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Pyronaridine combined with diminazene aceturate inhibits Babesia in vitro and in vivo

Asian Pacific Journal of Tropical Biomedicine 2024年第3期14卷 93-99页

作者： Shimaa Abd El-Salam El-sayed mohamed z.sayed-ahmed Shaimaa ahmed Awad Ali Nourah Alsadaan Nawazish Alam Mahmoud S.Alkhoudary Ikuo Igarashi mohamed Abdo Rizk National Research Center for Protozoan Diseases Obihiro University of Agriculture and Veterinary MedicineInada-ChoObihiroHokkaido 080-8555Japan Department of Biochemistry and Chemistry of Nutrition Faculty of Veterinary MedicineMansoura UniversityMansoura 35516Egypt Department of Clinical Pharmacy College of PharmacyJazan UniversityJazan 45142Saudi Arabia Medical-Surgical Department College of NursingJouf UniversitySakaka 72388Saudi Arabia Critical Care and Emergency Nursing Faculty of NursingMansoura UniversityEgypt College of Nursing Jouf UniversitySakaka 72388Saudi Arabia Faculty of Pharmacy Mansoura UniversityMansoura 35516DakahliaEgypt Department of Internal Medicine and Infectious Diseases Faculty of Veterinary MedicineMansoura UniversityMansoura 35516Egypt

Objective:To evaluate the combination therapy of pyronaridine tetraphosphate and diminazene aceturate against Babesia in vitro and in ***:Bioinformatic analysis was performed using atom pair *** in vitro combination test was performed against Babesia bovis and Theileria ***,the in vivo chemotherapeutic efficacy of pyronaridine tetraphosphate in combination with diminazene aceturate was investigated against the growth of Babesia microti in mice using a fluorescence inhibitory ***:Pyronaridine tetraphosphate and diminazene aceturate exhibited nearly similar molecular *** in vitro combination of pyronaridine tetraphosphate and diminazene aceturate was synergistic on Babesia bovis and additive on Theileria *** addition,5 mg/kg pyronaridine tetraphosphate combined with 10 mg/kg diminazene aceturate inhibited Babesia microti growth significantly compared with those observed after treatment with 25 mg/kg diminazene aceturate alone from day 6 post treatment to day 12 post *** combination therapy also normalized the hematological parameters of infected ***:An oral dose of pyronaridine tetraphosphate combined with a subcutaneous dose of diminazene aceturate inhibits Babesia in vitro and in mice,suggesting it might be a new paradigm for the treatment of babesiosis.

关键词： Babesia Pyronaridine tetraphosphate Diminazene aceturate Babesiosis Theileria

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Microstructure and mechanical properties of hot extruded 6016 aluminum alloy/graphite composites

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Journal of Materials Science & Technology 2018年第9期34卷 1580-1591页

作者： mohamed M.El-sayed Seleman mohamed M.z.ahmed Sabbah Ataya Department of Metallurgical and Materials Engineering Faculty of Petroleum and Mining Engineering Suez University 43518 Suez Egypt Suez and Sinai Metallurgical and Materials Research Center of Scientific Excellence (SSMMR-CSE) 43518 Suez Egypt The British University in Egypt Mechanical Engineering Deportment El-Sherouk City 11837 Cairo Egypt Department of Mechanical Engineering College of Engineering AI Imam Mohammad Ibn Saud Islamic University Riyadh 11432 saudi Arabia

The incorporation of graphite particles into AA6016 aluminum alloy matrix to fabricate metal/ceramic composites is still a great challenge and various parameters should be considered. In this study, dense AA6016 aluminum alloy/（0-20 wt%） graphite composites have successfully been fabricated by powder metallurgy process. At first, the mixed aluminum and graphite powders were cold compacted at 200 MPa and then sintered at 500 ℃ for 1 h followed by hot extrusion at 450 ℃. The influence of ceramic phases（free graphite and in-situ formed carbides） on microstructure, physical and mechanical properties of the produced composites were finally investigated. The results show that the fabricated composites have a relative density of over 98%. SEM observations indicate that the graphite has a good dispersion in the alloy matrix even at high graphite content. Hardness of all the produced composites was higher than that of aluminum alloy matrix. No cracks were observed at strain less than 23% for all hot extruded *** strength, reduction in height, ultimate tensile stress, fracture stress, yield stress, and fracture strain of all Al/graphite composites were determined by high precision second order equations. Both compressive and ultimate tensile strengths have been correlated to microstructure constituents with focusing on the in-situ formed ceramic phases, silicon carbide（SiC） and aluminum carbide（Al4 C3）. The ductile fracture mode of the produced composites became less dominant with increasing free graphite content and in-situ formed carbides. Wear resistance of Al/graphite composites was increased with increasing graphite content. Aluminum/20 wt% graphite composite exhibited superior wear resistance over that of AA6016 aluminum alloy.

