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Advances in Breast Cancer Research 2020年第3期9卷 55-65页

作者： Ahmed Refaat Dalia O. mohamed Elsayed Mostafa Ali salah Mabrouk Khallaf Medical Oncology Department South Egypt Cancer Institute Assiut University Assiut Egypt Radiation Oncology Department South Egypt Cancer Institute Assiut University Assiut Egypt Clinical Oncology and Nuclear Medicine Department Faculty of Medicine Sohag Egypt

Introduction: The treatment of metastatic breast cancer (MBC) is still challenging. Many studies documented the efficacy of pegylated liposomal doxorubicin (PLD) in patients with MBC, but there is a limited data about the cardiac safety with high cumulative dose (HCD) of PLD. Aim of the work: We conducted this trial to outline the cardiac safety of HCD of PLD in patients with MBC who previously received conventional anthracyclines. Methods: During the period of nine years (January 2011 to December 2019). We extracted the data of the patients with MBC receiving PLD at Medical Oncology Department, South Egypt Cancer Institute, Assiut University. These included patients’ demographics and therapeutic data including the full data of PLD, prior conventional anthracyclines, prior trastuzumab, and prior radiotherapy. Also, data about comorbidities as well as cardiac and other toxicities of PLD were obtained. The data was analysed using SPSS v. 21. Results: For all

关键词： Metastatic Breast Cancer Pegylated Liposomal Doxorubicin High Cumulative Dose Cardiac Toxicity

miR-29a Promotes Lipid Droplet and Triglyceride Formation in HCV Infection by Inducing Expression of SREBP-1c and CAV1

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Journal of Clinical and Translational Hepatology 2016年第4期4卷 293-299页

作者： Mennatallah Mamdouh Mahdy Nada Magdy El-Ekiaby Rana Mahmoud Hashish Radwa Ayman salah Rasha Sayed Hanafi Hassan mohamed El-Said Azzazy Ahmed Ihab Abdelaziz Department of Pharmaceutical Chemistry German University in Cairo New Cairo City Egypt Department of Pharmacology and Toxicology German University in Cairo New Cairo City Egypt School of Medicine New Giza University Cairo Egypt Department of Pharmaceutical Biology German University in Cairo New Cairo City Egypt Department of Stem Cells and Regenerative Medicine Zewail City of Science and TechnologyGiza Egypt Department of Chemistry Novel Diagnostic & Therapeutics American University in Cairo New Cairo City Egypt

Aims:To examine the regulation of SREBP-1c and CAV1 by microRNA-29a (miR-29a) in cells infected with hepatitis C virus (HCV) in an attempt to control HCV-induced nonalcoholic fatty liver ***:In order to examine the manipulation of SREBP-1c and CAV1 by miR-29a,oleic acid (OA)-treated JFH-I-infected Huh-7 cells were *** was added 24 h post-transfection and gene expression was investigated by qRT-PCR at 48 h post *** functional impact of the observed alteration in SREBP-1c and CAV1 expression was analyzed by examining lipid droplet (LD) and triglyceride (TG) content at 72 h post-OA treatment using light microscopy and spectrophotometry,*** load was quantified by qRT-PCR at 72 h ***:OA treatment induced the expression of miR-29a and SREBP-1c,as compared to untreated *** miR-29a expression led to a significant up-regulation of SREBP-1c as well as CAV1 compared to mock untransfected *** expression of miR-29a resulted in a marked increase in LDs and their respective TGs,while miR-29a antagomirs decreased both the LD and TG content compared to mock untransfected ***,forcing the expression of miR-29a in JFH-1 HCV-infected Huh-7 cells resulted in 53% reduction in viral titers compared to mock untransfected Huh-7 ***:Inducing miR-29a expression significantly induces SREBP-1c and CAV1 expression,thereby increasing LDs as well as their respective ***,forcing the expression of miR-29a resulted in reduction of HCV RNA levels in Huh-7 cells.

关键词： Caveolin-1 HCV Lipid droplets MicroRNA-29a SREBP-1c

The Differential Quadrature Solution of Reaction-Diffusion Equation Using Explicit and Implicit Numerical Schemes

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Applied Mathematics 2014年第3期5卷 327-336页

作者： mohamed salah R. M. Amer M. S. Matbuly Department of Engineering Mathematics and Physics Faculty of Engineering Zagazig University Zagazig Egypt

In this paper, two different numerical schemes, namely the Runge-Kutta fourth order method and the implicit Euler method with perturbation method of the second degree, are applied to solve the nonlinear thermal wave in one and two dimensions using the differential quadrature method. The aim of this paper is to make comparison between previous numerical schemes and detect which is more efficient and more accurate by comparing the obtained results with the available analytical ones and computing the computational time.

