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Posterior Lumbar Interbody Fusion versus Posterolateral Fusion in Surgical Treatment of Lumbar Spondylolithesis

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Open Journal of Modern Neurosurgery 2020年第1期10卷 135-145页

作者： Khaled Ismail Abdelaziz Radwan Nouby mohammad Fekry Elshirbiny Ahmed Salaheldin Mahmoud Department of Neurosurgery Faculty of Medicine Aswan University Aswan Egypt Department of Neurosurgery Faculty of Medicine Assiut University Assiut Egypt

Background: The optimal surgical technique for lumbar spondylolithesis remains debated. Although posterior lumbar interbody fusion (PLIF) theoretically offers more advantages than posterolateral lumbar fusion (PLF), the evidence remains inconclusive. Aim: The aim of this study is to compare the clinical and functional outcomes of PLIF versus PLF in patients with lumbar spondylolithesis. Patients and Methods: We enrolled 38 patients with lumbar spondylolithesis (degenerative and isthmic) who underwent PLIF (N = 19) or PLF (N = 19). We collected operative data and performed follow-up for 12 months after the surgery. The collected data were analyzed using the SPSS software to detected significant differences between both groups. Results: The PLF and PLIF groups exhibited similar pre-operative characteristics between both groups in terms of age (p = 0.57), sex (p = 0.73), clinical presentation (p = 1), required levels of fixation (p = 1), pre-operative VAS score (p = 0.43) or muscle weakness (p = 1). However, the PLIF group had significantly more blood loss and longer operative time than the PLF group. Moreover, both groups had similar levels of postoperative pain (up to six months after surgery), and post-operative complications. The rates of arthrodesis were higher in PLIF group than PLF group within six months while no significant difference within 12 months of follow-up. Conclusion: In our comparative study, we achieved comparison between pedicle screw fixation with posterolateral fusion alone (PLF) in compare with pedicle screw fixation with posterior lumbar interbody fusion (PLIF). Results indicate better results of fusion rate in PLIF as regards arthrodesis with slightly more rate of complication than PLF. So we recommend PLIF in cases of lumbar spondylolithesis than PLF.

关键词： Arthrodesis Lumbar Spondylolithesis Posterior Lumbar Interbody Fusion (PLIF) Posterolateral Fusion (PLF)

Association of Vitamin D Deficiency with Diabetic Retinopathy in Young People with Type 1 Diabetes Mellitus

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Open Journal of Ophthalmology 2023年第1期13卷 48-63页

作者： Abir Bin Sajj Bedowra Zabeen mohammad Zafar Khaled Nuzhat Choudhury Tohura Sharmin Vision Eye Hospital Dhaka Bangladesh Department of Paediatric Endocrinology CDIC Bangladesh Institute of Research and Rehabilitation in Diabetes Endocrine and Metabolic Disorder (BIRDEM) Dhaka Bangladesh Department of Ophthalmology Bangabandhu Sheikh Mujib Medical University (BSMMU) Dhaka Bangladesh Department of Community Medicine Ad-Din Women’s Medical College Dhaka Bangladesh

Background: Diabetic retinopathy is among the most common diabetic complications, and is one of the leading causes of blindness in the world. Recent studies have linked vitamin D to the pathogenesis of diabetes and there is growing evidence that vitamin D can interfere with the mechanisms involved in diabetes and its complications. Despite improvements in treatment, diabetic retinopathy remains a significant complication of type 1 diabetes mellitus. Identification of early treatable predictors of diabetic retinopathy such as vitamin D deficiency, may allow more aggressive management of those at high risk. Purpose: To assess the association of vitamin D deficiency with diabetic retinopathy in young people with type 1 diabetes mellitus. Design: Observational study with case control design. Method: 60 young people with type 1 diabetes aged between 11 to 24 years were included in this study. Among them, 30-young people have diabetic retinopathy and 30-young people do not have diabetic retinopathy. Purposive sampling technique was applied as per inclusion criteria. Statistical analysis of the results was done by using computer-based software, SPSS version 26. P value of less than 0.05 was considered as statistically significant. Results: Vitamin D deficiency was present in 83% of the young people with diabetic retinopathy and in 53% without diabetic retinopathy. The mean vitamin D level in young people with and without diabetic retinopathy was 17.38 ± 3.77 ng/ml and 20.15 ± 5.06 ng/ml respectively and the difference was statistically significant (p = 0.019). Vitamin D deficiency was increased with the severity of diabetic retinopathy. Univariate and multivariate logistic regression showed vitamin D deficiency was independently associated with diabetic retinopathy with a crude odds ratio of 5.69 with a p value of 0.008 and adjusted odds ratio of 16.08 with a p value of 0.002 respectively. Conclusion: Result of the study revealed that vitamin D deficiency was strongly asso

