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Monitoring of the Physico-Chemical Parameters of the Waters of Lake Sonfonia,Municipality of Ratoma(Republic of Guinea)2021

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Journal of Environmental Science and Engineering(B) 2023年第3期12卷 105-114页

作者： mohamed lamine Komara Adama Moussa sacko Aboubacar Diallo Cheick Ahmed Tawel camara Mamadou Kabirou Bah Teacher-Researcher Department of Biology Gamal Abdel Nasser University of Conakry Republic of Guinea Laboratory technique Higher Institute of Technology of MamouRepublic of Guinea DGA-Research/ISAU Conakry 324 Republic of Guinea Director of the Biochemistry degree program at Gamal Abdel Nasser University of Conakry Republic of Guinea Center for Environmental Studies and Research(CERE) Conakry 324 Republic of Guinea

As part of the determination of the possible impact of human activities on surface waters, case of Lake Sonfonia, six sampling sites were selected according to their solicitation by the population and their exposure to probable sources of pollution. The objective of this work is to monitor the physico-chemical quality of the waters of Lake Sonfonia during the low water level (March) and during the flood period (August) of the year 2021. Two sampling campaigns of water were carried out in dry weather and two others in cold weather. Parameters such as temperature, pH, EC (Electrical Conductivity), dissolved oxygen, TDS (Total Dissolved Solids) were measured in situ. Suspended matter, phosphate, nitrate, nitrite, sulphates, total iron, COD (Chemical Oxygen Demand) were measured in the laboratory by the colorimetric method. Stata 15 software was applied for the statistical analysis of the data and the correlation test between the parameters gave highly significant correlations. It has been noted that the situation is not very good and that this pollution comes mainly from human activities.

关键词： Surface water physico-chemical parameters Lake Sonfonia anthropogenic eutrophication.

Transient Diabetes Induced by L-Asparaginase

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Open Journal of Pediatrics 2023年第6期13卷 862-865页

作者： Mamadou Moustapha Diop M’mah Aminata Bangoura Aissata Barry Emmanuel camara Kolié Ouo Ouo Pé Neabei Beimy mohamed lamine Diallo Kaba Bangoura Moustapha Kouyate mohamed lamine Kaba Aka Nbga Department of Paediatrics Faculty of Health Sciences and Techniques Gamal Abdel Nasser University Conakry Republic of Guinea Urgence Pédiatrique CHU Donka Ministère de l’enseignement de la recherche scientifique et de l’innovation Conakry Republic of Guinea Haemodialysis Department CHU Donka Ministry of Education Scientific Research and Innovation Conakry Republic of Guinea

Background: Although hyperglycaemia is one of the known side effects of L-asparaginase, its contribution to the development of diabetic ketoacidosis (DKA) is less well known in the literature. Asparaginase is an essential component of treatment protocols for acute lymphoblastic leukaemia (ALL) in combination with other chemotherapeutic drugs. On further evaluation, she was found to have high anion gap metabolic acidosis, hyperglycaemia and ketonuria. In recent decades, the use of these chemotherapeutic agents has led to a decrease in mortality and disease-free survival in ALL. L-asparaginase is one of the chemotherapy protocols used in the treatment of acute lymphoblastic leukaemia (ALL) and can induce hyperglycaemia which is aggravated by the concomitant use of corticosteroids. We report the observation of a 14-year-old girl treated with chemotherapy (GFA LAL protocol) who developed transient diabetes following the use of L-asparaginase. She was treated at the Donka paediatric haemato-oncology unit by a multidisciplinary team including a paediatric oncologist, a psychologist and a diabetologist. The aim of this study was to highlight blood glucose monitoring before and after the use of asparaginase in acute lymphoblastic leukaemia. Conclusion: We conclude that the occurrence of ketoacidosis following the use of asparaginase is a rare event. We recommend close monitoring of blood glucose levels for hyperglycaemia in patients with ALL receiving L-asparaginase.

关键词： Asparaginase Diabetes ALL Donka

Acute Alithiasis Cholecystitis in Children: Diagnostic and Therapeutic Approach in the Pediatric Surgery Department of the CHU of Conakry

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Open Journal of Pediatrics 2023年第1期13卷 86-91页

作者： Balla Keita Mamadou Alpha Toure mohamed lamine Sadou sacko Thierno Saidou Barry mohamed lamine Diallo Mamadou Madiou Barry Daniel Agbo-Panzo Department of Pediatric Surgery National Hospital of Donka/CHU Conakry Guinea Faculty of Science and Technology University Gamal Abdel Nasser of Conakry Conakry Guinea

Acute alithiasic cholecystitis (AAC) is the inflammatory disease of the gallbladder in the absence of gallstones. It is a rare pathology in children. The aim was to describe the clinical, diagnostic and therapeutic characteristics of this disease. Materials and Method: This was a 3-year retrospective study (January 2008 to December 2010) including 66 patient records collected for CAA. Results: The frequency of AAC was 3.57%, the mean age of the patients was 8 ± 3.52 years, and there were 36 boys and 30 girls. The main clinical features were right hypochondrial pain (66 cases), positive Murphy’s (66 cases), fever (53 cases) and jaundice or sub-jaundice (51 cases). The main ultrasound signs were thickened vesicular wall 50 cas (75.76%), vesicular distension 50cas (75.76%) and positive ultrasound Murphy 47 cas (71.21%). Medical treatment was exclusive in 64 patients (96.97%) and surgical treatment in 2 patients (3.03%). Conclusion: Acute alithiasic cholecystitis is a rare pathology in children, the clinical picture is not very specific and abdominal ultrasound is the key to early diagnosis. Conservative treatment is the first choice in the absence of any complications.

