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Oncology Research 2024年第3期32卷 477-487页

作者： SAMANEH MOSTAFAVI ZUHAIR mohammad hassan Department of Immunology Faculty of Medical SciencesTarbiat Modares UniversityTehranIran

Intracellular communications between breast cancer and fibroblast cells were reported to be involved in cancer proliferation,growth,and therapy *** hallmarks of cancer fibroblast interactions,consisting of caveolin 1(Cav1)and mono-carboxylate ransporter 4(MCT4)(metabolic coupling markers),along with IL-6,TGFB,and lactate secretion,are considered robust biomarkers predicting recurrence and *** order to promote a novel phenotype in normal fibroblasts,we predicted that breast cancer cells could be able to cause loss of Cavl and increase of MCT4,as well as elevate IL 6 and TGF in nearby nomal *** created a co culture model using breast cancer(4T1)and normal fibroblast(NIH3T3)cell lines cultured under specific experimental conditions in order to directly test our ***,we show that long-term co-culture of breast cancer cells and normal fibroblasts promotes loss of Cavl and gain of MCT4 in adjacent fibroblasts and increase lactate *** results were validated using the monoculture of each group separately as a *** this system,we show that me tformin inhibits IL-6 and TGFB secretion and re expresses Cavl in both ***,MCT4 and lactate stayed high after treatment with *** conclusion,our work shows that co-culture with breast cancer cells may cause signifcant alterations in the phenotype and secretion of normal ***,however,may change this state and affect fibroblasts'acquired ***,mitochondrial inhibition by metformin after 8 days of treatment,signi ficantly hinders tumor growth in mouse model of breast cancer.

关键词： Caveolin 1 Lactic acid Metformin NIH 3T3 cells Neoplasms

Transparent and Accurate COVID-19 Diagnosis:Integrating Explainable AI with Advanced Deep Learning in CT Imaging

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Computer Modeling in Engineering & Sciences 2024年第6期139卷 3101-3123页

作者： mohammad Mehedi hassan Salman A.AlQahtani Mabrook S.AlRakhami Ahmed Zohier Elhendi Department of Information Systems College of Computer and Information SciencesKing Saud UniversityRiyadh11543Saudi Arabia Department of Computer Engineering College of Computer and Information SciencesKing Saud UniversityRiyadh11543Saudi Arabia Science Technology and Innovation Department King Saud UniversityRiyadh11543Saudi Arabia

In the current landscape of the COVID-19 pandemic,the utilization of deep learning in medical imaging,especially in chest computed tomography(CT)scan analysis for virus detection,has become increasingly *** its potential,deep learning’s“black box”nature has been a major impediment to its broader acceptance in clinical environments,where transparency in decision-making is *** bridge this gap,our research integrates Explainable AI(XAI)techniques,specifically the Local Interpretable Model-Agnostic Explanations(LIME)method,with advanced deep learning *** integration forms a sophisticated and transparent framework for COVID-19 identification,enhancing the capability of standard Convolutional Neural Network(CNN)models through transfer learning and data *** approach leverages the refined DenseNet201 architecture for superior feature extraction and employs data augmentation strategies to foster robust model *** pivotal element of our methodology is the use of LIME,which demystifies the AI decision-making process,providing clinicians with clear,interpretable insights into the AI’s *** unique combination of an optimized Deep Neural Network(DNN)with LIME not only elevates the precision in detecting COVID-19 cases but also equips healthcare professionals with a deeper understanding of the diagnostic *** method,validated on the SARS-COV-2 CT-Scan dataset,demonstrates exceptional diagnostic accuracy,with performance metrics that reinforce its potential for seamless integration into modern healthcare *** innovative approach marks a significant advancement in creating explainable and trustworthy AI tools for medical decisionmaking in the ongoing battle against COVID-19.