关键词： Vitamin D Deficiency Type 1 Diabetes Mellitus Diabetic Retinopathy Young People

Bioconversion of Fish Hatchery Waste as Feed in the Production of Live Feed

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Advances in Bioscience and Biotechnology 2020年第7期11卷 289-300页

作者： Sujjat Al Azad Al-Najib Bin Benjamin mohammad Tamrin Bin Mohamad Lal Borneo Marine Research Institute University Malaysia Sabah Kota Kinabalu Malaysia

Purple Non-Sulfur Bacteria (PNSB), also known as phototrophic bacteria are widely distributed in both freshwater and marine environment and capable to grow in wide range of substrates. In this study, Bacterium Rhodobacter sphaeroides strain UMS2, a freshwater isolate was used in this study in utilization of fish hatchery waste. This study was conducted to determine the nutritional values of bioprocess product that was grown in fish hatchery waste. Finally, the waste bio-converted product was used as feed supplement to monitor the growth performance of live feed Tubifex spp. Inoculum of Rhodobacter sphaeroides strain UMS2 was developed in 112 synthetic media and 48-h culture of 30% (v/v) inoculum was used in fish hatchery waste during the bioprocess. The nutritional values of bio-converted product, except total ash (%), were not significantly improved with 30% (v/v) inoculum of Rhodobacter sphaeroides, strain UMS2. Feeding trial in bloodworm (Tubifex spp.) with bioconversion product conducted for 15 days to monitor growth (w/v) of live feed. Initial growth 1.42 ± 0.001 g/L of Tubifex spp. was stocked in 15 × 75 × 15 cm plastic tray connected with recirculated system. Tubifex

关键词： Hatchery Waste Bioprocess Microbe and Live Hatchery Waste Bioprocess Microbe and Live Feed Growth

Performance Study of Locality and Its Impact on Peer-to-Peer Systems

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Communications and Network 2015年第1期7卷 12-20页

作者： Mohammed Younus Talha Rabah W. Aldhaheri mohammad H. Awedh Department of Electrical and Computer Engineering King Abdulaziz University Jeddah Saudi Arabia

This paper presents the measurement study of locality-aware Peer-to-Peer solutions on Internet Autonomous System (AS) topology by reducing AS hop count and increase nearby source nodes in P2P applications. We evaluate the performance of topology-aware BT system called TopBT with BitTorrent (BT) by constructing AS graph and measure the hops between nodes to observe the impact of quality of service in P2P applications.

关键词： Peer-to-Peer BitTorrent TopBT Locality Autonomous System

DFT-Based Chemical Reactivity Descriptors, Pharmacokinetics and Molecular Docking Studies of Thymidine Derivatives

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Computational Chemistry 2023年第4期11卷 81-103页

作者： mohammad Ahad Hossain Shahin Sultana mohammad Mazherul Islam Sonia Akhter Faria Nur Fatima Majabin Kantom Islam Kazi Jawad Hossain Yasuhiro Ozeki Sarkar M. A. Kawsar Laboratory of Carbohydrate and Nucleoside Chemistry (LCNC) Department of Chemistry Faculty of Science University of Chittagong Bangladesh Graduate School of NanoBio Sciences Yokohama City University Yokohama Japan

