检索结果-南通市图书馆

Reducing Condensation Inside the Photovoltaic(PV)Inverter according to the Effect of Diffusion as a Process of Vapor Transport

引用

frontiers in Heat and Mass Transfer 2024年第4期22卷 1189-1207页

作者： Amal El Berry Marwa M.Ibrahim A.A.Elfeky mohamed f.nasr Mechanical Engineering Department Engineering and Renewable Energy Research InstituteNational Research Centre(NRC)Cairo12622Egypt

A photovoltaic(PV)inverter is a vital component of a photovoltaic(PV)solar ***(PV)inverter failure can mean a solar system that is no longer *** electronic devices such as photovoltaic(PV)inverter devices are subjected to vapor condensation,a risk could *** the amount of moisture in the air,saturation occurswhen the temperature drops to the dewpoint,and condensationmay formon *** simulation with“COMSOL Software”is important for obtaining knowledge relevant to preventing condensation by using two *** first,the assumption was that the device’s water vapor concentration was homogeneous to evaluate the amount of liquid water accumulated on the internal walls of the photovoltaic(PV)inverter ***,by considering the effect of external wind velocity onmoisture transport at the air interface to evaluate water vapor transport outdoors and reduce *** factorial designs are utilized for analyzing the nature of the relationship between the vapor condensation response and the *** vapor condensation inside the solar inverter by the effect of external wind speed on diffusion as a process of transporting moister air outside the inverter box is the main solution for this *** the movement and assessment of the flow of water vapor,the impact of vapor condensation is *** saturation period was determined by using a Boolean saturation *** saturation indicator was set to 1 when saturation was detected(relative humidity greater than or equal to 1)and 0 *** the flow and dispersion of moist air as a function of wind speed helped solve the problem.

关键词： Photovoltaic inverter failure vapor condensation wind velocity diffusion transport and general factorial

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effects of P301L-TAU on post-translational modifications of microtubules in human iPSC-derived cortical neurons and TAU transgenic mice

引用

Neural Regeneration Research 2025年第8期20卷 2348-2360页

作者： mohamed Aghyad Al Kabbani Christoph Köhler Hans Zempel Institute of Human Genetics Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Center for Molecular Medicine Cologne(CMMC) University of CologneCologneGermany Center Anatomy Department ⅡMedical FacultyUniversity of CologneCologneGermany

TAU is a microtubule-associated protein that promotes microtubule assembly and stability in the *** is missorted and aggregated in an array of diseases known as *** are essential for neuronal function and regulated via a complex set of post-translational modifications,changes of which affect microtubule stability and dynamics,microtubule interaction with other proteins and cellular structures,and mediate recruitment of microtubule-severing *** impairment of microtubule dynamics causes neuronal dysfunction,we hypothesize cognitive impairment in human disease to be impacted by impairment of microtubule *** therefore aimed to study the effects of a disease-causing mutation of TAU(P301L)on the levels and localization of microtubule post-translational modifications indicative of microtubule stability and dynamics,to assess whether P301L-TAU causes stability-changing modifications to *** investigate TAU localization,phosphorylation,and effects on tubulin post-translational modifications,we expressed wild-type or P301L-TAU in human MAPT-KO induced pluripotent stem cell-derived neurons(i Neurons)and studied TAU in neurons in the hippocampus of mice transgenic for human P301L-TAU(p R5 mice).Human neurons expressing the longest TAU isoform(2N4R)with the P301L mutation showed increased TAU phosphorylation at the AT8,but not the p-Ser-262 epitope,and increased polyglutamylation and acetylation of microtubules compared with endogenous TAU-expressing neurons.P301L-TAU showed pronounced somatodendritic presence,but also successful axonal enrichment and a similar axodendritic distribution comparable to exogenously expressed 2N4R-wildtype-TAU.P301L-TAU-expressing hippocampal neurons in transgenic mice showed prominent missorting and tauopathy-typical AT8-phosphorylation of TAU and increased polyglutamylation,but reduced acetylation,of microtubules compared with non-transgenic *** sum,P301L-TAU results in changes in micr

关键词： human induced pluripotent stem cell microtubules P301L pR5 mice TAU tauopathy tubulin code

