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Detection of Different Stages of Alzheimer’s Disease Using CNN Classifier

Computers, Materials & Continua 2023年第9期76卷 3933-3948页

作者： S M Hasan Mahmud Md Mamun Ali mohammad fahim shahriar Fahad Ahmed Al-Zahrani Kawsar Ahmed Dip Nandi Francis M.Bui Department of Computer Science American International University-Bangladesh(AIUB)Dhaka1229Bangladesh Centre for Advanced Machine Learning and Applications(CAMLAs) DhakaBangladesh Department of Software Engineering Daffodil International UniversityDhakaBangladesh Department of Computer Engineering Umm Al-Qura UniversityMecca24381Saudi Arabia Department of ECE University of SaskatchewanSaskatoonSK S7N5A9Canada Group of Biophotomatiχ Department of ICTMBSTUSantoshTangail1902Bangladesh

Alzheimer’s disease(AD)is a neurodevelopmental impairment that results in a person’s behavior,thinking,and memory *** common symptoms ofADare losingmemory and early *** addition to these,there are several serious impacts ***,the impact ofADcanbemitigatedby early-stagedetection though it cannot be cured ***-stage detection is the most challenging task for controlling and mitigating the impact of *** study proposes a predictive model to detect AD in the initial phase based on machine learning and a deep learning approach to address the *** build a predictive model,open-source data was collected where five stages of images of AD were available as Cognitive Normal(CN),Early Mild Cognitive Impairment(EMCI),Mild Cognitive Impairment(MCI),Late Mild Cognitive Impairment(LMCI),and *** stage of AD is considered as a class,and then the dataset was divided into three parts binary class,three class,and five *** this research,we applied different preprocessing steps with augmentation techniques to efficiently *** integrates a random oversampling technique to handle the imbalance problem from target classes,mitigating the model overfitting and *** three machine learning classifiers,such as random forest(RF),K-Nearest neighbor(KNN),and support vector machine(SVM),and two deep learning methods,such as convolutional neuronal network(CNN)and artificial neural network(ANN)were applied on these *** analyzing the performance of the used models and the datasets,it is found that CNN with binary class outperformed 88.20%*** result of the study indicates that the model is highly potential to detect AD in the initial phase.

关键词： Alzheimer’s disease early detection convolutional neural network data augmentation random oversampling machine learning

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Cracks coalescence mechanism and cracks propagation paths in rock-like specimens containing pre-existing random cracks under compression

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Journal of Central South University 2014年第6期21卷 2404-2414页

作者： Hadi Haeri Kourosh shahriar mohammad Fatehi Marji Parviz Moarefvand Department of Mining Engineering Science and Research BranchIslamic Azad University Department of Mining and Metallurgical Engineering Amirkabir University of Technology Mine Exploitation Engineering Department Faculty of Mining and MetallurgyInstitution of EngineeringYazd University

The mechanism of cracks propagation and cracks coalescence due to compressive loading of the brittle substances containing pre-existing cracks （flaws） was modeled experimentally using specially made rock-like specimens from Portland Pozzolana Cement （PPC）. The breakage process of the specimens was studied by inserting single and double flaws with different inclination angles at the center and applying uniaxial compressive stress at both ends of the specimen. The first crack was oriented at 50＆#176; from the horizontal direction and kept constant throughout the analysis while the orientation of the second crack was changed. It is experimentally observed that the wing cracks are produced at the first stage of loading and start their propagation toward the direction of uniaxial compressive loading. The secondary cracks may also be produced in form of quasi-coplanar and/or oblique cracks in a stable manner. The secondary cracks may eventually continue their propagation in the direction of maximum principle stress. These experimental works were also simulated numerically by a modified higher order displacement discontinuity method and the cracks propagation and cracks coalescence were studied based on Mode I and Mode II stress intensity factors （SIFs）. It is concluded that the wing cracks initiation stresses for the specimens change from 11.3 to 14.1 MPain the case of numerical simulations and from 7.3 to 13.8 MPa in the case of experimental works. It is observed that cracks coalescence stresses change from 21.8 to 25.3 MPa and from 19.5 to 21.8 MPa in the numerical and experimental analyses, respectively. Comparing some of the numerical and experimental results with those recently cited in the literature validates the results obtained by the proposed study. Finally, a numerical simulation was accomplished to study the effect of confining pressure on the crack propagation process, showing that the SIFs increase and the crack initiation angles change in this case.

