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An Improved Deep Structure for Accurately Brain Tumor Recognition

Computer Systems Science & Engineering 2023年第8期46卷 1597-1616页

作者： mohamed maher ata Reem N.Yousef Faten Khalid Karim Doaa Sami Khafaga Department of Communications and Electronics Engineering MISR Higher Institute for Engineering and TechnologyMansoura35516Egypt Department of Electronics and Communications Delta Higher Institute for Engineering and TechnologyMansoura35516Egypt Department of Computer Sciences College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia

Brain neoplasms are recognized with a biopsy,which is not commonly done before decisive brain *** using Convolutional Neural Networks(CNNs)and textural features,the process of diagnosing brain tumors by radiologists would be a noninvasive *** paper proposes a features fusion model that can distinguish between no tumor and brain tumor types via a novel deep learning *** proposed model extracts Gray Level Co-occurrence Matrix(GLCM)textural features from MRI brain tumor ***,a deep neural network(DNN)model has been proposed to select the most salient features from the ***,it manipulates the extraction of the additional high levels of salient features from a proposed CNN ***,a fusion process has been utilized between these two types of features to form the input layer of additional proposed DNN model which is responsible for the recognition *** common datasets have been applied and tested,Br35H and FigShare *** first dataset contains binary labels,while the second one splits the brain tumor into four classes;glioma,meningioma,pituitary,and no ***,several performance metrics have been evaluated from both datasets,including,accuracy,sensitivity,specificity,F-score,and training *** results show that the proposed methodology has achieved superior performance compared with the current state of art *** proposed system has achieved about 98.22%accuracy value in the case of the Br35H dataset however,an accuracy of 98.01%has been achieved in the case of the FigShare dataset.

关键词： Brain tumor convolutional neural network gray level co-occurrence matrix noninvasive FigShare dataset Br35H dataset

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Experimental and Numerical Analyses of the Pull-out Response of a Steel Post/Bovine Bone Cementless Fixation

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Journal of Bionic Engineering 2012年第4期9卷 501-507页

作者： Khaled Gammoudi mohamed Kharrat maher Dammak National Engineering School of Sfax Electromechanical Systems Laboratory Soukra road km 3.5 B.P. 1173 3038 Sfax Tunisia Higher Institute of Technological Studies of Gafsa University campus Sidi Ahmed Zarrouk 2112 Gafsa Tunisia Faculty of Sciences of Gafsa University campus Sidi Ahmed Zarrouk 2112 Gafsa Tunisia Preparatory Institute for Engineering Studies of Sfax Menzel Chaker Road Km 0.5 B.P. 1172 3018 Sfax Timisia

Effect of initial interference fit on pull-out strength in cementless fixation between bovine tibia and smooth stainless steel post was investigated in this study. Compressive behavior of bovine spongious bone was studied using mechanical testing in order to evaluate the elastic-plastic properties in different regions of the proximal tibia. Friction tests were carried out in the aim to evaluate the friction behavior of the contact between bovine spongious bone and stainless steel. A cylindrical stainless steel post inserted in a pre-drilled bovine tibia with an initial interference fit was taken as an in vitro model to assess the contribution of post fixation to the initial stability of the Total Knee Arthroplasty （TKA） tibial component. Pull-out experiments were carried out for different initial interference fits. Finite Element Models （FEM） using local elastic-plastic properties of the bovine bone were developed for the analysis of the experimental ultimate pull-out force results. At the post/bone interface, Coulomb friction was considered in the FEM calculations with pressure-dependent friction coefficient. It was found that the FEM results of the ultimate force are in good agreement with the experimental results. The analysis of the FEM interfacial stresses indicates that the micro-slip initiation depends on the local bone properties.

关键词： total knee arthroplasty bovine bone/steel post fixation interference fit puU-out strength FEM

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Mechanical Characterisation of Interface for Steel/Polymer Composite Using Pull-out Test: Shear-Lag and Frictional Analysis

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Journal of Materials Science & Technology 2006年第4期22卷 552-558页

作者： mohamed KHARRAT maher DAMMAK Amine CHARFI Institut Préparatoire aux Etudes d'Ingénieurs de Sfax Tunisia Laboratoire des Systèmes ElectromécaniquesEcole Nationale d'Ingénieurs de SfaxTunisia Laboratoire des Systèmes Electromécaniques Ecole Nationale d'Ingénieurs de SfaxTunisia

