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Epigenetic regulation of insulin-like growth factor axis in hepatocellular carcinoma

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World Journal of Gastroenterology 2016年第9期22卷 2668-2677页

作者： Hend mohamed el Tayebi Ahmed Ihab Abdelaziz The Molecular Pathology Research Group Department of Pharmacology and Toxicology Faculty of Pharmacy and Biotechnology German University in Cairo

The insulin-like growth factor(IGF) signaling path-way is an important pathway in the process of hepa-tocarcinogenesis,and the IGF network is clearly dysregulated in many cancers and developmental *** hepatocellular carcinoma(HCC),only a minority of patients are eligible for curative treatments,such as tumor resection or liver ***,there is a high recurrence of HCC after surgical tumor *** research efforts have focused on targeting IGF axis members in an attempt to find therapeutic options for many health *** this review,we shed lights on the regulation of members of the IGF axis,mainly by micro RNAs in *** RNAs in HCC attempt to halt the aberrant expression of the IGF network,and a single micro RNA can have multiple downstream targets in one or more signaling *** micro RNAs is a relatively new approach for identifying an efficient radical cure for HCC.

关键词： Hepatocellular carcinoma Insulin-like growth factors Insulin-like growth factor receptors Epigenetics microRNAs

A Novel Approach in Hydrogeochemical Exploration for Uranium Mineralization:an Example from West Central Sinai,Egypt

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Acta Geologica Sinica(English Edition) 2015年第6期89卷 1895-1913页

作者： Ahmed E.el-RAYES mohamed O.ARNOUS Suez Canal University Faculty of SciencesGeology Department

Groundwater in contact with ore deposits may acquire a chemical composition that could be used as a guide for exploration. Eight well-water samples are collected from a known uraniummineralized area near Abu Zenima, west central Sinai to examine the applicability of using the hydrogeochemical technique in the search for uranium mineralization in similar arid areas. The analytical chemical data of the ground water is compared with ground radiometric measurements. The obtained results indicate that groundwater affected by uranium mineralization has a specific relativity of major anions expressed essentially as SO_4〉Cl〉HCO_3 and to a lesser extent as Cl〉SO_4〉HCO_3, associated as a rule with low magnesium content. This association constitutes a signature of uranium mineralization on the composition of groundwater in west central Sinai and could be used as an important exploration guide in the search for uranium deposits in similar areas. Anomalies in Ni, Fe, Zn and Cr and other pathfinder elements in groundwater can furnish geochemical guides to uranium ores. The immobile trace element anomalies, including Zn, Ni and Fe are strongly distributed near the orebody; whereas the relatively mobile trace elements, including Co, U, V and Cr, constitute the dispersion haloes away from the orebody. A new hydrogeochemical discrimination diagram is constructed to be used as a quick and cost effective exploration tool in the search for uranium occurrences in environmentally similar arid areas. Based on the obtained results, a new site for uranium occurrence, west of W. Baba, is delineated and recommended for future detailed geological and geochemical surveying.

关键词： Hydrogeochemical exploration Uranium ores geospatial mapping graphical explorationtool remote sensing Sinai

Micro-fabrication of ceramics:Additive manufacturing and conventional technologies

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Journal of Advanced Ceramics 2021年第1期10卷 1-27页

作者： Hany HASSANIN Khamis ESSA Amr elSHAER mohamed IMBABY Heba H.el-MONGY Tamer A.el-SAYED School of Engineering Canterbury Christ Church UniversityCanterburyCT11QUUK University of Birmingham EdgbastonB152TTUK Kingston University London Penrhyn RoadKingston Upon ThamesSurreyKT12EEUK Department of Mechanical Design Faculty of EngineeringMatariaHelwan UniversityP.O.Box.11718CairoEgypt Jubail University College Mechanical EngineeringKingdom of Saudi Arabia Center for Applied Dynamics Research(CADR) School of EngineeringUniversity of AberdeenAberdeenAB243UEUK

Ceramic materials are increasingly used in micro-electro-mechanical systems(MEMS)as they offer many advantages such as high-temperature resistance,high wear resistance,low density,and favourable mechanical and chemical properties at elevated ***,with the emerging of additive manufacturing,the use of ceramics for functional and structural MEMS raises new opportunities and *** paper provides an extensive review of the manufacturing processes used for ceramic-based MEMS,including additive and conventional manufacturing *** review covers the micro-fabrication techniques of ceramics with the focus on their operating principles,main features,and processed *** that need to be addressed in applying additive technologies in MEMS include ceramic printing on wafers,post-processing at the micro-level,resolution,and quality *** paper also sheds light on the new possibilities of ceramic additive micro-fabrication and their potential applications,which indicates a promising future.