关键词： crack propagation crack coalescence rock-like specimen numerical simulation experiment

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Thermo-hydro-mechanical modeling of fault discontinuities using zero-thickness interface element

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Journal of Rock Mechanics and Geotechnical Engineering 2020年第1期12卷 74-88页

作者： Ali Ranjbar Hossein Hassani Kourosh shahriar mohammad Javad Ameri Shahrabi Department of Petroleum Engineering Amirkabir University of TechnologyTehranIran Department of Mining and Metallurgy Engineering Amirkabir University of TechnologyTehranIran

In this paper,a coupled thermo-hydro-mechanical(THM)simulation in a faulted deformable porous medium is *** model involves solving the mass conservation,linear momentum balance,and energy balance equations which are derived from the Biot’s consolidation *** pore pressure,solid displacement,and temperature are chosen as initial variables in these equations,and the finite element method in combination with the interface element is used for spatial discretization of continuous and discontinuities(fault)parts of the medium to solve the *** main purpose of this study is providing precise formulations,applicability,and ability of the triple-node zero-thickness interface element in THM modeling of *** should be noted that the system of equations is solved using a computer code written in Matlab *** order to verify the developed method,simulations of index problems such as Mandel’s problem,and coupled modeling of a faulted porous medium and a faulted aquifer are *** modeling results obtained from the developed method show a very good agreement with those by other modeling methods,which indicates its accuracy.

关键词： Thermo-hydro-mechanical(THM) simulation Geomechanical coupling Zero-thickness element Joint element Finite element

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Detecting anomalies in blockchain transactions using machine learning classifiers and explainability analysis

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Blockchain(Research and Applications) 2024年第3期5卷 106-122页

作者： mohammad Hasan mohammad shahriar Rahman Helge Janicke Iqbal H.Sarker Department of Computer Science and Engineering Premier University4000 ChitagongBangladesh Department of Computer Science and Engineering United International University1212 DhakaBangladesh Cyber Security Cooperative Research Centre 6027 PerthAustralia Centre for Securing Digital Futures Edith Cowan University6027 PerthAustralia

As the use of blockchain for digital payments continues to rise,it becomes susceptible to various malicious *** detecting anomalies within blockchain transactions is essential for bolstering trust in digital ***,the task of anomaly detection in blockchain transaction data is challenging due to the infrequent occurrence of illicit *** several studies have been conducted in the field,a limitation persists:the lack of explanations for the model’s *** study seeks to overcome this limitation by integrating explainable artificial intelligence(XAI)techniques and anomaly rules into tree-based ensemble classifiers for detecting anomalous Bitcoin *** shapley additive explanation(SHAP)method is employed to measure the contribution of each feature,and it is compatible with ensemble ***,we present rules for interpreting whether a Bitcoin transaction is anomalous or ***,we introduce an under-sampling algorithm named XGBCLUS,designed to balance anomalous and non-anomalous transaction *** algorithm is compared against other commonly used under-sampling and over-sampling ***,the outcomes of various tree-based single classifiers are compared with those of stacking and voting ensemble *** experimental results demonstrate that:(i)XGBCLUS enhances true positive rate(TPR)and receiver operating characteristic-area under curve(ROC-AUC)scores compared to state-of-the-art under-sampling and over-sampling techniques,and(ii)our proposed ensemble classifiers outperform traditional single tree-based machine learning classifiers in terms of accuracy,TPR,and false positive rate(FPR)scores.

