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Black radish root extract alleviates sodium valproate-induced liver damage via inhibiting mitochondrial membrane potential collapse and oxidative stress in mice

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Asian Pacific Journal of Tropical Biomedicine 2024年第7期14卷 298-306页

作者： mohammad hadi zarei Sami Akbulut Maryam Zafari Elham Saghaei Zahra Lorigooini Hossein AminiKhoei Somaye Khosravi Elham Bijad Medical Plants Research Center Basic Health Sciences InstituteShahrekord University of Medical SciencesShahrekordIran Department of Liver Transplant Institute and Biostatistics Inonu University Faculty of Medicine44280MalatyaTurkey Student Research Committee Shahrekord University of Medical SciencesShahrekordIran Physiology and Pharmacology Department School of MedicineShahrekord University of Medical SciencesShahrekordIran Department of Anatomical Sciences School of MedicineShahrekord University of Medical SciencesShahrekordIran

Objective:To explore the effect of black radish(Raphanus sativus *** niger)root extract on liver enzymes,oxidative stress,and histopathological alterations in mice with sodium valproate-induced ***:Thirty-two mice were divided into four groups:the control group received drinking water by gavage,the second group was administered with 100 mg/kg of sodium valproate,the third group received 300 mg/kg of black radish root extract,and the fourth group was given both sodium valproate(100 mg/kg)and black radish root extract(300 mg/kg).After 28 days,the mice were euthanized,and serum levels of aspartate aminotransferase(AST),alanine aminotransferase(ALT),and alkaline phosphatase(ALP),along with liver malondialdehyde(MDA),reactive oxygen species(ROS),mitochondrial parameters,tumor necrosis factor-alpha(TNF-α)gene expression,and histopathological changes were ***:Sodium valproate caused hepatic damage in mice,characterized by elevated serum levels of liver enzymes,increased MDA and ROS levels and TNF-αgene expression,as well as histopathological *** black radish root extract significantly alleviated sodium valproate-caused hepatic injury by decreasing the serum levels of ALT and AST,MDA,ROS,TNF-αgene expression,as well as mitochondrial impairment,but did not have a significant effect on sodium valproate-induced histopathological ***:The black radish root extract demonstrates protective effects against sodium valproate-induced liver injury,possibly through mitigating oxidative stress,mitochondrial impairment,and inflammatory mediator expression.

关键词： Black radish Raphanus sativus Sodium valproate Hepatotoxicity Oxidative stress Anti-inflammation

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Behavior Analysis of Biomimetic Soft Bending Actuators in Free Motion and Contact

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Journal of Bionic Engineering 2023年第3期20卷 967-981页

作者： mohammad hadi Namdar Ghalati Sepideh Akbari Hamed Ghafarirad mohammad zareinejad Department of Mechanical Engineering Amirkabir University of TechnologyTehran***Iran New Technologies Research Center(NTRC) Amirkabir University of TechnologyTehran***Iran

Bioinspired Soft Bending Actuators (SBA) are increasingly being used in rehabilitation, assistant robots, and grippers. Despite many investigations on free motion modeling, understanding how these actuators interact with the environment requires more detailed research. It is caused by high compliance and nonlinearity of bioinspired soft material, which leads to serious challenges in contact conditions. In this paper, a continuous deformation analysis is presented to describe the free motion nonlinear behavior of the actuator. Based on the achieved result, this study proposes static modeling of SBA affected by a concentrated external force. For this purpose, the finite rigid element method is utilized, which is based on discretizing the actuator into smaller parts and assuming these parts as rigid serial links connected by nonlinear torsional springs. To verify the proposed model, two kinds of forces are considered to be acting on the actuator, i.e. following force and constant direction force. In addition, the effect of gravity on the actuator configuration is also investigated. The validity of the model has been demonstrated through experiments in free motion, contact conditions and the presence of gravity. It generally shows that the prediction error of robot configuration is lower than 7.5%.

