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The impact of chemotherapy-naïve open radical cystectomy delay and perioperative transfusion on the recurrence-free survival: A perioperative parameters-based nomogram

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Asian Journal of Urology 2024年第2期11卷 294-303页

作者： Ahmed M.Harraz Ahmed Elkarta mohamed H.Zahran Ahmed Mosbah Atallah A.shaaban Hassan Abol-Enein Urology and Nephrology Center Mansoura UniversityEgypt

Objective: To develop and internally validate a nomogram to predict recurrence-free survival (RFS) including the time to radical cystectomy (RC) and perioperative blood transfusion (PBT) as potential ***: Patients who underwent open RC and ileal conduit between January 1996 to December 2016 were split into developing (n=948) and validating (n=237) cohorts. The time to radical cystectomy (TTC) was defined as the interval between the onset of symptoms and RC. The regression coefficients of the independent predictors obtained by Cox regression were used to construct the nomogram. Discrimination, validation, and clinical usefulness in the validation cohort were assessed by the area under the curve, the calibration plot, and decision curve ***: In the developing dataset, the 1-, 5-, and 10-year RFS were 83.0%, 47.2%, and 44.4%, respectively. On multivariate analysis, independent predictors were TTC (hazards ratio [HR] 1.07, 95% confidence interval [CI] 1.05-1.08, p<0.001), PBT (one unit: HR 1.40, 95% CI 1.03-1.90, p=0.03;two or more units: HR 1.72, 95% CI 1.29-2.29, p<0.001), bilateral hydronephrosis (HR 1.54, 95% CI 1.21-1.97, p<0.001), squamous cell carcinoma (HR 0.60, 95% CI 0.45-0.81, p=0.001), pT3-T4 (HR 1.77, 95% CI 1.41-2.22, p<0.001), lymph node status (HR 1.53, 95% CI 1.21-1.95, p<0.001), and lymphovascular invasion (HR 1.28, 95% CI 1.01-1.62, p=0.044). The areas under the curve in the validation dataset were 79.3%, 69.6%, and 76.2%, for 1-, 5-, and 10-year RFS, respectively. Calibration plots showed considerable correspondence between predicted and actual survival probabilities. The decision curve analysis revealed a better net benefit of the ***: A nomogram with good discrimination, validation, and clinical utility was constructed utilizing TTC and PBT in addition to standard pathological criteria.

关键词： Radicalcystectomy Blood transfusion Time to radical cystectomy Survival Nomogram

Optimal FOPID Controllers for LFC Including Renewables by Bald Eagle Optimizer

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Computers, Materials & Continua 2022年第12期73卷 5525-5541页

作者： Ahmed M.Agwa mohamed Abdeen shaaban M.shaaban Department of Electrical Engineering College of EngineeringNorthern Border UniversityArar1321Saudi Arabia Electrical Engineering Department Faculty of EngineeringAl-Azhar UniversityCairo11651Egypt Department of Engineering Basic Science Faculty of EngineeringMenoufia UniversityShebin El-Kom32511Egypt

In this study,a bald eagle optimizer(BEO)is used to get optimal parameters of the fractional-order proportional-integral-derivative(FOPID)controller for load frequency control(LFC).SinceBEOtakes only a very short time in finding the optimal solution,it is selected for designing the FOPID controller that improves the system stability and maintains the frequency within a satisfactory range at different *** and demonstrations are carried out using *** performance of the BEOFOPID controller is evaluated using a two-zone interlinked power system at different loads and under uncertainty of wind and solar *** robustness of the BEO-FOPID controller is examined by testing its performance under varying system time *** results obtained by the BEOFOPID controller are compared with those obtained by BEO-PID and PID controllers based on recent metaheuristics optimization algorithms,namely the sine-cosine approach,Jaya approach,grey wolf optimizer,genetic algorithm,bacteria foraging optimizer,and equilibrium optimization *** results confirm that the BEO-FOPID controller obtains the finest result,with the lowest frequency *** results also confirm that the BEOFOPID controller is stable and robust at different loads,under varying system time constants,and under uncertainty of wind and solar energies.

