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Contribution of Anti-p63 Antibodies in the Interpretation of benign Label Prostatic biopsies

Open Journal of Pathology 2024年第2期14卷 31-44页

作者： Ibou Thiam Fabrice Senghor Frenette Codja Kor Ndiaye mohamed Moustapha Cherif Dial Pathological Anatomy Department Aristide Le Dantec University Hospital Dakar Senegal Pathological Anatomy Department H&#244pital de la Paix Ziguinchor Senegal Pathological Anatomy Department Idrissa Pouye University Hospital Dakar Senegal

Introduction: Prostate cancer is the second most common cancer in men. The diagnosis is most often based on the prostate biopsies’ analysis and on histological criteria recognizable on standard coloring. In some cases, the use of immunohistochemistry is important. Objectives: This paper aims to specify the p63 phenotypic profile of lesions diagnosed benign, with minimal suspect foci, difficult to interpret, HGPIN (high grade intraepithelial neoplasia) and LGPIN (low-grade prostatic intraepithelial neoplasia) and evaluate the manual technique of p63 immunohistochemistry. Patients and Method: This was a retrospective, descriptive study of prostate biopsies recorded in the PAC service of the HALD from January 1st, 2018 to December 31st, 2018. It was completed by a manual immunohistochemical study of the blocks enrolled from November 19th to December 4th, 2020 in the PAC department of the HPD. The studied parameters were: registry number, age, clinical stage, prostate volume, PSA level, microscopic appearance and p63 immunohistochemical profile. Results: Our study included 60 prostate biopsies. The ages of our patients varied from 45 to 77 years, with an average of 64.2 years and a standard deviation of 6.2. The majority of patients were at clinical stage cT2b (33%) with a prostate volume varying between 33.15 and 169.4 cc. The minimum value of PSA in our series is 5 ng/ml, the maximum being 100 ng/ml with an average level of 24.1 ng/ml and a standard deviation of 21.2. Our series included 50 adenomyomatous hyperplasias, 7 adenomyomatous hyperplasias associated with chronic prostatitis, 2 HGPIN and 1 LGPIN. After re-reading we found 5 discordant cases, which corresponded to minimal suspect foci (kappa = 0.5098). The p63 marking was informative in 53 cases, i.e. 88%, and non-informative in 7 cases, i.e. 12%. Among the uninformative markings, 2 were due to lack of tissue adhesion to the slides. Among the informative markings, 11 were negative. p63 immunohistochemistry was

关键词： Prostate Cancer Diagnosis Anti-p6 Antibody

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Paraconductivity study in Erba_2Cu_(3-x)M_xO_(7-δ)(M=Zn, Fe) superconductors

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Chinese Physics b 2013年第11期22卷 562-568页

作者： A.Sedky S.b.mohamed Physics Department Faculty of Science King Faisal University Physics Department Faculty of Science Assiut University

We report here the paraconductivity of Erba2Cu3-xMxO7-δ （M = Zn and Fe） superconductors. The logarithmic plots of excess conductivity Δσ and reduced temperature C reveal two different exponents corresponding to crossover temperature as a result of shifting the order parameter from 2 to 3. The first exponent in the normal field region is close to 1, in which the order parameter dimensionality （OPD） is 2. The second exponent in the critical field region is close to 0.5, in which the OPD is 3. The coherence length, interlayer coupling, interlayer separation and carrier concentration decrease with increasing doping content, and their values for Fe samples are different from those of Zn samples. While anisotropy is increased with increasing doping content, it is generally higher for a Zn sample than that for an Fe sample. We also estimate several physical parameters such as upper critical magnetic fields in the a–b plane and along the c axis （bab and bc）, and critical current density J at 0 K. Although bab and bc are generally increased with doping content increasing, the value of bab is found to be twice more than that of bc. A similar behavior is obtained for J （0 K） and its value is higher in the Fe sample than that in the Zn sample. These results are discussed in terms of oxygen deficiency, localization of carriers, and flux pinning, which are produced by doping.

关键词： ceramics chemical synthesis X-ray diffraction electrical properties transport properties

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biochemical Liver Functions and Molecular Identification of Fasciola hepatica from Experimentally Infected Rat Model

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Open Journal of Animal Sciences 2024年第2期14卷 88-100页

作者： Omnia M. Kandil Emad b. Ata Margarita P. Gabrashanska Hatem A. Shalaby Tamer H. Abd El-Aziz Noha M. F. Hassan Soad M. Nasr mohamed A. Helal Ebtesam M. Al-Olayan Department of Parasitology & Animal Diseases Veterinary Research Institute National Research Centre Giza Egypt Institute of Experimental Morphology Pathology and Anthropology with Museum Bulgarian Academy of Sciences Sofia Bulgaria Department of Zoology Collage of Science King Saud University Riyadh Saudi Arabia