关键词： Biomimetic soft bending actuator Static modeling Contact Force constraints Rigid finite element

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Improvement in IBC-silicon solar cell performance by insertion of highly doped crystalline layer at heterojunction interfaces

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Chinese Physics B 2017年第10期26卷 508-514页

作者： hadi Bashiri mohammad Azim Karami Shahramm mohammadnejad School of Electrical Engineering Iran University of Science &Technology (IUST)

By inserting a thin highly doped crystalline silicon layer between the base region and amorphous silicon layer in an interdigitated back-contact （IBC） silicon solar cell, a new passivation layer is investigated. The passivation layer performance is characterized by numerical simulations. Moreover, the dependence of the output parameters of the solar cell on the additional layer parameters （doping concentration and thickness） is studied. By optimizing the additional passivation layer in terms of doping concentration and thickness, the power conversion efficiency could be improved by a factor of 2.5%, open circuit voltage is increased by 30 mV and the fill factor of the solar cell by 7.4%. The performance enhancement is achieved due to the decrease of recombination rate, a decrease in solar cell resistivity and improvement of field effect passivation at heterojunction interface. The above-mentioned results are compared with reported results of the same conventional interdigitated back-contact silicon solar cell structure. Furthermore, the effect of a-Si：H/c-Si interface defect density on IBC silicon solar cell parameters with a new passivation layer is studied. The additional passivation layer also reduces the sensitivity of output parameter of solar cell to interface defect density.

关键词： IBC silicon solar cells interface layer recombination interface defect density

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Fracture analyses of different pre-holed concrete specimens under compression

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Acta Mechanica Sinica 2015年第6期31卷 855-870页

作者： hadi Haeri Alireza Khaloo mohammad Fatehi Marji Department of Civil Engineering Sharif University of Technology Member of National Elites Foundation Center of Excellence in Structure and Earthquake Engineering Sharif University of Technology Mine Exploitation Engineering Department Faculty of Mining and Metallurgy Yazd University

Crack propagation processes in specially prepared concrete discs and rectangular specimens containing a single cylindrical hole or multiple holes of varying diameters have been studied both experimentally and numerically. In this research, the cracks coalescence paths in Brazilian disc and rectangular specimens made from rock-like material containing multi-holes are investigated. These concrete specimens are specially prepared from an appropriate mixture of Portland Pozzolana Cement （PPC）, fine sands, and water. The pre-holed Brazilian discs and rectangular specimens are experimentally tested under compression. The breakage load in the ring type disc specimens containing an axial hole with varying diameters is measured and the distribution of the induced lateral stress is obtained. The mechanism of cracks propagation in the wall of the ring type specimens is also stud- ied. In the case of multi-hole Brazilian disc and rectangular specimens, the cracks propagation and cracks coalescence are also investigated. These experiments are numerically modeled by a modified higher order displacement discontinuity method. It has been shown that the corresponding experimental and numerical results are in good agreement with each other. The results presented in this research vali date the accuracy and applicability of these crack analyses procedures.

关键词： Concrete rings Pre-holed Brazilian disc ·Rectangular specimens Crack analyses Coalescence ·Induced lateral stress

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A robust subband adaptive filter algorithm for sparse and block-sparse systems identification

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Journal of Systems Engineering and Electronics 2021年第2期32卷 487-497页

作者： ZAHRA Habibi hadi Zayyani mohammad Shams Esfand Abadi Research Institute for Information and Communications Technologies Academic Center for EducationCulture and ResearchTehran ***Iran Department of Electrical and Computer Engineering Qom University of TechnologyQom 371951519Iran Faculty of Electrical Engineering Shahid Rajaee Teacher Training UniversityTehran ***Iran

This paper presents a new subband adaptive filter(SAF)algorithm for system identification scenario under impulsive interference,named generalized continuous mixed p-norm SAF(GCMPN-SAF)*** proposed algorithm uses a GCMPN cost function to combat the impul-sive *** further accelerate the convergence rate in the sparse and the block-sparse system identification processes,the proportionate versions of the proposed algorithm,the L0-norm GCMPN-SAF(L0-GCMPN-SAF)and the block-sparse GCMPN-SAF(BSGCMPN-SAF)algorithms are also ***,the convergence analysis of the proposed algorithm is *** results show that the proposed algorithms have a better performance than some other state-of-the-art algorithms in the literature with respect to the convergence rate and the tracking capability.