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Comparison of drug release from liquid crystalline monoolein dispersions and solid lipid nanoparticles using a flow cytometric technique

引用

Acta Pharmaceutica Sinica B 2016年第2期6卷 163-169页

作者： mohamed Z.Dawoud mohamed nasr Department of Pharmaceutics and Industrial Pharmacy Faculty of Pharmacy Helwan University

Colloidal lipid particles such as solid lipid nanoparticles and liquid crystalline nanoparticles have great opportunities as drug carriers especially for lipophilic drugs intended for intravenous administration. In order to evaluate drug release from these nanoparticles and determine their behavior after administration, emulsion droplets were used as a lipophilic compartment to which the transfer of a model drug was measured. The detection of the model drug transferred from monoolein cubic particles and trimyristin solid lipid nanoparticles into emulsion droplets was performed using a flow cytometric technique. A higher rate and amount of porphyrin transfer from the solid lipid nanoparticles compared to the monoolein cubic particles was observed. This difference might be attributed to the formation of a highly ordered particle which leads to the expulsion of drug to the surface of the crystalline ***, the sponge-like structure of the monoolein cubic particles decreases the rate and amount of drug transferred. In conclusion, the flow cytometric technique is a suitable technique to study drug transfer from these carriers to large lipophilic acceptors. Monoolein cubic particles with their unique structure can be used successfully as a drug carrier with slow drug release compared with trimyristin nanoparticles.

关键词： Cubic particles Drug release Drug transfer flow cytometric technique Emulsion droplets Solid lipid nanoparticles Porphyrin

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

In vitro and in vivo evaluation of cubosomes containing 5-fluorouracil for liver targeting

引用

Acta Pharmaceutica Sinica B 2015年第1期5卷 79-88页

作者： mohamed nasr mohamed K.Ghorab Ahmed Abdelazem Department of Pharmaceutics and Industrial Pharmacy Faculty of Pharmacy Helwan University Department of Pharmaceutical Chemistry Faculty of Pharmacy Helwan University

The objective of this study was to prepare cubosomal nanoparticles containing a hydrophilic anticancer drug 5-fluorouracil(5-fU) for liver targeting. Cubosomal dispersions were prepared by disrupting a cubic gel phase of monoolein and water in the presence of Poloxamer 407 as a *** loaded with 5-fU were characterized in vitro and in vivo. In vitro, 5-fU-loaded cubosomes entrapped 31.21% drug and revealed nanometer-sized particles with a narrow particle size distribution. In vitro 5-fU release from cubosomes exhibited a phase of rapid release of about half of the entrapped drug during the first hour, followed by a relatively slower drug release as compared to 5-fU solution. In vivo biodistribution experiments indicated that the cubosomal formulation significantly(Po 0.05) increased5-fU liver concentration, a value approximately 5-fold greater than that observed with a 5-fU ***, serum serological results and histopathological findings revealed greater hepatocellular damage in rats treated with cubosomal formulation. These results demonstrate the successful development of cubosomal nanoparticles containing 5-fU for liver targeting. However, further studies are required to evaluate hepatotoxicity and in vivo antitumor activity of lower doses of 5-fU cubosomal formulation in treatment of liver cancer.

关键词： 5-fluorouracil Hydrophilic drug Cubosomes Liver targeting Hepatotoxicity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Dynamic Interaction Analysis of Coupled Axial-Torsional-Lateral Mechanical Vibrations in Rotary Drilling Systems

引用

Structural Durability & Health Monitoring 2025年第1期19卷 77-103页

作者： Sabrina Meddah Sid Ahmed Tadjer Abdelhakim Idir Kong fah Tee mohamed Zinelabidine Doghmane Madjid Kidouche Applied Automation Laboratory Faculty of Hydrocarbons and ChemistryUniversity of BoumerdesBoumerdes35000Algeria Institute of Electrical and Electronic Engineering(IGEE) University of BoumerdesBoumerdes35000Algeria Laboratory of the Electrification of Industrial Enterprises University of BoumerdesBoumerdes35000Algeria Electrical Engineering Department Mohamed Boudiaf University of M’silaM’sila28000Algeria Department of Civil and Environmental Engineering King Fahd University of Petroleum&MineralsDhahran31261Saudi Arabia Interdisciplinary Research Center for Construction and Building Materials King Fahd University of Petroleum&Minerals(KFUPM)Dhahran31261Saudi Arabia