关键词： Fractional order PID control load frequency control renewable energy bald eagle optimizer

Novel markers of endothelial dysfunction in hepatitis C virus-related cirrhosis: More than a mere prediction of esophageal varices

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World Journal of Hepatology 2020年第10期12卷 850-862页

作者： Amr shaaban Hanafy mohamed Abdel Khalik Basha Fady Maher Wadea Department of Internal Medicine Gastroenterology and Hepatology DivisionZagazig University HospitalZagazig 44519Egypt Department of Diagnostic Radiology Zagazig UniversityZagazig 44519Egypt

BACKGROUND Hepatitis C virus(HCV)infection may affect lipid metabolism by enhancing the circulating levels of inflammatory cytokines,together with its impact on endothelial *** To evaluate the potential correlation of changes in lipid profile,carotid intimamedia thickness(CIMT),and ankle-brachial index with the severity of fibrosis,grades of esophageal varices(EVs),and fibrosis *** The study included 240 subjects who were divided into 3 groups;group 1(n=90,HCV-related cirrhotic patients with EVs),group 2(n=90,HCV-related cirrhotic patients without EVs),and group 3(n=60,served as the healthy control group).All patients underwent routine laboratory tests,including a lipid profile ***-density lipoproteins(LDL)/platelet count and platelet/splenic diameter ratios were *** ultrasonography,CIMT by carotid Doppler,bedside ankle-brachial index(ABI),liver stiffness measurement,and upper gastrointestinal endoscopy were *** Multivariate logistic regression revealed that very-low-density lipoprotein(VLDL)(β=0.988,odds ratio 2.5,P=0.001),LDL/platelet count ratio(β=1.178,odds ratio 3.24,P=0.001),CIMT(β=1.37,odds ratio 3.9,P=0.001),and ABI(β=2.3,odds ratio 5.9,P=0.001)were the key variables associated with significant fibrosis,EVs and endothelial *** and LDL/platelet count ratio were predictive of advanced fibrosis and EVs at cutoff values of 1.1 mm and 1 mm,respectively,with an area under the curve(AUC)of 0.966 and 0.960(P=0.001),while VLDL and ABI at a cutoff of 16.5 mg/dL and 0.94 were predictive of advanced fibrosis and EVs with an AUC of 0.891 and 0.823,respectively(P=0.001).CONCLUSION CIMT,ABI,VLDL,LDL/platelet count ratio are good non-invasive predictors of advanced fibrosis,presence of EVs,and endothelial dysfunction in liver cirrhosis.

关键词： Lipid profile Liver cirrhosis Esophageal varices Carotid-intima media thickness Ankle-brachial index

Right Ventricular Dysfunction in Patients with Acute STEMI, Radionuclide-Based Assessment

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World Journal of Cardiovascular Diseases 2019年第12期9卷 915-929页

作者： Samir El-Hadidy Abdalla mohammed shaaban Alramlawy Waheed Radwan mohamed Affify Critical Care Medicine Department Cairo Egypt Biophysics Department Faculty of Medicine Cairo University Cairo Egypt

Background: An acute myocardial infarction, particularly one that is large and transmural, can produce alterations in the topography of both the infarcted and noninfarcted regions of the ventricle. Cardiac remodeling after acute myocardial infarction (AMI) is characterized by molecular and cellular mechanisms involving both left and right ventricles. Objective: To study the right ventricular affection in patients with acute myocardial infarction of the left ventricle and treated with primary PCI. Methods: The study was done in the critical care department, Cairo University (in which 2,500 primary percutaneous coronary interventions (PCIs) are done annually). Forty patients with acute ST-elevation myocardial infarction (STEMI) were subjected to primary (PCI), we excluded all patients with RV infarction and patients with pulmonary hypertension. RV function was assessed by first pass radionuclide angiocardiography within 48 hours of admission. Results: Regarding the incidence of right ventricular dysfunction in patients with acute left ventricular STEMI who treated with 1ry PCI, there were 21 patients (52.5%) with RV EF% patients (47.5%) with RV time to peak filling rate (TPFR) > 180 msec. There was a significant relationship between right ventricular dysfunction and duration of ICU stay, impairment of LV systolic function, failure of complete resolution of ST segment elevation, failure of early peaking of cardiac enzymes, occurrence of in-hospital complications and one year mortality. Conclusion: The incidence of right ventricular dysfunction in patients with acute left ventricular STEMI is higher than expected and has a negative impact on their outcome.

