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Theoretical insights into the degradation mechanisms, kinetics and eco-toxicity of oxcarbazepine initiated by OH radicals in aqueous environments

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Journal of Environmental Sciences 2023年第7期129卷 189-201页

作者： Yanhui Sun Ming Li mohammad hassan hadizadeh Lin Liu Fei Xu College of Environment and Safety Engineering Qingdao University of Science and TechnologyQingdao 266042China Environment Research Institute Shandong UniversityQingdao 266237China

As an anticonvulsant,oxcarbazepine(OXC)has attracted considerable attention for its potential threat to aquatic *** functional theory has been used to study the mechanisms and kinetics of OXC degradation initiated by OH radicals in aqueous environment.A total of fourteen OH-addition pathways were investigated,and the addition to the C8 position of the right benzene ringwas themost vulnerable pathway,resulting in the intermediate *** H-abstraction reactions initiated by OH radicalswere also explored,where the extraction site of the methylene group(C14)on the seven-member carbon heterocyclic ring was found to be the optimal *** calculations show that the total rate constant of OXC with OH radicals is 9.47×10^(9)(mol/L)^(−1)sec^(−1),and the half-life time is 7.32 s at 298 K with the[·OH]of 10^(−11) mol/***,the branch ratio values revealed that OH-addition(89.58%)shows more advantageous than H-abstraction(10.42%).To further understand the potential eco-toxicity of OXC and its transformation products to aquatic organisms,acute toxicity and chronic toxicity were evaluated using ECOSAR *** toxicity assessment revealed that most degradation products such as OXC-2OH,OXC-4OH,OXC-1O-1OOH,and OXC-1OH’are innoxious to fish and ***,green algae are more sensitive to these *** study can provide an extensive investigation into the degradation of OXC by OH radicals and enrich the understanding of the aquatic oxidation processes of pharmaceuticals and personal care products(PPCPs).

关键词： Oxcarbazepine OH radicals Degradation mechanisms Kinetic calculation Eco-toxicity evaluation

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The Effects of a Novel Multicomponent Transition Metal Dichalcogenide on Nervous System Regeneration

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Journal of Bionic Engineering 2022年第5期19卷 1449-1459页

作者： Nahid Askari mohammad Bagher Askari Ali Shafieipour Behnaz Salek Esfahani Morteza hadizadeh Department of Biotechnology Institute of Science and High Technology and Environmental SciencesGraduate University of Advanced TechnologyKermanP.O.Box ***Iran Semiconductor Research Department Institute of Science and High Technology and Environmental SciencesGraduate University of Advanced TechnologyKermanP.O.Box ***Iran Graduated Student of Veterinary Medicine Faculty of Veterinary MedicineShahid Bahonar University of KermanKermanP.O.Box 76169133Iran Department of Genetics and Molecular Biology School of MedicineIsfahan University of Medical SciencesIsfahanIran Physiology Research Center Institute of Basic and Clinical Physiology SciencesKerman University of Medical SciencesKermanIran

In regenerative medicine,a scaffold is needed to provide physical support for the growth of cells at the injury *** composites are also widely used in *** research aimed to see if(MoWCu)S/rGO could be used in peripheral and central neural regeneration as a carbon-based *** material was created using a one-step hydrothermal *** used Scanning Electron Microscopy with Energy Dispersive X-ray analysis(SEM–EDX),X-ray diffraction,and Field-Emission Scanning Electron Microscopy(FE-SEM)to describe *** researchers used animal models of spinal cord injury and sciatic nerve injury to assess its effect as a scaffold of anti-inflammatory and electrical *** Basso Beattie Bresnahan locomotor rating scale and von Frey Filament were used to assess neuronal function after(MoWCu)S/rGO *** addition,the expression of p75 NTR and neurotrophic factors(BDNF,NT3,and NGF)mRNA in the experimental rats nerve was compared to the normal ones using Real-Time *** the experimental groups,the use of(MoWCu)S/rGO resulted in a significant increase in neurotrophic factor gene expression,while p75 NTR was inversely *** conclusion,we found that the nerve regeneration activity of the(MoWCu)S/rGO scaffold in rat models significantly increased motor function recovery in the treated ***,the current study explained the response of this composite to inflammatory neurodegenerative diseases.(MoWCu)S incorporation in graphene is thought to have excellent properties and may be used in regenerative medicine.