Maintaining the integrity and longevity of structures is essential in many industries,such as aerospace,nuclear,and *** achieve the cost-effectiveness of large-scale systems in petroleum drilling,a strong emphasis on structural durability and monitoring is *** study focuses on the mechanical vibrations that occur in rotary drilling systems,which have a substantial impact on the structural integrity of drilling *** study speciﬁcally investigates axial,torsional,and lateral vibrations,which might lead to negative consequences such as bit-bounce,chaotic whirling,and high-frequency *** events not only hinder the efﬁciency of drilling but also lead to exhaustion and harm to the system’s components since they are difﬁcult to be detected and controlled in real *** study investigates the dynamic interactions of these vibrations,speciﬁcally in their high-frequency modes,usingﬁeld data obtained from measurement while ***ﬁndings have demonstrated the effect of strong coupling between the high-frequency modes of these vibrations on drilling sys-tem *** obtained results highlight the importance of considering the interconnected impacts of these vibrations when designing and implementing robust control ***,integrating these compo-nents can increase the durability of drill bits and drill strings,as well as improve the ability to monitor and detect ***,by exploiting theseﬁndings,the assessment of structural resilience in rotary drilling systems can be ***,the study demonstrates the capacity of structural health monitoring to improve the quality,dependability,and efﬁciency of rotary drilling systems in the petroleum industry.

关键词： Rotary drilling systems mechanical vibrations structural durability dynamic interaction analysis ﬁeld data analysis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Design and simulation of a 1-GWp solar photovoltaic power station in Sudan

引用

Clean Energy 2021年第1期5卷 57-78页

作者： Sohaib nasr mohamed Abdalla HakanÖzcan Department of Mechanical Engineering Ondokuz Mayis UniversitesiSamsun 55139Turkey

Developing nations have a critical need to increase electricity *** has much unrealized potential for generating solar energy,particularly in the northern *** research study focuses on designing a 1-GW solar power station in northern Sudan using the PVsyst7.0 software *** determine the appropriate location for the solar-energy station,14 criteria were *** process is generic and suitable for use in any other *** method for conducting cash-flow estimates and return on investment is illustrated in the economic *** city of Dongola,the capital of the northern state,was selected because of its high annual irradiance on a horizontal surface at~2333.2 kWh/*** simulation results show that the annual optimum tilt angle of inclination for photovoltaic(PV)modules is 30°,the energy production is 1979259 MWh/yr and the average annual performance rate is *** addition,the electric power consumption per capita in Sudan is 269 kWh/yr,so the proposed solar power plant with 1979259 MWh/yr can provide energy to 7.4 million people per year annually and reduce carbon emissions by~18 million tons of carbon dioxide per *** calculations show that the levelized cost of electricity(LCOE)is$0.06/kWh,the discounted payback period is~11 years and the net present value is$*** a result,the proposed grid-connected PV solar plant is considered economically,technically and environmentally feasible in Sudan.

关键词： solar energy Sudan design simulation evaluation analytic hierarchy process photovoltaic

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The impact of alpha-fetoprotein (AfP), child-turcotte-pugh (CTP) score and disease staging on the survival of hepatocellular carcinoma (HCC) patients: a retrospective cohort from single oncology center

引用

Oncology research 2025年第1期33卷 149-160页

作者： Nasser Mulla Yousef Katib Asim M Almughamsi Duaa S Alkhayat mohamed Mosaad Samir T Alfotih Rawan Alaofi Department of Internal Medicine Faculty of Medicine Taibah University Madinah 42278 Saudi Arabia. Department of Radiology Faculty of Medicine Taibah University Madinah 42278 Saudi Arabia. Department of Surgery Faculty of Medicine Taibah University Madinah 42278 Saudi Arabia. Department of Endemic and Infectious Diseases Suez Canal University Ismailia 41522 Egypt. King Salman bin Abdulaziz Medical City Madinah 42311 Saudi Arabia. Prince Mohammed Bin Abdulaziz Hospital Madinah 41511 Saudi Arabia.

