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Persistent alanine aminotransferase elevation among the general Iranian population: Prevalence and causes

World Journal of Gastroenterology 2008年第18期14卷 2867-2871页

作者： Raika Jamali Mahmoodreza Khonsari Shahin Merat Masoud Khoshnia Elham jafari Alireza Bahram Kalhori Hassan Abolghasemi Sedighe Amini Mahtab Maghsoudlu mohammad Reza Deyhim Houri Rezvan Akram Pourshams Digestive Disease Research Center Shariati Hospital Medical Sciences/University of Tehran Tehran 14117 Iran Department of Internal Medicine Hamadan Hamadan University of Medical Sciences Iran Department of Radiology Gonbad Social Insurance Organization Khatam Hospital Golestan Iran Iranian Blood Transfusion Research Center Tehran 14117 Iran

AIM: To determine the prevalence and causes of persistently elevated alanine aminotransferase (ALT) levels among the general population in northern Iran. METHODS: A total of 2292 (1376 female, aged 18-75 year), were selected by systematic clustered random sampling from the cities and villages of Gonbad and Kalaleh in Golestan Province and invited to participate in the study. A comprehensive history regarding alcohol drinking and medication was taken. Body mass index (BMI), viral markers and ALT levels were measured. If ALT level was ≥ 40 U/L, it was rechecked twice within 6 mo. Those with ≥ 2 times elevation of ALT were considered as having persistently elevated ALT level. Non-alcoholic fatty liver disease (NAFLD) was diagnosed based on evidence of fatty liver upon sonography and excluding other etiology. RESULTS: A total of 2049 (1351 female) patients participated in the study, 162 (7.9%) had elevated ALT level at the first measurement. Persistently elevated ALT level was detected in 64 (3.1%) participants, with51 (79.6%) with no obvious etiology, six (9.3%) with Hepatitis B, four (6.2%) with Hepatitis C virus (HCV) infection and three (4.6%) with alcoholic hepatitis. The prevalence of NAFLD and alcoholic hepatitis was 2.04% (42 patients) and 0.1% (three), respectively. There was correlation between NAFLD and male gender, overweight, diabetes and living in an urban area [odds ratio = 3.03 (95% CI: 1.6-5.72), 4.21 (95% CI: 1.83-9.68), 2.86 (95% CI: 1.05-7.79) and 2.04 (95% CI: 1.00-4.16) respectively]. CONCLUSION: NAFLD is the most common cause of persistently elevated serum ALT level among the general population of Iran.

关键词： Alanine aminotransferase Iran Non-alcoholic fatty liver disease Viral hepatitis

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Parsley: a review of ethnopharmacology, phytochemistry and biological activities

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Journal of Traditional Chinese Medicine 2013年第6期33卷 815-826页

作者： mohammad Hosein Farzaei Zahra Abbasabadi mohammad Reza Shams Ardekani Roja Rahimi Fatemeh Farzaei Faculty of Pharmacy Kermanshah University of Medical Science Department of Traditional Pharmacy Faculty ofTraditional MedicineTehran University of Medical Science Department of Pharmacognosy Faculty of Pharmacy Tehran University of Medical Science Department of Traditional Pharmacy Faculty of Traditional Medicine Tehran University of Medical Science College of Veterinary Medicine Kermanshah Razi University

OBJECTIVE:To summarize comprehensive information concerning ethnomedicinal uses, phytochemistry, and pharmacological activities of parsley. METHODS: Databases including PubMed, Scopus, Google Scholar, and Web of Science were searched for studies focusing on the ethnomedicinal use, phytochemical compounds and biological and pharmacological activities of parsley. Data were collected from 1966 to 2013. The search terms were: "Parsley" or "Petroselinum crispum" or "Petroseli-num hortence ". RESULTS: Parsley has been used as carminative, gastro tonic, diuretic, antiseptic of urinary tract, anti-urolithiasis, anti-dote and anti-inflammatory and for the treatment of amenorrhea, dysmenorrhea, gastrointestinal disorder, hypertension, cardiac disease, urinary disease, otitis, sniffle, diabetes and also various dermal disease in traditional and folklore medicines. Phenolic compounds and flavonoids particularly apigenin, apiin and 6"-Acetylapiin; essential oil mainly myristicin and apiol; and also coumarins are the active compounds identified in Petroselinum crispum. Wide range of pharmacological activity including antioxidant, hepatoprotective, brain protective, anti-diabetic, analgesic, spasmolytic, immunosuppressant, anti-platelet, gastroprotective, cytoprotective, laxative, estrogenic, diuretic, hypotensive, antibacterial and antifungal activities have been exhibited for this plant in modern medicine. CONCLUSION: It is expectant that this study resulted in improvement the tendencies toward Petroselinum crispum as a useful and important medicinal plant with wide range of proven medicinal activity.

关键词： Petroselinum jafari Medicine, tradition-al Pharmacological processes Chemistry

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杜安眼球后退综合征和染色体组异常(英文)

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国际眼科杂志 2008年第9期8卷 1747-1748页

作者： Alireza K-jafari Seyed-Masoud Hoshmand Iraj Ahadzadeghan Faramarz Anvari Ahmad Ameri mohammad-Reza Akbari mohammad Taher Rajabi 伊朗德黑兰大学医学院眼科 Farabi眼科医院眼科研究中心伊朗德黑兰大学医学院遗传学系

目的:观察I型杜安眼球后退综合征患者的第8染色体。方法:连续观测了29例I型杜安眼球后退综合征患者的第8染色体。采用质粒DNA提取试剂盒方法从患者的外周血白细胞里分离提取DNA,选取D8S553和D8S1797做标记,用PCR法进行测定。结果:实验... 详细信息