关键词： Acute Alithiasic Cholecystitis Children Medical Treatment

Open Fractures of Limbs by the Bite of Domestic Donkeys: An Unusual Aetiology

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Open Journal of Orthopedics 2022年第12期12卷 485-492页

作者： mohamed Sidibé mohamed lamine Bah Fodé Mahamoud Sylla Tafsir camara Serge Ntungwanayo Orthopedic-Traumatology Department of the Tambacounda Regional Hospital Tambacounda Senegal Orthopedic-Traumatology Department of the Ignace Deen National Hospital in the Republic of Guinea Conakry Guinea

Introduction: The aim of this study is to describe the epidemiological, lesional, therapeutic and evolutionary profile of open fractures of limbs by bites of domestic donkeys. Patients and Methods: This is a prospective descriptive study over 28 months made in the Orthopedics-Traumatology department of the Tambacounda Regional Hospital in Senegal, concerning patients bitten by donkeys, resulting in an open fracture of the thoracic and pelvic limbs. Results: Twelve male patients were included. The average age was 10.50 years ± 2.60. The most common circumstance was the bite when two donkeys were separated. The thoracic limbs were the most affected by the occurrence of the arm. Cauchoix-Duparc type II and AO A2 and B2 were predominant. The essential trimming/osteosynthesis was carried out within 24 hours of the bite. Serovaccination was systematic, but on the other hand, a single dose of anti-rabies serum was administered. Pinning was the most commonly used bone synthesis. Complications were mainly infectious, followed by a case of radial nerve palsy and non-union on pins. Conclusion: The typical profile of an open donkey bite fracture is a male child/adolescent who is bitten during the separation of two fighting donkeys. The lesions are most often found in the thoracic limbs with a predominance of Cauchoix-Duparc type II and type A2 and B2 fractures of the AO, whose treatment consisted of trimming and pinning. The infectious complications of the soft tissues marked the evolution.

关键词： Open Fractures Limbs Bite Donkeys

Cerebral Malaria: Epidemiological, Clinical and Prognosis Aspects in the Anesthesia-Resuscitation Department CHU Ignace Deen

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Open Journal of Emergency Medicine 2023年第4期11卷 162-173页

作者： Abdoulaye Touré Amadou Yalla camara Almamy Bangoura M’mah lamine camara mohamed Soumah Saramba Nabe Department of Anesthesia-Resuscitation University Hospital of Ignace Deen of Conakry Conakry Guinea Department of Medical and Surgical Emergency Donka University Hospital Conakry Guinea Department of Anesthesia-Resuscitation Donka University Hospital Conakry Guinea

Objective: To describe the epidemiological, clinical, paraclinical and prognostic aspects of cerebral malaria received in the anesthesia-resuscitation department. Methodology: This was a prospective descriptive type study carried out in the anesthesia-resuscitation department over a period of three (03) months (June 01 to August 31, 2022). All patients admitted for cerebral malaria were included. Sociodemographic, clinical and prognostic parameters were studied. Results: We collected 25 cases out of 105 admitted patients (23.8%). The average age was 27.6 ± 9.5 years with extremes of 11 and 50 years. The sex ratio was 0.7 (M/F). Students and housewives were in the majority, i.e. 52% and 24%. Neurological disorders were found on admission in all patients, dominated by impaired consciousness at 100% followed by convulsion (60%), prostration (44%), confusion (36%) associated with deep coma in (68%). Gross hemoglobinuria was present in (84%) of cases. On the blood count, anemia was present in (70%) of the patients followed by thrombocytopenia in more than half of the cases (60%) and transfusion was necessary in 19 cases. P Falciparum malaria was found in all patients (100%), the average parasite density was 60342.8 ± 30425.6 trophozoites/μl with extremes of 9000 to 100000 trophozoites/μl. All our patients were treated with intravenous injectable artesunate. Transfusion was performed in 76% of our patients. Eighty percent of the patients had benefited from dialysis. High oxygen therapy was performed in (92%) of cases. The average duration of hospitalization was 5.74 ± days with extremes of 1 to 17 days. Mortality was 48%. Conclusion: Cerebral malaria can take different clinical forms, the most important of which is cerebral involvement. Prompt initiation of appropriate resuscitation can reduce mortality.