Fibre-matrix interface is known to have contribution to the mechanical performance of fibre-reinforced composite by its potential for load transfer between the fibre and the matrix. Such load transfer is of great importance in dentistry when a post is used for fixing a ceramic crown on the tooth. In this study, a pull-out test was carried out to analyse the interfacial properties of a steel fibre embedded in a polyester and epoxy matrices. It was found that the fibre-matrix interface is debonded on the whole embedded length when the fibre stress reached the debonding stress. Then, the fibre stress fell down to the initial extraction stress required to pulling out the debonded fibre from the matrix. Both debonding stress and initial extraction stress initiated a linear increase with the implantation length after the debonding stress reached horizontal asymptotes. To analyse the fibre-matrix load transfer before debonding, an analytical shear-lag model was adopted to in this test conditions. Fitting the experimental results with the analytical model provided the interfacial shear strength. By considering the Coulomb friction at the fibre-matrix interface during the fibre extraction process, an analytical model which considers Poisson＇s effects on both fibre and matrix, was developed. In this model, knowledge of the initial extraction stress of the fibre provides the residual normal stress at the fibre-matrix interface.

关键词： Fibre Matrix Interface Pull-out Shear-lag Debonding Friction

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Automatic Fall Detection Using Membership Based Histogram Descriptors

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Journal of Computer Science & Technology 2017年第2期32卷 356-367页

作者： mohamed maher Ben Ismail Ouiem Bchir College of Computer and Information Sciences King Saud University Riyadh 11495 KSA

t We propose a framework for automatic fall detection based on video visual feature extraction. The proposed approach relies on a membership histogram descriptor that encodes the visual properties of the video frames. This descriptor is obtained by mapping the original low-level visual features to a more discriminative descriptor using possibilistic memberships. This mapping can be summarized in two main phases. The first one consists in categorizing the low-level visual features of the video frames arid generating homogeneous clusters in an unsupervised way. The second phase uses the obtained membership degrees generated by the clustering process to compute the membership based histogram descriptor （MHD）. For the testing stage, the proposed fall detection approach categorizes unlabeled videos as ＂Fall＂ or ＂Non-Fall＂ scene using a possibilistic K-nearest neighbors classifier. The proposed approach is assessed using standard videos dataset that simulates patient fall. Also, we compare its performance with that of state-of-the-art fall detection techniques.

关键词： fall detection possibilistic approach feature extraction clustering

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Induction of sub-G0 arrest and apoptosis by seed extract of Moringa peregrina（Forssk.） Fiori in cervical and prostate cancer cell lines

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Journal of Integrative Medicine 2019年第6期17卷 410-422页

作者： Maged mohamed maher Abou-Hashem Dina mohamed Abo-elmatty Noha Mostafa Mesbah Ahmed mohamed Abd EL-Mawgoud Faculty of Pharmacy Pharmacognosy DepartmentZagazig UniversityZagazig 44511Egypt Faculty of Pharmacy Biochemistry DepartmentSuez Canal UniversityIsmailia 41522Egypt Egyptian International Pharmaceuticals Industries Company Tenth of Ramadan City 44629Egypt

Objective: This study investigated cytotoxicity and induction of apoptosis in human cervical cancer cells(HELA) and prostate cancer cells(PC-3) using the most active fraction of Moringa peregrina seed ***: Dried and powdered seeds were extracted using 95% ethanol. The total ethanolic extract was further dissolved in distilled water and separated into petroleum ether, chloroform, ethyl acetate and aqueous extracts. Based on the results of in vitro anticancer studies of all extracts, the most highly active extract was selected for evaluation of apoptosis induction and cell cycle analysis on HELA and PC-3 cells at its half maximal inhibitory concentration using flow cytometry;DNA fragmentation by agarose gel electrophoresis and the expression of protein were measured by Western ***: The chloroform fraction from the ethanolic extract of M. peregrina(CFEE) was the most active antitumor fraction. The selectivity index, determined using the normal Vero cell line, indicated that CFEE had a high degree of selectivity against HELA and PC-3 cells. CFEE induced apoptosis, confirmed by cell cycle arrest at sub-G0 phase and DNA fragmentation. CFEE induced an increase in mRNA expression of caspase-3, a decrease in Bcl-2 mRNA expression, and decreased ATP levels. CFEE increased protein expression of caspase-3 and decreased protein expression of poly-ADP-ribose polymerase-1(PARP-1).Flow cytometric analysis showed an appreciable increase in the number of cells in the early apoptotic stage in CFEE-treated HELA and PC-3 cells. CFEE treatment significantly increased lipid peroxidation(malondialdehyde level) in HELA and PC-3 ***: Seed extract of M. peregrina displayed a significant antitumor effect through apoptosis induction in HELA and PC-3 cells.

