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嘉兴火车站,嘉兴,浙江,中国

世界建筑 2024年第4期 36-41页

作者： mad Architects Tongji Architectural Design (Group) Co.,Ltd. mad建筑事务所同济大学建筑设计研究院(集团)有限公司

嘉兴火车站位于浙江嘉兴老城市中心的南湖区,是中国首个全下沉式火车站。由mad负责规划和改造设计的片区占地面积35.4hm,包含嘉兴火车站、车站南北广场以及人民公园。改造前的火车站已达到吞吐量上限,周边片区交通混乱、配套不完善、公... 详细信息

嘉兴火车站位于浙江嘉兴老城市中心的南湖区,是中国首个全下沉式火车站。由mad负责规划和改造设计的片区占地面积35.4hm,包含嘉兴火车站、车站南北广场以及人民公园。改造前的火车站已达到吞吐量上限,周边片区交通混乱、配套不完善、公共设施短缺等一系列问题导致火车站周边发展受阻、产业结构低端。

关键词：产业结构占地面积嘉兴火车站公共设施下沉式交通混乱南湖区

Visceral Leishmaniasis at the National Reference University Hospital Center of N’Djamena (Chad): epidemiological, Clinical, Diagnostic, Therapeutic and Prognostic Aspects

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Advances in Infectious Diseases 2024年第2期14卷 478-486页

作者： Joseph mad-Toïngué Mahamat Ali Ahmat Oumaïma Mahamat Djarma Alifa Adjibera Philippe Ali Mahamat Moussa Ngakoutou Rangar Choua Ouchemi Mahamat Ali Bolti Djiddi Ali Sougoudi Mamissou Didi Mahamat Doungous Atim Service des Maladies Infectieuses CHU de Référence Nationale N’Djamena Chad Service de Gastroentérologie et Médecine Interne CHU de Référence Nationale N’Djamena Chad Service de Pneumologie et Phtisiologie CHU de Référence Nationale N’Djamena Chad Service de Chirurgie viscérale CHU de Référence Nationale N’Djamena Chad Service de Médecine CHU de la Renaissance N’Djamena Chad

Introduction: leishmaniasis is a group of parasitic diseases caused by a parasite of the genus Leishmania transmitted by the bite of an infected vector called a sandfly. There are four forms. Visceral leishmaniasis is the most severe form. The aim of our work is to study the epidemiological, clinical, diagnostic, therapeutic and prognostic aspects of the disease in the Infectious Diseases Department of the Centre Hospitalier Universitaire de Référence Nationale in N'Djaména. Methodology: Patients were recruited on the basis of clinical signs suggestive of visceral leishmaniasis, i.e. prolonged fever, splenomegaly and altered general condition. Biological confirmation was performed with a rapid diagnostic test using recombinant K39 parasite antigen, which is known to have good specificity and sensitivity. epidata version 3.1 software was used to process patient data. Results: From 05/04/21 to 15/12/23, 153 positive cases were managed. The mean age of patients was 18 years, with a sex ratio of 9.2. Of these patients, 103 (67.3%) had recently stayed at gold mining sites. Patients testing positive were treated with sodium stibogluconate combined with paromomycin for 17 days. The mortality rate was 13.2%. Conclusion: Leishmaniasis is a serious and little-known disease in Chad. In order to respond to the disease, it is necessary to reinforce the capacities of health structures and to carry out appropriate actions in the outbreaks.

关键词： Visceral Leishmaniasis Gold Mining Sites Chad

New Algorithm for CBR-RBR Fusion with Robust Thresholds

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Chinese Journal of Mechanical engineering 2012年第6期25卷 1255-1263页

作者： XU mad YU Haiyan SHeN Jiang TeDA College Nankai University Tianjin 300457 China College of Management and economics Tianjin University Tianjin 300072 China

