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Open Journal of Marine Science 2020年第4期10卷 218-232页

作者： Nur Alam Sanjay Chakraborty Md. Muzammel Hossain mohammad abdul baki Shayer Mahmood Ibney Alam Chenhong Li Department of Zoology Faculty of Life and Earth Science Jagannath University Dhaka Bangladesh Shanghai Universities Key Laboratory of Marine Animal Taxonomy and Evolution College of Fisheries and Life Science Shanghai Ocean University Shanghai China

As habitat and distribution, in the study a total of 18 crab species were identified, belonging to 10 families (Calappidae, Epialtidae, Gecarcinidae, Grapsidae, Matutidae, Ocypodidae, Panopeidae, Sesarmidae, Varunidae, and Xanthidae) order Decapoda under subphylum crustacean with relevant distinguish morphological and meristic character and geographical position. We investigated crab species of Bangladesh from December 2013 to October 2014. All species samples were collected by hand picking on a baseline survey in Saint Martin’s Island (the only coral island of Bangladesh) and adjacent marine water body of Bay of Bengal, Satkhira area (brackish and freshwater) and mangrove forest area (Sundarban). Among 18 species, 10 crab species from Family Epialtidae (1 species), Gecarcinidae (2 species), Ocypodidae (1 species), Panopeidae (1 species), Sesarmidae (1 species) and Xanthidae (4 species) were newly occurred in the Bay of Bengal, Bangladesh. Cardisoma armatum and Zosymus aeneus species were larger than other enlisted species.

关键词： Crab Species Morphology Distribution Coral Island Bangladesh

Brachyuran Crab Fauna Character Estimated from Marine Water of Bangladesh and Noted New Record (Crustacea: Decapoda) as Distribution

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A randomized controlled trial of imipramine in patients with irritable bowel syndrome

Open Journal of Marine Science（海洋科学期刊） 2020年第4期

作者： Nur Alam Sanjay Chakraborty Md. Muzammel Hossain mohammad abdul baki Shayer Mahmood Ibney Alam Chenhong Li

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World Journal of Gastroenterology 2009年第29期15卷 3636-3642页

作者： Heitham abdul-baki Ihab I El Hajj Lara ElZahabi Cecilio Azar Elie Aoun Assaad Skoury Hani Chaar Ala I Sharara Department of Internal Medicine Division of Gastroenterology American University of Beirut Medical Center Riad El Solh 110 72020 Beirut Lebanon

AIM: To study the efficacy of low-dose imipramine in relieving symptoms associated with the irritable bowel syndrome (IBS). METHODS: A randomized, double-blind trial of 25 mg imipramine vs matched placebo for 12 wk was performed. Doubling the dose was allowed once at week 2 in case of an unsatisfactory early response. Primary efficacy variables were subjective global symptom relief and quality of life (QoL) using SF-36 at week 12. RESULTS: One hundred and seven patients were enrolled by advertisement or referral by general practitioners and 56 (31 imipramine: 25 placebo) completed the 16-wk study. Baseline characteristics were comparable. A high overall dropout rate was noted in the imipramine and placebo arms (47.5% vs 47.9%, P > 0.05), a mean of 25.0 and 37.4 d from enrollment, respectively (P 0.05). CONCLUSION: Imipramine may be effective in the treatment of IBS patients and is associated with improved QoL. Careful patient selection, initiation of a low dose with gradual escalation and monitoring for side effects may result in an improved therapeutic response.

关键词： Tricyclic antidepressants Quality of life Functional gastrointestinal disorders Irritable bowelsyndrome Pain

Old vs new: Risk factors predicting early onset colorectal cancer

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World Journal of Gastrointestinal Oncology 2019年第11期11卷 1011-1020页

作者： Aslam R Syed Payal Thakkar Zachary D Horne Heitham abdul-baki Gursimran Kochhar Katie Farah Shyam Thakkar Division of Gastroenterology Allegheny Health NetworkPittsburghPA 15212United States Allegheny Singer Research Institute Allegheny Health NetworkPittsburghPA 15212United States Division of Radiation Oncology Allegheny Health Network Cancer InstitutePittsburghPA 15212United States

BACKGROUND Colorectal cancer(CRC)is the second leading cause of all cancer related deaths in the United States and *** the incidence has been decreasing for individuals’≥50,it has been on the rise for individuals<*** To identify potential risk factors for early-onset *** A population-based cohort analysis using a national database,Explorys,screened all patients with an active electronic medical record from January 2012 to December 2016 with a diagnosis of *** were stratified based on age(25–49 years vs≥50 years).Demographics,comorbidities,and symptom profiles were recorded and compared between both age ***,the younger group was also compared with a control group consisting of individuals aged 25-49 years within the same timeframe without a diagnosis of *** points for CRC related factors were analyzed to identify potential risk factors specific to early-onset *** A total of 68860 patients were identified with CRC,of which 5710(8.3%)were younger than 50 years old,with 4140(73%)between 40-49 years of *** analysis was reported using odds ratio(OR)with 95%CI and demonstrated that several factors were associated with an increased risk of CRC in the early-onset group versus the later-onset *** factors included:African-American race(OR 1.18,95%CI:1.09-1.27,P<0.001),presenting symptoms of abdominal pain(OR 1.82,95%CI:1.72-1.92,P<0.001),rectal pain(OR 1.50,95%CI:1.28-1.77,P<0.001),altered bowel function(OR 1.12,95%CI:1.05-1.19,P=0.0005),having a family history of any cancer(OR 1.78,95%CI:1.67-1.90,P<0.001),gastrointestinal(GI)malignancy(OR 2.36,95%CI:2.18-2.55,P<0.001),polyps(OR 1.41,95%CI:1.08-1.20,P<0.001),and obesity(OR 1.14,95%CI:1.08-1.20,P<0.001).Comparing the early-onset cohort versus the control group,factors that were associated with an increased risk of CRC were:male gender(OR 1.34,95%CI:1.27-1.41),P<0.001),Caucasian(OR 1.48,95%CI:1.40-1.57,P<0.001)and African-American race(OR 1

