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Synthesis and antitumor activity of some new pyrazolo[1,5-α]pyrimidines

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Chinese Chemical Letters 2017年第2期28卷 388-393页

作者： Ashraf S.Hassan mohamed F.Mady Hanem M.Awad Taghrid S.hafez Department of Organometallic and Organometalloid Chemistry National Research Centre Dokki 12622 CairoEgypt Department of Green Chemistry National Research Centre Dokki 12622 Cairo Egypt Department of Mathematics and Natural Science Faculty of Science and Technology University of Stavanger N-4036 Stavanger Norway Department of Tanning Materials and Leather Technology National Research Centre Dokki 12622 Cairo Egypt

New series of pyrazolo[1,5-α]pyrimidine derivatives 7a-i,11a-c and Schiff bases 13a-c were synthesized and screened for their in vitro antitumor activity against three human carcinoma cell lines,namely colorectal carcinoma（HCT116）,prostate adenocarcinoma（PC-3） and liver carcinoma（HepG-2） using MTT cytotoxicity assay at 100 μg/*** of the tested compounds displayed good anticancer activities against HCT-116 and PC-3 ***,compounds 7d and 11 a showed better antitumor activity than the rest of the compounds against both cell lines.A structure-activity relationship（SAR） has been discussed and structures of the newly synthesized compounds were confirmed by different spectral data（MS,IR,^1H NMR and ^13C NMR） and elemental analysis.

关键词： 5-Amino-1H-pyrazole Pyrazolo[1 5-α]pyrimidine Schiff bases MIT assay Anticancer activity Structure activity relationship

Fermentation, formulation and evaluation of PGPR Bacillus subtilis isolate as a bioagent for reducing occurrence of peanut soil-borne diseases

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Journal of Integrative Agriculture 2019年第9期18卷 2080-2092页

作者： Abdel-Gayed M.Ahmad Abo-Zaid G.Attia Matar S.mohamed hafez E.Elsayed Onion Garlic and Oil Crops Research DepartmentPlant Pathology Research InstituteAgricultural Research CenterGiza 12619Egypt Bioprocess Development Department Genetic Engineering and Biotechnology Research InstituteCity of Scientific Research and Technological ApplicationsNew Borg El-Arab CityAlexandria 21934Egypt Chemical Engineering Department Faculty of EngineeringJazan UniversityJazan 45142Saudi Arabia Plant Protection and Biomolecular Diagnosis Department Arid Lands Cultivation Research InstituteCity of Scientific Research and Technological ApplicationsNew Borg El-Arab CityAlexandria 21934Egypt

Four isolates of Bacillus subtilis coded,B4,B7,B8 and B10 were examined as biocontrol agents for their abilities and antagonistic effect on the in vitro growth of certain phytopathogenic fungi of peanut,Rhizoctonia solani and Sclerotium *** subtilis isolate B4(GenBank accession ***150884)was the highly effective one for inhibiting the fungal mycelial *** fermentation of *** isolate B4 was carried out and the maximum biomass achieved was 4.53 g L-1 at 11 *** subtilis isolate B4 was formulated and evaluated as a biofungicide to reduce peanut soil-borne diseases under greenhouse and field conditions at the side of Rizolex-T(fungicide)as *** by formulated plant growth-promoting rhizobacteria(PGPR)*** B4 and Rizolex-T in a soil infested with ***,*** and mixture of them were more effective in decreasing percentage of damping-off,root and pod rot disease incidence(%)in greenhouse and open field environment during the two seasons 2015 and *** by PGPR gave highly dry weight and number of healthy pods compared to control of fungi treatment which was nearby to dry weights of healthy pods achieved by treatments by Rizolex-T in a soil infested with ***,*** and mixture of *** PGPR *** B4 gave higher increasing of yield percentage than treatment by Rizolex-T in the two evaluated seasons 2015 and *** can conclude that the produced bioforumlated agent was more efficient as fungicide when compared with the other chemical synthesized fungicides,safe for human and the environment and economy.

