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An Enhanced Lung Cancer Detection Approach Using Dual-Model Deep Learning Technique

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 835-867页

作者： Sumaia mohamed elhassan Saad mohamed Darwish Saleh Mesbah elkaffas Department of Information Technology Institute of Graduate Studies and ResearchAlexandria UniversityAlexandria21526Egypt College of Computing and Information Technology Arab Academy for ScienceTechnology and Maritime TransportAlexandriaP.O.Box 1029Egypt

Lung cancer continues to be a leading cause of cancer-related deaths worldwide,emphasizing the critical need for improved diagnostic *** detection of lung tumors significantly increases the chances of successful treatment and ***,current diagnostic methods often fail to detect tumors at an early stage or to accurately pinpoint their location within the lung ***-model deep learning technologies for lung cancer detection,while beneficial,cannot capture the full range of features present in medical imaging data,leading to incomplete or inaccurate ***,it may not be robust enough to handle the wide variability in medical images due to different imaging conditions,patient anatomy,and tumor *** overcome these disadvantages,dual-model or multi-model approaches can be *** research focuses on enhancing the detection of lung cancer by utilizing a combination of two learning models:a Convolutional Neural Network(CNN)for categorization and the You Only Look Once(YOLOv8)architecture for real-time identification and pinpointing of *** automatically learn to extract hierarchical features from raw image data,capturing patterns such as edges,textures,and complex structures that are crucial for identifying lung ***8 incorporates multiscale feature extraction,enabling the detection of tumors of varying sizes and scales within a single *** is particularly beneficial for identifying small or irregularly shaped tumors that may be challenging to ***,through the utilization of cutting-edge data augmentation methods,such as Deep Convolutional Generative Adversarial Networks(DCGAN),the suggested approach can handle the issue of limited data and boost the models’ability to learn from diverse and comprehensive *** combined method not only improved accuracy and localization but also ensured efficient real-time processing,which is crucial for practical clinical applicati

关键词： Lung cancer detection dual-model deep learning technique data augmentation CNN YOLOv8

Effects of P301L-TAU on post-translational modifications of microtubules in human iPSC-derived cortical neurons and TAU transgenic mice

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Neural Regeneration Research 2025年第8期20卷 2348-2360页

作者： mohamed Aghyad Al Kabbani Christoph Köhler Hans Zempel Institute of Human Genetics Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Center for Molecular Medicine Cologne(CMMC) University of CologneCologneGermany Center Anatomy Department ⅡMedical FacultyUniversity of CologneCologneGermany

TAU is a microtubule-associated protein that promotes microtubule assembly and stability in the *** is missorted and aggregated in an array of diseases known as *** are essential for neuronal function and regulated via a complex set of post-translational modifications,changes of which affect microtubule stability and dynamics,microtubule interaction with other proteins and cellular structures,and mediate recruitment of microtubule-severing *** impairment of microtubule dynamics causes neuronal dysfunction,we hypothesize cognitive impairment in human disease to be impacted by impairment of microtubule *** therefore aimed to study the effects of a disease-causing mutation of TAU(P301L)on the levels and localization of microtubule post-translational modifications indicative of microtubule stability and dynamics,to assess whether P301L-TAU causes stability-changing modifications to *** investigate TAU localization,phosphorylation,and effects on tubulin post-translational modifications,we expressed wild-type or P301L-TAU in human MAPT-KO induced pluripotent stem cell-derived neurons(i Neurons)and studied TAU in neurons in the hippocampus of mice transgenic for human P301L-TAU(p R5 mice).Human neurons expressing the longest TAU isoform(2N4R)with the P301L mutation showed increased TAU phosphorylation at the AT8,but not the p-Ser-262 epitope,and increased polyglutamylation and acetylation of microtubules compared with endogenous TAU-expressing neurons.P301L-TAU showed pronounced somatodendritic presence,but also successful axonal enrichment and a similar axodendritic distribution comparable to exogenously expressed 2N4R-wildtype-TAU.P301L-TAU-expressing hippocampal neurons in transgenic mice showed prominent missorting and tauopathy-typical AT8-phosphorylation of TAU and increased polyglutamylation,but reduced acetylation,of microtubules compared with non-transgenic *** sum,P301L-TAU results in changes in micr

关键词： human induced pluripotent stem cell microtubules P301L pR5 mice TAU tauopathy tubulin code

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Experimental and numerical investigation of the abrasive waterjet machining of aluminum-7075-T6 for aerospace applications

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Advances in Manufacturing 2021年第2期9卷 286-303页

作者： Joseck Nyaboro Mahmoud Ahmed hassan el-Hofy mohamed el-Hofy Department of Industrial and Manufacturing Engineering Egypt-Japan University of Science and Technology(E-JUST)Alexandria 21934Egypt Department of Energy Resources Engineering Egypt-Japan University of Science and Technology(E-JUST)Alexandria 21934Egypt Advanced Manufacturing Research Centre(AMRC)with Boeing The University of SheffieldRotherham S605TZUK