Thymidine-containing derivatives are considered to be among the most significant derivatives in medicinal chemistry. In this study, we employed a combined computational approach involving density-functional theory (DFT) calculations, molecular docking simulations, and absorption, distribution, metabolism, excretion, and toxicity (ADMET) property predictions. Prediction of activity spectra for substances (PASS) revealed promising antiviral, antimicrobial and anti-carcinogenic activities of these thymidine derivatives. Using Gaussian 09, we optimized the molecular structures of the thymidine derivatives to obtain their stable conformations and calculate their electronic properties. Subsequently, molecular docking simulations were performed to explore the binding interactions between the thymidine derivatives and the active site of the Candida albicans (PDB: 1IYL and 2Y7L) proteins. The docking results were evaluated based on docking scores, hydrogen bonding, and hydrophobic interactions and revealed favorable binding interactions between the thymidine derivatives and the proteins, suggesting their potential as antifungal agents. The thermodynamic properties, including binding free energy, enthalpy, and entropy changes were determined to assess the stability and strength of the ligands-protein complexes. The calculated pharmacokinetic parameters, such as ADMET properties, provided insights into the drug-likeness and potential bioavailability of the thymidine derivatives. These results offer a foundation for further experimental investigations and the design of novel antifungal agents targeting Candida albicans infections.

关键词： Thymidine DFT Molecular Docking Pharmacokinetics Candida albicans

Blockchain Application in Banking System

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Journal of Software Engineering and Applications 2021年第7期14卷 298-311页

作者： Minhaj Uddin Chowdhury Khairunnahar Suchana Syed Md Eftekhar Alam mohammad Monirujjaman Khan Department of Electrical and Computer Engineering North South University Dhaka Bangladesh

The 21st Century is all about technology. People are open to accepting new technologies as the need for modernization is increasing every single day. Blockchain is one of those new and revolutionary technologies that will have a significant impact on the market and industry. In layman’s terms, Blockchain is a data structure that stores transactional records while also ensuring security, transparency, and decentralization. There is a digital signature on every transaction on a blockchain, which proves the authenticity of the blockchain. In a Blockchain, data is stored which is tamper-proof and cannot be changed as it uses encryption and digital signatures. To change a record on a blockchain, one needs to change several records, and one needs to change the distributed ledger. That’s why it’s quite impossible to change the data which has already been entered into a Blockchain. The Blockchain is a technology that will allow transactions simply, safely, effectively, and also safely. This is a very promising technology. It’s already in a lot of places. It can also solve any problem in the banking sector. This technology became famous after introducing the first cryptocurrency, which is known as bitcoin. Right now, there is a huge problem with banking, and the Blockchain can solve these problems. This paper will demonstrate transacting over a secure, blockchain-based network and therefore eliminate the need for intermediary entities. This paper is a review-based paper that provides the application and opportunities of the Blockchain in the banking system. The purpose of this paper is to provide a review of the application and opportunities of the Blockchain for a secure banking system. In this review investigation and analysis of this paper at the beginning, related work from other authors in the same fields has been discussed. Then the working method of the Blockchain technology has been introduced with analysis. The use of bl

关键词： Blockchain Banking Immutable Record Distributed Ledger Hash Application

Preparedness of community-based organisations in biohazard: reliability and validity of an assessment tool

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Family Medicine and Community Health 2019年第3期7卷 30-36页

作者： Fatemeh Rezaei mohammad R Maracy mohammad H Yarmohammadian Ali Ardalan Mahmood Keyvanara Department of health in emergencies and disasters Isfahan University of Meical scienceIsfahanIran(the Islamic Republic of) School of Public Health Department of Epidemiology&BiostatisticsIsfahan University of Medical SciencesIsfahanIran(the Islamic Republic of) Health Management and Economics Research Center Isfahan University of Medical SciencesIsfahanIran(the Islamic Republic of) Department of Health in Emergencies and Disasters School of Public HealthTehran University of Medical SciencesTehranIran(the Islamic Republic of) Faculty of Management and Medical Informatics Isfahan University of Medical SciencesIsfahanIran(the Islamic Republic of)