The current study was performed to evaluate the liver function status as well as molecular characterization of the recovered worms in rats experimentally infected with F. hepatica. Sixteen male Wister rats aged 30 days were randomly allocated into two groups (n = 8). The first group was infected orally with 15 viable encysted metacercaria of F. hepatica per animal. The other group was kept non-infected (control group). At zero time (before infection), the 2nd, 4th, 6th, 8th, 10th, 12th and 14th weeks post-infection (WPI), blood and serum samples were collected via puncture of retro-orbital plexus of veins from each rat. Serum enzyme level (AST and ALT) and total protein were measured, and the serum protein profile was carried out using agarose gel electrophoresis. During the period of the experiment, serum ALT and AST activities and serum total globulins significantly increased while serum total proteins and albumin markedly decreased in the infected group. On the 14th WPI, the data of the electropherogram showed that globulin fractions (α1-, β- and γ-globulin) levels were significantly increased while α2-globulin was markedly decreased in the infected group. The molecular analysis confirmed the amplification of the ITS1, ITS2 and NDI genes of F. hepatica recovered from the infected liver of rats with amplicon sizes of 630, 510 and 560 bp, respectively. Sequencing of the amplified ITS gene resulted in the determination of 3 strains (PP108836, PP108837, and PP108838). Also, analysis of the ITS2 gene resulted in obtaining 3 isolates under the accession numbers (PP109065, PP109066, and PP109067). In conclusion, fasciolosis in the rat model is suitable for routine experimental infections and caused a pronounced liver dysfunction with discharging of the Fasciola eggs in the faeces and the development of adult stages in the bile ducts. Furthermore, molecular techniques are a sensitive

关键词： Fasciola hepatica Liver Functions Serum Enzymes Serum Protein Electrophoresis Molecular Characterization

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Electron Acceleration by Microwave Radiation Inside a Rectangular Waveguide

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Plasma Science and Technology 2011年第3期13卷 357-361页

作者： b. F. mohamed A.M. GOUDA Plasma Physics Department N.R.C. Atomic Energy Authority Cairo Egypt

Electron dynamics in the fields associated with a transverse magnetic （TM） wave propagating inside a rectangular waveguide is analytically studied. The relativistic momentum and energy equations for an electron are solved, which was injected initially along the propagation direction of the microwave. Expressions of the acceleration gradient and deflection angle are obtained. In principle, it is shown that the electron can be accelerated in this condition and there is no deflection when the electron is injected from the centre of the waveguide front. However, it is found that the acceleration gradient and deflection angle depend strongly on the parameters of the microwave （intensity, frequency, etc.） and the dimensions of the waveguide.

关键词： waveguide electron acceleration polarized microwave

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The Prevalence and Clinical Manifestations of Co-Infection in Pediatric Infectious Mononucleosis: A Single-Centered, Retrospective Study

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Open Journal of Pediatrics 2024年第3期14卷 459-475页

作者： Abdishakur Abdukadir Muse Zakaria Ahmed mohamed Pu Yang Lihong Liao bibek Dhar Shrestha Agness Nicholaus Kanusya Paul Mwale Youping Deng Dongchi Zhao Department of Pediatrics Zhongnan Hospital of Wuhan University Wuhan China Department of Ophthalmology Zhongnan Hospital of Wuhan University Wuhan China

background: Recent studies indicate that the incidence of infectious mononucleosis (IM) has increased in China. Furthermore, it has been shown that children diagnosed with IM are prone to acquiring other pathogens. However, there is limited research on the prevalence of these co-infections in children with IM. Thus, we conducted this study to determine the prevalence of coinfections and common pathogens, as well as to compare clinical manifestations in children with and without coinfections. Methods: This retrospective observational study was conducted at the Department of Pediatrics Zhongnan Hospital of Wuhan University, Wuhan, China, with data from January 2018 to January 2023. Data, including demographics, symptoms, lab results, and complications, were collected from the hospital’s electronic database and analyzed. The statistical analysis included descriptive statistics, independent samples t-tests and Mann-Whitney tests to compare the means of continuous variables. Statistical significance was determined by p-values less than 0.05. Results: The study involved 216 participants diagnosed with IM, predominantly males (61.6%) aged 0 - 4 years (50.9%). Coinfection was detected in 39.8% of children, with multiple pathogens present in 33.72% of these cases. Among coinfection cases, 40% occurred in children under 5 years old, and females made up 54.2% of these cases. Mycoplasma pneumoniae (MP) was the most prevalent pathogen, accounting for 18.1% of cases. Influenza b (IFb) and Influenza A (IFA) viruses were found in 16.7% and 13.9% of participants, respectively, indicating a notable occurrence of respiratory pathogen coinfections. Male gender, fever, tonsillopharyngitis, lower HGb levels, higher ESR, CRP, and AST levels were correlated with coinfections. Conclusion: In summary, the study revealed a high prevalence of coinfections among children diagnosed with IM, particularly involving Mycoplasma pneumoniae and influenza viruses. These coinfections were notably