The machining of hard-to-cut materials with a high degree of precision and high surface quality is one of the most critical considerations when fabricating various state-of-the-art engineered *** this investigation,a comprehensive three-dimensional model was developed and numerically simulated to predict kerf profiles and material removal rates while drilling the aluminum-7075-T6 aerospace *** profile and material removal prediction involved three stages:jet dynamic flow modeling,abrasive particle tracking,and erosion rate *** investigations were conducted to validate the developed *** results indicate that the jet dynamic characteristics and flow of abrasive particles alter the kerf profiles,where the top kerf diameter increases with increasing jet pressure and standoff *** kerf depth and hole aspect ratio increase with jet pressure,but decrease with standoff distance and machining *** profiles were characterized by progressive edge rounding and parabolic *** can be minimized by utilizing high jet pressure and small standoff *** material removal rate increases with increasing jet pressure,abrasive particle size,and exposure time,but decreases with increasing standoff distance.

关键词： Non-traditional machining Abrasive waterjet machining Computational fluid dynamics(CFD) Erosion modeling Kerf characteristics

Magnetoresistive properties of Ni-doped La_(0.7)Sr_(0.3)MnO_3 manganites

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Rare Metals 2016年第7期35卷 551-558页

作者： Ahmed mohamed Ahmed Abd el-Moez Ahmed mohamed Medhat Abdelrady Abdellateef hassan Ahmed Abd el-Ghanny Physics Department Faculty of ScienceSohag University

Lao.7Sr0.3Mnl_xNixO3 （x = 0, 0.025, 0.050 and 0.075） ceramics were prepared by the conventional solid-state reaction method. The partial substitution of Mn by Ni2＋ leads to a decrease in cell volume as well as a structural transition from the rhombohedral to the orthorhombic structure. Ni2＋ doping increases the electrical resistivity, decreases the semiconductor-metal transition temperature （Tms） and relatively enhances the room temperature magnetoresistance （MR）, especially in x = 0.025 and around Tins. With respect to conduction mechanism, the small polaron hopping （SPH） and the variable range hopping （VRH） models were used to ex- amine conduction in the semiconducting region.

关键词： Manganites X-ray diffraction Structure electrical resistivity Magnetoresistance

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Structural, electronic, and optical studies of chalcogenides stannite Cu2CdSnX4（X=S, Se, and Te）: insights from the DFT study

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Optoelectronics Letters 2025年第2期21卷 69-76页

作者： Jamal GUERROUM mohamed AL-HATTAB Lhoucine MOUDOU Khalid RAHMANI Youssef LACHTIOUI Omar BAJJOU Laboratory of Engineering in Chemistry and Physics of Matter Faculty of Sciences and Technics Sultan Moulay Slimane University Ecole Normale Supérieure Mohammed V University in Rabat College of Graduate Studies University of South Africa

In this paper,we have calculated the structural,electronic,and optical properties of chalcogenide stannite Cu2CdSnX4（X=S,Se,Te） *** calculations are based on the density functional theory （DFT） method and are performed using the Cambridge sequential total energy package （CASTEP） code included in the Biovia Material Studio 20 *** optical properties have been studied in a domain that extends energetically from 10 meV to 40 *** results show that Cu2CdSnX4（X=S,Se,Te） stannite exhibits absorption in the visible region,the refractive index decreases with increasing energy,and the refractive index values are n=3.2,3.73 and 3.75 for Cu2CdSnS4,Cu2CdSnSe4and Cu2CdSnTe4,*** show also high conductivity,which implies that this material is promising for solar *** results argue in favor of the use of these materials in various potential *** density of state,band structures,and structural properties of Cu2CdSnX4（X=S,Se,and Te） stannite are also studied in this work.

关键词： Refractive index

Generation of sodium hypochlorite (NaOCl) from sodium chloride solution using C/PbO_2 and Pb/PbO_2 electrodes

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International Journal of Minerals,Metallurgy and Materials 2012年第6期19卷 561-566页

作者： Nasser Abu Ghalwa hassan Tamos mohamed elAskalni Abed Rhman el Agha Chemistry Department Al-Azhar University of GazaP.O.Box 1277Palestine

Two modified electrodes （Pb/PbO2 and C/PbO2） were prepared by electrodepositing a lead oxide layer on lead and carbon sub- strates. These modified electrodes were used as anodes for the generation of sodium hypochlorite （NaOC1） from sodium chloride solution. Different operating conditions and factors affecting the treatment process of NaOC1 generation, including current density, pH values, con- ductive electrolytes, and electrolysis time, were studied and optimized. By comparison the C/PbO2 electrode shows a higher efficiency than the Pb/PbO2 electrode for the generation of NaOC1.