关键词： Anomaly detection Blockchain Bitcoin transactions Data imbalance Data sampling Explainable AI Machine learning Decision tree Anomaly rules

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The off-site implications of deforestation on sedimentation rates and pollution in Abkenar open water (Anzali Lagoon, Caspian Sea) using radionuclide techniques and sediment quality indices

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International Journal of Sediment Research 2022年第3期37卷 370-382页

作者： mohammadreza Gharibreza mohammad Zaman Mahmood Arabkhedri shahriar Sobh-Zahedi Soil Conservation and Watershed Management Research Institute Agricultural Research Education and Extension Organization (AREEO) Soil and Water Management & Crop Nutrition Section Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture International Atomic Energy AgencyVienna International Centre Guilan Agricultural and Natural Resources Research and Education Center AREEO

Abkenar open water(AOW) has a 35 km~2 distribution and is the largest part of the Anzali Lagoon in the southern coastal zone of the Caspian Sea. The effects of deforestation in the upstream basin of the AOW were assessed by measuring the rate of sedimentation, sediment contamination, and ecological risk for aquatic life and end-users using radioisotopes Cesium-137 and Lead-210. The chronology of the AOW sediment column was studied using the Constant Rate of Supply model. Correlations between environmental changes and the sedimentary regime of the study area highlight the contribution of the AOW authorized international and local wood harvesting companies pre-and-post 1950 in the catchment in terms of the rate of sediment supply and the influx of toxic metals. Historical evidence shows that two specific layers formed during World Wars I and II with the mean rates of 0.185 ± 0.04(±STD) and 0.32 ± 0.02 kg/(m·y), respectively. The highest influx of alkali elements and toxic metals(nickel, cadmium, lead, zinc, and copper) into the basin occurred in 1945. Two layers of gray mud(16-50 cm) and organic-rich dark loss mud(0-16 cm) correlated well with the programmed wood harvesting *** layers accumulated from 1953 to 2000 with a mean rate of 0.6 ± 0.2 and 2 ± 0.7 kg/(m~2·y). Thus,aquatic life and end-users have been exposed to moderate to extremely high levels of toxic metals and a moderate level of contamination since the 1950 s.

关键词： Abkenar open water Accumulation rate Anzali Lagoon Sediment contamination CRS model Radioisotopes

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Genotype×tillage interaction and the performance of winter bread wheat genotypes in temperate and cold dryland conditions

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Journal of Integrative Agriculture 2022年第11期21卷 3199-3215页

作者： Ebrahim ROOHI Reza mohammadI Abdoul Aziz NIANE Javad VAFABAKHSH Mozaffar ROUSTAEE mohammad Reza JALAL KAMALI shahriar SOHRABI shahriar FATEHI Hossain TARIMORADI Horticulture and Crop Science Research Department Kurdistan Agricultural and Natural Resources Research and Education CenterAgricultural ResearchEducation and Extension Organization(AREEO)Sanandaj 66169-36311Iran Dry Land Agricultural Research Institute(DARI) Sararood CampusAREEOKermanshah 67441-61377Iran International Center for Agriculture Research in the Dry Area(ICARDA) Dubai 13979United Arab Emirates Seed and Plant Improvement Research Department Khorasan Razavi Agricultural and Natural Resources Research and Education CenterAREEOMashhad 91859-86111Iran Cereal Research Department DARIAREEOMaragheh 119Iran International Maize and Wheat Improvement Center(CIMMYT) Karaj 31585-4119Iran Kurdistan Jehade Agricultural Organization Sanandaj 66169-35383Iran

