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Updates on management of gliomas in the molecular age

World Journal of Clinical Oncology 2024年第2期15卷 178-194页

作者： Ali Ahmed mohamed Rakan Alshaibi Steven Faragalla youssef mohamed Brandon Lucke-Wold Charles E.Schmidt College of Medicine Florida Atlantic UniversityBoca RatonFL 33431United States Herbert Wertheim College of Medicine Florida International UniversityMiamiFL 33199United States College of Osteopathic Medicine Kansas City UniversityJoplinMO 64804United States Department of Neurosurgery University of FloridaGainesvilleFL 32611United States

Gliomas are primary brain tumors derived from glial cells of the central nervous system,afflicting both adults and children with distinct characteristics and therapeutic *** developments have ushered in novel clinical and molecular prognostic factors,reshaping treatment paradigms based on classi-fication and grading,determined by histological attributes and cellular *** review article delves into the diverse treatment modalities tailored to the specific grades and molecular classifications of gliomas that are currently being discussed and used clinically in the year *** adults,the therapeutic triad typically consists of surgical resection,chemotherapy,and *** contrast,pediatric gliomas,due to their diversity,require a more tailored *** complete tumor excision can be curative based on the location and grade of the glioma,certain non-resectable cases demand a chemotherapy approach usually involving,vincristine and ***-tionally,if surgery or chemotherapy strategies are unsuccessful,Vinblastine can be *** recent advancements in treatment methodologies,there remains a need of exploration in the literature,particularly concerning the efficacy of treatment regimens for isocitrate dehydrogenase type mutant astrocytomas and fine-tuned therapeutic approaches tailored for pediatric *** review article explores into the therapeutic modalities employed for both adult and pediatric gliomas in the context of their molecular classification.

关键词： Gliomas Chemotherapy Radiotherapy Isocitrate dehydrogenase type mutant Pediatric gliomas Astrocytoma Oligodendroglioma 1p/19q-codeleted

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Landslide susceptibility mapping using machine learning algorithms and comparison of their performance at Abha Basin,Asir Region,Saudi Arabia

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Geoscience Frontiers 2021年第2期12卷 639-655页

作者： Ahmed mohamed youssef Hamid Reza Pourghasemi Geology Department Faculty of ScienceSohag UniversityEgypt Geological Hazards Department Applied Geology SectorSaudi Geological SurveyP.O.Box 54141Jeddah21514Saudi Arabia Department of Natural Resources and Environmental Engineering College of AgricultureShiraz UniversityShirazIran

The current study aimed at evaluating the capabilities of seven advanced machine learning techniques(MLTs),including,Support Vector Machine(SVM),Random Forest(RF),Multivariate Adaptive Regression Spline(MARS),Artificial Neural Network(ANN),Quadratic Discriminant Analysis(QDA),Linear Discriminant Analysis(LDA),and Naive Bayes(NB),for landslide susceptibility modeling and comparison of their *** machine learning algorithms with spatial data types for landslide susceptibility mapping is a vitally important *** study was carried out using GIS and R open source software at Abha Basin,Asir Region,Saudi ***,a total of 243 landslide locations were identified at Abha Basin to prepare the landslide inventory map using different data *** the landslide areas were randomly separated into two groups with a ratio of 70%for training and 30%for validating *** landslide-variables were generated for landslide susceptibility modeling,which include altitude,lithology,distance to faults,normalized difference vegetation index(NDVI),landuse/landcover(LULC),distance to roads,slope angle,distance to streams,profile curvature,plan curvature,slope length(LS),and *** area under curve(AUC-ROC)approach has been applied to evaluate,validate,and compare the MLTs *** results indicated that AUC values for seven MLTs range from 89.0%for QDA to 95.1%for *** findings showed that the RF(AUC=95.1%)and LDA(AUC=941.7%)have produced the best performances in comparison to other *** outcome of this study and the landslide susceptibility maps would be useful for environmental protection.

关键词： Landslide susceptibility Machine learning algorithms Variables importance Saudi Arabia

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Paleoecology of Benthic Foraminifera in Coral Reefs Recorded in the Jurassic Tuwaiq Mountain Formation of the Khashm Al-Qaddiyah Area, Central Saudi Arabia

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Journal of Earth Science 2015年第2期26卷 224-235页

作者： mohamed youssef Abdelbaset S.El-Sorogy Department of Geology and Geophysics College of Science King Saud University Department of Geology Faculty of Science South Valley University Department of Geology Faculty of Science Zagazig University

Thirty three benthic foraminiferal species belong to 23 genera and 16 families have been recorded from the coral reefs of the Callovian Tuwaiq Formation, Khashm AI-Qaddiyah area, Central Saudi Arabia. Three species： Astacolus qaddiyahensis, Nodosaria riyadhensis, Siderolites jurassica are believed to be new. Nearly all identified foraminifera are of Atlantie-Miditeranean affinity. The foraminiferal assemblage recorded in the present work is mixed of open marine, moderately deep marine conditions associations and shallow to deep lagoon. The reefal part of upper Twiaq Formation may have been deposited in shallow water of lower to middle shelf depth （20-50 m） as indicated by abundant corals and benthic foraminifera. The coral fauna and bearing benthic foraminifera indicated moderate water energy.