关键词： Cerebral Malaria Mortality Resuscitation

Giant Cell Tumor of the Proximal Phalanx of the Little Finger about One Case in Our Milieu

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Open Journal of Orthopedics 2022年第8期12卷 345-350页

作者： mohamed Sidibé mohamed lamine Bah Fodé Mahamoud Sylla Minkailou camara Alhassane Soumah Serge Ntungwanayo Orthopedic-Traumatology Department of the Tambacounda Regional Hospital Tambacounda Senegal Orthopedic-Traumatology Department of the Ignace Deen National Hospital Conakry Republic of Guinea

Giant cell tumor is a benign primary bone tumor. The phalangeal localization is rare. It is distinguished from other locations by the local aggressiveness of the tumor and a high rate of recurrence. We report one case of a 25-year-old right-handed nurse with no reported pathological history who complained about an ulcero-budding mass of the right little finger evolving one year ago. She would have initially consulted a bonesetter who would have taken care of her by using decoctions. The hand X-ray showed an osteolytic tumor of the first phalanx of the right little finger with a “honeycomb” appearance invading the soft tissues. We carried out the amputation of the radius. The postoperative course was simple with healing of the surgical wound and disappearance of the axillary adenopathy. The surgical specimen after anatomopathology exam concluded to be a grade 2 giant cell tumor of Senerkin.

关键词： Giant Cell Tumor Phalanx Little Finger Amputation of the Radius

Familial Lateral Sclerosis with Juvenile Onset: About 3 Cases and Review of the Literature

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生物科学与医学(英文) 2023年第10期11卷 55-62页

作者： camara Mamady Barry Souleymane Djigué Dore Male Toure mohamed lamine Diallo mohamed Tafsir Toure Laïla Youla Seny Konate Ibrahimasory Barry Louceny Fatoumata camara mohamed Salif camara Idrissa Doumbouya Idrissa Djibo Hamani Bachir Conde mohamed lamine Cisse Fodé Abass Department of Neurology Ignace Deen National Hospital Conakry University Hospital Conakry Guinea

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease deadly. In Africa, little data exists on this condition and the form familial is the most common with a younger age of onset. Our observations relate to three brothers, born from a consanguineous marriage. The diagnosis of amyotrophic lateral sclerosis was certain placed in all patients according to the criteria of Awaji. The average age of patients was 16.66 years, and the average age of onset of symptoms was 10.33 years old. The female gender was the most represented with a sex ratio of 0.5. Our patients benefited from rilusole, vitamin D and physiotherapy. A only patient presented with dysphagia. However, no cases have been observed at this day.

关键词： ALS Familial Juvenile

Uterovaginal Prolapse in the Newborn: A Case Report from the University Hospital of Conakry

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Open Journal of Pediatrics 2023年第1期13卷 69-73页

作者： Balla Keita sacko mohamed lamine Sadou Toure Mamadou Alpha Barry Thierno Saidou Barry Mamadou Madiou Agbo-Panzo Daniel Pediatric Surgery Department Donka University Hospital Conakry Guinea Gamal Abdel Nasser University of Conaky Conakry Guinea

Uterovaginal prolapse is an exceptional pathology in the newborn. It is defined by the descent and protrusion of the uterus and vaginal walls to the outside via the vaginal orifice. It particularly affects newborns with neural tube defects. The diagnosis is usually made at birth. Different types of conservative or surgical treatment have been suggested for genital prolapse in neonates. We report the case of a newborn of 6 hours of life who was received for congenital utero-vaginal without neural tube closure anomaly. He was successfully treated with digital reduction of the mass associated with a cerclage of the vaginal orifice. Conclusion: Digital reduction of the prolapse associated with a cerclage of the vaginal orifice is simple, effective and avoids any recurrence.

关键词： Newborn Utero-Vaginal Prolapsed Congenital

Case Report for Two Hemodialysed Patients Diagnosed for COVID-19 at the Donka National Hemodialysis Center

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Open Journal of Nephrology 2020年第3期10卷 241-244页

作者： Mamadou Saliou Baldé Abdoulaye Touré Amadou Yalla camara Joseph Donamou Aly Traoré Boubacar Atigou Drame M’mah lamine camara Almamy Bangoura Mariam mohamed camara mohamed lamine Kaba Department of Nephrology-Hemodialysis Hospital National Donka Conakry Guinea Department of Reanimation Hospital Ignace Deen Conakry Guinea Department of Reanimation Hospital National Donka Conakry Guinea

In December 2019, coronavirus disease (COVID-19) due to infection with the novel SARS-CoV-2 virus began to break out. Hemodialysis patients are at high risk because of the co-morbidities. We report the clinical and biological characteristics of two patients who developed COVID-19 infection in our dialysis center in Donka National Hospital. None of the patients had contact with an infected person. The age was 38 and 54 years. The symptoms common to both patients were: fatigue, diarrhea, fever. Lymphopenia was present in both patients. None of them had a chest X-ray or chest scan because they were positive for the test before admission.

关键词： Hemodialysis COVID-19 Coronavirus Donka