关键词： Reaction-Diffusion Implicit Euler Runge-Kutta Differential Quadrature Perturbation

An Efficient Method to Solve Thermal Wave Equation

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Applied Mathematics 2014年第3期5卷 542-552页

作者： mohamed salah R. M. Amer M. S. Matbuly Department of Engineering Mathematics and Physics Faculty of Engineering Zagazig University Zagazig Egypt

In this paper, an efficient technique of differential quadrature method and perturbation method is employed to analyze reaction-diffusion problems. An efficient method is presented to solve thermal wave propagation model in one and two dimensions. The proposed method marches in the time direction block by block and there are several time levels in each block. The global method of differential quadrature is applied in each block to discretize both the spatial and temporal derivatives. Furthermore, the proposed method is validated by comparing the obtained results with the available analytical ones and also compared with the hybrid technique of differential quadrature method and Runge-Kutta fourth order method.

关键词： Reaction-Diffusion Block Marching Differential Quadrature Perturbation

Comorbidity of Attention-Deficit/Hyperactivity Disorder (ADHD) in Children with Epilepsy, Egyptian Study

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Neuroscience & Medicine 2020年第4期11卷 119-129页

作者： Nahed salah El-din Ahmed Maha Ali Nada Randa mohamed Amin Omar Sayed Khalifa Ali mohamed Hamdy Ibrahim Neurology Department Faculty of Medicine Ain Shams University Cairo Egypt Neurology Department Faculty of Medicine Minia University Cairo Egypt

Background: Epilepsy is one of the most common neurological conditions with about 65 million people affected worldwide. It is also a common condition in children, where its prevalence is approximately 3.2 - 5.5/1000 in the developed world. Children with epilepsy (CWE) experience not only seizures but also multiple cognitive, behavioral, and emotional problems. ADHD is one of the more common comorbidities of childhood epilepsy. Objectives: To discuss the relationship between childhood epilepsy and comorbidities especially ADHD. Study Design: This is a prospective observational analytical cross-sectional study carried out on one hundred and fifteen patients at Ain Shams University and Nasr-city Health Insurance out-patient clinics, Cairo, Egypt fulfilling the inclusion criteria. Patients were selected by simple random sample. Results: ADHD is very common epilepsy comorbidity in Egyptian epileptic children with under-diagnosis and treatment. Conclusion: Frequent assessment for ADHD in epileptic children is mandatory for better quality of life.

关键词： Attention Deficit Seizures Comorbidity Egyptian Study

Rotate Two Different Mode of Actions of Green Chemicals to Combat Virachola livia （Klug） on Date Palm Fruit, Egypt

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Journal of Agricultural Science and Technology(A) 2014年第7期4卷 620-625页

作者： Sobhy Ahmed Temerak Ahmed Amin Sayed salah Mahmoud mohamed Gameel Amr Moussa Plant Protection Department Faculty of Agriculture Assiut University Assiut 71515 Egypt Plant protection Research Institute Agricultural Research Center Ministry of Agriculture (MOA) Cairo 11728 Egypt Plant protection Research Institute Agricultural Research Center MOA Cairo 1172 Egypt Research & Development Department Dow Agro Sciences Company Cairo 11771 Egypt

Alternation of two different modes of action of green chemicals： spinosad and methoxyfenozide to combat Virachola livia on dates in Dakhla Oasis, New Valley, Egypt, were done in 2010 and 2011. Based on infestation levels in fruit, the three spray programs including rotations with spinosad 24 SC at 20 mL/100 L were not significantly different. Based on minimum effective rotation doses, alternation of spinosad at 20 mL/100 L followed by methoxyfenozide 24 SC at 15 mL/100 L on a three-week interval showed 0.3% and 0.6% infestation, before harvest for 2010 and 2011, respectively, compared to check treatments which showed 33% and 70% infestations. Also, successful penetration and survival of V. livia （% live larvae） into the fruit by following a spinosad and methoxyfenozide rotation program resulted in 1.8% and 1% larvae, before harvest in 2010 and 2011, respectively, compared to fhait infestation levels of 97% and 89% in the untreated in 2010 and 2011, respectively. Fruit were penetrated by first instar larvae upon hatching, in case no chemical treatment. The last data reflect the excellent performance of this rotation. During the same period, reduction of the three rotation programs was 97.8%-100% and 99%-100% for 2010 and 2011, respectively. Both products proved to be working under dry hot temperatures in these areas.

关键词： Alternation green chemicals V. livia date fruit.