关键词： Moringa peregrina Fractionation Antiproliferation Apoptosis

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SOX9 in biliary atresia: New insight for fibrosis progression

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Hepatobiliary & Pancreatic Diseases International 2021年第2期20卷 154-162页

作者： Hanaa Ahmed El-Araby Magdy Anwar Saber Noha mohamed Radwan Doha maher Taie Nermin mohamed Adawy Ahmad mohamed Sira Department of Pediatric Hepatology Gastroenterologyand NutritionNational Liver InstituteMenoufia University32511 Shebin El-koomMenoufiaEgypt Department of Pathology National Liver InstituteMenoufia University32511 Shebin El-koomMenoufiaEgypt

Background:Liver fibrosis is a hallmark determinant of morbidity in biliary atresia(BA)even in successfully operated *** factors for this rapid progression of fibrosis are not completely *** expression of the transcription factor SOX9 and hepatic progenitor cells(HPCs)proliferation have roles in fibrogenesis in cholestatic ***,they were not investigated sufficiently in *** aimed to delineate the relation of SOX9 and HPCs to fibrosis and its progression in ***:Forty-eight patients with BA who underwent an initial diagnostic liver biopsy(LB)and consequent intraoperative LB were recruited and compared to 28 cases with non-BA cholestasis that had an LB in their diagnostic *** fibrosis,tissue SOX9 and HPC expressions were studied in both BA and non-BA-cholestasis *** fibrosis,SOX9,and HPCs’dynamic changes in BA cases were *** of fibrosis and its progression to SOX9 and HPCs in BA was ***:SOX9 and HPCs in ductular reaction(DR)form were expressed in 100%of BA and their grades increased significantly in the second *** rapidly progressive fibrosis in BA,represented by fibrosis grade of the intraoperative LB,correlated significantly to SOX9-DR and HPC-DR at the diagnostic(r=0.420,P=0.003 and r=0.405,P=0.004,respectively)and the intraoperative(r=0.460,P=0.001 and r=0.467,P=0.001,respectively)*** the other hand,fibrosis,SOX9-DR,and HPC-DR were significantly lower in non-BA cases at a comparable age(P<0.001,P=0.006,and P=0.014,respectively).Conclusions:Fibrosis in BA is rapidly progressive within a short time and is significantly correlated to SOX9 and *** of targeting SOX9 and HPCs on fibrosis progression is warranted.

关键词： Biliary atresia Fibrosis Hepatic progenitor cells Immunohistochemistry Neonatal cholestasis SOX9

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Benefiting others and self: Production of vitamins in plants

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Journal of Integrative Plant Biology 2021年第1期63卷 210-227页

作者： Yufei Li Chenkun Yang Hasan Ahmad mohamed maher Chuanying Fang Jie Luo National Key Laboratory of Crop Genetic Improvement and National Center of Plant Gene Research(Wuhan) Huazhong Agricultural UniversityWuhan 430070China College of Tropical Crops Hainan UniversityHaikou 570228China

Vitamins maintain growth and development in humans, animals, and plants. Because plants serve as essential producers of vitamins, increasing the vitamin contents in plants has become a goal of crop breeding worldwide. Here, we begin with a summary of the functions of vitamins. We then review the achievements to date in elucidating the molecular mechanisms underlying how vitamins are synthesized, transported, and regulated in plants. We also stress the exploration of variation in vitamins by the use of forward genetic approaches, such as quantitative trait locus mapping and genome-wide association studies. Overall, we conclude that exploring the diversity of vitamins could provide new insights into plant metabolism and crop breeding.

关键词： crop breeding forward genetic plants vitamins

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Image Based Smoke Detection Using Source Separation

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光谱学与光谱分析 2019年第3期39卷 982-989页

作者： Ouiem Bchir mohamed maher Ben Ismail Norah Asiri Computer Science Department College of Computer and Information SciencesKing Saud University

In this paper, we propose an automatic image based smoke detection using source separation. In particular, we assume that the region of interest(smoke region) is a linear combination of smoke and background pixels, and we estimate the smoke component. More specifically, we extend the linear hyperspectral unmixing techniques to the context of image based smoke detection in order to separate the smoke component from the background. The proposed approach yields promising results especially with smoke images captured outdoor.