关键词： AA6016/graphite composites Hot extrusion In-situ carbides Mechanical properties Wear resistance Fracture behavior

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Experimental and parametrical investigation of pre-stressed ultrahigh-performance fiberreinforced concrete railway sleepers

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Frontiers of Structural and Civil Engineering 2023年第3期17卷 411-428页

作者： sayed ahmed Hossam ATEF mohamed HUSAIN Department of Structural Engineering Faculty of EngineeringZagazig UniversityZagazig 44519Egypt Track Work Department National Authority for TunnelsCairo 11522Egypt

In this study,ultrahigh-performance fiber-reinforced concrete(UHPFRC)used in a type B70 concrete sleeper is investigated experimentally and *** main parameters investigated are the steel fiber volume fractions(0%,0.5%,1%,and 1.5%).Under European standards,35 UHPFRC sleepers are subjected to static bending tests at the center and rail seat sections,and the screw on the fastening system is pulled *** first cracking load,failure load,failure mode,crack propagation,load–deflection curve,load–crack width,and failure load from these tests are measured and compared with those of a control sleeper manufactured using normal concrete *** accuracy of the parametric study is verified ***,the results of the study are applied to UHPFRC sleepers with different concrete volumes to investigate the effects of the properties of UHPFRC on their *** and parametric study results show that the behavior of UHPFRC sleepers improves significantly when the amount of steel fiber in the mix is *** manufactured using UHPFRC with a steel fiber volume fraction of 1%and a concrete volume less than 25%that of standard sleeper B70 can be used under the same loads and requirements,which contributes positively to the cost and surrounding environment.

关键词： pre-stressed concrete sleeper ultrahigh performance fiber-reinforced concrete pull-out test static bending test steel fiber aspect ratio volume fraction

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Investigating energy policies to boost grid-connected rooftop solar PV in Sudan

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Clean Energy 2023年第5期7卷 994-1005页

作者： Tarig z.ahmed Ayah mohamed Mawahib Eltayeb ahmed ahmed Osman Elamin Abdalgader mohamed G.Hassan-sayed Cambridge Institute for Sustainability Leadership(CISL) University of CambridgeCambridgeCB21QAUK Energy and Climate Change Division Faculty of Engineering and Physical ScienceThe University of SouthamptonSouthamptonSO171BJUK Institute of Engineering Research and Material Technology National Centre for ResearchKhartoumSudan/University of KhartoumSudan University of California Davis1 Shields AveDavisCA 95616USA School of Chemistry Faculty of Engineering and Physical SciencesThe University of SouthamptonSouthamptonSO171BJUK

Grid-connected rooftop solar photovoltaic(PV)systems can reduce the energy demand from the grid and significantly increase the power available to ***,rooftop solar PV has not yet been widely adopted in many sub-Saharan African countries,such as Sudan,although they are endowed with high solar radiation and in dire need of additional *** paper investigates risks and policies to increase grid-connected rooftop solar PV adoption in Sudan.A simplified United Nations Development Program Derisking Renewable Energy Investment framework is adopted to investigate this over three *** Stage 1,a list of risks and barriers was produced based on a literature review of solar PV studies in Sudan and interviews with nine *** was the risk most often mentioned(eight times from nine interviewees),followed by concerns about poor utility grid *** Stage 2,policy de-risking instruments and financial de-risking instruments were listed to overcome the *** include the intro-duction of net metering,the use of a third-party organization to monitor policy implementation,upgrade of the grid infrastructure,public awareness campaigns and energy-saving *** Stage 3,the levelized cost of electricity was estimated for a typical 2-kW rooftop PV system without policies(0.11$/kWh)and with a net-metering policy(0.07$/kWh).

关键词： energy policy rooftop solar PV Sudan energy poverty sustainable development photovoltaics

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Review on friction stir welding of dissimilar magnesium and aluminum alloys: Scientometric analysis and strategies for achieving high-quality joints

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Journal of Magnesium and Alloys 2023年第11期11卷 4082-4127页

作者： mohamed M.z.ahmed mohamed M.El-sayed Seleman Dariusz Fydrych Gürel ÇAM Department of Mechanical Engineering College of Engineering at Al KharjPrince Sattam Bin Abdulaziz UniversityAl Kharj 11942Saudi Arabia Department of Metallurgical and Materials Engineering Faculty of Petroleum and Mining EngineeringSuez UniversitySuez 43512Egypt Faculty of Mechanical Engineering and Ship Technology Institute of Machines and Materials TechnologyGdańsk University of TechnologyGabriela Narutowicza Street 11/12Gdańsk 80-233Poland Department of Mechanical Engineering Iskenderun Technical UniversityIskenderunHatay 31200Turkiye