关键词： Prevalence Mononucleosis Coinfection Children Epstein-barr Virus Features

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恶嗪N-稠合咪唑-2-硫酮合成的机理研究:添加剂和溶剂的作用（英文）

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分子科学学报 2024年第3期40卷 256-266页

作者： mohamed Hend 袁海艳张景萍东北师范大学化学学院

采用密度泛函理论计算了在无催化剂协助、水协助、三氟乙酸（TFA）协助条件下，2,2-二羟基-1-苯乙酮（1）,（2-氨基苯）甲醇（2）和KSCN（3）合成3-苯基-2,5-二氢-1-氢-苯并[d]咪唑并[5,1-b][1,3]恶嗪-1-硫酮的反应机理。计算结果表明，... 详细信息

采用密度泛函理论计算了在无催化剂协助、水协助、三氟乙酸（TFA）协助条件下，2,2-二羟基-1-苯乙酮（1）,（2-氨基苯）甲醇（2）和KSCN（3）合成3-苯基-2,5-二氢-1-氢-苯并[d]咪唑并[5,1-b][1,3]恶嗪-1-硫酮的反应机理。计算结果表明，TFA、水和底物2可以改变和促进该反应。基于底物不同的反应顺序共探究了3种机理M1（1+2然后与3反应）、M2（1+3然后与2反应）和M3（2+3然后与1反应）,并发现底物2的亲核性强于底物3。计算表明TFA-水共同协助机理M1的路径最优，决速步是[3+2]环加成过程。TFA和水分子在整个反应中起着至关重要的作用，通过N—H…O,O—H…O及C—H…O相互作用来稳定过渡态和中间体的结构。它们还作为氢键（Hbs）给体和受体，通过改变乙二醛-水合物和KSCN的反应形式来提高底物的反应活性。底物2作为Hbs受体促进了烯醇-酮互变异构和质子转移过程。进一步发现该反应可以用水替换CH3CN,为合成绿色恶嗪杂环类化合物提供了新的方案。

关键词：密度泛函理论反应机理添加剂和溶剂多组分反应

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Entanglement and Its Dynamics with Atomic Spontaneous Decay

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Chinese Physics Letters 2008年第7期25卷 2492-2495页

作者： H. A. Hessian A.-b. A. mohamed Faculty of Science Assiut University Assiut Egypt

The atomic decay for a two-level atom interacting with a single mode of electromagnetic tield is considered. For a chosen initial state, the exact solution of the master equation is found. Therefore, effect of the atomic damping on entanglement （purity loss）, degree of entanglement by the negativity, mutual information and atomic coherence through the master equation are studied.

关键词： the power-law exponents precipitation durative abrupt precipitation change

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Comparison among the UECM Model, and the Composite Model in Forecasting Malaysian Imports

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Open Journal of Statistics（统计学期刊） 2024年第2期 163页

作者： mohamed A. H. Milad Hanan Moh. b. Duzan

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Calculation of Radii and Density of ^(7-19)b Isotopes Using Effective Skyrme Force

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Communications in Theoretical Physics 2008年第3期49卷 696-702页

作者： E.tel S.Okuducu G.Tatar N.N.Akti M.H.blükdemir Gazi University Faculty of Arts and SciencesAnkaraTurkey

Abstract In this study, the proton and neutron densities, charge densities, rms nuclear charge radii, rms nuclear mass radii, rms nuclear proton, neutron radii, and neutron skin thickness are calculated by using Harfree-Fock method with an effective nucleon-nucleon Skyrme interactions with SⅠ, SⅡ, SⅣ, T3, SKM, and SKM^＊ parameters. These nuclear properties for the neutron-rich isotopes of b （boron） are presented. The calculated results are compared with the experimental and theoretical results of other researchers.

关键词： ^7-9b isotopes halo nuclei Skyrme force Hartree-Fock calculations

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Entropy and Entanglement in Master Equation of Effective Hamiltonian for Jaynes-Cummings Model

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Communications in Theoretical Physics 2009年第4期51卷 723-728页

作者： H.A.Hessian F.A.Mohammed A.-b.A.mohamed Faculty of Science Assiut University

In this paper, we analytically solve the master equation for Jaynes-Cummings model in the dispersive regime including phase damping and the field is assumed to be initially in a superposition of coherent states. Using an established entanglement measure based on the negativity of the eigenvalues of the partially transposed density matrix we find a very strong sensitivity of the maximally generated entanglement to the amount of phase damping. Qualitatively this behavior is also reflected in alternative entanglement measures, but the quantitative agreement between different measures depends on the chosen noise model The phase decoherence for this model results in monotonic increase in the total entropy while the atomic sub-entropy keeps its periodic behaviour without any effect.

关键词： entanglement phase damping master equation superposition state

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