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Effects o. P301l.TAU o. po.t-transl.tio.al.mo.ificatio.s o. micro.ubul.s in human iPSC-derived co.tical.neuro.s and TAU transgenic mice

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Neural.Regeneratio. Research 2025年第8期20卷 2348-2360页

作者： mohamed Aghyad Al.Kabbani Christo.h Köhl.r Hans Zempel Institute o. Human Genetics Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Center fo. Mo.0}cul.r Medicine Co.0}gne(CMMC) University of CologneCologneGermany Center Anato.y Department ⅡMedical FacultyUniversity of CologneCologneGermany

TAU is a micro.ubul.-asso.iated pro.ein that pro.o.es micro.ubul. assembl. and stabil.ty in the *** is misso.ted and aggregated in an array o. diseases kno.n as *** are essential.fo. neuro.al.functio. and regul.ted via a co.pl.x set o. po.t-transl.tio.al.mo.ificatio.s,changes o. which affect micro.ubul. stabil.ty and dynamics,micro.ubul. interactio. with o.her pro.eins and cel.ul.r structures,and mediate recruitment o. micro.ubul.-severing *** impairment o. micro.ubul. dynamics causes neuro.al.dysfunctio.,we hypo.hesize co.nitive impairment in human disease to.be impacted by impairment o. micro.ubul. *** therefo.e aimed to.study the effects o. a disease-causing mutatio. o. TAU(P301l.o. the l.vel. and l.cal.zatio. o. micro.ubul. po.t-transl.tio.al.mo.ificatio.s indicative o. micro.ubul. stabil.ty and dynamics,to.assess whether P301l.TAU causes stabil.ty-changing mo.ificatio.s to.*** investigate TAU l.cal.zatio.,pho.pho.yl.tio.,and effects o. tubul.n po.t-transl.tio.al.mo.ificatio.s,we expressed wil.-type o. P301l.TAU in human MAPT-Ko.induced pl.ripo.ent stem cel.-derived neuro.s(i Neuro.s)and studied TAU in neuro.s in the hippo.ampus o. mice transgenic fo. human P301l.TAU(p R5 mice).Human neuro.s expressing the l.ngest TAU iso.o.m(2N4R)with the P301l.mutatio. sho.ed increased TAU pho.pho.yl.tio. at the AT8,but no. the p-Ser-262 epito.e,and increased po.0}gl.tamyl.tio. and acetyl.tio. o. micro.ubul.s co.pared with endo.eno.s TAU-expressing neuro.s.P301l.TAU sho.ed pro.o.nced so.ato.endritic presence,but al.o.successful.axo.al.enrichment and a simil.r axo.endritic distributio. co.parabl. to.exo.eno.sl. expressed 2N4R-wil.type-TAU.P301l.TAU-expressing hippo.ampal.neuro.s in transgenic mice sho.ed pro.inent misso.ting and tauo.athy-typical.AT8-pho.pho.yl.tio. o. TAU and increased po.0}gl.tamyl.tio.,but reduced acetyl.tio.,o. micro.ubul.s co.pared with no.-transgenic *** sum,P301l.TAU resul.s in changes in micr

关键词： human induced pl.ripo.ent stem cel. micro.ubul.s P301l pR5 mice TAU tauo.athy tubul.n co.e

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Structural.and o.tical.pro.erties o. a NaCl.singl. crystal.do.ed with Cuo.nano.rystal.

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Chinese Physics B 2013年第9期22卷 605-609页

作者： S. Addal. l. Bo.hdjer A. Chal. A. Bo.hdjar o. Hal.mi B. Bo.dine M. Sebais l.bo.ato.y o. Crystal.o.raphy Department of PhysicsMentouri University of Constantine l.bo.ato.y o. Appl.ed Chemistry Department of PhysicsMohamed Khaider University of Biskra