The case-based reasoning（CBR） and rule-based reasoning（RBR） fusion systems include a diverse range of fusion methods and their tasks are characterized by interleaving combination of the reasoning procedures. existing approaches cannot clarify the complex relationships between data from the knowledge sources nor uniformly represent the heterogeneous case and rule knowledge in one fusion space. As a result, existing approaches fail to solve system fragility due to knowledge uncertainty and reasoning unreliability. For the purpose of addressing the difficulties, a novel algorithm for CBR-RBR fusion with robust thresholds（CRFRT） is proposed. Heterogeneous case and rule knowledge are uniformly represented in one defined fusion unitary space. The robust thresholds have been achieved to distinguish the complex relationships between meta-knowledge in the fusion space and to enhance system capacity of knowledge identification. Furthermore, fusion reasoning strategies are constructed for CRFRT and its procedure based on which robust solution of the fusion reasoning problem is obtained. Finally, CRFRT is validated by benchmark problems in machine learning. Compared with other CBR and RBR approaches, the reasoning efficiency and accuracy are increased by 5% and 2.2% respectively. The variations of system accuracy are decreased by 2% to 3.8%. The above results show that the CRFRT algorithm boosts the system＇s effectiveness and robustness. The proposed CRFRT can solve the fragility of complex intelligence decision system and give quality performance for fault diagnosis.

关键词： case-based reasoning (CBR) rule-based reasoning (RBR) robust thresholds fusion reasoning system (FRS)

enhanced angiogenesis in porous poly(ε-caprolactone)scaffolds fortified with methacrylated hyaluronic acid hydrogel after subcutaneous transplantation

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Biomaterials Translational 2024年第1期5卷 59-68页

作者： Huaxin Yang Mengjia Zheng Yuyue Zhang Chaochang Li Joseph Ho Chi Lai Qizheng Zhang Kannie wy Chan Hao Wang Xin Zhao Zijiang Yang Chenjie Xu Department of Biomedical engineering City University of Hong KongHong Kong Special Administrative RegionChina Center for Pluripotent Stem Cell Research and engineering Research Institute of TsinghuaGuangzhouGuangdong ProvinceChina Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina

A composite scaffold composed of a porous scaffold and hydrogel filling can facilitate engraftment,survival,and retention in cell transplantation *** study presents a composite scaffold made of poly(ε-caprolactone)(PCL)and methacrylated hyaluronic acid(MeHA)hydrogel and describes the corresponding physical properties(surface area,porosity,and mechanical strength)and host response(angiogenesis and fibrosis)after subcutaneous ***,we synthesise MeHA with different degrees of substitution and fabricate a PCL scaffold with different ***,we construct a series of PCL/MeHA composite scaffolds by combining these hydrogels and *** experiments with mice,the scaffold composed of 3%PCL and 10-100 kDa,degree of substitution 70%MeHA results in the least fibrosis and a higher degree of *** study highlights the potential of PCL/MeHA composite scaffolds for subcutaneous cell transplantation,given their desirable physical properties and host response.

关键词： angiogenesis cell transplantation hyaluronic acid poly(ε-caprolactone) scaffold

Characteristics and properties of goat meat gels and balls as affected by setting conditions

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Food Quality and Safety 2019年第2期3卷 129-136页

作者： Sulaiman mad-Ali Soottawat Benjakul Department of Food Technology Faculty of Agro-IndustryPrince of Songkla UniversityHat YaiSongkhlaThailand

The properties of goat meat gels without and with 120 mmol/kg CaCl_(2)as influenced by setting time(30-120 min)at 60℃ were studied.A gel set for 60 min with subsequent cooking for 20 min in the presence of CaCl_(2)had the highest breaking force and deformation with coincidentally lowest expressible moisture content(Pever,no differences in the trichloroacetic acid-soluble peptide content were observed for all gels tested(P>0.05).A decrease in the myosin heavy-chain band intensity was noticeable when CaCl_(2)was incorporated,suggesting increased protein *** setting time increased,the L*values increased with varying a*values,whereas no differences in b*values of gels were found,regardless of CaCl_(2)addition(P>0.05).The gel containing CaCl_(2)with setting time of 60 min had the highest hardness,cohesiveness,gumminess,and chewiness(Ped the compact network with high interconnection between *** meat balls prepared under aforementioned conditions had higher texture and overall likeness scores,compared with the control(Perefore,prior setting at 60℃ for 60 min in the presence of CaCl_(2)is recommended for the manufacture of goat meat balls with improved quality.