关键词： coral reef benthic foraminifera Jurassic Tuwaiq Formation Saudi Arabia.

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Preparation and Reactions of 2-Methyl-7-（3-methyl-5-oxo-1- phenyl-2-pyrazolin-4-yl）-5-arylthiazolo[3,2-a]- pyrimido[4,5-d]oxazin-4（5H）-one

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Chinese Journal of Chemistry 2011年第7期29卷 1473-1482页

作者： youssef, mohamed Salah K. Abbady, mohamed S. Ahmed, Ragaa A. Omar, Ahmed A. Chemistry Department Faculty of Science Assiut University Assiut 71516 Egypt

Ethyl 7-amino-3-（3-methyl-5-oxo- 1-phenyl-2-pyrazolin-4-yl）-5-aryl-5H-thiazolo[3,2-a]pyrimidine-6-carboxy- late was hydrolyzed with an ethanolic sodium hydroxide and the sodium salt thus formed underwent cyclization with acetic anhydride to afford 2-methyl-7-（3-methyl-5-oxo-l-phenyl-2-pyrazolin-4-yl）-5-arylthiazolo[3,2-a]- pyrimido[4,5-d]oxazin-4（SH）-one. This compound was transformed to related heterocyclic systems via its reaction with various reagents. The biological activity of the prepared compounds was tested against Gram positive and Gram negative bacteria as well as yeast-like and filamentous fungi. They revealed in some cases excellent biocidal properties.

关键词： thiazolopyrimidooxazinone thiazolopyrimidopyrimidines antimicrobial activity

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Mapping the Mega Paleodrainage Basin Using Shuttle Radar Topography Mission in Eastern Sahara and Its Impact on the New Development Projects in Southern Egypt

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Geo-Spatial Information Science 2009年第3期12卷 182-190页

作者： Ahmed mohamed youssef Geological Engineering and GIS Geology Department Faculty of Science Sohag University

In the current study, the shuttle radar topography mission (SRTM) data, with～90 m horizontal resolution, were used to delineate the paleodrainage system and their mega basin extent in the East Sahara area. One mega-drainage basin has been detected, covering an area of 256 000 km2. It is classified into two sub mega basins. The Uweinate sub mega basin, which is composed of four main tributaries, collected water from a vast catchment region and drained eastward from the north, west, and southwest, starting at highland areas. The first subwatershed basin is in the northern plateau, south of the Abu-Balas area, with a total catchment area of 25 045 km2. The second subwatershed is in the Gilf Kebir plateau and has a total catchment area of 38 257 km2. The third subwatershed drains from the Uweinate highlands and has a catchment area of 46 154 km2. The fourth subwatershed, which is known in literature as Wadi Mokhtafi in its upper reach and Wadi Arid in its lower reach, drains the northwestern highlands of Sudan and has a total catchment area of 28 653 km2. The Tushka sub mega basin includes one watershed that drains from the northeast highlands of Sudan and has a total catchment area of 63 019 km2. The Uweinate and Tushka sub mega basins are joined together to the North of the Tushka depression, which drains northward toward the Kharga depression. This study indicates that the Eastern Sahara Mega Basin is a closed hydrological system independent of the other drainage systems, such as the Nile hydrosystem and the Qena Valley system. The present research illustrates the capability of the SRTM data in mapping the paleochannel networks, as well as estimate the catchment area and direction of the water flow. Finally, the study reveals that the four areas could be potentially used for different reclamation activities due to the ground water accumulations possibilities.