关键词： Regenerative medicine Carbon nanomaterial (MoWCu)S/rGO Spinal cord injury Sciatic nerve injury

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Period–Luminosity Relationship forδScuti Stars Revisited

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Research in Astronomy and Astrophysics 2024年第2期24卷 138-143页

作者： Atila Poro S.Javad Jafarzadeh Roghaye Harzandjadidi mohammad Madani Elnaz Bozorgzadeh Esfandiar Jahangiri Ahmad Sarostad Ailar Alizadehsabegh Maryam hadizadeh mohammad EsmaeiliVakilabadi The Raderon AI Laboratory Astronomy DepartmentBurnabyBCCanada Department of Physics University of Texas at Dallas800 W.Campbell Rd.RichardsonTX 75080USA Department of Theoretical Physics and Astrophysics University of ZanjanZanjanIran Independent researcher TehranIran Department of Electronics and Telecommunications Politecnico Di TorinoTurinItaly Independent researcher IsfahanIran Yazd Desert Night Sky Astronomy Institute YazdIran Department of Photonics Tabriz UniversityTabrizIran Khayyam Astronomy Association FarsFasaIran

The Gaia DR3 parallax approach was used to estimate the absolute parameters of 2375δScuti stars from the ASAS *** selected stars have a variety of observational characteristics,with a higher than 80%probability of beingδScuti *** have displayed all the stars in the Hertzsprung-Russell diagram along with theδScuti instability strip,the Zero Age Main Sequence and the Terminal Age Main ***,we determined which fundamental and overtone modes each star belongs to using pulsation constant(Q)*** addition,we evaluated the parameters in the Q calculation equation using three machine learning methods,which showed that surface gravity and temperature have the greatest effect on its *** Period-Luminosity(P-L)relationship of theδScuti stars was also ***,using least squares linear regression,we made four linear fits for fundamental and overtone modes and updated their relationships.

关键词： stars variables delta Scuti--stars fundamental parameters-methods data analysis

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Evaluating the safety and efficacy of mesenchymal stem cell-derived exosomes for treatment of refractory perianal fistula in IBD patients:clinical trial phaseⅠ

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Gastroenterology Report 2022年第1期10卷 585-593页

作者： Hojjatollah Nazari Foroogh Alborzi Asieh Heirani-Tabasi Alireza hadizadeh Reza Akbari Asbagh Behnam Behboudi mohammad Sadegh Fazeli Mojgan Rahimi mohammad Reza Keramati Amir Keshvari Alireza Kazemeini Masoud Soleimani Seyed Mohsen Ahmadi Tafti Department of Colorectal Surgery Colorectal Research CenterImam Khomeini Hospital ComplexTehran University of Medical SciencesTehranIran Department of Biomedical Engineering School of Biomedical EngineeringUniversity of Technology SydneySydneyNSWAustralia Department of Gastroenterology Division of GastroenterologyImam Khomeini HospitalSchool of MedicineTehran University of Medical SciencesTehranIran Department of Cardiovascular Surgery Research Center for Advanced Technologies in Cardiovascular MedicineCardiovascular Research InstituteTehran University of Medical SciencesTehranIran Division of Colorectal Surgery Department of SurgeryTehran University of Medical SciencesTehranIran Department of Cell Therapy and Hematology Faculty of Medical SciencesTarbiat Modares UniversityTehranIran Department of Tissue Engineering and Applied Cell Sciences School of Advanced Technologies in MedicineStudent Research CommitteeShahid Beheshti University of Medical SciencesTehranIran

Background:Exosome administration is a novel medical approach that promises excellent immunomodulatory properties without the conventional side effects of current antitumor necrosis factor drugs and *** study aimed to assess the safety and efficacy of usingmesenchymal stemcell(MSC)exosomes to treat refractory fistulas in patients with inflammatory bowel ***:MSCs were derived from the umbilical cords and their exosomes were *** patients with refractory perianal Crohn’s disease fistulas with amedian age of 35 years(range 31–47 years)were enrolled in the *** injections were administered in the operating roomto patients with refractory fistula(fistulas that are irresponsive to anti-tumor necrosis factor-αadministration within 6months).Sixmonths later,a physical examination,face-to-face interviews,andmagnetic resonance imaging were employed to evaluate the therapy responses of ***:The outcomes within 6 months after initiation of therapy showed that four patients had responded to *** patients who received exosome injections exhibited complete healing,while one reported no improvement and active discharge from the fistula *** addition,five patients(100%)reported neither systemic nor local adverse ***:Injection of exosomes extracted from MSCs demonstrates safety and a satisfactory therapeutic effect,as evidenced in this and other studies,and may play a significant role in the future treatment of gastrointestinal fistulas.

关键词： IBD exosome Crohn’s disease MSCs fistula

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