Growing concerns for food security and the alleviation of hunger necessitate knowledge-based crop management technologies for sustainable crop *** this study,13 winter bread wheat genotypes(old,relatively old,modern,and breeding lines)were evaluated under three different tillage systems,i.e.,conventional tillage(CT,full tillage with residue removed),reduced tillage(RT,chisel tillage with residue retained)and no-tillage(NT,no-tillage with residue retained on the soil surface)in farmer’s fields under rainfed conditions using strip-plot arrangements in a randomized complete block design with three replications in the west of Iran(Kamyaran and Hosseinabad locations)over two cropping seasons(2018–2019 and 2019–2020).The main objectives were to investigate the effects of tillage systems and growing conditions on the agronomic characteristics,grain yield and stability performance of rainfed winter bread wheat ***(P<0.01)genotype×tillage system interaction effects on grain yield and agronomic traits suggested that the genotypes responded differently to the different tillage *** number of grains per spike and plant height were positively(P<0.0)associated with grain yield under the NT system,so they may be considered as targeted traits for future wheat *** statistical models,the modern cultivars(“Sadra”and“Baran”)were identified as high yielding and showed yield stability across the different tillage *** per each tillage system,genotype“Sadra”followed by“Zargana-6//Dari 1-7 Sabalan”exhibited higher adaption to CT;while cultivars“Jam”and“Azar2”showed better performance under the RT system;and cultivars“Varan”and“Baran”tended to have better performance expression in the NT *** increased grain yields achieved in combination with lower costs and greater profits from conservation agriculture suggest that adapted cultivar and NT systems should be evaluated and promoted more widely to farmers in the west of Iran as an a

关键词： bread wheat no-tillage reduced tillage grain yield yield stability

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Androgen receptor signaling and mutations in prostate cancer

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Asian Journal of Andrology 2010年第5期12卷 639-657页

作者： shahriar Koochekpour Department of Urology and Stanley S. Scott Cancer Center School of Medicine Louisiana State University HealthSciences Center New Orleans LA 70112 USA

Normal and neoplastic growth of the prostate gland are dependent on androgen receptor （AR） expression and function. Androgenic activation of the AR, in association with its coregulatory factors, is the classical pathway that leads to transcriptional activity of AR target genes. Alternatively, cytoplasmic signaling crosstalk of AR by growth factors, neurotrophic peptides, cytokines or nonandrogenic hormones may have important roles in prostate carcinogenesis and in metastatic or androgen-independent （AI） progression of the disease. In addition, cross-modulation by various nuclear transcription factors acting through basal transcriptional machinery could positively or negatively affect the AR or AR target genes expression and activity. Androgen ablation leads to an initial favorable response in a significant number of patients; however, almost invariably patients relapse with an aggressive form of the disease known as castration-resistant or hormone-refractory prostate cancer （PCa）. Understanding critical molecular events that lead PCa cells to resist androgen-deprivation therapy is essential in developing successful treatments for hormone-refractory disease. In a significant number of hormone-refractory patients, the AR is overexpressed, mutated or genomically amplified. These genetic alterations maintain an active presence for a highly sensitive AR, which is responsive to androgens, antiandrogens or nonandrogenic hormones and collectively confer a selective growth advantage to PCa cells. This review provides a brief synopsis of the AR structure, AR coregulators, posttranslational modifications of AR, duality of AR function in prostate epithelial and stromal cells, AR-dependent signaling, genetic changes in the form of somatic and germline mutations and their known functional significance in PCa cells and tissues.

关键词： androgen receptor germline mutation prostate cancer signaling somatic

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DNA methylome and the complexity, of discovering prostate cancer biomarkers

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Asian Journal of Andrology 2011年第5期13卷 661-662页

作者： shahriar Koochekpour Departments of Cancer Genetics and Urology RoswellPark Cancer Institute Elm and Carlton Streets BuffaloNY 14263 USA

Prostate cancer （PCa） remains the most common malignancy and a leading cause of cancer-related ＇deaths in men. Molecular discrimination at an early stage between indolent and aggressive primary tumors in pathologic... 详细信息

关键词： Cancer immunotherapy Non-small-cell lung cancer Targeted therapies

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Caraway extract alleviates atopic dermatitis by regulating oxidative stress,suppressing Th2 cells,and upregulating Th1 cells in mice

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Asian Pacific Journal of Tropical Biomedicine 2022年第10期12卷 421-429页