Magnesium and aluminum alloys continually attract interest as lightweight structural materials for transport applications. However, joining these dissimilar alloys is very challenging. The main obstacle that hinders progress in dissimilar Mg-Al joining is the formation of brittle intermetallic compounds(IMCs). As a solid-state joining technique, FSW is an excellent candidate to attenuate the deleterious IMC effects in dissimilar Al-Mg joining due to the inherent low heat inputs involved in the process. However, the IMCs, namely Al_(3)Mg_(2) and Al_(12)Mg_(17) phases, have also been reported to form during Al-Mg dissimilar FSW;their amount and thickness depend on the heat input involved;thus,the weld parameters used. Since the heat dissipated in the material during the welding process significantly affects the amount of IMCs,the heat input during FSW should be kept as low as possible to control and reduce the amount of IMCs. This review aims to critically discuss and evaluate the studies conducted in the dissimilar Al/Mg FSW through a scientometric analysis and also with a focus on the strategies recently applied to enhance joint quality. The scientometric analysis showed that the main research directions in Mg/Al FSW are the technological weldability of aluminum and magnesium during FSW, structural morphology, and mechanical properties of dissimilar welded joints. Considering the scope of application of the aforementioned joints, the low share of articles dealing with environmental degradation and operational cracking is surprising. This might be attributed to the need for well-developed strategies for obtaining high-quality and sustainable joints for applications. Thus, the second part of this review is conventional, focusing mainly on the new strategies for obtaining high-quality Mg/Al joints. It can be concluded that in addition to the necessity to optimum welding parameters to suppress the excessive heat to limit the amount and thickness of IMC formed and improv

关键词： Friction stir welding(FSW) Al-alloys Mg-alloys Dissimilar material welding Intermetallics Weld performance

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Position Control of Synchronous Motor Drive by Modified Adaptive Two-phase Sliding Mode Controller

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International Journal of Automation and computing 2008年第4期5卷 406-412页

作者： mohamed Said sayed ahmed Automation Science and Electrical Engineering School Beijing University of Aeronautics and Astronautics

A modified adaptive two-phase sliding mode controller for the synchronous motor drive that is highly robust to uncertain- ties and external disturbances is proposed in this *** proposed controller uses two-phase sliding mode control (SMC) where the 1st phase mainly controls the system in steady states and disturbed states-it is a smoothing *** 2nd phase is used mainly in the case of disturbed ***,it is an autotuning phase and uses a simple adaptive algorithm to tune the gain of conventional variable structure control (VSC).The modified controller is useful in position control of a permanent magnet synchronous drive.

关键词： Reaching law adaptive control sliding mode control (SMC) chattering.

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Gastrointestinal and hepatic diseases during the COVID-19 pandemic:Manifestations,mechanism and management

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World Journal of Gastroenterology 2021年第28期27卷 4504-4535页

作者： Dina zakaria mohamed Mai El-sayed Ghoneim Sally El-sayed Abu-Risha Ramy ahmed Abdelsalam mohamed Abdelhalem Farag Department of Pharmacology and Toxicology Faculty of PharmacyTanta UniversityTanta 31511Egypt Department of Pharmacology and Toxicology Faculty of PharmacyUniversity of Sadat CityMenoufia 32632Egypt Department of Pathology Faculty of MedicineMansoura UniversityMansoura 35511Egypt Department of Pediatrics Nebru General HospitalNebru 35511Egypt

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is considered the causative pathogen of coronavirus disease 2019(COVID-19)and has become an international danger to human *** respiratory transmission and symptoms are still the essential manifestations of COVID-19,the digestive system could be an unconventional or supplementary route for COVID-19 to be transmitted and manifested,most likely due to the presence of angiotensin-converting enzyme 2(ACE2)in the gastrointestinal *** addition,SARS-CoV-2 can trigger hepatic injury via direct binding to the ACE2 receptor in cholangiocytes,antibodydependent enhancement of infection,systemic inflammatory response syndrome,inflammatory cytokine storms,ischemia/reperfusion injury,and adverse events of treatment *** symptoms,including anorexia,nausea,vomiting,and diarrhea,which are unusual in patients with COVID-19,and some digestive signs may occur without other respiratory ***,SARS-CoV-2 can be found in infected patients’stool,demonstrating the likelihood of transmission through the fecal-oral *** addition,liver function should be monitored during COVID-19,particularly in more severe *** review summarizes the evidence for extra-pulmonary manifestations,mechanisms,and management of COVID-19,particularly those related to the gastrointestinal tract and liver.

关键词： COVID-19 Angiotensin-converting enzyme 2 Gastrointestinal Inflammatory bowel disease Liver Management

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Transient elastography compared to liver biopsy and morphometry for predicting fibrosis in pediatric chronic liver disease: Does etiology matter?