关键词： Explainable AI COVID-19 CT images deep learning

Fully flexible implantable neural probes for electrophysiology recording and controlled neurochemical modulation

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MICROSYSTEMS & NANOENGINEERING 2024年第1期10卷 1-17页

作者： Malekoshoaraie, mohammad hassan Wu, Bingchen Krahe, Daniela D. Ahmed, Zabir Pupa, Stephen Jain, Vishal Cui, Xinyan Tracy Chamanzar, Maysamreza Carnegie Mellon Univ Elect & Comp Engn Pittsburgh PA 15213 USA Carnegie Mellon Univ Carnegie Mellon Neurosci Inst Pittsburgh PA 15213 USA Univ Pittsburgh Bioengn Pittsburgh PA 15260 USA Univ Pittsburgh Ctr Neural Basis Cognit Pittburgh PA 15213 USA Carnegie Mellon Univ Pittburgh PA 15213 USA Univ Pittsburgh McGowan Inst Regenerat Med Pittsburgh PA 15219 USA

Targeted delivery of neurochemicals and biomolecules for neuromodulation of brain activity is a powerful technique that, in addition to electrical recording and stimulation, enables a more thorough investigation of neural circuit dynamics. We have designed a novel, flexible, implantable neural probe capable of controlled, localized chemical stimulation and electrophysiology recording. The neural probe was implemented using planar micromachining processes on Parylene C, a mechanically flexible, biocompatible substrate. The probe shank features two large microelectrodes (chemical sites) for drug loading and sixteen small microelectrodes for electrophysiology recording to monitor neuronal response to drug release. To reduce the impedance while keeping the size of the microelectrodes small, poly(3,4-ethylenedioxythiophene) (PEDOT) was electrochemically coated on recording microelectrodes. In addition, PEDOT doped with mesoporous sulfonated silica nanoparticles (SNPs) was used on chemical sites to achieve controlled, electrically-actuated drug loading and releasing. Different neurotransmitters, including glutamate (Glu) and gamma-aminobutyric acid (GABA), were incorporated into the SNPs and electrically triggered to release repeatedly. An in vitro experiment was conducted to quantify the stimulated release profile by applying a sinusoidal voltage (0.5 V, 2 Hz). The flexible neural probe was implanted in the barrel cortex of the wild-type Sprague Dawley rats. As expected, due to their excitatory and inhibitory effects, Glu and GABA release caused a significant increase and decrease in neural activity, respectively, which was recorded by the recording microelectrodes. This novel flexible neural probe technology, combining on-demand chemical release and high-resolution electrophysiology recording, is an important addition to the neuroscience toolset used to dissect neural circuitry and investigate neural network connectivity.

关键词： CONVECTION-ENHANCED DELIVERY CONTROLLED-RELEASE DRUG-DELIVERY NEURONS MICROELECTRODES ASTROCYTES DEXAMETHASONE POLYPYRROLE RESPONSES SYSTEM

Stable Isotopic Signatures of NO₃ in Waste Water Effluent and Los Angeles River

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Journal of Water Resource and Protection 2024年第1期16卷 102-122页

作者： Isaac Hall mohammad hassan Rezaie Boroon Department of Geography Geology and Environment California State University Los Angeles California USA

A metropolitan city such as Los Angeles (LA) is an ideal study site with a very high population density, and it houses at least 3 treatment plants where sewage is treated preliminarily and then progressing to tertiary treatment before discharging into the LA River. We will gain a better understanding of the water quality in the LA River and the nitrate load in the watershed system by examining the influence of waste water treatment plants (WWTPs). The goal of this study is to pinpoint the exact source of nitrate in the LA River using the isotope signatures. We have selected sampling locations both upstream and downstream of the WWTP. This serves to monitor nitrate levels, aiding in the assessment of treatment plant effectiveness, pinpointing nitrate pollution sources, and ensuring compliance with environmental regulations. The research explores the isotopic composition of NO3 in relation to atmospheric nitrogen and Vienna Standard Mean Ocean Water, shedding light on the contributions from various sources such as manure, sewage, soil organic nitrogen, and nitrogen fertilizers. Specifically, there is a change in the δ15NAir value between the dry and wet seasons. The isotope values in the Tillman WWTP sample changed between dry and wet seasons. Notably, the presence of nitrate originating from manure and sewage is consistent across seasons, emphasizing the significant impact of anthropogenic and agricultural activities on water quality. This investigation contributes to the broader understanding of nitrogen cycling in urban water bodies, particularly in the context of wastewater effluent discharge. The findings hold implications for water quality management and highlight the need for targeted interventions to mitigate the impact of nitrogen-containing compounds on aquatic ecosystems. Overall, the study provides a valuable framework for future research and environmental stewardship efforts aimed at preserving the health and sustainability of urban water resources. This