关键词： GIS paleodrainages SRTM hydro-tools groundwater potentiality

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Association analysis of FTO gene polymorphisms and obesity risk among Egyptian children and adolescents

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Genes & Diseases 2017年第3期4卷 170-175页

作者： Samar Samir Abdelmajed mohamed youssef Moushira Erfan Zaki Naglaa Abu-Mandil Hassan Somaia Ismail October University for Modern Sciences and Arts(MSA) GizaEgypt Organic chemistry Department Faculty of scienceCairo UniversityEgypt Biological Anthropology Department Medical Research DivisionNational Research CentreEgypt Medical Molecular Genetics Department Human Genetics and Genome Research DivisionNational Research CentreGizaEgypt

Obesity is a common disorder that has a significant impact on human health as it may lead to many serious diseases and sometimes *** genome-wide association studies(GWAS)confirmed that there is a relationship between some variants in the first intron of the fat mass and obesity associated(FTO)gene and obesity in adults and children in different ethnic *** our study,the association of the FTO rs9939609 and rs17817449 variants with obesity was investigated in Egyptian children and *** examined rs9939609 and rs17817449 polymorphisms in 100 control and 100 obese cases,we used the restriction fragment length polymorphism(RFLP)technique to genotype the *** current study showed that there were no significant differences(P>0.05)between the cases and controls in both variants of rs17817449 and rs9939609 ***,there were significant correlations between rs17817449 and cholesterol and between rs9939609 and *** Current Study although the two variants(rs9939609 and rs17817449)didn’t show an association with obesity,but there was a correlation between the lipid profile and these two variants.

关键词： Children Egyptians Fat mass and obesity associated gene(FTO) Obesity Variants

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Surgical Outcome of Fusion in Recurrent Lumbar Disc Herniation

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Open Journal of Modern Neurosurgery 2020年第1期10卷 157-166页

作者： Ahmed Taha mohamed youssef Neurosurgery Department Faculty of Medicine Al-Azhar University Damietta Egypt

Background Data: Recurrent lumbar disc herniation means re-herniation of disc on the same site and at the same level where a previous discectomy had been performed: recurrent lumbar disc herniation occurs in 7% to 24% of patient underwent discectomy. Tow mean surgical options after reherniated lumbar disc are revision discectomy alone or revision discectomy with fusion discectomy alone in recurrent lumbar disc herniation may not be an efficient treatment without fusion. Objective: To evaluate the efficacy and safety of revision discectomy with fusion in management of recurrent lumbar disc. Study Design: Retrospective study reviewed all patient underwent revision discectomy with fusion, they were 40 patients operated for recurrent lumbar disc from September 2014 to April 2018 in Al-Azhar University Hospital Damietta. Pre- and post-operative data collection and analysis of the outcome were completed based on the “Japanese Orthopedic Association score” (JOAs), and radiographic follow-up. Patients and Methods: 40 patients (30 male and 10 female) underwent revision discectomy with fusion as surgical management for reherniated lumbar disc from September 2014 to April 2018. All patients presented with low back pain and radicular pain with mean duration of 18 months. The patients were investigated by standard plain X-ray CT SCAN and MRI of the lumbar spine. All patients had a discectomy and postero-lateral fusion in revision surgery. These patients followed post operatively clinically for improving pain and neural function, and radiologically for disc removal stability and fusion. Results: The age ranged from 30 to 60 years, mean age was 45 years, male to female ratio 3:1. Follow-up ranged from 18 - 30 months with a mean follow-up 24 months. 30 patients had an excellent outcome, 6 patients had a good outcome, 2 patients had a fair outcome, and 2 patients had a poor outcome. Conclusion: Recurrent lumbar disc herniation occurs in 7% to 24% of patient underwent discectomy. Rev

关键词： Reherniated Lumbar Disc Postero-Lateral Fusion Revision Discectomy

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Surgical Results of Posterior Lumbar Interbody Fusion with Transpedicular Fixation in Management of Spondylolisthesis

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Open Journal of Modern Neurosurgery 2020年第1期10卷 146-156页

作者： Ahmed Taha mohamed youssef Neurosurgery Department Faculty of Medicine Al-Azhar University Damietta Egypt

Objective: To evaluate the surgical results of posterior lumber interbody fusion with transpedicular fixation with rod screw system in management of spondylolisthesis. Study Design: Retrospective study reviewed all patient treated by lumber interbody fusion with transpedicular fixation with rod screw system. Patients and Methods: They were 40 patients operated for lumber and lumbosacral spondylolisthesis from Feb 2014 to April 2017 in Al-Azhar university hospital. These patients followed postoperatively clinically for improved neural function and for fusion stability and hardware fixation by radiological investigation. Data about pain intensity (by Visual Analogue Scale) was collected pre- and postoperatively;and outcome was assessed by Oswetry disability index (ODI). Outcome was graded as excellent, good, fair, or poor. Pre- and Post-operative data were statistically compared. Results: The mean age was 45 years (range between 30 - 60 years) with female sex predominance (male:female = 1:3). They had lytic (n = 30) or degenerative (n = 10) spondylolisthesis;and all underwent PLIF (posterior lumbar interbody fusion). In lytic group, the level was L4/L5 in 19 patients and L5/S1 in 11 patients, while in degenerative group the level was L4/L5 in 4 patients, L5/S1 in 3 patients, L2/L3 in 2 and L3/L4 in one patient. The spondylolisthesis grade was grade I among 25 subjects, grade two among 11 subjects and retrolisthesis among 4 subjects. Sensory deficits reported in 22 subjects (19 had lytic and 3 had degenerative spondylolisthesis);while motor deficits reported among 10 subjects and reduced reflexes among 8 subjects. The outcome was excellent, good, and fair among 30, 7, and 3 subjects respectively. The return to previous levels of activity was reported among 32 patients. VAS was 3.5 ± 2.94 at the end of follow up, while ODI was 28% and 36.0% and 3 and 6 months respectively. Conclusion: PLIF associated with transpedicular rod screw fixation system for management of spondy