目的:观察I型杜安眼球后退综合征患者的第8染色体。方法:连续观测了29例I型杜安眼球后退综合征患者的第8染色体。采用质粒DNA提取试剂盒方法从患者的外周血白细胞里分离提取DNA,选取D8S553和D8S1797做标记,用PCR法进行测定。结果:实验的所有病人样本中没有D8S553和D8S1797标记阳性。结论:我们的发现提示所观察的I型杜安眼球后退综合征患者的可能病因是属散发病例而没有家族史,建议纳入更多病例、选取其他的标记和不同的染色体进行进一步的研究。

关键词：杜安眼球后退综合征聚合酶链反应染色体

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Synbiotic for Prevention of SARS-Cov2 Infection in High Risk Hospital Staffs: A Randomized Controlled Trial

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Open Journal of Nursing 2021年第5期11卷 281-290页

作者： Hamid Ahanchian Alireza Ranjbar Hamidreza Reihani Arash Peivandi Yazdi Seyed Ali jafari mohammad Ali Kiani Rana Tafrishi Nasrinsadat Motevalli Haghi Nasrin Moazzen Ali Khalshour Faezeh Mirzaei Zahra Abbasi Shaye Sadegh Ebrahimi Hamidreza Kianifar Child Health Research Centre University of Queensland South Brisbane Australia Allergy Research Center Faculty of Medicine Mashhad University of Medical Sciences Mashhad Iran Institute for Interventional Allergology and Immunology Cologne/Bonn Germany Department of Emergency Medicine Faculty of Medicine Mashhad University of Medical Sciences Mashhad Iran Lung Disease Research Center Faculty of Medicine Mashhad University of Medical Sciences Mashhad Iran Department of Pediatrics Faculty of Medicine Mashhad University of Medical Sciences Mashhad Iran Faculty of Medicine M.V. Lomorosov Moscow State University (MSU) Moscow Russia

Introduction: COVID-19 pandemic caused by the novel coronavirus SARS-CoV-2 increasingly involves people worldwide. Probiotics can improve immune system functions via different mechanisms. We proposed that Synbiotic Lactocare? may also reduce SARS-Cov2 infection in high-risk medical staff working in COVID-19 hospital wards. Method: In a randomized, controlled trial, 60 hospital staff without any history of clinical or laboratory evidence of SARS-Cov2 infection were received either once-daily oral synbiotic capsule (Lactocare?) that contains 1 billion CFU/Cap of L. (Lactobacillus) casei, L. rhamnosus, Streptococcus thermophilus, Bifidobacterium breve, L. acidophilus, Bifidobacterium infantis, L. bulgaricus, and Fructooligosacharide (Zist Takhmir, Tehran, Iran) or placebo with the same appearance for 30 days. They were followed for two months. Result: During the two-month period of this study, SARS-COV-2 RT-PCR test results were positive in three participants (9.67%) in placebo group compared to zero positive tests in synbiotic group. The differences were not statistically significant (p = 0.238). During the study, two persons (7 %) of placebo group had respiratory complaints such as cough, rhinorrhea and/or dyspnea, compared with one in synbiotic group (p = 0.492). Conclusion: This study showed that overall frequency of SARS-COV2 infection in participants receiving synbiotic and those receiving placebo did not differ significantly. However, 3 hospital staff in placebo group compared to no one in synbiotic group had SARS-COV2 infection. Further studies with greater power and alternative pro

关键词： COVID-19 Synbiotic Prevention Lactocare SARS-Cov2

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先天性上睑下垂患者100例弱视致病原因的探讨(英文)

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国际眼科杂志 2011年第3期11卷 390-393页

作者： Abolfazl Kasaee Alireza Yazdani-Abyaneh Syed Ziaeddin Tabatabaie Alireza K.jafari Ahmad Ameri Bahram Eshraghi Vafa Samarai Meysam Mireshghi mohammad Taher Rajabi 德黑兰医科大学Farabi医院眼科眼科研究中心

目的:评估先天性上睑下垂患者的弱视发病情况。方法:在本横断面研究中,包括1岁以上的先天性上睑下垂患者100例(114眼)。最佳矫正视力小于10/10或两眼之间至少相差2/10者定义为弱视。年幼患者不能进行斯内伦视力表检测者,观察其注视情况... 详细信息

目的:评估先天性上睑下垂患者的弱视发病情况。方法:在本横断面研究中,包括1岁以上的先天性上睑下垂患者100例(114眼)。最佳矫正视力小于10/10或两眼之间至少相差2/10者定义为弱视。年幼患者不能进行斯内伦视力表检测者,观察其注视情况。不同弱视患者的类型:1)屈光参差性弱视:散光性屈光参差≥1.00D;远视性球镜屈光参差≥1.00D,近视性球镜屈光参差≥-3.00D(睫状肌麻痹);2)斜视性弱视,3)形觉剥夺性弱视(SDA)。观察弱视的总发病率及类型,并对单侧和双侧上睑下垂患者进行比较。结果:弱视的发生率在上睑下垂患者为39/114(34.2%),其具体原因:屈光参差性弱视占29.8%,SDA占10.5%,斜视性弱视4.3%,严重的上睑下垂患者弱视发病率更高,视轴遮盖者(OA)占76%,而视轴未遮盖者只占22%。在视轴遮盖的单侧眼睑下垂患者,散光屈光参差性弱视发生率更高,在双侧眼睑下垂至少1眼视轴遮盖者,球镜屈光参差性弱视发生率更高。无论单侧和双侧上睑下垂,如果有视轴遮盖,则SDA比较多见。结论:由于屈光参差性弱视比SDA发生率更高,关注导致的弱视所有原因对于预防儿童上睑下垂所致的弱视极其重要。

关键词：弱视弱视致病因素先天性上睑下垂

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