关键词： Metropolitan City Los Angeles Treatment Plants Sewage Treatment Nitrate Source Isotope Signatures Water Quality

An evolutionary ensemble learning for diagnosing COVID-19 via cough signals

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Intelligent Medicine 2023年第3期3卷 200-212页

作者： mohammad hassan Tayarani Najaran University of Hertfordshire School of Physics Engineering and Computer Science HatfieldUnited Kindom

Objective The spread of the COVID-19 disease has caused great concern around the world and detecting the positive cases is crucial in curbing the *** of the symptoms of the disease is the dry cough it *** has previously been shown that cough signals can be used to identify a variety of diseases including tuberculosis,asthma,*** this paper,we proposed an algorithm to diagnose the COVID-19 disease via cough *** The proposed algorithm was an ensemble scheme that consists of a number of base learners,where each base learner used a different feature extractor method,including statistical approaches and convolutional neural networks(CNNs)for automatic feature *** were extracted from the raw signal and some transforms performed it,including Fourier,wavelet,Hilbert-Huang,and short-term Fourier *** outputs of these base-learners were aggregated via a weighted voting scheme,with the weights optimised via an evolutionary *** paper also proposed a memetic algorithm for training the CNNs in the base-learners,which combined the speed of gradient descent(GD)algorithms and global search space coverage of the evolutionary *** Experiments were performed on the proposed algorithm and different rival algorithms which included a number of CNN architectures in the literature and generic machine learning *** results suggested that the proposed algorithm achieves better performance compared to the existing algorithms in diagnosing COVID-19 via cough *** COVID-19 may be diagnosed via cough signals and CNNs may be employed to process these signals and it may be further improved by the optimization of CNN architecture.

关键词： Optimization Evolutionary algorithms COVID-19

Selecting proper sites for underground dam construction using Multi-Attribute Utility Theory in arid and semi-arid regions

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Journal of Mountain Science 2023年第1期20卷 197-208页

作者： mohammad hassan SADEGHIRAVESH hassan KHOSRAVI Azam ABOLHASANI Department of Environment College of AgricultureTakestan BranchIslamic Azad UniversityTakestanIran Department of Reclamation of Arid and Mountainous Regions Faculty of Natural ResourcesUniversity of TehranTehranIran

Although the construction of underground dams is one of the best methods to conserve water resources in arid and semi-arid regions,applying efficient methods for the selection of suitable sites for subsurface dam construction remains a *** to the costly and time-consuming methods of site selection for underground dam construction,this study aimed to present a new method using geographic information systems techniques and decision-making *** exclusionary criteria including fault,slope,hypsometry,land use,soil,stream,geology,and chemical properties of groundwater were selected for site selection of dam construction and inappropriate regions were omitted by integration and scoring layers in ArcGIS based on the Boolean ***,appropriate sites were prioritized using the Multi-Attribute Utility *** to the results of the utility coefficient,seven sites were selected as the region for underground dam construction based on all criteria and experts’*** site of Nazarabad dam was the best location for underground dam construction with a utility coefficient of 0.7137 followed by sites of Akhavan with a utility coefficient of 0.4633 and Mirshamsi with a utility coefficient of *** study proposed a new approach for the construction of the subsurface dam at the proper site and help managers and decision-makers achieve sustainable water resources with limited facilities and capital and avoid wasting national capital.