关键词： micro-electro-mechanical system(MEMS) micro-fabrication ceramics micro parts additive manufacturing

Induction of sub-G0 arrest and apoptosis by seed extract of Moringa peregrina（Forssk.） Fiori in cervical and prostate cancer cell lines

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Journal of Integrative Medicine 2019年第6期17卷 410-422页

作者： Maged mohamed Maher Abou-Hashem Dina mohamed Abo-elmatty Noha Mostafa Mesbah Ahmed mohamed Abd el-Mawgoud Faculty of Pharmacy Pharmacognosy DepartmentZagazig UniversityZagazig 44511Egypt Faculty of Pharmacy Biochemistry DepartmentSuez Canal UniversityIsmailia 41522Egypt Egyptian International Pharmaceuticals Industries Company Tenth of Ramadan City 44629Egypt

Objective: This study investigated cytotoxicity and induction of apoptosis in human cervical cancer cells(HelA) and prostate cancer cells(PC-3) using the most active fraction of Moringa peregrina seed ***: Dried and powdered seeds were extracted using 95% ethanol. The total ethanolic extract was further dissolved in distilled water and separated into petroleum ether, chloroform, ethyl acetate and aqueous extracts. Based on the results of in vitro anticancer studies of all extracts, the most highly active extract was selected for evaluation of apoptosis induction and cell cycle analysis on HelA and PC-3 cells at its half maximal inhibitory concentration using flow cytometry;DNA fragmentation by agarose gel electrophoresis and the expression of protein were measured by Western ***: The chloroform fraction from the ethanolic extract of M. peregrina(CFEE) was the most active antitumor fraction. The selectivity index, determined using the normal Vero cell line, indicated that CFEE had a high degree of selectivity against HelA and PC-3 cells. CFEE induced apoptosis, confirmed by cell cycle arrest at sub-G0 phase and DNA fragmentation. CFEE induced an increase in mRNA expression of caspase-3, a decrease in Bcl-2 mRNA expression, and decreased ATP levels. CFEE increased protein expression of caspase-3 and decreased protein expression of poly-ADP-ribose polymerase-1(PARP-1).Flow cytometric analysis showed an appreciable increase in the number of cells in the early apoptotic stage in CFEE-treated HelA and PC-3 cells. CFEE treatment significantly increased lipid peroxidation(malondialdehyde level) in HelA and PC-3 ***: Seed extract of M. peregrina displayed a significant antitumor effect through apoptosis induction in HelA and PC-3 cells.

关键词： Moringa peregrina Fractionation Antiproliferation Apoptosis

Effect of smart sprinkler irrigation utilization on water use efficiency for wheat crops in arid regions

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International Journal of Agricultural and Biological Engineering 2014年第1期7卷 26-35页

作者： Hussein Mohammed Al-Ghobari mohamed Said Abdalla el Marazky Department of Agricultural Engineering College of Food and Agriculture Sciences King Saud UniversityRiyadh 11451Kingdom of Saudi Arabia

The smart irrigation system(SIS)developed in this research is a valuable tool for scheduling irrigation and quantifying water required by *** was implemented and tested under sprinkler irrigation system to irrigate wheat crops(YecoraRojo).Results obtained from this system were compared with the control irrigation system(CIS),whose scheduling method was based on data from an automatic weather *** indicated significant savings in applied water using the *** addition,the use of the SIS conserved 12%of irrigation water compared to CIS and obtained an economical *** water use efficiency(WUE)under SIS had generally higher values(1.64 kg/m^(3))compared to CIS(1.46 kg/m^(3)).Hence,the application of SIS technology provides significant advantages on WUE and irrigation water use efficiency(IWUE).Relatively high WUE and IWUE were found for the irrigation treatment(80%of evapotranspiration under SIS).Results showed that the irrigation requirements of wheat increased(100%of ETc under CIS)with increasing evapotranspiration(ETc)but excessive irrigation could decrease WUE and *** results indicated that extreme irrigation might not produce higher yield or optimal economic benefit,thus,suitable irrigation schedules by using SIS must be established and extendable to other agricultural crops.

关键词： smart irrigation system(SIS) sprinkler irrigation scheduling water use efficiency arid region evapotranspiration grain yield

Amination of biochar surface from watermelon peel for toxic chromium removal enhancement

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Chinese Journal of Chemical Engineering 2021年第8期34卷 199-222页

作者： mohamed A.el-Nemr Ibrahim M.A.Ismail Nabil M.Abdelmonem Ahmed el Nemr Safaa Ragab Department of Chemical Engineering Faculty of EngineeringCairo UniversityGizaEgypt Renewable Energy Program Zewail City of Science and TechnologyEgypt Environmental Division National Institute of Oceanography and FisheriesKayet BeyEl-AnfoushyAlexandriaEgypt