关键词： characteristic gel goat meat setting meat ball calcium chloride

不同神经通路调控了神经病理性疼痛早期和晚期阶段脾脏TH2细胞比例变化

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中国疼痛医学杂志 2024年第4期30卷 308-308页

作者： Zhu X Huang JY Dong wy 史翔君(译) 张瑛(校) 不详北京大学神经科学研究所

在神经病理性疼痛的不同阶段,分别由躯体感觉皮质和中央杏仁核(central amygdala,CeA)调控了迷走神经背核向脾脏的神经投射,从而差异性调控脾脏TH2细胞比例。这一发现揭示了大脑调节疼痛状态特异性免疫反应的可能机制。首先,研究人员在... 详细信息

在神经病理性疼痛的不同阶段,分别由躯体感觉皮质和中央杏仁核(central amygdala,CeA)调控了迷走神经背核向脾脏的神经投射,从而差异性调控脾脏TH2细胞比例。这一发现揭示了大脑调节疼痛状态特异性免疫反应的可能机制。首先,研究人员在雄性小鼠上制作了选择性神经损伤(spared nerve injury,SNI)的神经病理性疼痛模型。基于该模型,他们检测了疼痛不同阶段脾脏不同免疫细胞的比例。通过流式细胞学筛选,发现术后1天(急性痛阶段)脾脏中表达IL-4和IL-10的TH2细胞比例显著增加,而在术后4周(慢性疼痛阶段)上述细胞的比例显著降低,表明慢性疼痛不同痛阶段可以引发不同的脾脏免疫细胞改变。

关键词：迷走神经背核神经病理性疼痛细胞改变慢性疼痛流式细胞学中央杏仁核免疫细胞神经通路

Syntheses of fluoroalkyl derivatives of two biologically active oligopeptides

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Chinese Journal of Chemistry 1995年第6期13卷 558-564页

作者： Li, RQ Huang, wy CHINeSe ACAD SCI SHANGHAI INST ORGAN CHEMSHANGHAI 200032PEOPLES R CHINA

Fluoroalkyl derivatives of two biologically active oligopeptides [(m-CF3)Tyr(1)]-Leu-enkephalin, [(m-C2F4Cl)Tyr(1)]-Leu-enkephalin and [(m-COCF2Cl)Tyr(2)]-melanocyte-stimulating hormone releasing hormone have been syn... 详细信息

关键词： fluoroalkyl derivatives of oligopeptides peptide synthesis

Dissolution-facilitating Dislocation emission, Motion andInitiation of SCC in 310 Stainless Steel

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Journal of Materials Science & Technology 1997年第6期13卷 483-486页

作者： Huang, YH Chen, QZ Chu, wy Univ Sci & Technol Beijing Dept Mat Phys Beijing 100083 Peoples R China

Using a special constant deflection device, the in situ TeM observations of dislocation emission, motion and the initiation of nanocrack in 310 stainless steel in water were carried out. The results show that SCC in thin foil specimen of 310 stainless steel can occur in water. A nanocrack initiated in the DFZ or at the blunt crack tip in corrosion solution after dislocation emission, multiplication and motion, which were induced by the localized anodic dissolution, reached a critical condition. The nanocrack propagated by a cleavage mode because of the influence of the corrosion solution.

关键词： Stainless steel

BIS-PeR(POLY)FLUOROALKYLATION OF PARA-SUBSTITUTeD PHeNOLS BY R_FI/Na_2S_2O_4 ReAGeNT SYSTeM

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Chinese Chemical Letters 1996年第5期7卷 425-426页

作者： Huang, wy Yu, HB CHINeSe ACAD SCI SHANGHAI INST ORGAN CHEMSHANGHAI 200032PEOPLES R CHINA

Abstracts: In the presence of detonate, excess per(poly)fluoroalkyl iodide reacted with parasubstituted phenolates to provide his-por(poly)fluoroalkyl substituted phenols in fair to good yields.

关键词： BIS-PeR POLY)FLUOROALKYLATION PeR Na FI