关键词： Prioritization Geographic information system Multi-Attribute decision making Arid region

Modeling and numerical simulation of electrical and optical characteristics of a quantum dot light-emitting diode based on the hopping mobility model:Influence of quantum dot concentration

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Chinese Physics B 2022年第6期31卷 725-735页

作者： Pezhman Sheykholeslami-Nasab Mahdi Davoudi-Darareh mohammad hassan Yousefi Faculty of Science Malek Ashtar University of TechnologyShahin-ShahrIran

We present a comprehensive numerical framework for the electrical and optical modeling and simulation of hybrid quantum dot light-emitting diodes(QD-LEDs).We propose a model known as hopping mobility to calculate the carrier mobility in the emissive organic layer doped with quantum dots(QDs).To evaluate the ability of this model to describe the electrical characteristics of QD-LEDs,the measured data of a fabricated QD-LED with different concentrations of QDs in the emissive layer were taken,and the corresponding calculations were performed based on the proposed *** simulation results indicate that the hopping mobility model can describe the concentration dependence of the electrical behavior of the ***,based on the continuity equation for singlet and triplet excitons,the exciton density profiles of the devices with different QD concentrations were ***,the corresponding luminance characteristics of the devices were calculated,where the results are in good agreement with the experimental data.

关键词： hybrid quantum dot light-emitting diode(QD-LED) concentration-dependent hopping mobility effective transport model Gaussian band structure

Effects of synbiotic supplementation on anthropometric indices and body composition in overweight or obese children and adolescents:a randomized,double-blind,placebo-controlled clinical trial

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World Journal of Pediatrics 2023年第4期19卷 356-365页

作者： mohammad Amin Atazadegan Motahar Heidari-Beni mohammad hassan Entezari Fariborz Sharifianjazi Roya Kelishadi Department of Clinical Nutrition School of Nutrition and Food SciencesIsfahan University of Medical SciencesIsfahanIran Department of Nutrition Child Growth and Development Research CenterResearch Institute for Primordial Prevention of Non-Communicable DiseaseIsfahan University of Medical SciencesIsfahanIran Department of Clinical Nutrition School of Nutrition and Food ScienceIsfahan University of Medical SciencesIsfahanIran School of Science and Technology The University of GeorgiaTbilisiGeorgia Department of Pediatrics Child Growth and Development Research CenterResearch Institute for Primordial Prevention of Non-Communicable DiseaseIsfahan University of Medical SciencesIsfahanIran

Background Recently,beneficial effects of probiotics and/or prebiotics on cardio-metabolic risk factors in adults have been ***,existing evidence has not been fully established for pediatric age *** study aimed to assess the effect of synbiotic on anthropometric indices and body composition in overweight or obese children and *** This randomized double-blind,placebo-controlled trial was conducted among 60 participants aged 8-18 years with a body mass index(BMI)equal to or higher than the 85th *** were randomly divided into two groups that received either a synbiotic capsule containing 6x109 colony forming units(CFU)Lactobacillus coagulans SC-208,6 x 109 CFU Lactobacillus indicus HU36 and fructooligosaccharide as a prebiotic(n=30)or a placebo(n=30)twice a day for eight *** indices and body composition were measured at baseline and after the *** The mean(standard deviation,SD)age was 11.07(2.00)years and 11.23(2.37)years for the placebo and synbiotic groups,respectively(P=0.770).The waist-height ratio(WHtR)decreased significantly at the end of the intervention in comparison with baseline in the synbiotic group(0.54±0.05 vs.0.55±0.05,P=0.05).No significant changes were dem-onstrated in other anthropometric indices or body composition between *** Synbiotic supplementation might be associated with a reduction in *** were no significant changes in other anthropometric indices or body composition.

