毒治疗（序贯治疗组），主要观察终点为全因死亡率。

关键词：结核病患者治疗期抗HIV药物给药时机 CD4^+细胞计数人类免疫缺陷病毒抗病毒治疗全因死亡率

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扁头泥蜂

环球人文地理 2016年第19期 114-114页

作者：杨瓦 Muhammad Mahdi karim

扁头泥蜂常被称为自然界中的"摄魂怪",虽然体型微小,但它却能轻而易举地控制蟑螂的思想。被扁头泥蜂吸去"魂魄"后,蟑螂就算要为其"慷慨赴死",也不会拒绝。扁头泥蜂主要分布在南亚、非洲、太平洋三大群岛等热带地区,其胸部和腹部连接处纤... 详细信息

扁头泥蜂常被称为自然界中的"摄魂怪",虽然体型微小,但它却能轻而易举地控制蟑螂的思想。被扁头泥蜂吸去"魂魄"后,蟑螂就算要为其"慷慨赴死",也不会拒绝。扁头泥蜂主要分布在南亚、非洲、太平洋三大群岛等热带地区,其胸部和腹部连接处纤细,属细腰蜂科。扁头泥蜂通体

关键词：扁头泥蜂蟑螂

In Vitro Development and Germination of Immature Embryos of Sweet Oranges Parson Brown and Pineapple(Citrus sinensis)

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Journal of Agricultural Science and Technology(B) 2018年第7期8卷 405-419页

作者： karim Mahmoudi Najat Handaji Mohammed Ibriz Najat Arsalane Tarik Aderdour Kawtar Label Hanae Ennaciri Hamid Benyahya Laboratory for the Improvement and Conservation of Plant Genetic Resources National Institute of Agronomic Research(INRA)KenitraBP 257Morocco Laboratory of Genetics and Biometry Faculty of SciencesUniversity Ibn TofailKenitraMorocco

Oranges are classified as the most traded fruit variety *** diversification of the varietal profile of this group is among the objectives of the Citrus breeding ***,the creation of new triploid hybrids via immature embryos rescue,can lead to an increase in gene pool and produce seedless *** addition,flow cytometry was successfully used for analyzing ploidy levels and genetic origin of triploid *** present study was aimed at optimizing immature embryos in vitro germination and plantlet development based on medium chemical composition of the two orange varieties,Pineapple and Parson *** the fruit gets matured,they are harvested and the seeds extracted are classified according to their *** those which are small are cultured in a sterile Murashige and Tucker(MT)basal *** different concentrations of growth regulators are put to the test in order to gain the best medium for seeds development.M1(MT+1 mg/L gibberellic acid(GA3)),M2(MT+1 mg/L kenitin+0.5 mg/L 6-benzylaminopurine(BAP)+0.1 naphthalene acetic acid(NAA)),M3(MT+25 mg/L adenine sulfate(ADS)),M4(MT+0.5 mg/L kenitin+0.5 mg/L BAP+1 mg/L GA3).Percentage of germinated embryos(PGE)is the highest in M3 with 100%and 90%for both Pineapple and Parson Brown varieties,*** addition,the germination interval average(GIA)is shorter in M1 for both varieties,which takes 6 d and 7 d,*** regard to speed seedling growth(mm/week),both varieties undergo significant change in all four ***,the highest rate of acclimatization for the Pineapple and Parson Brown varieties is 80%and 90%in *** general,the smaller the embryos are,the more sensitive they are to culture medium *** is therefore essential to optimize the medium components in order to stimulate their in vitro ***,M1(MT+1 mg/L GA3)remains the best to promote short term good germination and produce a better rate of acclimatization.

关键词： Citrus orange triploids in vitro germination immature embryos flow cytometry genetic