关键词： Spondylolisthesis Posterior Lumbar Interbody Fusion Transpedicular Fixation

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Experimental study and numerical modeling of the thermal behavior of an industrial prototype ceramic furnace:Energy and environmental optimization

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Energy and Built Environment 2024年第2期5卷 244-254页

作者： Lahcen BALLI mohamed HLIMI youssef ACHENANI Adil ATIFI Bachir HAMRI Engineering Sciences and Applications Laboratory(LSIA) National School of Applied Sciences(ENSAH)Abdelmalek Essaadi UniversityTetouanMorocco Faculty of Sciences and Techniques Moulay Ismaïl UniversityP.O.Box 509-BoutalamineErrachidiaMorocco Engineering and Health Sciences and Technologies Research Center M2SMENSAMMohammed.V UniversityRabatMorocco Research Team Quality Maintenance Safety QSMMechanical EngineeringDepartment Mohammadia School of EngineersMohammed V UniversityRabatMorocco

This article focuses on the experimental and numerical study of an industrial prototype furnace intended for the production of ceramics in order to improve the energy efficiency and therefore optimize the fuel consumption and the corresponding carbon dioxide *** order to understand the thermal behavior from which stems the energy efficiency of the experimental prototype,we establish in this work,a simplified modeling allowing to establish a mathematical model describing the thermal behavior of the *** model is able to accurately predict the spatial and temporal distribution of the temperature at each point of the furnace to control the firing of the refractory product so that the final product is of good quality in terms of resistance and *** addition,the power consumed by the prototype must be optimized in order to reduce energy and environmental *** particular,this efficient technology has allowed us to save 83% of energy used in the traditional furnace and to reduce 87.36% of the relative carbon dioxide *** simulation of the mathematical model made it possible to compare the numerical results with the experimental measurements obtained by the prototype as well as to validate the model and to adjust the heat transfer parameters.

关键词： Numerical modeling Thermal behavior Ceramic furnace Refractory materials Energy efficiency

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Rod and Screw Fixation for Cranio-Cervical Instability

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Open Journal of Modern Neurosurgery 2020年第1期10卷 19-26页

作者： Hedaya Hendam Ahmed Taha mohamed youssef Department of Neurosurgery Al Azhar Faculty of Medicine Damietta Egypt

Background Data: Atlanto-occipital dislocation is a rare and fatal condition. Pain, limitation of movements, and weakness, were the main complaints of patients with upper cervical lesions. Internal fixation and fusion was indicated in all patients of Atlanto occipital dislocation with deficits. CT scan is the imaging modality of choice for evaluation. Objective: To evaluate the efficacy and safety of rod and screw fixation in cranio-cervical instability. Study Design: Retrospective study reviewed all patient treated by rod and screw fixation, they were 12 patient operated for atlanto-occipital instability from April 2013 to April 2016 in Alazher University Hospital Damietta. Pre and postoperative data collection and analysis of the outcome were completed based on the Frankel classification and grading. Patients and Methods: We operated 12 patients, 10 with traumatic and 2 with pathologically diagnosed Atlanto occipital instability. From April 2013 to April 2016. All patients presented with neck pain, limitation of neck movement, and neurological deficits. The patients were investigated by standard plain X ray to the cervical spine, CT scan and MRI of the cervical spine pre-operatively, and they operated thorough posterior Cranio-cervical fixation. These patients followed post-operatively clinically for improving neural functions and radiologically for alignment, stability, fusion and efficacy of hard ware fixation. Results: The mean age of the studied cases was 42.1 years, trauma was the cause of instability in 10 patients, and 2 patients one with rheumatoid arthritis and one with neoplastic lesion. The mean follows up period is 14.7 months. We used screw rod system in posterior craniocervical fixation with iliac bone graft without operative or post-operative complications. All our patients were improved neurologically post-operatively and no hardware failure during the follow up period. Conclusion: Craniocervical instability was rare condition, with miss diagnosis

关键词： Spine Atlanto-Axial Atlanto-Occipital Cranio-Cervical Internal Fixation

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