关键词： subband adaptive filter(SAF) generalized continuous mixed p-norm(GCMPN) sparse system block-sparse system impulsive interference

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Experimental investigation of density current patterns using dynamic fractal analysis

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International Journal of Sediment Research 2021年第2期36卷 165-176页

作者： mohammad Hosseini mohammad hadi Fattahi Saeid Eslamian Department of Civil Engineering Najafabad Branch Islamic Azad University Department of Civil Engineering Marvdasht Branch Islamic Azad University Department of Water Engineering Isfahan University of Technology

Density currents are caused by a difference in density, though low, of an entering fluid with the ambient fluid. This type of current is two-phased and found on riverbeds or in reservoirs behind dams, and is nonlinear in nature, complex, and sensitive to initial conditions. Fractal geometry is used as a powerful tool for studying complex natural phenomena. Using experimental studies and changes in inlet current conditions, the fractal and multi-fractal analyses of the interface between the density current and the ambient fluid were done. In addition, a search was made to find a possible connection between the nonlinear patterns. According to the results, with an increase in the inlet discharge and inlet density of the current the fractal dimension decreased. Further, the smaller the range of the singularity spectrum diagram was, i.e., the more it was less than 0.34, the lower the system’s tendency was to be multi-fractal,and the system sensitive to large local changes. In the interface between the density current and the ambient fluid, using the fractal dimension-based Richardson number could improve experimental data by 12.4%. Moreover, with an increase in the Richardson number, the Reynolds number of the current decreased. Further, upon considering the fractal dimension, the Reynolds number improved by 23% and a good correlation with a coefficient of determination of 0.76.

关键词： Density current Fractal geometry Richardson number Multi-fractal analysis Fluid interface

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Investigation of the stability and hydrodynamics of Tetrosomus gibbosus carapace in different pitchangles

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Journal of Hydrodynamics 2019年第2期31卷 368-378页

作者： Mahyar Malekidelarestaqi Alireza Riasi hadi Moradi mohammad Samadpour School of Mechanical Engineering University of TehranTehranIran Intelligent Systems Research Institute Sungkyunkwan UniversitySeoulKorea School of Electrics and Computer Engineering University of TehranTehranIran School of Mechanical Engineering Amirkabir University of TechnologyTehranIran

In this paper,stability properties of Tetrosomus gibbosus have been experimentally and numerically studied in pitching *** fish lives in southern offshores of *** usually live in extremely turbulent parts of seas and oceans,with high stability and maneuverability that has caught the attention of *** body shape let them swim with a quite rapid *** on Boxfishes have had influences on automotive and marine *** CAD file of the boxfish was created using optical *** a model was built and tested in a subsonic wind tunnel and a numerical study was conducted in virtual wind *** experimental results are consistent with the numerical ones and also support the findings of other studies on similar *** results show that the flow around the fish,which is a consequence of its body shape,tries to maintain the stable position of the fish by resisting against the external force tilting the fish from its stable horizontal *** ventral and dorsal keels of the boxfish generate column-like vortices in horizontal direction which play an imperative role in maintaining the stability of the fish.

