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Thiol-yne Click Adamantane Monolithic Stationary Phase for Capillary Electrochromatography

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Chinese Journal of Chemistry 2012年第10期30卷 2281-2284页

作者： Dao,Thi Thu Hien Guerrouache,mohamed Carbonnier,Benjamin Institut de Chimie et des Materiaux Paris Est UMRCNRS 7182&Universite Paris-Est Creteil2-8 rue Henri Dunant94320 ThiaisFrance

A porous crosslinked organic polymer based on N-acryloxysuccinimide （nas. and ethylene dimethacrylate （EDMA） was prepared inside 75 μm i.d. fused silica capillary as functionalizable monolithic stationary phase for electrochromatographic applications. Succinimide groups on the monolith surface provide reactive sites able to re- act readily through standard electrophile-nucleophile chemistry. Propargylamine was used to prepare alkyne func- tionalized poly（nas.co-EDMA）. Onto this thiol-reactive polymer surface was grafted adamantane units via a photochemically-driven addition reaction. Chemical characterization was performed in situ after each synthetic step by means of Raman spectroscopy and grafting kinetics was investigated to ensure quantitative grafting of 1-adamantanethiol. The as-designed monolithic stationary phase exhibited typical reversed-phase separation mechanism as evidenced by the linear increase of the logarithm of retention factor of neutral aromatic solutes with the increase of the aqueous buffer content in the mobile phase.

关键词： adamantane electrochromatography porous monolith surface chemistry thiol-yne click

Deep Stacked Ensemble Learning Model for COVID-19 Classification

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Computers, Materials & Continua 2022年第3期70卷 5467-5486页

作者： G.Madhu B.Lalith Bharadwaj Rohit Boddeda Sai Vardhan K.Sandeep Kautish Khalid Alnowibet Adel F.Alrasheedi Ali Wagdy mohamed Department of Information Technology VNRVJIETHyderabad500090India Department of Computer Science and Engineering VNRVJIETHyderabad500090India LBEF Campus Kathmandu44600Nepal Statistics and Operations Research Department College of ScienceKing Saud UniversityRiyadh11451Kingdom of Saudi Arabia Operations Research Department Faculty of Graduate Studies for Statistical ResearchCairo UniversityGiza12613Egypt Wireless Intelligent Networks Center(WINC) School of Engineering and Applied SciencesNile UniversityGiza12588Egypt

COVID-19 is a growing problem worldwide with a high mortality *** a result,the World Health Organization(WHO)declared it a *** order to limit the spread of the disease,a fast and accurate diagnosis is required.A reverse transcript polymerase chain reaction(RT-PCR)test is often used to detect the ***,since this test is time-consuming,a chest computed tomography(CT)or plain chest X-ray(CXR)is sometimes *** value of automated diagnosis is that it saves time and money by minimizing human *** significant contributions are made by our *** initial purpose is to use the essential finetuning methodology to test the action and efficiency of a variety of vision models,ranging from Inception to Neural Architecture Search(nas.***,by plotting class activationmaps(CAMs)for individual networks and assessing classification efficiency with AUC-ROC curves,the behavior of these models is visually ***,stacked ensembles techniques were used to provide greater generalization by combining finetuned models with six ensemble neural *** stacked ensembles,the generalization of the models ***,the ensemble model created by combining all of the finetuned networks obtained a state-of-the-art COVID-19 accuracy detection score of 99.17%.The precision and recall rates were 99.99%and 89.79%,respectively,highlighting the robustness of stacked *** proposed ensemble approach performed well in the classification of the COVID-19 lesions on CXR according to the experimental results.

关键词： COVID-19 classification class activation maps(CAMs)visualization finetuning stacked ensembles automated diagnosis deep learning

A Descriptive Cross-Sectional Study to Assess the Perception and Knowledge of Staff Nurses regarding Physical Restrains

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Open Journal of Nursing 2019年第3期9卷 239-248页

作者： Imad Fashafsheh Salwa mohamed Ahmad Ayed Deyaaldeen ALRababah Nursing Department University of Bisha Bisha Saudi Arabia Nursing College Arab American University Jenin Palestine Nursing College Fayoum University Fayoum Egypt Alfarabi Colleges of Dentistry and Nursing Riyadh Saudi Arabia