关键词： STEMI RV Affection First Pass Radionuclide

Isolation, purification and structure elucidation of three newbioactive secondary metabolites from Streptomyces lividans AM

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BIOCELL 2021年第5期45卷 1263-1271页

作者： MOHAMMAD EL-METWALLY MAMDOUH ABDEL-MOGIB MANAL ELFEDAWY GAAD SOHSAH AHMED REZK MAHMOUD MOUSTAFA mohamed shaaban Botany and Microbiology Department Faculty of ScienceDamanhour UniversityDamanhour22511Egypt Chemistry Department Faculty of ScienceMansoura UniversityEl-Mansoura35516Egypt Bioprocess Development Department Genetic Engineering and Biotechnology Research InstituteCity of Scientific Research and Technological Applications(SRTA-City)New Borg El-Arab CityAlexandria21934Egypt Biology Department College of ScienceKing Khalid UniversityAbha9004Saudi Arabia Chemistry of Natural Compounds Department Division of Pharmaceutical IndustriesNational Research CentreDokki-Cairo12622Egypt Organic and Bioorganic Chemistry Department of ChemistryBielefeld UniversityBielefeld33615Germany

Microorganisms are a huge mine of bioactive metabolites,and actinomycetes are one of the very active groups in this *** this article,we are concerned about the full taxonomical characterization of Streptomyces lividans AM,isolated from Egyptian *** isolate produced three new bioactive metabolites,namely:1-Nona-decanoyl,4-oleyl disuccinate(1),filoboletic acid;(9Z,11E)-8,13-dihydroxy octadeca-9,11-dienoic acid(2),and sitosteryl-3β-D-glucoside(3).Extensive 1D and 2D NMR and HR-mass spectrometry were used to elucidate the structures of the three ***,ten known compounds were also *** antimicrobial activity of the producing organism and newly reported compounds(1–3)was investigated against a selected group of pathogenic microorganisms.A full taxonomical characterization of the strain was described as well.

关键词： Bioactive metabolites Streptomyces sp. Taxonomy Biological activity

Determination of a novel ACE inhibitor in the presence of alkaline and oxidative degradation products using smart spectrophotometric and chemometric methods

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Journal of Pharmaceutical Analysis 2014年第2期4卷 132-143页

作者： Maha Abdel-Monem Hegazy Maya shaaban Eissa Osama Ibrahim Abd El-Sattar mohamed mohamed Abd El-Kawy Analytical Chemistry Department Faculty of PharmacyCairo UniversityCairoEgypt Analytical Chemistry Department Faculty of PharmacyEgyptian Russian UniversityCairoEgypt National Organization of Drug Control and Research GizaEgypt

Simple, accurate, sensitive and validated UV spectrophotometric and chemometric methods were developed for the determination of imidapril hydrochloride （IMD） in the presence of both its alkaline （AKN） and oxidative （OXI） degradation products and in its pharmaceutical formulation. Method A is the fourth derivative spectra （D4） which allows the determination of IMD in the presence of both AKN and OXD, in pure form and in tablets by measuring the peak amplitude at 243.0 nm. Methods B, C and D, manipulating ratio spectra, were also developed. Method B is the double divisor-ratio difference spectrophotometric one （DD-RD） by computing the difference between the amplitudes of IMD ratio spectra at 232 and 256.3 nm. Method C is the double divisor-first derivative of ratio spectra method （DD-DR1） at 243.2 nm, while method D is the mean centering of ratio spectra （MCR） at 288.0 nm. Methods A, B, C and D could successfully determine IMD in a concentration range of 4.0-32.0 mg/mL. Methods E and F are principal component regression （PCR） and partial least-squares （PLS）, respectively, for the simultaneous determination of IMD in the presence of both AKN and OXI, in pure form and in its tablets. The developed methods have the advantage of simultaneous determination of the cited components without any pre-treatment. The accuracy, precision and linearity ranges of the developed methods were determined. The results obtained were statistically compared with those of a reported HPLC method, and there was no significant difference between the proposed methods and the reported method regarding both accuracy and precision.

关键词： Double divisor-ratio difference Double divisor-ratio derivative Mean centering of ratio spectra Chemometry Imidapril hydrochloride

Simulation and Modelling of near Infrared Spectroscopy (NIRS) as Brain Monitor

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Spectral Analysis Review 2014年第2期2卷 3-5页

作者： mohamed shaaban Ali Anesthesia Faculty of Medicine Assiut University Assiut Egypt

Near infrared spectroscopy (NIRS) is a method for non-invasive monitoring of cerebral oxygenation and haemodynamics. Different devices provide information on changes of oxygenated (HbO2) and deoxygenated haemoglobin (HHb), oxidized cytochrome aa3 (CytOx) or regional oxygen saturation (rSO2). NIRS has been used during adult and paediatric cardiac surgery.

