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Decoding molecular mechanisms:brain aging and Alzheimer's disease

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Neural Regeneration Research 2025年第8期20卷 2279-2299页

作者： Mahnoor Hayat Rafay ali Syed Hammad Qaiser mohammad Uzair Khalid Al-Regaiey Roaa Khallaf Lubna Abdullah Mohammed Albassam Imdad Kaleem Xueyi Wang Ran Wang Mehwish SBhatti Shahid Bashir Atta-ur-Rahman School of Applied Biosciences(ASAB) National University of Sciences and Technology(NUST)IslamabadPakistan Department of Biotechnology Quaid-i-Azam UniversityIslamabadPakistan Department of Biological Sciences Faculty of Basic&Applied SciencesInternational Islamic University Islamabad(IIUI)IslamabadPakistan Department of Bioengineering King Fahd University of Petroleum and MineralsDhahranSaudi Arabia Department of Physiology College of MedicineKing Saud UniversityRiyadhSaudi Arabia Department of Neurology Neuroscience CenterKing Fahad Specialist HospitalDammamSaudi Arabia Department of Mental Health Neuroscience CenterKing Fahad Specialist HospitalDammamSaudi Arabia Department of Biosciences Commission on Science and Technology for Sustainable Development in the South(COMSATS University)IslamabadPakistan Department of Psychiatry The First Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Mental Health Institute of Hebei Medical University ShijiazhuangHebei ProvinceChina Department of Neurobiology and Behavior University of CaliforniaIrvineCAUSA Neuroscience Center King Fahad Specialist Hospital DammamDammamSaudi Arabia

The complex morphological,anatomical,physiological,and chemical mechanisms within the aging brain have been the hot topic of research for *** aging process alters the brain structure that affects functions and cognitions,but the worsening of such processes contributes to the pathogenesis of neurodegenerative disorders,such as Alzheimer's *** these observable,mild morphological shifts,significant functional modifications in neurotransmission and neuronal activity critically influence the aging *** these changes is important for maintaining cognitive health,especially given the increasing prevalence of age-related conditions that affect *** review aims to explore the age-induced changes in brain plasticity and molecular processes,differentiating normal aging from the pathogenesis of Alzheimer's disease,thereby providing insights into predicting the risk of dementia,particularly Alzheimer's disease.

关键词： Alzheimer’s disease brain aging cognitive health dementia molecular mechanisms neuronal activity neuroplasticity neurotransmission

Eco-friendly green synthesis of novel magnetic Fe3O4/SiO2/ZnO-Pr6O11 nanocomposites for photocatalytic degradation of organic pollutant

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Journal of Rare Earths 2020年第1期38卷 13-20页

作者： mohammad ali Ebrahimzadeh Sobhan Mortazavi-Derazkola mohammad ali Zazouli Pharmaceutical Sciences Research Center Hemoglobinopathy Institute and Department of Medicinal ChemistrySchool of PharmacyMazandaran University of Medical ScienceSariP.O.Box 48471-93698Iran Department of Environmental Health Engineering Health Science Research CenterFaculty of HealthMazandaran University of Medical ScienceSariP.O.Box 48471-16548Iran

This study reports the successful so nochemical synthesis of novel Fe3O4/SiO2/ZnO-Pr6O11(Fe/Si/Zn-Pr6O11) nanocomposites using fructose as a green capping *** influence of various parameters containing capping agent,power and time of ultrasound irradiation was investigated to reach optimum morphology and size *** products obtained were characterized by transmission electron microscopy(TEM),UV/Vis diffuse reflectance spectroscopy(DRS),Fourier transform infrared spectra(FT-IR),vibration sample magnetometer(VSM),scanning electron microscopy(SEM),energy dispersive X-ray microanalysis(EDS) and X-ray diffraction(XRD).The Fe3O4/SiO2/ZnO-Pr6O11 nanocomposites display remarkably enhanced photocatalytic activity towards rhodamine b degradation(89.6%)and Congo red(84.7%) under UV irradiation compared with the other *** results illustrate that the photocatalytic efficiency of magnetic nanocomposites is very much higher than pure *** photocatalyst still has good stability after five successive ***,these recyclable nanocomposites can play a role in the treatment of both industrial and domestic contaminated water.