关键词： peanut soil-borne diseases Bacillus subtilis biocontrol fermentation formulation

Template Match Object Detection for Inertial Navigation Systems

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Positioning 2011年第2期2卷 78-83页

作者： Wiedo Hu Ahmed mohamed Gharuib Alaa El-Din Sayed hafez 不详

This paper devoted to propose template match object detection for inertial navigation systems (INS). The proposed method is an image processing technique to improve the precision of the INS for detecting and tracking the ground objects from flying vehicles. Template matching is one of the methods used for ground object detection and tracking. Robust and reliable object detection is a critical step of object recognition. This paper presents a proposed mathematical morphological template matching method for detection and tracking of ground objects. Our focus is on flying systems equipped with camera to capture photos for the ground and recognize it. The proposed method is independent on the altitude or the orientation of the object. The algorithm is simulated using Matlab program and the numerical experiments are shown which verify the object detection for a wide range altitude and orientation. The results show superiority of this method for identifying and recognizing the ground objects.

关键词： Template Match Hit / Miss Transform INS

The Need for Cardiac Pacing after Isolated Coronary Artery Bypass Graft Surgery

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Open Journal of Thoracic Surgery 2022年第2期12卷 21-32页

作者： Montaser Elsawy Abd Elaziz Eman Gomaa Saleh mohamed Gaber Elsayed Bassem A. hafez Cardiothoracic Surgery Department Faculty of Medicine Menoufia University Menoufia Egypt Faculty of Medicine Jazan University Jazan Saudi Arabia Neuropsychiatry Department Faculty of Medicine Menoufia University Menoufia Egypt

Background: The aim of this study is to assess the necessity of temporary cardiac pacing and identify the predictors of pacing after coronary artery bypass graft (CABG). Methods: This was a retrospective observational study of 150 patients who had isolated CABG between November 2013 and December 2021. Patients were classified into two groups: group A, (n = 135) who did not need to be paced and group B, (n = 15) who needed temporary epicardial pacing. Only 10% (15/150) of patients in the study needed pacing. The primary outcome variable was assessment of the need for postoperative temporary cardiac pacing (TCP) (patients were paced during chest closure or at any time during hospital admission). The incidence of pacing during the postoperative period was observed. Univariate and multivariate predictors for postoperative pacing were determined and specicific predictors for cardiac pacing were found. Results: In both univariate and multivariate analysis, Old age > 65 years, diabetes mellitus, pacing to come off cardiopulmonary bypass (CPB), CPB time > 100 min, cardioversion to leave OR, antiarrhythmics to leave OR and new onset of atrial fibrillation (AF), were found to be significant predictors for the need to cardiac pacing. Conclusion: After coronary artery bypass surgery, a small percentage of patients require TCP. We emphasize unique predictors for postoperative pacing in this study.

关键词： Temporary Epicardial Pacing Coronary Artery Bypass Arrhythmias

Effect of Using Baker＇s Yeast and Exogenous Digestive Enzymes as Growth Promoters on Growth, Feed Utilization and Hematological Indices of Nile tilapia, Oreochromis niloticus Fingerlings

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Journal of Agricultural Science and Technology(B) 2012年第1期2卷 15-28页

作者： Ashraf mohamed Abdelsamee Goda hafez Abdel-Hamid Hassan Mabrouk mohamed Abd EI-Hamid Wafa Tarek mohamed E1-Afifi National Institute of Oceanography and Fisheries （NIOF） Fish Nutrition Laboratory Cairo 24135 Egypt Regional Center for Foods and feeds Agriculture Research Center Ministry of Agriculture Cairo 24135 Egypt