关键词： Near infrared spectroscopy (NIRS)

Synthesis of an eco-friendly nanocomposite fertilizer for common bean based on carbon nanoparticles from agricultural waste biochar

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Pedosphere 2021年第6期31卷 923-933页

作者： Dina M.SALAMA Mahmoud E.ABD EL-AZIZ Mehrez E.EL-NAGGAR Essam A.shaaban mohamed S.ABD EL-WAHED Vegetable Research Department National Research Centre33 El Bohouth StreetDokkiGiza 12622(Egypt) Polymers&Pigments Department National Research Centre33 El Bohouth StreetDokkiGiza 12622(Egypt) Textile Research Division National Research Centre33 El Bohouth StreetDokkiGiza 12622(Egypt) Pomology Department National Research Centre33 El Bohouth StreetDokkiGiza 12622(Egypt) Botany Department National Research Centre33 El Bohouth StreetDokkiGiza 12622(Egypt)

The burning of agricultural waste is a major cause of environmental *** this study,we sought to prepare biochar from agricultural waste as a source material for the preparation of carbon nanoparticles(CNPs).Surface morphology,hydrodynamic particle size,and purity and crystallinity of CNPs were extensively investigated using transmission electron microscopy(TEM),zeta sizing,and X-ray diffraction(XRD)spectroscopy,*** CNPs were subsequently immersed in a solution of potassium nitrate(KNO_(3))to prepare a CNPs/NK nanocomposite(CNPs loaded with nitrogen(N)and potassium(K))as a nanocomposite fertilizer for common bean(Phaseolus vulgaris L.).The CNPs/NK nanocomposite was sprayed as a foliar fertilizer at 0,10,20,30,and 40 mg L^(-1) on common bean plants 25 d after sowing on a farm in Shebin El-Kom,El-Monifia,*** growth,yield,and quality of common bean were investigated during two successive growing seasons(2017 and 2018).The highest seed yields of 2.04 and 2.01 t ha^(-1) and the highest values of growth parameters including plant height of 61.5 and 59.2 cm,number of leaves per plant of 35 and 35,number of flowers per plant of 83.3 and 82.7,and plant fresh weight of 148.7 and 152.8 g plant^(-1) were obtained when using the CNPs/NK nanocomposite at a concentration of 20 mg L^(-1) during the 2017 and 2018 growing seasons,respectively.

关键词： foliar fertilizer N and K-loaded nanosized carbon particles Phaseolus vulgaris L. plant growth yield

Synthesis,antimicrobial, antiquorum-sensing and cytotoxic activities of new series of benzothiazole derivatives

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Chinese Chemical Letters 2015年第12期26卷 1522-1528页

作者： Moustafa T.Gabr Nadia S.El-Gohary Eman R.El-Bendary mohamed M.El-Kerdawy Nanting Ni Mona I.shaaban Department of Medicinal Chemistry Faculty of Pharmacy Mansoura University Department of Chemistry Georgia State University Department of Microbiology Faculty of Pharmacy Mansoura University Department of Microbiology College of Pharmacy Taibah University

New series of benzothiazole derivatives were designed and synthesized. The newly synthesized compounds were screened for their antibacterial activity against Escherichia coli, Staphylococcus aureus and Bacillus cereus. Compounds 6j and 6o showed the highest activity against E. coli and S. aureus. The antifungal activity of these compounds was also tested against Candida albicans and Aspergillus fumigatus293. Compounds 4c, 4g and 6j exhibited the highest activity against C. albicans. In addition, compounds4 a and 6j displayed promising activity against A. fumigatus 293. The same compounds were examined for their antiquorum-sensing activity against Chromobacterium violaceum ATCC 12472, whereas compounds4 a, 6j and 6p showed moderate activity. The in vitro cytotoxicity testing of the synthesized compounds was performed against cervical cancer（Hela） and kidney fibroblast cancer（COS-7） cell lines. Results indicated that all tested compounds have IC50 values 〉50 mmol/L against both cell lines. Molecular properties, toxicities, drug-likeness, and drug score profiles of compounds 4a–c, 5a, 6g,h, 6j, 6l, 6o and7 c,d were also assessed.

关键词： antibacterial moiety antifungal antimicrobial cytotoxic screened moderate substituent Candida albicans