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World Journal of Gastroenterology 2016年第16期22卷 4238-4249页

作者： Behairy El-sayed Behairy Mostafa mohamed Sira Khaled Refat zalata El-sayed Ebrahem Salama mohamed ahmed Abd-Allah Department of Pediatric Hepatology National Liver Institute Menofiya University Department of Pathology Faculty of Medicine Mansura University

AIM: To evaluate transient elastography (TE) as a noninvasive tool in staging liver fibrosis compared with liver biopsy and morphometry in children with different chronic liver ***: A total of 90 children [50 with chronic hepatitis C virus (HCV), 20 with autoimmune hepatitis (AIH) and 20 with Wilson disease] were included in the study and underwent liver stiffness measurement (LSM) using TE. Liver biopsies were evaluated for fibrosis, qualitatively, by Ishak score and quantitatively by fibrosis area fraction (FAF) using digital image analysis (morphometry). LSM was correlated with fibrosis and other studied variables using spearman correlation. A stepwise multiple regression analysis was also performed to examine independent factors associated with LSM. Different cut-off values of LSM were calculated for predicting individual fibrosis stages using receiver-operating characteristic curve. Cut-off values with optimal clinical performance (optimal sensitivity and specificity simultaneously) were ***: The majority of HCV group had minimal activity (80%) and no/mild fibrosis (72%). On the other hand, the majority of AIH group had mild to moderate activity (70%) and moderate to severe fibrosis (95%) and all Wilson disease group had mild to moderate activity (100%) and moderate to severe fibrosis (100%). LSM correlated significantly with both FAF and Ishak scores and the correlation appeared better with the latter (r = 0.839 vs 0.879, P < 0.0001 for both). LSM discriminated individual stages of fibrosis with high performance. Sensitivity ranged from 81.4% to 100% and specificity ranged from 75.0% to 97.2%. When we compared LSM values for the same stage of fibrosis, they varied according to the different etiologies. Higher values were in AIH (16.15 ± 7.23 kPa) compared to Wilson disease (8.30 ± 0.84 kPa) and HCV groups (7.43 ± 1.73 kPa). Multiple regression analysis revealed that Ishak fibrosis stage was the only ind

关键词： Autoimmune hepatitis Chronic hepatitis C Liver fibrosis Liver stiffness Morphometry Pediatrics Transient elastography Wilson disease

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Seismic performance of high-rise buildings in selected regions in Saudi Arabia according to different seismic codes

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Earthquake Engineering and Engineering Vibration 2021年第1期20卷 179-191页

作者： sayed Mahmoud mohamed Alsearheed Waleed Abdallah Department of Civil and Construction Engineering College of EngineeringImam Abdulrahman Bin Faisal UniversitySaudi Arabia Department of Building Engineering College of ArchitectureImam Abdulrahman Bin Faisal UniversitySaudi Arabia Department of Civil Engineering College of Engineering at MatariaHelwan UniversityCairoEgypt

The design code for each country is revised and updated based on an expected zone’s seismic intensities,geotechnical site classifications,structural systems,construction materials and methods of construction in order to provide more realistic considerations of seismic demand,seismic response,and seismic *** on the aforementioned provisions,structures designed according to different seismic codes may yield different performances for the same level of *** study aims to investigate and compare the induced responses related to the earthquake-resistant design of reinforced concrete(RC)buildings according to the Saudi building code(SBC-301),American code(ASCE-7),uniform building code(UBC-97),and European code(EC-8).In order to account for the provision regarding the hazard specification and its effect on the induced seismic responses,four regions in the Kingdom of Saudi Arabia with different seismic levels are *** code provisions related to the specification of site classification and its effect on the induced design base shear are investigated as *** differences are observed in the induced responses with the variation in seismic design codes for the considered seismic hazards and site classifications.

关键词： high-rise building SBC-301 international seismic codes seismic zones site classifications

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Investigation on the mechanical properties of sintered porous copper compacts

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China Particuology 2007年第6期5卷 391-394页

作者： Yasser M.z. ahmed mohamed I. Riad ahmed I. zaky Mohammed Abdel-Aziz mohamed M.H. Shalabi Central Metallurgical Research and Development Institute CMRDI El-Felzat Street El-Tabbin P.O. Box 87 Helwan Cairo Egypt

In line with recent attention on porous metals having low and medium porosities in the range of 20-50%, this paper studies the effect of porosity on the mechanical properties of sintered copper compacts. Experiments were designed to investigate the effect of porosity, applied stress and sliding velocity on the wear rate of copper compacts, leading to the finding that the effects of both porosity and applied stress of the wear test on the wear rate are approximately similar and higher than that of sliding velocity. The investigation concerning the effect of porosity on compressive strength indicated that the stress-strain curve of high-porosity compact exhibited identifiable ultimate strength points, though low-porosity compact showed distinct stages of elastic plastic behavior.

关键词： Porous copper Wear rate Compressive strength Experimental design technique

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