Transabdominal Pre-Peritoneal Mesh for Inguinal Hernia Repair with External Fixation versus Mesh Stapling

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Surgical Science 2013年第11期4卷 516-519页

作者： mohamed Abdelhamid Ahmed mohamed Sadat Ayman Refaat Abdelhaseeb Tamer mohamed Nabil mohamed salah Abdelbasset Amro mohamed Ali Bechet Hesham Ahmed Nafady Kalid Ahmed Shawky Faculty of Medicine Bani Swif University Bani Swif Egypt

Background: It is unknown whether stapling the mesh affects recurrence rate, incidence of neuralgia, and port-site hernia. We chose to fix it to the exterior reducing port size, cost and pain, at the same comparing this with traditional mesh stapling. Methods: We conducted a prospective trial for laparoscopic TAPP inguinal hernia repair on 120 patients in which we fixed the mesh to the anterior abdominal wall using either two prolene threads that passed to the exterior and tied in place or traditional mesh stapling. Results: The operative time is ranged from 35 to 70 minutes for external fixation, 30 to 60 minutes for mesh stapling, and 4 to 51 months for follow-up, and no recurrence occurred in both groups during the procedure. Two cases with post TAPP pain in mesh stapling patients are discussed with reduction of the cost and port size in external fixation patients. Conclusion: It is not necessary to secure the mesh during laparoscopic TAPP inguinal hernia repair from the interior and it is fixed only to the exterior allowing a reduction in size of the ports and considerable reduction in cost with elimination of TAPP associated post operative pain.

关键词： Laparoscopic Transabdominal Preperitoneal Inguinal Hernia Repair Mesh Prosthesis Fixation Cost-Stapling

Barriers for resuming endoscopy service in the context of COVID-19 pandemic:A multicenter survey from Egypt

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World Journal of Gastroenterology 2020年第43期26卷 6880-6890页

作者： Omar Elshaarawy Sameh Aldesoky Lashen Nahed A Makhlouf Doaa Abdeltawab Mariam salah Zaghloul Rasha M Ahmed Hayam Fathy Shimaa Afifi Muhammad Abdel-Gawad Eman Abdelsameea Sherief Abd-Elsalam Salem Youssef mohamed Mohammed Tag-Adeen Mina Tharwat Ahmed Alzamzamy Ahmed Nasr Bekhit Alshaimaa M Eid Abeer Awad mohamed-Naguib Wifi Mohammad Aamr Waleed A Abd El Dayem mohamed Alboraie Department of Hepatology Gastroenterology and Liver TransplantationNational Liver InstituteMenoufia UniversityShebine Elkom 32511Egypt Department of Internal Medicine and Center of Alcohol Research and Liver Diseases Salem Medical CenterHeidelberg UniversityHeidelberg 69121Germany Department of Internal Medicine Faculty of MedicineUniversity of AlexandriaAlexandria 21521Egypt Department of Tropical Medicine and Gastroenterology Faculty of MedicineAssiut UniversityAssiut 71515Egypt Department of Hepatology Gastroentrology and Infectious DiseasesKafrelsheikh UniversityFaculty of MedicineKafrelsheikh 33565Egypt Department of Internal Medicine Faculty of MedicineAssiut UniversityAssiut 71515Egypt National Hepatology and Tropical Medicine Research Institute Cairo 11638Egypt Department of Hepatology Gastroenterology and Infectious DiseasesFaculty of MedicineAl-Azhar UniversityAssiut 71524Egypt Department of Tropical Medicine and Infectious Diseases Faculty of MedicineTanta UniversityTanta 31527Egypt Department of Internal Medicine Gastroenterology and Hepatology UnitFaculty of MedicineZagazig UniversityZagazig 44519Egypt Department of Internal Medicine Gastroenterology UnitQena Faculty of MedicineSouth Valley UniversityQena 83523Egypt Department of Tropical Medicine and Gastroenterology Faculty of MedicineAswan UniversityAswan 81528Egypt Department of Gastroenterology and Hepatology Military Medical AcademyCairo 11771Egypt Department of Tropical Medicine Zagazig General HospitalZagazig 42511Egypt Department of Hepatology and Gastroenterology and Infectious Disease Faculty of MedicineAlAzhar UniversityCairo 11562Egypt Department of Internal Medicine Faculty of MedicineCairo UniversityCairo 11759Egypt Department of Hepatology and Gastroentorolgy Shebin Elkom Teaching HospitalShebine Elkom 3521Egypt Department of Tropical Medicine Faculty of MedicineZagazig UniversityZagazig 44519Egypt Department of Internal Medicine Al-Azhar UniversityCairo 11651Egypt