关键词： Sonochemical synthesis Nanocomposite Photocatalysis Electron microscopy Rhodamine b Praseodymium oxide

A Galvanostatic Modeling for Preparation of Electrodeposited Nanocrystalline Coatings by Control of Current Density

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Journal of Materials Science & Technology 2012年第12期28卷 1071-1076页

作者： ali mohammad Rashidi School of Engineering Razi UniversityP.O. Box 67149-67346 Kermanshah Iran

The correlation between the grain size of electrodeposited coatings and the current densities was modeled by considering galvanostatic conditions. In order to test the model by experimental results, nanocrystalline （NC） nickel samples were deposited at different current densities using a Watts bath. The grain size of the deposits was evaluated by X-ray diffraction （XRD） technique. Model predictions were validated by finding a curve being the best-fit to the experimental results which were gathered from literature for different NC coatings in addition to those data measured in this research for NC nickel coatings. According to our model, the variation of grain size with the reciprocal of the current density follows a power law. A good agreement between the experimental results and model predictions was observed which indicated that the derived analytical model is applicable for producting the nanocrystalline electrodeposits with the desired grain size by controling current density.

关键词： Electrodeposition Galvanostatic modeling Grain size control Nanocrystalline

Probability calculation of rebars corrosion in reinforced concrete using css algorithms

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Journal of Central South University 2015年第8期22卷 3141-3150页

作者： Mohsen-ali Shayanfar mohammad-ali Barkhordari mohammad Ghanooni-Bagha The Centre of Excellence for Fundamental Studies in Structural Engineering Iran University of Science and TechnologyP.O.BOX: 16765-163 Narmak Tehran Iran

Reinforcement inside the concrete is protected from corrosion and its damages until several years after the construction. After corrosion initiation, the cross section of reinforcement begins to reduce and often load bearing of the reinforced concrete structure will be reduced significantly. Corrosion of reinforcements in concrete in polluted and contaminated areas can occur in two ways: chloride and carbonation. In this work, meta-heuristic approach of charged system search(CSS) is used to calculate corrosion occurrence probability due to chloride ions penetration. The model efficiency is verified by comparing the available examples in technical literature and results of Monte Carlo analysis. According to the analyses performed, using different probabilistic distributions regardless of probabilistic moments based on real distribution leads to diverse results. In addition, influence of each effective parameter in corrosion occurrence varies by changing other parameters.

关键词： reinforced concrete reliability index chloride diffusion carbonation charged system search (CSS) optimization

A VERSATILE AND REGIOSELECTIVE SYNTHESIS OF VICINAL AZIDOALCOHOLS USING CROSS-LINKED POLY(4-VINYLPYRIDINE) SUPPORTED AZIDE ION UNDER SOLVENT-FREE CONDITIONS

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Chinese Journal of Polymer Science 2013年第12期31卷 1660-1669页

作者： mohammad ali Karimi Zarchi ali Tarabsaz Department of Chemistry College of ScienceYazd University

A new polymeric reagent, cross-linked poly（4-vinylpyridine） supported azide ion, [P4-VP]N3, was introduced as polymeric reagents for efficient and regioselective conversion of epoxides to azidohydrins in the presence of cross-linked poly（4-vinylpyridine） supported sulfuric acid, [P4-VP]H2SO4, as a solid proton source and as catalyst under solvent-free conditions. The advantages of this polymeric reagent over some of those reported in the literature are easy work-up procedure and regeneration of the reagent.

关键词： Ring opening of epoxide fl-Azidoalcohols Poly(4-vinytpyridine) Solvent-free conditions Regioselectivity.

A Simplified Model, Dynamic Analysis and Force Estimation for a Large-scale Orinthopter in Forward Flight Based on Flight Data

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Journal of Bionic Engineering 2020年第5期17卷 989-1008页

作者： mohammad ali Amini Moosa Ayati mohammad Mahjoob School of Mechanical Engineering College of EngineeringUniversity of TehranNorth Kargar StreetTehranIran

Similarities and differences of a large-scale flapping-wing robot with fixed-wing UAVs in equations of motion,trim curves,and aerodynamic forces in forward flight are discussed in this paper and a simplified model for flapping flight is *** to the high Wing to Total Weight(WTW)ratio of large-scale omithopters,simple rigid body dynamics is not accurate enough for flight dynamics *** the other hand,the multi-body dynamics associated with flapping gives little insight into the behavior of the resulting model due to complexity of *** is also difficult to design proper controllers for such complicated *** this paper,the effects of different terms of multi-body equations of ornithopter on the estimated aerodynamic forces are studied via experimental flight data.A simpler but yet accurate set of equations is obtained by removing less effective terms from original *** presented model is in the form of normal aircraft equations plus some additional terms which can be used in different control and estimation *** addition,trim conditions of forward flight are extracted using several flight tests,and corresponding periodic behavior of states and forces are *** studies are applicable for identifying time-periodic models.