作者： Fardin Khajepour mohammad Reza Zangouyee Arezu Khosravimashizi Ali Afgar Vahideh Abdollahi shahriar Dabiri Reza Nosratabadi Department of Medical Immunology Afzalipour Faculty of MedicineKerman University of Medical SciencesKermanIran Research Center for Hydatid Disease in Iran Afzalipour Faculty of MedicineKerman University of Medical SciencesKermanIran Student Research Committee Afzalipour Faculty of MedicineKerman University of Medical SciencesKermanIran Department of Animal Biology Kharazmi UniversityTehranIran Department of Pathology Afzalipour Faculty of MedicineKerman University of Medical SciencesKermanIran Pathology and Stem Cells Research Center Afzalipour Faculty of MedicineKerman University of Medical SciencesKermanIran Gastroenterology and Hepathology Research Center Institute of Basic and Clinical Physiology SciencesKerman University of Medical SciencesKermanIran

Objective:To explore the anti-inflammatory and antioxidant effects of caraway on atopic dermatitis(AD)in ***:AD was induced in two stages,including sensitization and challenge with the application of 2,4 dinitrochlorobenzene 2% and 0.2%,*** symptoms and histological analysis of the skin were *** effects of caraway on oxidant/antioxidant parameters as well as Th1-and Th2-related cytokines were also ***:Caraway reduced the severity of dermatitis in AD-induced mice,as evidenced by significant inhibition of Th2-related cytokines(IL-4 and IL-13)and increased Th1-related cytokine(IFN-γ).Additionally,treatment with caraway significantly increased superoxide dismutase and catalase activity and decreased the malondialdehyde level in the serum of AD ***,caraway inhibited the differentiation of Th2 cells while favoring Th1 cell differentiation in the spleen via regulating their master transcription factors GATA3 and ***:Caraway could improve AD autoimmune responses and could be considered a potential candidate to treat AD disease.

关键词： Carum carvi L. Caraway Atopic dermatitis 2,4 dinitrochlorobenzene Th2 Th1 Oxidative stress

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Impact of coronary artery bypass grafting surgery on the chorioretinal biomicroscopic characteristics

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World Journal of Clinical Cases 2023年第28期11卷 6754-6762页

作者： Mansoor shahriari Homayoun Nikkhah mohammad Parsa Mahjoob Nazanin Behnaz shahriar Barkhordari Kasra Cheraqpour Department of Ophthalmology Imam Hossein Educational HospitalTehran ***Iran Department of Ophthalmology Torfe Medical CenterTehran ***Iran Cardiovascular Diseases Imam Hossein Educational HospitalTehran ***Iran Department of Ophthalmology Shahid Beheshti University of Medical SciencesTehran ***Iran Department of Ophthalmology Farabi Eye HospitalTehran ***Iran

BACKGROUND Most patients with cardiovascular disorders suffer from coronary artery diseases,which can be treated successfully using coronary artery bypass grafting(CABG).One of the unpleasant events following CABG is postoperative vision loss(POVL).Vulnerability of retinal vessels to hemodynamic changes,an expectable event following CABG,may contribute to the development of POVL,which might be associated with the changes in the choroidal and retinal *** To investigate postoperative changes in chorioretinal and peripapillary nerve fiber layer(NFL)thickness,and progression of diabetic and hypertensive retinopathy after *** In this prospective,cross-sectional study,49 eyes in 25 candidates for CABG underwent both ophthalmic and cardiovascular examinations within 6 mo prior to and 9 mo after *** Among the study participants,56%were male with a mean age of 62.84 years±10.49 years(range 33–80 years).Diabetes mellitus was observed in eight participants(32%).None of the patients suffered from postoperative anterior or posterior ischemic optic neuropathy,central retinal artery occlusion,and cortical *** mean value of the preoperative best corrected visual acuity was 0.11±0.10 logMAR(range,0–0.4),which worsened to 0.15±0.08 logMAR(range,0–0.4)after CABG(P=0.031).No significant difference was observed between the preand postsurgical choroidal(P=0.853)and macular(P=0.507)thickness,NFL thickness in the subfoveal(P>0.999)and peripapillary areas(P=0.659),as well as the severity of diabetic and hypertensive *** CABG may reduce visual acuity without affecting ocular *** vision reduction might be attributable to molecular or cellular variations,changes in visual pathway function,or central nervous system.

关键词： Coronary artery bypass grafting Nerve fiber layer Diabetic retinopathy Hypertensive retinopathy

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