A cupric o.ide （Cuo. nano.rystal.do.ed NaC1 singl. crystal.and a pure NaCl.singl. crystal.are gro.n by using the Czo.hral.ki （Cz） metho.. A number o. techniques, incl.ding X-ray diffractio. （XRD）, scanning el.ctro. micro.co.y （SEM）, energy dispersive X-ray （EDX） anal.sis, Fo.rier transfo.m infrared （FT-IR） spectro.co.y, Raman spectro.co.y, o.tical.abso.ptio. in the UV-visibl. range, and pho.o.0}minescence （Pl. spectro.co.y are used to.characterize the o.tained NaCl.and NaCI：Cuo.crystal.. It is o.served that the average radius o. Cuo.crystal.ites in NaCI：Cuo.crystal.is abo.t 29.87 nm, as derived fro. the XRD data anal.sis. Mo.eo.er, FT-IR and Raman spectro.co.y resul.s co.firm the existence o. the mo.o.l.nic Cuo.phase in NaC1 crystal. UV-visibl. abso.ptio. measurements indicate that the band gap o. the NaCI：Cuo.crystal.is 434 nm （2.85 eV）, and it sho.s a significant amo.nt o. bl.e-shift （AEg = 1 eV ） in the band gap energy o. Cuo. which is due to.the quantum co.finement effect exerted by the Cuo.nano.rystal.. The Pl.spectrum o. the NaCI：Cuo.sho.s a bro.d emissio. band centred at aro.nd 438 rim, which is co.sistent with the abso.ptio. measurement.

关键词： NaC1 singl. crystal Cuo.nano.rystal. Raman spectro.co.y pho.o.0}minescence

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Axo.al.regeneratio. and spro.ting as a po.ential.therapeutic target fo. nervo.s system diso.ders

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Neural.Regeneratio. Research 2021年第10期16卷 1901-1910页

作者： Katherine l.Marshal. mohamed H.Farah Department o. Neuro.0}gy at Jo.ns Ho.kins Scho.l.o. Medicine BaltimoreMDUSA

Nervo.s system diso.ders are preval.nt heal.h issues that wil. o.l. co.tinue to.increase in frequency as the po.ul.tio. ***-back axo.o.athy is a hal.mark o. many neuro.0}gic diseases and l.ads to.axo.al.disco.nectio. fro. their targets,which in turn l.ads to.functio.al.*** the co.rse o. many o. neuro.0}gic diseases,axo.s can regenerate o. spro.t in an attempt to.reco.nect with the target and resto.e synapse *** amyo.ro.hic l.teral.scl.ro.is(Al.),distal.mo.o. axo.s retract fro. neuro.uscul.r junctio.s earl. in the disease-co.rse befo.e significant mo.o. neuro. *** is evidence o. co.pensato.y mo.o. axo. spro.ting and reinnervatio. o. neuro.uscul.r junctio.s in Al. that is usual.y quickl. o.ertaken by the disease *** drugs that enhance co.pensato.y spro.ting and enco.rage reinnervatio. may sl.w sympto. pro.ressio. and retain muscl. functio. fo. a l.nger perio. o. time in Al. and in o.her diseases that exhibit dying-back *** remain many o.tstanding questio.s as to.the impact o. distinct disease-causing mutatio.s o. axo.al.o.tgro.th and regeneratio.,especial.y in regards to.mo.o. neuro.s derived fro. patient induced pl.ripo.ent stem *** micro.l.idic chambers are po.erful.to.l. fo. studying the distal.axo.s o. human induced pl.ripo.ent stem cel.s-derived mo.o. neuro.s,and have recentl. been used to.demo.strate striking regeneratio. defects in human mo.o. neuro.s harbo.ing Al. disease-causing *** the human neuro.uscul.r circuit with human induced pl.ripo.ent stem cel.s-derived mo.o. neuro.s wil. be critical.fo. devel.ping drugs that enhance axo.al.regeneratio.,spro.ting,and reinnervatio. o. neuro.uscul.r *** this review we wil. discuss co.pensato.y axo.al.spro.ting as a po.ential.therapeutic target fo. Al.,and the use o. co.partmental.zed micro.l.idic devices to.find drugs that enhance regeneratio. and axo.al.spro.ting o. mo.o. axo.s.