The purpose of this study was to develop a tool for community-based health organisations(CBHOs)to evaluate the preparedness in biohazards concerning epidemics or *** searched concepts on partnerships of CBHOs with health systems in guidelines of the Centers for Disease Control and Prevention and ***,we validated the researcher-made tool by face validity,content validity,exploratory factor analysis(EFA),confirmatory factor analysis(CFA)and criterion *** were collected by sending the tool to 620 CBHOs serving under supervision of Iran’s ministry of *** of health professionals and stakeholders in CBHOs were used to assess face and content *** loads in EFA were based on three-factor structure that verified by *** used SPSS V.18 and Mplus7 software for statistical *** 105 health-based CBHOs *** conducting face validity and calculating content validity ratio and content validity index,we reached 54 items in the field of planning,training and *** conducted construct validity using 105 *** items exchanged between the fields according to factor loads in EFA,and CFA verified the model fit as Comparative Fit Index,Tucker-Lewis index and root mean square error of approximation were 0.921,0918 and 0.052,*** Cronbach’s of the whole tool was *** correlation coefficient confirmed criterion validity as coefficient was ***,training and infrastructure fields are the most important aspects of preparedness in health-based *** the new assessment tool in future studies will show the weaknesses and capabilities of health-based CBHOs in biohazard and clear necessary intervention actions for health authorities.

关键词： hazard validity verified

Calcium Hydroxide in Endodontics: An Overview

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Open Journal of Stomatology 2016年第12期6卷 274-289页

作者： Raidan Ba-Hattab Manar Al-Jamie Haya Aldreib Lujain Alessa mohammad Alonazi College of Dentistry Princess Nourah bint Abdulrahman University Riyadh Kingdom of Saudi Arabia Security Forces Clinics Riyadh Kingdom of Saudi Arabia

Background: Calcium hydroxide has been used in dentistry since several decades. It has been used in a number of applications in the field of endodontics such as root resorption, intracanal medicament, and root canal sealers. Although this material exhibits several advantages, it also has some limitations. Objectives: To review the role of calcium hydroxide in the field of endodontics, focusing on its mechanism of action, antimicrobial effects, different applications, cytotoxicity or biocompatibility, and its removal from the root canals. Materials and Methods: An electronic search was done using different databases. Out of 2,664 articles, only 33 articles have been selected to be included in this review because they are directly related to the topic and matched the inclusion criteria of this review: “Language: English” and “Year: 2000-2016”. Results: The antimicrobial effect of calcium hydroxide is controversial. Although some studies supported the effectiveness of calcium hydroxide against some bacteria others reported its limitation against fungal infection. Calcium hydroxide can be used effectively as intracanal medicament, root canal sealer, in weeping canals, for perforation management and root resorption. Conclusions: Despite the limitation of antimicrobial activity of calcium hydroxide, it is used effectively in a number of treatment modalities in endodontics. Due to its biological and therapeutical properties, calcium hydroxide is the material of choice for all pulp therapy. However, when using calcium hydroxide as a dressing material in root canal treatment caution should be taken to prevent the overextension of the paste beyond the tooth apex and avoid the harmful side effects.

关键词： Calcium Hydroxide Endodontics Root Canal Treatment Applications in Endodontics Mechanism of Action Cytotoxicity Biocompatibility Removal of Calcium Hydroxide from the Canals

Statistical Debugging Effectiveness as a Fault Localization Approach: Comparative Study

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Journal of Software Engineering and Applications 2016年第8期9卷 412-423页

作者： Ishaq Sandoqa Fawaz Alzghoul Hamad Alsawalqah Isra Alzghoul Loai Alnemer mohammad Akour Department of Computer Information Systems The University of Jordan Amman Jordan Department of Computer Information System Yarmouk University Irbid Jordan

Fault localization is an important topic in software testing, as it enables the developer to specify fault location in their code. One of the dynamic fault localization techniques is statistical debugging. In this study, two statistical debugging algorithms are implemented, SOBER and Cause Isolation, and then the experimental works are conducted on five programs coded using Python as an example of well-known dynamic programming language. Results showed that in programs that contain only single bug, the two studied statistical debugging algorithms are very effective to localize a bug. In programs that have more than one bug, SOBER algorithm has limitations related to nested predicates, rarely observed predicates and complement predicates. The Cause Isolation has limitations related to sorting predicates based on importance and detecting bugs in predicate condition. The accuracy of both SOBER and Cause Isolation is affected by the program size. Quality comparison showed that SOBER algorithm requires more code examination than Cause Isolation to discover the bugs.

关键词： Testing and Debugging Dynamic Language Statistical Debugging Fault Localization