关键词： Anthropometry Body composition Pediatrics Synbiotics

Theoretical insights into the degradation mechanisms, kinetics and eco-toxicity of oxcarbazepine initiated by OH radicals in aqueous environments

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Journal of Environmental Sciences 2023年第7期129卷 189-201页

作者： Yanhui Sun Ming Li mohammad hassan Hadizadeh Lin Liu Fei Xu College of Environment and Safety Engineering Qingdao University of Science and TechnologyQingdao 266042China Environment Research Institute Shandong UniversityQingdao 266237China

As an anticonvulsant,oxcarbazepine(OXC)has attracted considerable attention for its potential threat to aquatic *** functional theory has been used to study the mechanisms and kinetics of OXC degradation initiated by OH radicals in aqueous environment.A total of fourteen OH-addition pathways were investigated,and the addition to the C8 position of the right benzene ringwas themost vulnerable pathway,resulting in the intermediate *** H-abstraction reactions initiated by OH radicalswere also explored,where the extraction site of the methylene group(C14)on the seven-member carbon heterocyclic ring was found to be the optimal *** calculations show that the total rate constant of OXC with OH radicals is 9.47×10^(9)(mol/L)^(−1)sec^(−1),and the half-life time is 7.32 s at 298 K with the[·OH]of 10^(−11) mol/***,the branch ratio values revealed that OH-addition(89.58%)shows more advantageous than H-abstraction(10.42%).To further understand the potential eco-toxicity of OXC and its transformation products to aquatic organisms,acute toxicity and chronic toxicity were evaluated using ECOSAR *** toxicity assessment revealed that most degradation products such as OXC-2OH,OXC-4OH,OXC-1O-1OOH,and OXC-1OH’are innoxious to fish and ***,green algae are more sensitive to these *** study can provide an extensive investigation into the degradation of OXC by OH radicals and enrich the understanding of the aquatic oxidation processes of pharmaceuticals and personal care products(PPCPs).

关键词： Oxcarbazepine OH radicals Degradation mechanisms Kinetic calculation Eco-toxicity evaluation

Application of unified protocol as a transdiagnostic treatment for emotional disorders during COVID-19: An internet-delivered randomized controlled trial

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World Journal of Clinical Cases 2022年第24期10卷 8599-8614页

作者： Kou Yan mohammad hassan Yusufi Nabi Nazari School of Humanities and Education Xi'an Eurasia UniversityXi'an 710065Shaanxi ProvinceChina Education Administration Bamyan UniversityBamyan 22502Afghanistan Department of Psychology Faculty of Human SciencesLorestan UniversityKhorramabadLorestanIran

BACKGROUND The coronavirus disease 2019(COVID-19)pandemic has been an emotionally challenging time,especially for young *** is associated with a substantial increase in the prevalence of mental health problems,negative symptoms,and stressful experiences that compromise *** low-income countries,internet-delivered psychological services could have a remarkable impact on the population’s mental health,given the lack of mental health *** To investigate the efficacy of internet-delivered cognitive-behavior therapy(CBT)-transdiagnostic intervention for adults with emotional *** In this internet-delivered randomized controlled trial,102 students with an emotional disorder(mean age=28.20 years,standard deviation=5.07)were randomly allocated to receive unified protocol(UP)(n=51)or treatment as the usual *** a semi-structured clinical interview,participants completed an online survey including the Overall Anxiety Severity and Impairment Scale,Overall Depression Severity and Impairment Scale,Difficulties in Emotion Regulation Scale,Positive and Negative Affect Schedule,and Emotional Style *** The participants showed a high degree of *** total,78%(n=40)of the experimental group participants completed the UP *** the intention to treat procedure,the results of the analysis of covariance indicated that participants who received UP showed statistically significant changes in depression symptoms[Cohen’s d=-1.50 with 95%confidence interval(CI):-1.90 to-1.10],anxiety(Cohen’s d=-1.06 with 95%CI:-1.48 to-0.65),difficulties with emotion regulation(Cohen’s d=-0.33 with 95%CI:-0.7 to-0.06),positive affect(Cohen's d=1.27 with 95%CI:0.85 to 1.68),negative affect(Cohen’s d=-1.04 with 95%CI:-1.46 to-0.63),and healthy emotionality(Cohen’s d=0.53 with 95%CI:0.09 to 0.13)compared with the control *** This study’s findings highlight the potential value of transdiagnostic interne

关键词： Unified protocol COVID-19 Internet-delivered Emotion regulation Transdiagnostic Depression Anxiety