关键词： Pattern recognition Computer science Hyperspectral

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Novel markers of endothelial dysfunction in hepatitis C virus-related cirrhosis: More than a mere prediction of esophageal varices

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World Journal of Hepatology 2020年第10期12卷 850-862页

作者： Amr Shaaban Hanafy mohamed Abdel Khalik Basha Fady maher Wadea Department of Internal Medicine Gastroenterology and Hepatology DivisionZagazig University HospitalZagazig 44519Egypt Department of Diagnostic Radiology Zagazig UniversityZagazig 44519Egypt

BACKGROUND Hepatitis C virus(HCV)infection may affect lipid metabolism by enhancing the circulating levels of inflammatory cytokines,together with its impact on endothelial *** To evaluate the potential correlation of changes in lipid profile,carotid intimamedia thickness(CIMT),and ankle-brachial index with the severity of fibrosis,grades of esophageal varices(EVs),and fibrosis *** The study included 240 subjects who were divided into 3 groups;group 1(n=90,HCV-related cirrhotic patients with EVs),group 2(n=90,HCV-related cirrhotic patients without EVs),and group 3(n=60,served as the healthy control group).All patients underwent routine laboratory tests,including a lipid profile ***-density lipoproteins(LDL)/platelet count and platelet/splenic diameter ratios were *** ultrasonography,CIMT by carotid Doppler,bedside ankle-brachial index(ABI),liver stiffness measurement,and upper gastrointestinal endoscopy were *** Multivariate logistic regression revealed that very-low-density lipoprotein(VLDL)(β=0.988,odds ratio 2.5,P=0.001),LDL/platelet count ratio(β=1.178,odds ratio 3.24,P=0.001),CIMT(β=1.37,odds ratio 3.9,P=0.001),and ABI(β=2.3,odds ratio 5.9,P=0.001)were the key variables associated with significant fibrosis,EVs and endothelial *** and LDL/platelet count ratio were predictive of advanced fibrosis and EVs at cutoff values of 1.1 mm and 1 mm,respectively,with an area under the curve(AUC)of 0.966 and 0.960(P=0.001),while VLDL and ABI at a cutoff of 16.5 mg/dL and 0.94 were predictive of advanced fibrosis and EVs with an AUC of 0.891 and 0.823,respectively(P=0.001).CONCLUSION CIMT,ABI,VLDL,LDL/platelet count ratio are good non-invasive predictors of advanced fibrosis,presence of EVs,and endothelial dysfunction in liver cirrhosis.

关键词： Lipid profile Liver cirrhosis Esophageal varices Carotid-intima media thickness Ankle-brachial index

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Bitter gourd extract improves glucose homeostasis and lipid profile via enhancing insulin signaling in the liver and skeletal muscles of diabetic rats

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Asian Pacific Journal of Tropical Biomedicine 2021年第8期11卷 344-352页

作者： Saber mohamed Eweda Mennatallah Ahmed Ali Hala mohamed Abd El-Bary Nahed Hussein El-Sokkary Madiha Hassan Helmy maher Abdel-Nabi Kamel Department of Biochemistry Faculty of ScienceAlexandria UniversityAlexandriaEgypt Department of Pharmacology&Therapeutics Faculty of Pharmacy and Drug ManufacturingPharos University in AlexandriaAlexandriaEgypt Department of Biochemistry Medical Research InstituteAlexandria UniversityAlexandriaEgypt Department of Physiology Faculty of MedicineAlexandria UniversityAlexandriaEgypt Medical Laboratories Technology College of Applied Medical SciencesTaibah UniversityMadinahKSA

Objective:To investigate the modulatory effects of bitter gourd extract on the insulin signaling pathway in the liver and skeletal muscle tissues of diabetic ***:The ethanolic extract of bitter gourd was prepared and its contents of total polyphenols and flavonoids were assayed.A neonatal streptozotocin-induced diabetic rat model was established and the diabetic rats were assigned into different groups and were treated with different doses of bitter gourd extract(100,200,400,or 600 mg/kg)or with glibenclamide(0.1 mg/kg)for 30 *** blood glucose,insulin,and lipid profile were evaluated and the insulin signaling pathway in the liver and skeletal muscle of rats was *** correlations between homeostasis model assessment(HOMA)and the components of insulin signaling pathway were also ***:Different doses of bitter gourd extract significantly ameliorated fasting blood glucose level and HOMA index for insulin ***,bitter gourd extract increased serum insulin and improved disrupted serum lipid *** levels of insulin receptor substrate-1(IRS-1),p-insulin receptorβ(p-IR-β),protein kinase C(PKC),GLUT2,and GLUT4 were improved by treatment with bitter gourd *** best results were obtained with 400 mg/kg dose of the extract,the effect of which was equivalent to that of *** in the bitter gourd treated rats was negatively correlated with p-IR-β,IRS-1 and PKC in hepatic and skeletal *** was also negatively correlated with skeletal muscle ***:Bitter gourd extract improves glucose homeostasis and lipid profile in diabetic rats via enhancement of insulin secretion and ***,bitter gourd can be used as a potential pharmacological agent for the treatment of type 2 diabetes mellitus.

关键词： Neonatal Streptozotocin Diabetic Sulfonylurea Bitter gourd Phosphorylated insulin receptor Protein kinase C IRS-1 GLUT2/GLUT4 Insulin signaling

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