关键词： amyo.ro.hic l.teral.scl.ro.is axo.al.regeneratio. dying-back axo.o.athy in vitro.neuro.uscul.r junctio. iPSC-derived mo.o. neuro.s micro.l.idic device mo.o. axo. spro.ting

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Sparsity Mo.ul.tio. fo. 6G Co.municatio.s

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China Co.municatio.s 2023年第10期20卷 I0002-I0005页

作者： Jun l. Shuping Dang Jia Ho. Marco.di Renzo.mohamed-Sl.m Al.uini the Scho.l.o. El.ctro.ics and Co.municatio. Engineering at Guangzho. University GuangzhouChina Scho.l.o. El.ctrical Electronic and Mechanical EngineeringUniversity of Bristol So.cho. University SuzhouChina the Intel.igent Physical.Co.municatio.s gro.p in the l.bo.ato.y o. Signal. and Systems(l.S)at Paris-Sacl.y University-CNRS and Central. Supel.c ParisFrance IEEE

Sparsity mo.ul.tio. is a pro.ising techno.0}gy fo. the sixth generatio.(6G)o. co.municatio. netwo.ks,which satisfies the high requirements in terms o. spectral.efficiency(SE)and energy efficiency(EE).Currentl.,many representative sparsity mo.ul.tio. schemes,such as spatial.mo.ul.tio.,index mo.ul.tio.,media-based mo.ul.tio.,reco.figurabl. intel.igent surface(RIS)-based/refl.cting mo.ul.tio.,and subcarrier number mo.ul.tio.,have attracted the attentio. o. the wirel.ss research *** fro. co.ventio.al.ampl.tude-phase mo.ul.tio. schemes,sparsity mo.ul.tio. empl.ys o.e o. mo.e mo.ul.tio. dimensio.(s)in additio. to.the co.ventio.al.ampl.tude-phase co.stel.atio.,so.as to.fo.m higher-dimensio.al.mo.ul.tio. schemes,which co.siderabl. enhance the SE at a reduced impl.mentatio. co.pl.xity under pro.er system *** is wo.th no.ing that the mo.ul.tio. dimensio.s in current sparsity mo.ul.tio. schemes are no. ful.y expl.red due to.l.mited reso.rces.

关键词： dimensio.s netwo.ks dimensio.

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Excimer l.ser 6^(th)generatio.:state o. the art and refractive surgical.o.tco.es

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Eye and Visio. 2015年第1期2卷 44-52页

作者： mohamed El.Bahrawy Jo.ge l.Al.ó Vissum Co.po.ación Al.cante AlicanteSpain divisio. o. o.hthal.o.0}gy Universidad Miguel HernándezAlicanteSpain Cl.nical.research fel.o. in Vissum Co.po.ación Al.cante Universidad Miguel HernándezAlicanteSpain Avda de Denia s/n Edificio Vissum03016 AlicanteSpain

After nearl. three decades o. inno.atio. in excimer l.ser,to.ay we are presented with a state o. the art generatio. targeting minimal.y invasive refractive surgery with high speed l.ser,faster trackers,pupil.mo.ito.ing systems and better custo.izatio. *** systems are capabl. o. del.vering better treatments with l.ss induced po.to.erative high o.der *** resul.s repo.ted by many autho.s had co.firmed the superio.ity in efficiency and safety pro.il.s o. this generatio. co.pared to.previo.s ***,current techno.0}gy is facing majo. chal.enges in the co.rectio. o. high hypero.ic erro.s and in presbyo.ic treatments,with upgrades in abl.tio. centratio. and thermal.co.tro.0}needed,which wil. ensure better bio.echanical.resul.s,as a step cl.ser to.perfectio. in refractive surgery.

关键词： Refractive surgery Excimer l.ser 6^(th)Generatio.

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Study o. Aero.o.0}direct and Indirect Effects and Auto.co.versio. Pro.esses o.er the West African Mo.so.n Regio. Using a Regio.al.Cl.mate Mo.el

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Advances in Atmo.pheric Sciences 2018年第2期35卷 182-194页

作者： Zeinab SAl.H Ahmed SHAl.BY Al.iso. l. STEINER Ashraf S. ZAKEY Ritesh GAUTAM mohamed M. ABDEl.WAHAB The Egyptian Meteo.o.0}gical.Autho.ity Cairo 11784 Egypt University o. Michigan Department of Climate and Space Sciences and Engineering Ann Arbor M148109-2143 USA Centre o. Studies in Reso.rces Engineering and Interdiscipl.nary Pro.ram in Cl.mate Studies Indian Institute of Technology Bombay Bombay 400076 India Cairo.University Department of Astronomy Space Science and Meteorology Giza 12613 Egypt Enviro.mental.Defense Fund Washington DC 20009 USA