关键词： Colorectal cancer Early-onset colorectal cancer Colorectal cancer screening Epidemiology analysis Colorectal neoplasm Average-risk screening

Hepatocellular carcinoma in Lebanon: Etiology and prognostic factors associated with short-term survival

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World Journal of Gastroenterology 2006年第22期12卷 3575-3580页

作者： César Yaghi Ala I Sharara Paul Rassam Rami Moucari Khalil Honein Joseph BouJaoude Rita Slim Roger Noun Heitham abdul-baki Mohamad Khalifeh Sami Ramia Raymond Sayegh Service de Gastroenterologie Hotel Dieu de France University Hospital BeirutLebanon Service de Gastroenterologie Hotel Dieu de France University Hospital.Beirut.Lebanon Departments of Internal Medicine and Surgery American University of Beirut Medical CenterBeirutLebanon Service de Gastroenterologie Hotel Dieu de France University Hospital BeirutLebanon Service de GastroenterologieHopital Saint GeorgesBeirutLebanon Departments of Internal Medicine and Surgery American University of Beirut Medical Center BeirutLebanon

AIM： To study the epidemiology of HCC in Lebanon and prognostic factors predictive of early mortality. METHODS： An observational follow-up cohort study of HCC cases diagnosed over a five-year period was carried out. Multivariate analysis was conducted to identify prognostic factors in comparison to Cancer of the Liver italian Program （CUP） score. Multiple variables including the etiology of underlying liver disease, the demographic characteristics of patients, and the severity of liver disease evaluated by the Child-Pugh score were studied. Tumor parameters included the time of diagnosis of HCC, alpha-fetoprotein level, number and size of nodules, presence of portal vein thrombosis, and treatment modalities. Death or loss of follow-up was considered as an end-point event. RESULTS： Ninety-two patients （mean 60.5 ± 22.3 years） were included. Etiology of underlying disease was hepatitis B, C, and alcohol in 67%, 20%, and 23.5% respectively. Child-Pugh class at diagnosis was A, B, and C in 34.8%, 39.3% and 25.8% respectively. Overall survival was 44.8%, 32.8% and 17.6% at 1, 2 and 3 years respectively （mean F/U 40.2 ± 23.5 mo）. Multivariate analysis identified three predictors of early mortality （〈 6 mo）： bilirubin 〉 3.2 mg/dL （P 〈 0.01）, HCC as first presentation of liver disease （P = 0.035）, and creatinine 〉 1 mg/dL （P = 0.017）. A score based on these variables outperformed the CLIP score by Cox proportional hazard. ROC curve showed both models to be equivalent and moderately accurate.CONCLUSION： HBV is the leading cause of HCC in Lebanon. Independent predictors of early mortality are elevated bilirubin, creatinine and HCC as first manifestation of disease. Prospective validation of a score based on these clinical parameters in predicting short-term survival is needed.

关键词： Liver Epidemiology Hepatitis Neoplasm Cancer Cirrhosis

无饮食限制的少量多次与饮食限制的大剂量单次聚乙二醇电解质液进行结肠镜检前肠道准备的随机、单盲试验

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世界核心医学期刊文摘（胃肠病学分册） 2005年第11期1卷 41-42页

作者： Aoun E. abdul-baki H. Azar C. A.I. Sharara 陈云茹 Gastroenterology Division American University Beirut Medical Center P.O. Box 11- 0236Beirut 1107 2020 Lebanon Dr.

Background: Colonoscopy preparation regimens are poorly tolerated, requiring the use of a large volume of an unpalatable solution and diet restriction for adequate cleansing. The aim of this study was to compare the efficacy of two regimens of bowel preparation before colonoscopy: a whole dose of polyethylene glycol electrolyte solution (PEG-E), with diet restriction vs. a split dose with no diet restriction. Methods: A total of 141 patients (ages 20- 84 years, 81 men) were randomly assigned to receive either 4 L PEG-E, along with a liquid diet the day before colonoscopy (Group A) or 2 L PEG-E with a regular diet the day before colonoscopy followed by another 2 L PEG-E on the day of the procedure (Group B). The quality of the preparation was graded by the endoscopist (poor to excellent), who was blinded to the type of preparation. Tolerability of the assigned preparation and adverse effects were recorded by an independent investigator by using a questionnaire administered before colonoscopy. Intra- and interobserver variability was studied by using randomly chosen videotapes of colonoscopies performed as part of the study. Results: There were 73 patients in Group A and 68 patients in Group B. The quality of the preparation was significantly better in Group B (p = 0.011). The tolerability of the preparation regimen was not different overall between study groups in terms of side effects (except for bloating, which was more frequent in Group B, p = 0.039) or willingness to repeat the preparation. There was a nonsignificant trend toward improved adherence to the assigned preparation in favor of Group B (p = 0.062). Inter- and intraobserver variability analysis showed good to excellent correlation among endoscopists. Conclusions: Colonic preparation with split-dose PEG-E and no dietary restriction provides better quality colon cleansing than whole-dose preparation, with no significant impact on patient tolerability and side effects.

关键词：结肠镜检单盲试验肠道准备饮食限制限制饮食耐受程度胃胀气患者耐受性差异性分析影像学