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Risk factors for congenital nasolacrimal duct obstruction in children under two years of age

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国际眼科杂志 2025年第1期25卷 17-23页

作者： Rozhin Kasiri Gholamreza Khataminia Ali Kasiri mohammad Sadegh Mirdehghan mohammad Armin Kasiri Infectious Ophthalmologic Research Center Ahvaz Jundishapur University of Medical SciencesAhvaz ***Iran Islamic Azad University Tehran Medical Sciences Tehran ***Iran

·AIM:To identify various risk factors that may play a significant role in the development of congenital nasolacrimal duct obstruction(CNLDO).·METHODS:This observational case-control study included a case group of 122 children less than two years of age with CNLDO who underwent probing and irrigation treatment at the ophthalmology department of Imam Khomeini Hospital in Ahvaz,Iran,from June 2022 to June2024.A control group of 122 age-matched children without CNLDO was also included for *** was collected from the children's medical records.·RESULTS:The study found a significant correlation between the occurrence of CNLDO and several maternal factors,such as preeclampsia,the use of levothyroxine,hypothyroidism,having more than three pregnancies(gravidity>3),natural pregnancy,and gestational diabetes ***,in children,factors,such as oxygen therapy,anemia,reflux,jaundice,and a family history of CNLDO in first-degree relatives were associated with CNLDO,and maternal preeclampsia and hypothyroidism were found to significantly increase the risk of developing CNLDO in children.·CONCLUSION:Given that CNLDO affects both premature and full-term children,the present findings may potentially facilitate the early identification of children and infants at risk of nasolacrimal duct obstruction,thereby preventing the onset of chronic dacryocystitis.

关键词： risk factors congenital nasolacrimal duct obstruction children

Applying density functional theory on tautomerism in 3,4- dihydropyrimidin-2(1H)-ones

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Frontiers of Chemistry in China 2011年第2期6卷 142-146页

作者： Asadollah farhadi mohammad Ali TAKASSI Faculty of Science University of Petroleum Technology AhwazAhwaz 61981-44471Iran

In the present study,the density functional theory(DFT)and Gibbs free energy calculations were performed to investigate the stability and tautomerism of C4-substituted-3,4-dihydropyrimidin-2(1H)-*** different forms are possible for the ethyl 3,4-dihydropyrimidinones(ethyl 4-aryl-6-methyl-3,4-dihydropyrimidin-2(1H)-one-5-carboxylates,ethyl 4-aryl-2-hydroxy-6-methyl-1,4-dihydropyrimidine-5-carboxylates and ethyl 4-aryl-2-hydroxy-6-methyl-3,4-dihydropyrimidine-5-carboxylates)forms that the most stable form is ethyl 4-aryl-6-methyl-3,4-dihydropyrimidin-2(1H)-one-5-carboxylates(keto-form).The obtained data showed that the substitution on the C4-substitut position can be effective on the equilibrium constant(K_(eq)).

关键词： Gibbs free energy density functional theory(DFT) tautomerism dihydropyrimidin-2(1H)-ones Keto-Form

Human papillomavirus in squamous cell carcinoma of esophagus in a high-risk population

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World Journal of Gastroenterology 2005年第8期11卷 1200-1203页

作者： mohammad farhadi Zahra Tahmasebi Shahin Merat Farin Kamangar Dariush Nasrollahzadeh Reza Malekzadeh Digestive Disease Research Center Department of Molecular Biology Cancer Prevention Studies Branch

AIM: To investigate the relation of human papillomavirus (HPV) and esophageal squamous cell carcinoma (ESCC) in Iranian patients as compared to normal controls. METHODS: Using MY09/MY11 consensus primers, we compared the prevalence of a HPV L1 gene in tumor tissues from 38 ESCC cases and biopsied tissues from 38 endoscopically normal Iranian individuals. We also compared the presence of HPV16 and HPVA18 in the same samples using type-specific E6/E7 primers. RESULTS: Fourteen (36.8%) of the 38 ESCC samples but only 5 (13.2%) of the 38 control samples were positive for the HPV L1 gene (P= 0.02). Five (13.2%) of the ESCC samples but none of the control samples were positive for the HPV16 E6/E7 gene (P= 0.05). Three (7.9%) of the ESCC samples and 5 (13.2%) of the control samples were positive for the HPV18 E6/E7 gene (P= 0.71). CONCLUSION: Our data are consistent with HPV DNA studies conducted in other high-risk areas for ESCC. HPV should be considered as a potential factor contributing to the high incidence of ESCC in Iran and other high-incidence areas of the world.