BACKGROUND The current coronavirus disease 2019(COVID-19)pandemic has affected routine endoscopy service across the gastroenterology *** led to the suspension of service provision for elective *** To assess the potential barriers for resuming the endoscopy service in *** A national online survey,four domains,was disseminated over a period of 4 wk in August *** primary outcome of the survey was to determine the impact of the COVID-19 pandemic on the endoscopy service and barriers to the full resumption of a disabled center(s).RESULTS A hundred and thirteen Egyptian endoscopy centers participated in the *** waiting list was increased by≥50% in 44.9% of areas with clusters of COVID-19 cases(n=49)and in 35.5% of areas with sporadic cases(n=62).Thirty nine(34.8%)centers suffered from staff shortage,which was considered a barrier against service resumption by 86.4% of centers in per-protocol *** multivariate analysis,the burden of cases in the unit locality,staff shortage/recovery and the availability of separate designated rooms for COVID-19 cases could markedly affect the resumption of endoscopy practice(P=0.029,<0.001 and 0.02,respectively)and Odd’s ratio(0.15,1.8 and 0.16,respectively).CONCLUSION The COVID-19 pandemic has led to restrictions in endoscopic *** staff shortage/recovery and the availability of COVID-19 designed rooms are the most important barriers against *** working hours and dividing endoscopy staff into teams may help to overcome the current situation.

关键词： COVID-19 Endoscopy Practice Pandemic Egypt Barriers

Effect of Heart Failure on Acute Ischemic Stroke Severity

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Open Journal of Medical Imaging 2014年第3期4卷 103-107页

作者： Taha kamel Alloush Mahmoud Haroun Ibrahim Nahed salah El-Dein Ahmed Ghada Samir El-Shahed Lobna M. El-Nabil El-Sayed mohamed Hamdy Ibrahim Hosam Ahmed Azmy Faculty of Medicine Ain Shams University Cairo Egypt Ministry of Health Cairo Egypt

Objectives: To assess the impact of heart failure diseases on stroke severity and short term (1 month mortality). Materials and Methods: Totally, 200 patients admitted to Ain Shams university specialized hospital, were diagnosed clinically to have acute ischemic stroke within 3 days. History taking about previous heart disease was taken, and full general and neurological examinations were done. Full metabolic profile, cardiac examination and investigations were done. Carotid duplex, MRI stroke protocol and lastly clinical reevaluation using NIH Stroke Scale (NIHSS) after 1 month from stroke onset were done. Results: Patients with systolic dysfunction (EF ≤ 40%) had lacunar infarction in 18.75% of cases, partial anterior circulation infarction in 62.5% of cases, posterior circulation infarction in 6.25% of cases and total anterior circulation infarction in 12.5% of cases. Leucoaraiosis was present in 87% of cases and significant intracranial vessel stenosis was showed in 87.5% who had done MRI. Their median NIHSS score at admission was 10.5 with IQR of 5 - 21 and at follow-up it was 5 with IQR of 2.5 - 10.5. At follow-up 22.7% (5 patients) were dead. Conclusion: Systolic dysfunction (EF < 40) i.e. heart failure has no significant effect on stroke severity and 1 month follow up prognosis.

关键词： Heart Failure Stroke Prognosis Ejection Fraction

Effect of Natural Infection with Onion Yellow Dwarf Virus （OYDV） on Yield of Onion and Garlic Crops in Egypt

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Journal of Life Sciences 2011年第8期5卷 634-638页

作者： salah Elnagar mohamed Abdel-Kader El-Sheikh Abeer salah E1-Deen Abd E1-Wahab Department of Economic Entomology and Pesticides Faculty of Agriculture Cairo University Cairo 12613 Egypt

Present work highlights, first time in Egypt, the impact of OYDV infection on crops production. Plants grown in the field were individually labelled as either apparently healthy or diseased and were marked for harvesting. The percentage of yield loss due to viral infection was determined, on the basis of the average yield parameters of the healthy plant. The natural infection with OYDV in onion and garlic fields resulted in a substantial reduction in pseudo-stem length, number of leaves, plant weight and weight of bulb as well as number and weight of cloves. Results clearly indicate the impact of natural infection with OYDV on the crop yield of infected onion and garlic plants in comparison with the virus-free （uninfected） ones. The largest reduction in the yield of infected plants occurred in Chinese garlic （Seds40） followed by （Baladi） garlic and onion Giza 20. This information suggests that measures have to be taken to prevent natural infection with OYDV into and within onion and garlic fields in order to avoid yield loss.

关键词： Onion yellow dwarf virus (OYDV) yield reduction onion garlic.