关键词： sodium hypochlorite sodium chloride lead oxide electrodeposition electrodes

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Free radical scavenging activity of three different flowers-Hibiscus rosa-sinensis,Quisqualis indica and Senna surattensis

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Asian Pacific Journal of Tropical Biomedicine 2016年第9期6卷 771-777页

作者： Abd el-Moneim mohamed Radwan Afify Hazem mohamed Mahmoud hassan Biochemistry Department Faculty of AgricultureCairo University

Objective:To evaluate three flowers of Hibiscus rosa-sinensis(***-sinensis),Quisqualis indica(***) and Senna surattensis(***) for their antioxidant activity by different methods in addition to total phenolic,flavonoid and pigment ***:Antioxidant activity of water,ethanol and absolute ethanol extracts of three flowers; ***-sinensis,*** and *** was *** antioxidant activity was assessed by 1,1-diphenyl-2-picrylhydrazyl free radical scavenging activity,ferrous chelating activity,reducing power,nitric oxide scavenging activity,hydroxyl radical scavenging activity as well as total antioxidant *** flavonoids,total phenols and total pigments including chlorophylls and carotenoids were measured for the three ***:The results showed that the highest total antioxidant capacity at concentration of 500 mg/L was found in *** as 0.479 ± *** activity of ***,*** and *** flower extracts against 1,1-diphenyl-2-picrylhydrazyl radical showed the highest activity of(90.20 ± 0.29)% with 500 mg/*** screening of the three flowers extracts were carried out for alkaloids,flavonoids,saponins,tannins,steroids,glycosides,terpenoids,amino acid and ***-sinensis showed the total phenolic in water extract of(235.77 ± 14.31) mg/100 g,the other two flowers *** and *** had the total phenolic in ethanol extracts of(937.70 ± 25.06) and(850.30 ± 13.81) mg/100 g,*** the other hand total flavonoids were identified in absolute ethanol extracts in the three flowers[(32.83 ± 1.34),(49.24 ± 4.87) and(2.79 ± 0.23) mg/100 g,respectively].Conclusions:The extracts in the constituents of the three flowers could be used as additives as supplement fractions in foods.

关键词： Free radical Antioxidant Hibiscus rosa-sinensis Quisqualis indica Senna surattensis

On the gradient tracking problem for a bilinear reaction–diffusion equation excited by distributed bounded controls

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Journal of Control and Decision 2023年第3期10卷 365-373页

作者： el hassan Zerrik Abderrahman Ait Aadi mohamed Ouhafsaa MACS Laboratory Faculty of SciencesMoulay Ismail UniversityMeknesMorocco Department of Sciences Ecole Normale SupérieureMoulay Ismail UniversityMeknesMorocco

This paper addresses a gradient tracking problem of a bilinear reaction–diffusion equation evolvingin a spatial domainΩ ⊂ Rn, n ≤ 3. Such an equation is excited with distributed and boundedcontrols. The problem is formulated by the minimisation of a functional constituted of the deviationbetween the desired gradient and the current one all over a time interval and the energyterm. Then we prove the existence of an optimal control that we characterise by an optimalitysystem. Moreover, we discuss two sets of particular controls: the set of time dependent controlsand the space dependent ones. A computational approach and illustrative simulations are alsogiven.

关键词： Infinite dimensional systems bilinear systems reaction–diffusion equation controllability optimal control

Burden of pediatric hepatitis C

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World Journal of Gastroenterology 2013年第44期19卷 7880-7888页

作者： Mortada hassan el-Shabrawi Naglaa mohamed Kamal Alanani Pediatrics and Pediatric Hepatology Faculty of MedicineCairo University Giza 12411 Egypt

Hepatitis C virus(HCV)is a major health burden infecting 170-210 million people *** 3-4millions are newly-infected *** of pediatric infection varies from 0.05%-0.36%in the United States and Europe;up to 1.8%-5.8%in some developing *** highest prevalence occurs in Egypt,sub-Saharan Africa,Amazon basin and *** has been present in some populations for several centuries,notably genotypes 1 and 2 in West *** anti-schistosomal therapy practiced in the 1960s until the early 1980s had spread HCV infection throughout *** acquisition of HCV remains a major route for infection among Egyptian *** screening of transfusions,unsterilized injection equipment and re-used needles and syringes continue to be major routes of HCV transmission in developing countries,whereas vertical transmission and adolescent high-risk behaviors(e.g.,injection drug abuse)are the major routes in developed *** risk of vertical transmission from an infected mother to her unborn/newborn infant is approximately 5%.Early stages of HCV infection in children do not lead to marked impairment in the quality of life nor to cognitive,behavioral or emotional dysfunction;however,caregiver stress and family system strain may *** slowly progresses to serious complications as cirrhosis(1%-2%)and hepatocellular carcinoma(HCC)especially in the presence of risk factors as hemolytic anemias,obesity,treated malignancy,and concomitant human immune deficiency and/or hepatitis B virus *** vaccine remains elusive to *** the immune mechanisms in patients who successfully cleared the infection is essential for vaccine *** pediatric standard of care treatment consists of pegylated interferon-α2a or b plus ribavirin for 24-48 *** new oral direct acting antivirals,approved for adults,need further evaluation in *** virologic response varies depending on the viral lo

关键词： Hepatitis C virus Burden Genotypes Cost Pediatrics