关键词： Papillomavirus Squamous cell carcinoma of esophagus Population

Investigation of the interaction of ethyl acetoacetate with nano alumina particle as Lewis acid in acetonitrile solvent

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Frontiers of Chemistry in China 2011年第3期6卷 248-252页

作者： Asadollah farhadi mohammad Ali TAKASSI Mandana DAYER Faculty of Science Petroleum University of TechnologyAhwaz 61981-44471Iran Department of Chemistry Science and Research BranchIslamic Azad UniversityKhouzestanIran

The enol form of ethyl acetoacetate(EAA)displays interesting spectroscopic characteristics;this form of ethyl acetylacetate is very important in condensation *** this investigation,we have studied the interactions and the complex formation constants(K_(f))with nano alumina(10–20 nm)particle and alumina(mesh 135)compounds as Lewis acids in the acetonitrile solvent using absorption spectroscopy and related ***,in this study we calculated the thermodynamic parameters of this *** trend of reactivity of the ethyl acetoacetate(EAA)complexes toward the above Lewis acids,based on the solvent as follows:nano alumina compound>alumina compound.

关键词： complex formation constant ethyl acetoacetate nano alumina alumina thermodynamic

Non-acute effects of different doses of 3, 4-methylenedioxymethamphetamine on spatial memory in the Morris water maze in Sprague-Dawley male rats

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Neural Regeneration Research 2011年第22期6卷 1715-1719页

作者： Sara Soleimani Asl mohammad Hassan farhadi Nasser Naghdi Samira Choopani Alireza Samzadeh-Kermani Mehdi Mehdizadeh Anatomical Department Medicine Faculty Tehran University of Medical SciencesTehran *** Tehran Province Iran Substance Abuse and Dependence Research Center University of Social Welfare and Rehabilitation SciencesTehran *** Tehran Province Iran Physiological & Pharmacological Department Pasture Institute Tehran 13164 Tehran Province Iran Chemistry Department Faculty of Sciences Zabol UniversityZabol *** Sistan Baloochestan Province Iran Cellular & Molecular Research Center Tehran University of Medical SciencesTehran *** Tehran Province Iran

3, 4-methylenedioxymethamphetamine （MDMA; also known as ＇ecstasy＇） has been shown to impair learning and spatial memory in adult and neonatal rats. Many studies have focused on the acute effects of MDMA on memory. In the present study, we intraperitoneally administered MDMA （0, 5, 10, 20 mg/kg） to adult male rats to investigate the effects of different doses on rat spatial memory in the Morris water maze, body temperature, and mortality, twice a day, for 7 successive days. The results indicated that MDMA impaired spatial memory dose-dependently, with the highest dose （20 mg/kg） exerting the strongest effects. In addition, MDMA also caused hyperthermia and increased mortality in rats

关键词： 3, 4-methylendioxymethamphetamine Morris water maze spatial memory neural regeneration

Computational evaluation concerning the deviation of the atoms in 1-and 4-postions on the six-member ring and the effects on ^(1)HNMR chemical shift

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Frontiers of Chemistry in China 2011年第2期6卷 91-97页

作者： Asadollah farhadi mohammad Ali TAKASSI Hamid Reza MEMARIAN Mousa SOLEYMANI Faculty of Science University of Petroleum TechnologyAhwaz 61981-44471Iran Department of Chemistry Faculty of ScienceUniversity of IsfahanIsfahan 81746-73441Iran

Density functional theory(DFT)calculations were carried out on some cyclohexane derivatives to investigate the deviation atoms on the 1-and 4-positions of chair *** deviations of chair plane of two position in the cyclohexane derivatives were calculated at the B3LYP/6–31++G(d,p)***,we investigated the correlation between deviations of two positions from chair plane on the chemical shift hydrogen atoms on the 4-position.