Purpose: The purpose of this study was to examine the perceptions and knowledge regarding physical restraint used among registered nurses (RNs) and nursing assistants (nas.. Method and Sample: A descriptive cross-sectional design was used. A convenient sample was recruited from nursing staff from Palestinian and Saudi Hospitals. Perceptions of Restraint Use Questionnaire (PRUQ) were used [1]. Results: A total of 144 nursing staffs were included. Physical restraint use was perceived as more important in some circumstances than others. In the critical care unit/ICU, the most important perceived reason for physical restraint use was protecting from falling out of bed and preventing removing dressing. There were significant differences of overall score for the PRUQ among all nursing staff according to hospital, t (142) = 8.74, P = 0.001. The mean of Saudi Arabia hospitals group (M = 4.56) was higher than the mean of Palestinian hospital group (M = 3.67). At the same time, there were significant differences of overall score for the PRUQ among all nursing staff according to specialized education in geriatrics, t (40) = 3.60, P = 0.001. The mean of no specialized education in geriatrics group (M = 4.13) was higher than the mean of yes specialized education in geriatrics group (M = 3.69). Conclusion and Implications: Nursing staff showed positive attitudes towards restrains application with difference between Palestinian and Saudi Arabian nurses. Proper implementation and good awareness of the complications are prerequisite for application of physical restrains for patients.

关键词： Perception Knowledge Nursing Staff Physical Restraints

Interplay between micro RNA-17-5p, insulin-like growth factor-Ⅱ through binding protein-3 in hepatocellular carcinoma

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World Journal of Hepatology 2016年第23期8卷 976-984页

作者： Danira Ashraf Habashy Hend mohamed El Tayebi Injie Omar Fawzy Karim Adel Hosny Gamal Esmat Ahmed Ihab Abdelaziz Department of Pharmacology and Toxicology German University in Cairo Main Entrance Al Tagamoa Al Khames Department of General Surgery Faculty of Medicine Cairo University Department of Endemic Medicine and Hepatology Cairo University Department of Biology American University in Cairo

AIM: To investigate the effect of microR NA on insulinlike growth factor binding protein-3(IGFBP-3) and hence on insulin-like growth factor-Ⅱ(IGF-Ⅱ) bioavailability in hepatocellular carcinoma(HCC).METHODS: Bioinformatic analysis was performed using ***, DIANA lab and Segal lab softwares. Total RNA was extracted from 23 HCC and 10 healthy liver tissues using mir Vana mi RNA Isolation Kit. microR NA-17-5p(miR-17-5p) expression was mimicked and antagonized in Hu H-7 cell lines using Hi Per Fect Transfection Reagent, then total RNA was extracted using Biozol reagent then reverse transcribed into cD NA followed by quantification of mi R-17-5p and IGFBP-3 expression using Taq Man real-time quantitative PCR. Luciferase reporter assay was performed to validate the binding of miR-17-5p to the 3'UTR of IGFBP-3. Free IGF-Ⅱ protein was measured in transfected Hu H-7 cells using IGF-Ⅱ ELISA kit. RESULTS: Bioinformatic analysis revealed IGFBP-3 as a potential target for miR-17-5p. Screening of miR-17-5p and IGFBP-3 revealed a moderate negative correlation in HCC patients, where mi R-17-5p was extensively underexpressed in HCC tissues(P = 0.0012), while IGFBP-3 showed significant upregulation in the same set of patients(P = 0.0041) compared to healthy donors. Forcing mi R-17-5p expression in Hu H-7 cell lines showed a significant downregulation of IGFBP-3 mR NA expression(P = 0.0267) and a significant increase in free IGF-Ⅱ protein(P = 0.0339) compared to mock untransfected cells using unpaired t-test. Luciferase assay validated IGFBP-3 as a direct target of mi R-17-5p; luciferase activity was inhibited by 27.5% in cells co-transfected with miR-17-5p mimics and the construct harboring the wild-type binding region 2 of IGFBP-3 compared to cells transfected with this construct alone(P = 0.0474).CONCLUSION: These data suggest that regulating IGF-Ⅱ bioavailability and hence HCC progression can be achieved through targeting IGFBP-3 via manipulating the expression of miR nas.

关键词： Insulin-like growth factor binding protein-3 Insulin-like growth factor signaling pathway MicroR NA Insulin-like growth factor-Ⅱ Hepatocellular carcinoma