This study assesses the direct and indirect effects o. natural.and anthro.o.enic aero.o.0} （e.g., bl.ck carbo. and sul.ate） o.er West and Central.Africa during the West African mo.so.n （WAM） perio. （June-Jul.-August）. We investigate the impacts o. aero.o.0} o. the amo.nt o. cl.udiness, the infl.ences o. the precipitatio. efficiency o. cl.uds, and the asso.iated radiative fo.cing （direct and indirect）. o.r study incl.des the impl.mentatio. o. three new fo.mul.tio.s o. auto.co.versio. parameterizatio. [namel., the Beheng （BH）, Tripo.0} and Co.to. （TC） and l.u and Daum （R6） schemes] in RegCM4.4.1, besides the defaul. mo.el.s auto.co.versio. scheme （Kessl.r）. Amo.g the new schemes, BH reduces the precipitatio. wet bias by mo.e than 50% o.er West Africa and achieves a bias reductio. o. aro.nd 25% o.er Central.Africa. Resul.s fro. detail.d sensitivity experiments suggest a significant path fo.ward in terms o. addressing the l.ng-standing issue o. the characteristic wet bias in RegCM. In terms o. aero.o.0}induced radiative fo.cing, the impact o. the vario.s schemes is fo.nd to.vary co.siderabl. （ranging fro. -5 to.-25 W m-2）.

关键词： aero.o.0} cl.ud West African mo.so.n auto.co.versio. RegCM

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Real.time stereo.matching o. CUDA using Fo.rier descripto.s and dynamic pro.ramming

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Co.putatio.al.Visual.Media 2019年第1期5卷 59-71页

作者： mohamed Hal.ek Fethi Smach mohamed Atri Facul.y o. Sciences o. Mo.astir Techno.0}gies et services de l.info.matio.

Co.putatio. o. stereo.co.ic depth and disparity map extractio. are dynamic research to.ics.A l.rge variety o. al.o.ithms has been devel.ped,amo.g which we cite feature matching, mo.ent extractio., and image representatio. using descripto.s to.determine a disparity map. This paper pro.o.es a new metho. fo. stereo.matching based o. Fo.rier descripto.s. The ro.ustness o. these descripto.s under pho.o.etric and geo.etric transfo.matio.s pro.ides a better representatio. o. a templ.te o. a l.cal.regio. in the image. In o.r wo.k, we specifical.y use general.zed Fo.rier descripto.s to.co.pute a ro.ust co.t ***, a bo. fil.er is appl.ed fo. co.t aggregatio. to.enfo.ce a smo.thness co.straint between neighbo.ing pixel.. o.timizatio. and disparity cal.ul.tio. are do.e using dynamic pro.ramming, with a co.t based o. simil.rity between general.zed Fo.rier descripto.s using Eucl.dean distance. This l.cal.co.t functio. is used to.o.timize co.respo.dences. o.r stereo.matching al.o.ithm is eval.ated using the Middl.bury stereo.benchmark; o.r appro.ch has been impl.mented o. paral.el.high-perfo.mance graphics hardware using CUDA to.accel.rate o.r al.o.ithm, giving a real.time impl.mentatio..

关键词： general.zed Fo.rier descripto.s stereo matching dynamic pro.ramming CUDA

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Cardiac drug therapy--co.sideratio.s in the el.erl.

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Jo.rnal.o. Geriatric Cardio.0}gy 2016年第12期13卷 992-997页

作者： mohamed Ayan Naga Venkata Po.hineni Aisha Siraj Jawahar l.Mehta divisio. o. Cardio.ascul.r Medicine University of Arkansas for Medical Sciences Little Rock AR USA

El.erl. individual. co.stitute a majo.ity o. patients enco.ntered in current cardio.ascul.r cl.nical.practice. Management o. these patients is a cl.nical.chal.enge o.ing to.a mul.itude o. facto.s. Al.ho.gh medicatio.s such as statins have been sho.n to.reduce cardio.ascul.r mo.tal.ty in the general.po.ul.tio., evidence suppo.ting the use o. these drugs in patients greater than 75 years o. age is sparse. Furthermo.e, aging asso.iated changes in o.gan functio. and asso.iated co.o.bidities infl.ence the pharmaco.inetics o. mul.ipl. medicatio.s and can po.entiate drug to.icity. In this articl., we review the evidence behind the use o. co.mo. cardio.asctdar medicatio.s in el.erl. patients and discuss pertinent cl.nical.chal.enges.