关键词： cyclohexane heterocyclohexane deviation B3LYP/6-31++G(d p) chemical shift

Modeling the energy gain reduction due to shadow in flat-plate solar collectors;Application of artificial intelligence

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Artificial Intelligence in Agriculture 2021年第1期5卷 185-195页

作者： Morteza Taki Rouhollah farhadi Department of Agricultural Machinery and Mechanization Engineering Agricultural Sciences and Natural Resources University of KhuzestanP.O.Box:***MollasaniIran

Energy lost due to shadow in the absorber plate of solar collectors can decrease the solar energy *** some studies,mathematical modeling was applied for calculating the energy gain reduction due to shadow in flatplate solar *** this study,ANN method was developed for modeling the energy gain *** Perceptron(MLP)with one hidden layer and a range of neurons(5–30)by two training algorithms(LM and BR)and tangent sigmoid activation function(TanSig)were used by help of K-fold cross validation *** the first section,six set of solar collector dimensions were used(1×1;1×1.5;1×2;1.5×1.5;1.5×2 and 2×2).In the second section all the range of dimensions were used as the *** results of the first section showed thatMLPwith BR training algorithm can predict the energy gain reductionwith minimumMAPE and RMSE in all the *** best results related to(1.5×1.5)dimension that achieved a MAPE of 0.15±0.09%and RMASE of 4.42±2.43 KJm−2 year−1,*** results of the second section indicated that BR is a better training algorithm than *** MAPE and R2 factors for the best topology(5-27-1)were 0.0610±0.0051%and 0.9999±0.0001,*** results of the sensitivity analysis showed that height has the biggest impact on total energy gain reduction due to shadow in flat-plate solar ***,the results of this study indicated that by using ANN and decrease the energy lost,the efficiency of solar collectors can be increased in all applications such as industry and agriculture.

关键词： Multilayer perceptron Optimization Energy Sensitivity analysis

Computational investigation of powder coating of nanoparticles in supersonic and hypersonic impactors

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Particuology 2013年第3期11卷 273-281页

作者： Nima Niksefat Mousa farhadi Kurosh Sedighi Salman Nourouzi Faculty of Mechanical Engineering Babol University of Technology

In this study, numerical simulation of flow field in a supersonic/hypersonic impactor with one or two nozzles was carried out using a commercial computational fluid dynamics （CFD） software FLUENT. The objective was to investigate the effects of working parameters such as pressure ratio （50 〈 Po]Pb 〈 800）, nozzle diameters （D=0.23, 0.27, 0.45 mm）, nozzle to plate distance （0.5 〈L/D〈 50）, particle diameter （1 nm〈 dp 〈 100 nm ） and angle between two nozzles. A single-phase 3D unsteady-state model was implemented by the software. For this purpose, a user-defined function （UDF） was employed to implement nanoparticles for different assumptions of Cunningham correction factor. An axisymmetric form of the compressible Navier-Stokes and energy equations was used for both fluid flow and temperature; Lagrangian particle trajectory analysis was used for particle motion. Using the variable Cunningham cor- rection factor showed suitable agreement with experimental data in comparison with other methods. Results show that increase of the distance between nozzle and impaction plate causes increase of Mach number, the distance between bow shock and impaction plate, and the collection efficiency. Maximum jet velocity, distance between bow shock and impaction plate and collection efficiency increase by using two nozzles in supersonic and hypersonic imoactors.

关键词： Impactor Supersonic and hypersonic flow Nanoparticles Aerosol Aerodynamics

A selective, sensitive and label-free visual assay of fructose using anti-aggregation of gold nanoparticles as a colorimetric probe

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Chinese Chemical Letters 2016年第6期27卷 847-851页

作者： Foroogh Keshvari Morteza Bahram Khalil farhadi Department of analytical Chemistry Faculty of chemistry Urmia University

A new convenient colorimetric sensor for fructose based on anti-aggregation of citrate-capped gold nanoparticles（Au NPs） is presented. 4-Mercaptophenylboronic acid（MPBA） induces the aggregation of Au NPs, leading to a color change from red to blue. Fructose as a potent competitor has strong affinity for MPBA and a borate ester is formed between MPBA and fructose. There is an obvious color change from blue to red with increasing the concentration of fructose. The anti-aggregation effect of fructose on Au NPs was seen by the naked eye and monitored by UV–vis spectra. Our results showed that the absorbance ratio（A（519）/A（640）） was linear with fructose concentration in the range of 0.032–0.96 μmol/L（R^2= 0.996）, with a low detection limit of 0.01 μmol/L（S/N = 3）. Notably, a highly selective recognition of fructose was shown against other monosaccharide and disaccharide（glucose, mannose, galactose,lactose and saccharose）. With anti-aggregation assays higher selectivity is achievable. The results of this work provide a rapid method for evaluating the quantitative analysis of fructose in human plasma at physiologically meaningful concentrations and at neutral pH. The proposed procedure can be used as an efficient method for the precise and accurate determination of fructose.

关键词： Colorimetric sensor Gold nanoparticles Anti-aggregation Fructose