The present study was conducted to evaluate the effect of baker yeast, Saccharomyces cerevisiae （SC） and exogenous digestive enzymes （pepsin, papain and a-amylase, EDE） dietary supplementation on growth performance, feed utilization and hematological indices of Nile tilapia, Oreochromis niloticus fingerlings. A total of 630 Nile tilapia fingerlings with an average body weight of 26.4 ± 0.2 g were divided in the seven experimental net-pen treatments （three replicates each）. The experiment was conducted for 119 days. Seven isonitrogenous （26.50%） digestible protein and isocaloric （13.40 MJ kgl） digestible energy experimental diets were formulated. The control diet had no SC and EDE added. Diets 2-3 each contained SC at levels of 2 and 4 g 100 g diet-t, respectively, while diets 4-5 each contained EDE at levels of （0.64, 1.28, 0.16） and （1.28, 2.56, 0.32） g 100 gdiefI of pepsin, papain and a-amylase, respectively. Diet 6 contained mixture of SC and EDE at levels of 1 g yeast and 0.32, 0.64, 0.08 g of pepsin, papain and a-amylase, respectively 100 gdiet1 and diet D7 contained 2 g yeast and 0.64, 1.28, 0.16 g of pepsin, papain and a-amylase, respectively 100 g dietl. Growth performance and feed utilization efficiency of Nile tilapia were significantly （P 〈 0.05） higher in all treatments receiving SC and/or EDE supplemented-diets than the control diet which suggests that the addition of SC and EDE enhanced the growth performance. Red blood cells counts, hematocrit and hemoglobin were significantly （P 〈 0.05） highest in all treatments receiving mixture of SC and EDE supplemented-diets （D6 ＋ D7）. The same trend was observed for total plasma protein and total plasma globulin levels. The results of present study suggested that Nile tilapia fingerlings fed diets containing the mixture of I g yeast, SC and 0.32, 0.64, 0.08 g of pepsin, papain and a-amylase, respectively 100 gdiet^-1, for 119 days had enhanced growth performance, diet utilization efficiency and hematological ind

关键词： Baker yeast digestive enzymes growth feed utilization hematological indices Nile tilapia.

Postoperative Mechanical Axis Alignment and Components Position after Conventional and Patient-Specific Total Knee Arthroplasty

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Open Journal of Orthopedics 2016年第8期6卷 253-258页

作者： mohamed Mosa mohamed Maher A. El Assal Ahmed M. Abdel Aal Yaser E. Khalifa Mahmoud A. hafez Orthopaedic Department Alazhar University (Assiut Branch) Assiut Egypt Orthopaedic Department Assiut University Assiut Egypt Orthopaedic Department October 6 University Cairo Egypt

Introduction: Accurate postoperative alignment and implant positioning are determinant factors for successful total knee arthroplasty (TKA). Patient-specific template (PST) is a technique that uses computer technology for the planning, deigning and production of cutting guides. This study aims to compare PST to conventional technique in terms of mechanical axis alignment and component positioning. Patients and method: 109 TKA were performed for 78 patients in 2 groups. Group A included 69 conventional TKA in 55 patients and Group B included 40 patient-specific TKA in 23 patient. Postoperative long-film X-rays were done for all patients to observe the mechanical axis, anatomical axis, lateral distal femoral mechanical angle and medial proximal tibial angle. Results: No statistically significant difference was found between the two groups regarding alignment or component positioning. Conclusion: Both techniques have shown similar results in restoring the mechanical axis and alignment after TKA. However, PST had the advantages of reduced blood loss and shorter operative time.

关键词： Total Knee Arthroplasty Patient-Specific Templates Conventional TKA Mechanical Axis Limb Alignment Component Position

Infantile Hemangiopericytoma: Two Cases Report and Literature Review

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Surgical Science 2011年第7期2卷 379-384页

作者： Gamal Al-Saied Amin Abokifa mohamed Al-Saeed mohamed Abdul Aziz Medhat Ibrahim Moemen hafez Tharwat Hussain mohamed Shahin Dalal Nemenqani Naglaa Fawzy 不详

Hemangiopericytoma is a rare vascular tumour of infants. Although generally considered to be benign, local recurrence and metastases can occur. Herein, we report on two full term girls, delivered with lumbosacral swelling and left thigh swelling respectively. Complete surgical excision with safety margins was performed for each lesion. Histologic examination of both lesions showed picture of infantile hemangiopericytoma. There is no evidence of local recurrence or distant metastasis during last 20 and 17 months for 1st case and 2nd case respectively. In conclusion;most infantile hemangiopericytoma follow a benign course. Rarely these tumours behave aggressively with local infiltration, recurrences and even distant metastases. Careful follow up is therefore essential.