关键词： flapping wing robot bionic robot ornithopter trim condition analysis low-order modeling aerodynamic force estimation

Predicting seismic permanent displacement of soil walls under surcharge based on limit analysis approach

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Earthquake Engineering and Engineering Vibration 2018年第4期17卷 747-759页

作者： mohammad Mahdi Aminpour mohammad Maleki ali Ghanbari Faculty of Engineering Bu-Ali Sina University Faculty of Engineering Kharazmi University

Seismic permanent displacement of the soil walls plays an important role in design of these structures. Due to the increase in growth of urban areas and the limitations in use of flat grounds, many structures are built near slopes and retaining walls. During earthquakes, these structures can apply an additional surcharge on the wall. The intensity and location of the surcharge is of considerable importance on the seismic displacements of the soil wall. In this study, by using the limit analysis and upper bound theorem, seismic permanent displacement of the soil wall under surcharge has been analyzed. Thus, a formulation is presented for calculating the yield acceleration and seismic displacement for different surcharge conditions. The effect of seismic acceleration, surcharge intensity, its location and soil properties is investigated. A parameter called the ＂displacement coefficient＂ is proposed, and is a potential modification for Newmark’s sliding-block method.

关键词： limit analysis surcharge soil wall seismic displacement yield acceleration

Application of the Ion Pair of 2-(5-Bromo-2-pyridylazo)-5-diethylaminophenol and Ammonium Tetraphenylborate for Preconcentration of Trace Vanadium and Determination by Third Derivative Spectrophotometry

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Chinese Journal of Chemistry 2002年第12期20卷 1584-1590,1463页

作者： TAHER mohammad ali Department of Chemistry Shahid Bahonar University of Kerman Kerman IRAN Email: mohammad ali Taher (ma-taher@***)

Vanadium is quantitatively retained on 2-(5-bromo-2-pyridylazo)-5-diethylaminophenol (5-Br-PADAP)-ammonium tetraphenylborate with microcrystalline naphthalene or by a column method in the pH range of 2.1–4.5 from a large volume of aqueous solutions of various samples. After filtration, the solid mass consisting of the vanadium complex and naphthalene was dissolved with 5 mL of dimethylformamide and the metal was determined by the third derivative spectrophotometry. Vanadium complex can alternatively be quantitatively adsorbed on ammonium tetraphenylborate-naphthalene adsorbent packed in a column and determined similarly. About 0.05 μg of vanadium can be concentrated in a column from 250 mL of aqueous sample, where its concentration is as low as 0.2 ng/mL. The interference of a large number of anions and cations has been studied and the optimized conditions developed were utilized for the determination of trace amount of vanadium in various samples.

关键词： trace vanadium determination derivative spectrophotometry 5-Br-PADAP-TPB-naphthalene

Effect of graphene oxide and reduced graphene oxide nanosheets on the microstructure and mechanical properties of mild steel jointing by flux-cored arc welding

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International Journal of Minerals,Metallurgy and Materials 2020年第4期27卷 505-514页

作者： mohammad Khosravi mohammad Mansouri ali Gholami Yadollah Yaghoubinezhad Department of Mechanical Engineering Birjand University of Technology BirjandP.O.Box 97175-569235Iran Department of Materials Engineering Birjand University of Technology BirjandP.O.Box 97175-569315Iran

The effect of graphene oxide(GO)and reduced graphene oxide(RGO)nanosheets on the microstructure and mechanical properties of welded joints of mild steel was evaluated by flux-cored arc *** was synthesized by the Hummer’s method and was reduced under hydrothermal conditions at a pressure of 1.1 MPa at 180°C for 12 h.1,3,and 10 mg/mL paste fillers were used in GO and RGO,and applied to the weld *** results clearly showed that by increasing the concentration of RGO up to 10 mg/mL,the tensile strength and hardness of the weld metal were improved by approximately 20.5%and 38.4%,respectively,because the coarse grains were changed into fine *** domain of the nanosheets cluster was 19.85×10^?9 ***,the RGO nanosheets contributed to modifying the mechanical properties of the welded steel,likely due to dislocation pinning.

关键词： graphene oxide reduced graphene oxide flux-cored arc welding steel mechanical properties