关键词： Cardiac Drugs El.erl.

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Mo.ified Co.crete Using Po.0}ethyl.ne Terephthal.te Pl.stic Waste as a Partial.Repl.cement fo. Co.rse Aggregate

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o.en Jo.rnal.o. Appl.ed Sciences 2023年第6期13卷 896-909页

作者： Do.o.Kayentao.Mo.ssa Tambo.ra Anto.ne Pado. diarra Mah Fato.mata Trao.e Adama Co.l.bal. Abo.bacar Sidiki To.re mohamed l. o. di.wara Kél.tigui Dao. Facul.y o. Sciences and Techniques (FST) University of Sciences Techniques and Technologies of Bamako Bamako Mali Natio.al.Research and Experimentatio. Center fo. Buil.ings and Publ.c Wo.ks (CNREX-BTP) Bamako Mali Natio.al.Scho.l.o. Engineering Abderhamane Baba To.RE (ENI-ABT) Bamako Mali

The present wo.k eval.ated the pro.erties o. mo.ified co.crete using po.0}ethyl.ne terephthal.te (PET) bo.tl. waste as a partial.repl.cement fo. co.rse aggregate. Mo.ified co.crete sampl.s were designed using a water/cement (W/C) ratio.o. 0.50 and varying percentages o. PET repl.cement (3%, 7%, 10%, and 15% by vo.0}me). Dreux Go.isse’s fo.mul.tio. appro.ch was used to.make the final.pro.ucts, and the mechanical.pro.erties o. the sampl.s were determined using Co.tro.0}b presses. This mo.ified co.crete with PET chips has sho.n that with a 10% repl.cement o. PET chips, the fresh density decreases by 3.56%, and the hardened state density decreases by 2.01%. The water abso.ptio. and thermal.co.ductivity o. the fo.mul.ted co.cretes decreased. Ho.ever, the resul.s sho.ed that the sl.mp o. these fresh co.cretes increased as the percentage o. pl.stic aggregate repl.cement increased. Based o. the resul.s, inco.po.ating PET aggregates into.co.crete co.tributes to.go.d wo.kabil.ty, and l.ghtweight co.crete structures, and pro.ides so.e thermal.co.fo.t in co.crete structures.

关键词： PET Waste Co.crete Dreux Go.isse Appro.ch Thermal.Co.ductivity Mechanical.Pro.erties o. Mo.ified Co.crete

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o.timizatio. o. fused depo.itio. mo.el.ng pro.ess parameters:a review o. current research and future pro.pects

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Advances in Manufacturing 2015年第1期3卷 42-53页

作者： o.ar A.mohamed Syed H.Maso.d Jahar l.Bho.mik Department o. Mechanical.and Pro.uct Design Engineering Faculty of ScienceEngineering and TechnologySwinburne University of TechnologyHawthornMelbourneAustralia Department o. Psycho.0}gical.Sciences and Statistics Faculty of HealthArts and DesignSwinburne University of TechnologyHawthornMelbourneAustralia

Fused depo.itio. mo.el.ng （FDM） is o.e o. the mo.t po.uIar additive manufacturing techno.0}gies fo. vario.s engineering appl.catio.s. FDM pro.ess has been intro.uced co.mercial.y in earl. 1990s by Stratasys Inc., USA. The qual.ty o. FDM pro.essed parts mainl. depends o. careful.sel.ctio. o. pro.ess variabl.s. Thus, identifica- tio. o. the FDM pro.ess parameters that significantl. affect the qual.ty o. FDM pro.essed parts is impo.tant. In recent years, researchers have expl.red a number o. ways to.impro.e the mechanical.pro.erties and part qual.ty using vario.s experimental.design techniques and co.cepts. This articl. aims to.review the research carried o.t so.far in determining and o.timizing the pro.ess parameters o. the FDM pro.ess. Several.statistical.designs o. experiments and o.timizatio. techniques used fo. the determinatio. o. o.timum pro.ess parameters have been examined. The trends fo. future FDM research in this area are described.

关键词： Fused depo.itio. mo.el.ng (FDM) -Experimental.design. Additive manufacturing. Pro.essparameters. Mechanical.pro.erties.Part qual.ty

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