关键词： Boxfish Tetrosomus gibbosus humpback turretfish hydrodynamic stability experimental fluid mechanics bio-inspired engineering

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Reservoir volume optimization and performance evaluation of rooftop catchment systems in arid regions: A case study of Birjand, Iran

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Water Science and Engineering 2017年第2期10卷 125-133页

作者： Zinat Komeh hadi Memarian Seyed mohammad Tajbakhsh Faculty of Natural Resources and Environment University of Birjand Birjand 97175 Iran

This study evaluated the performance of rooftop catchment systems in securing non-potable water supply in Birjand, located in an arid area in southeastern Iran. The rooftop catchment systems at seven study sites of different residential buildings were simulated for dry, normal, and wet water years, using 31-year rainfall records. The trial and error approach and mass diagram method were employed to optimize the volume of reservoirs in five different operation scenarios. Results showed that, during the dry water year from 2000 to 2001, for reservoirs with volumes of 200-20000 L, the proportion of days that could be secured for non-portable water supply was on average computed to be 16.4%-32.6% across all study sites. During the normal water year from 2009 to 2010 and the wet water year from 1995 to 1996, for reservoirs with volumes of 200-20000 L, the proportions were 20.8%-69.6% and 26.8%-80.3%, respectively. Therefore, a rooftop catchment system showed a high potential to meet a significant portion of non-potable water demand in the Birjand climatic region. Reservoir volume optimization using the mass diagram method produced results consistent with those obtained with the trial and error approach, except at sites #1, #2, and #5. At these sites, the trial and error approach performed better than the mass diagram method due to relatively high water consumption. It is concluded that the rooftop catchment system is applicable under the same climatic conditions as the study area, and it can be used as a drought mitigation strategy as well.

关键词： Mass diagram analysis Non-potable water demand Reservoir volume optimization Rooftop catchment Rainwater harvesting

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Role of heat balance on the microstructure evolution of cold spray coated AZ31B with AA7075

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Journal of Magnesium and Alloys 2021年第4期9卷 1467-1478页

作者： Bahareh Marzbanrad mohammad hadi Razmpoosh Ehsan Toyserkani Hamid Jahed Mechanical and Mechatronics Engineering Department University of WaterlooCanada

A promising solid-state coating mechanism based on the cold spray technique provides highly advantageous conditions on thermal-sensitive magnesium *** study the effect of heat balance in cold spray coating on microstructure,experiments were designed to successfully coat AA7075 on AZ31B with two different heat balance conditions to yield a coated sample with tensile residual stress and a sample with compressive residual stress in both coating and *** effects of coating temperature on the microstructure of magnesium alloy and the interfaces of coated samples were then analyzed by SEM,EBSD,TEM in high-and low-heat input coating *** interface of the AA7075 coating and magnesium alloy substrate under both conditions consists of a narrow-band layer with very fine grains,followed by columnar grains of magnesium that have grown perpendicular to the *** higher temperatures,this layer became *** intermetallic phase was detected at the interface under either *** is shown that the microstructure of the substrate was affected by coating temperature,leading to stress relief,dynamic recrystallization and even dynamic grain growth of magnesium under high *** the heat input and increasing the heat transfer decreased microstructural changes in the substrate.

关键词： Cold spraying Heat balance Microstructural analysis Coating interface Magnesium Alloy AZ31B Residual Stress

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Preparation of 1-amidoalkyl-2-naphthol derivatives using barium phosphate nano-powders

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Chinese Chemical Letters 2016年第1期27卷 119-126页

作者： hadi Taghrir Majid Ghashang mohammad Najafi Biregan Devartment of Chemistry. Science and Research Branch Islamic Azad University Arak Iran Department of Chemistry Faculty of Sciences Najafabad Branch Islamic Azad University Najafabad Iran

Barium phosphate（Ba_3（PO_4）_2） nano-powder was successfully synthesized via a simple precipitation route without any surfactant. The prepared nano-powder was applied for the facile synthesis of 1-amidoalkyl-2-naph... 详细信息

关键词： Multi-component reaction 1-Amidoalkyl-2-naphthol Barium phosphate(Ba_3(PO_4)_2) 2-Hydroxydibenzofuran

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