Background:Hepatocellular carcinoma (HCC) is the most common cause of cancer-related death in Saudi Arabia. Our study aimed to investigate the patterns of HCC and the effect of TNM staging, Alfa-fetoprotein (AfP), and Child-Turcotte Pugh (CTP) on patients' overall survival (OS).Methods:A retrospective analysis was conducted on 43 HCC patients at a single oncology center in Saudi Arabia from 2015 to 2020. All patients had to fulfill one of the following criteria: (a) a liver lesion reported as definitive HCC on dynamic imaging and/or (b) a biopsy-confirmed diagnosis.Results:The mean patient age of all HCC cases was 66.8 with a male-to-female ratio of 3.3:1. All patients were stratified into two groups: viral HCC (n = 22, 51%) and non-viral HCC (n = 21, 49%). Among viral-HCC patients, 55% were due to HBV and 45% due to HCV. Cirrhosis was diagnosed in 79% of cases. Age and sex did not significantly statistically differ in OS among viral and non-viral HCC patients (-value > 0.05). About 65% of patients had tumor size >5 cm during the diagnosis, with a significant statistical difference in OS (-value = 0.027). AfP was >400 ng/ml in 45% of the patients. There was a statistically significant difference in the OS in terms of AfP levels (-value = 0.021). A statistically significant difference was also observed between the CTP score and OS (-value = 0.02). CTP class B had the longest survival. BSC was the most common treatment provided to HCC patients followed by sorafenib therapy. There was a significant statistical difference in OS among viral and non-viral HCC patients (-value = 0.008).Conclusions:The most common predictors for OS were the underlying cause of HCC, AfP, and tumor size. Being having non-viral etiology, a tumor size >5 cm, an AfP > 400 ng/mL, and a CTP score class C were all negatively associated with OS.

关键词： Alpha-fetoprotein (AfP) Child-turcotte-pugh Hepatocellular carcinoma Pattern Progression free survival

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Small heat shock protein B8:from cell functions to its involvement in diseases and potential therapeutic applications

引用

Neural Regeneration Research 2025年第10期20卷 2872-2886页

作者： Marta Chierichetti Riccardo Cristofani Valeria Crippa Veronica ferrari Marta Cozzi Elena Casarotto Paola Pramaggiore Laura Cornaggia Guglielmo Patelli Ali mohamed Margherita Piccolella Mariarita Galbiati Paola Rusmini Barbara Tedesco Angelo Poletti Laboratory of Experimental Biology Dipartimento di Scienze Farmacologiche e Biomolecolari“Rodolfo Paoletti”(DiSFeB)Universitàdegli Studi di MilanoMilanItaly

Heat shock protein family B(small)member 8(HSPB8)is a 22 kDa ubiquitously expressed protein belonging to the family of small heat shock ***8 is involved in various cellular mechanisms mainly related to proteotoxic stress response and in other processes such as inflammation,cell division,and ***8 binds misfolded clients to prevent their aggregation by assisting protein refolding or degradation through chaperone-assisted selective *** line with this function,the pro-degradative activity of HSPB8 has been found protective in several neurodegenerative and neuromuscular diseases characterized by protein misfolding and *** cancer,HSPB8 has a dual role being capable of exerting either a pro-or an anti-tumoral activity depending on the pathways and factors expressed by the model of cancer under ***,HSPB8 exerts a protective function in different diseases by modulating the inflammatory response,which characterizes not only neurodegenerative diseases,but also other chronic or acute conditions affecting the nervous system,such as multiple sclerosis and intracerebellar *** note,HSPB8 modulation may represent a therapeutic approach in other neurological conditions that develop as a secondary consequence of other *** is the case of cognitive impairment related to diabetes mellitus,in which HSPB8 exerts a protective activity by assuring mitochondrial *** review aims to summarize the diverse and multiple functions of HSPB8 in different pathological conditions,focusing on the beneficial effects of its ***-based and alternative therapeutic approaches targeting HSPB8 and its regulated pathways will be discussed,emphasizing how new strategies for cell and tissue-specific delivery represent an avenue to advance in disease treatments.