关键词： Infantile Hemangiopericytoma Vascular Tumour

The Effect of Longitudinal Stretching of Muscles and Nerve versus Deep Transverse Friction Massage in the Management of Patients with Carpal Tunnel Syndrome

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Open Journal of Therapy and Rehabilitation 2014年第4期2卷 199-206页

作者： Ashraf Ramadan hafez Aqeel Mohammed Alenazi Shaji John Kachanathu Abdulmohsen Meshari Alroumi Elham Saed mohamed Cairo University Hospital Cairo University Cairo Egypt Physical Therapy and Rehabilitation Department College of Applied Medical Sciences Salman Bin Abdulaziz University Alkharj Saudi Arabia Collage of Applied Medical Sciences King Saud University Riyadh Saudi Arabia Physical Therapy Department College of Applied Medical Sciences Shaqra University Shaqra Saudi Arabia

Background and Purpose: Carpal tunnel syndrome (CTS) is a common source of hand numbness and pain. The goal of this study was to compare longitudinal stretching of muscles and nerve to deep transverse friction massage for decreasing pain and improving hand function in patients with chronic CTS. Subjects and Methods: Thirty patients, 25 to 40 years old, were included in this study and randomized into two groups: the first group (36.8 ± 0.262) followed a physical therapy program group receiving stretching of wrist and hand flexors in combination with ultrasound, strengthening exercises of wrist and hand flexors, and wrist splint, three sessions per week for 12 weeks;and the second group (35.9 ± 0.225) followed the physical therapy program of deep transverse friction massage on the carpal tunnel site at the wrist joint, with using ultrasonic therapy, strengthening exercises of wrist and hand flexors and wrist splint, three sessions per week for 12 weeks. Outcome measures were range of motion (ROM), pain using visual analog scale (VAS), and hand grip strength measured with a sphygmomanometer. Results: There was a significant difference in both groups in all outcome measures compared to baseline. Over stretching group showed significant difference at the end of study in terms of range of motion of wrist flexion, extension and strength of handgrip when compared to deep friction massage group P < 0.05. However, there is no significant difference between groups in pain. Discussion and Conclusion: This study showed that the effect of stretching exercises is more beneficial than deep transverse friction massage in the treatment of patients with CTS in decreasing the compression of the median nerve in the tunnel.

关键词： Carpal Tunnel Syndrome Median Nerve Stretching Exercises Ultrasonic Therapy Deep Transversefriction Massage Hand Weakness and Numbness

Role of FOXP3 in Immunohistochemical Expression in Preeclampsia

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Open Journal of Obstetrics and Gynecology 2023年第4期13卷 699-711页

作者： Malames M. Faisal Hesham M. Harb Fatma S. hafez mohamed T. Elsaid Department of Obstetrics and Gynecology Faculty of Medicine Ain Shams University Cairo Egypt Department of Pathology Faculty of Medicine Ain Shams University Cairo Egypt

Background: FoxP3 gene variants have been linked to endometriosis, infertility, and autoimmune illnesses, according to numerous researches. Maternal sensitivity to the PE gene and the genetic variations of FoxP3 has not been thoroughly investigated. Objective: Investigation of the immune-histochemical expression of FoxP3 in placental tissue of PE patients. Methods: A total of 26 pre-eclamptic women as a case and 26 ethnically matched healthy pregnant women as a control group aged between 18 and 40 years old of different gravidity and parity referred to the labor ward for delivery either by vaginal delivery or cesarean section was enrolled to investigate the immunohistochemical expression of FOXP3 in placental tissue of PE patients. Results: Lower expression of FOXP3 IHC was statistically significant and noted in the group of preeclampsia compared to the healthy control group. Lower gestational age at delivery and a higher percentage of cesarean section were statistically significant and noted in the group of preeclampsia compared to the healthy control group. Conclusion: In comparison to the healthy control group, preeclampsia patients had statistically significantly lower FOXP3 IHC expression, and FOXP3 polymorphism was associated with the development of PE. Our findings can serve as a guide for statistical analyses and functional investigations that are more in-depth.

关键词： FOXP3 Immunohistochemical Expression Preeclampsia