关键词： aggregation autophagy cancer chaperone chaperone-assisted selective autophagy cognitive impairment HSPB8 neuroinflammation neuromuscular diseases therapy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

An update on the maize zein-gene family in the post-genomics era

引用

food Production, Processing and Nutrition 2019年第1期1卷 11-22页

作者： nasr Ullah Khan mohamed Sheteiwy Ning Lihua Muhammad Mohib Ullah Khan Zhao Han Institute of Crop Germplasm and Biotechnology Provincial Key Laboratory of AgrobiologyJiangsu Academy of Agricultural SciencesNanjing 210014China Department of Agronomy Faculty of AgricultureMansoura UniversityMansouraEgypt faculty of Agriculture Gomal UniversityDera Ismail KhanKPPakistan

Maize(Zea mays)is a cereal crop of global food ***,the deficiency of essential amino acids,more importantly lysine,methionine and tryptophan,in the major seed storage zein proteins makes corn nutritionally of low value for human *** idea of improving maize nutritional value prompted the search for maize natural mutants harboring low zein contents and higher amount of *** studies resulted in the identification of more than dozens of maize opaque mutants in the previous few decades,o2 mutant being the most extensively studied ***,the high lysine contents but soft kernel texture and chalky endosperm halted the widespread application and commercial success of maize opaque mutants,which ultimately paved the way for the development of Quality Protein Maize(QPM)by modifying the soft endosperm of o2 mutant into lysine-rich hard *** previous few decades have witnessed a marked progress in maize zein *** includes elucidation of molecular mechanism underlying the role of different zein genes in seed endosperm development by cloning different components of zein family,exploring the general organization,function and evolution of zein family members within maize species and among other cereals,and elucidating the cis-and trans-regulatory elements modulating the regulation of different molecular players of maize seed endosperm *** current advances in high quality reference genomes of maize lines B73 and Mo17 plus the completion of ongoing pan genome sequencing projects of more maize lines with NGS technologies are expected to revolutionize maize zein gene research in near *** review highlights the recent advances in QPM development and its practical application in the post genomic era,genomic and physical composition and evolution of zein family,and expression,regulation and downstream role of zein genes in endosperm ***,recent genomic tools and methods developed for functional valid

关键词： Zein Opaque mutants QPM NGS

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in clinical applications of bioceramics in the new regenerative medicine era

引用

World Journal of Clinical Cases 2024年第11期12卷 1863-1869页

作者： Noha Elshazly fayza Eid nasr Ayat Hamdy Safa Saied mohamed Elshazly Tissue Engineering Laboratory Faculty of DentistryAlexandria UniversityAlexandria 21526Egypt Department of Biochemistry Faculty of ScienceAlexandria UniversityAlexandria 21526Egypt Public Dental Clinic Central Administration of DentistryMinistry of Health and PopulationAlexandria 21554Egypt Department of Surgery Faculty of Veterinary MedicineAlexandria 21526Egypt

In this editorial,we comment on the hard and soft tissue applications of different ceramic-based scaffolds prepared by different mechanisms such as 3D printing,sol-gel,and *** new concept of regenerative medicine relies on biomaterials that can trigger in situ tissue regeneration and stem cell recruitment at the defect site.A large percentage of these biomaterials is ceramic-based as they provide the essential requirements of biomaterial principles such as tailored multisize porosity,antibacterial properties,and angiogenic *** these previously mentioned properties put bioceramics on top of the hierarchy of biomaterials utilized to stimulate tissue regeneration in soft and hard tissue *** clinical applications registered the use of these materials in triggering soft tissue regeneration in healthy and diabetic patients such as bioactive glass *** results were promising and opened new frontiers for utilizing these materials on a larger *** same results were mentioned when using different forms and formulas of bioceramics in hard defect *** bioceramics were used in combination with other polymers and biological scaffolds to improve their regenerative and mechanical *** this progress will enable a larger scale of patients to receive such services with ease and decrease the financial burden on the government.

关键词： Regenerative medicine Bioceramics Chronic wounds Bone defects Clinical applications

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：