Watermelon peel residues were used to produce a new biochar by dehydration *** new biochar has undergone two methods of chemical modification and the effect of this chemical modification on its ability to adsorb Cr(VI)ions from aqueous solution has been *** biochars,Melon-B,Melon-BO-NH_(2) and Melon-BO-TETA,were made from watermelon peel via dehydration with 50%sulfuric acid to give Melon-B followed by oxidation with ozone and amination using ammonium hydroxide to give Melon-BO-NH_(2) or Triethylenetetramine(TETA)to give *** prepared biochars were characterized by BET,BJH,SEM,FT-IR,TGA,DSC and EDAX *** highest removal percentage of Cr(VI)ions was 69%for Melon-B,98%for Melon-BO-NH_(2) and 99%for Melon-BO-TETA biochars of 100 mg·L^(−1) Cr(VI)ions initial concentration and 1.0 g·L^(−1) adsorbents *** unmodified biochar(Melon-B)and modified biochars(Melon-BO-NH_(2) and Melon-BO-TETA)had maximum adsorption capacities(Q_(m))of 72.46,123.46,and 333.33 mg·g^(−1),*** amination of biochar reduced the pore size of modified biochar,whereas the surface area was *** obtained data of isotherm models were tested using different error function *** Freundlich,Tempkin and Langmuir isotherm models were best fitted to the experimental data of Melon-B,Melon-BO-NH_(2) and Melon-BO-TETA,*** adsorption rate was primarily controlled by pseudo-second–order rate ***,the functional groups interactions are important for adsorption mechanisms and expected to control the adsorption *** adsorption for the Melon-B,Melon-BO-NH_(2) and Melon-BO-TETA could be explained for acid–base interaction and hydrogen bonding interaction.

关键词： Waste treatment Powder technology Citrullus lanatus Hexavalent chromium Biochar amination Adsorption

Enhancing mechanical behaviors of collapsible soil using two biopolymers

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Journal of Rock Mechanics and Geotechnical Engineering 2017年第2期9卷 329-339页

作者： mohamed Ayeldeen Abdelazim Negm Mostafa el-Sawwaf Masaki Kitazume Structural Engineering Department Tanta UniversityTantaEgypt Faculty of Engineering Zagazig UniversityZagazigEgypt Civil and Environmental Engineering Department Tokyo Institute of TechnologyTokyoJapan

This study aims to investigate the possibility of using biopolymer(environmental friendly material) to enhance the mechanical behaviors of collapsible *** types of biopolymers were(xanthan gum and guar gum) used in this study due to their stable behaviors under severe conditions and their availability with reasonable *** experimental program focused on three major soil properties,*** characterizations,collapsible potential and shear *** three properties are essential in process of soil *** biopolymer concentrations were used in this study and the experimental program was performed at two curing periods(soon after mixing the soil with the biopolymer and after one week curing time).Shear parameters were measured for the treated specimens under both soaked and unsoaked conditions,while a collapsible potential test was performed under different mixing conditions(wet mix and dry mix).A numerical model was built to predict the behavior of the treated collapsible soil after and before water *** results indicated that the ability of both xanthan gum and guar gum can be used as improvement materials for collapsible soil *** collapsible potential has been reduced from 9%to 1%after mixing the soil with 2%biopolymer concentration in the wet *** one week curing,the cohesion has been increased from 8.5 kPa to105 kPa by increasing the xanthan gum concentration from zero to 2%,leading to an overall improvement in soil shear *** also proves that the guar gum is superior to the xanthan *** shear strength of soil can be increased by about 30%when using the guar gum in comparison with the xanthan gum at the same conditions;however,the collapsible potential of soil material will be reduced by about 20%.

关键词： Collapsing soil Xanthan gum Guar gum Collapsible potential Shear strength Compaction characterizations Numerical model

Epidemiological and clinical characteristics of inflammatory bowel diseases in Cairo,Egypt

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World Journal of Gastroenterology 2014年第3期20卷 814-821页

作者： Serag Esmat mohamed el Nady mohamed elfekki Yehia elsherif Mazen Naga Division of Gastroenterology Department of Internal MedicineFaculty of MedicineCairo University Department of Internal Medicine Faculty of MedicineBeni Suef University Department of Tropical Medicine Faculty of MedicineCairo University

AIM: To study the natural history, patterns and clinical characteristics of inflammatory bowel diseases (IBD) in Egypt.

关键词： Natural history of Inflammatory bowel diseases, Epidemiology of Ulcerative colitis, Epidemiology of Crohn’ s disease, Epidemiology of inflammatory bowel diseases in Egypt, inflammatory bowel diseases Prevalence, Incidence of ulcerative colitis, Incidence of Crohn’ s disease

Filtered High Gain Observer for an electric Vehicle’s electro-hydraulic Brake: Design and Optimization Using Multivariable Newton-based Extremum Seeking

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Chinese Journal of electrical Engineering 2023年第4期9卷 73-87页

作者： Jamal el-bakkouri Hamid Ouadi Fouad Giri mohamed Khafallah ENSEM Hassan II University of CasablancaCasablanca BP 8118Morocco ENSAM Rabat Mohammed V UniversityRabat BP 6207Morocco Department of electrical Engineering University of Caen NormandyCaen 14032France

Designing high-gain observers(HGOs)for the state estimation of an electric vehicle’s electrohydraulic brake(EHB)system is *** type of observer is applicable to model nonlinearities and constant feature ***,they are very sensitive to measurement noise,which is unavoidable in *** first novelty of this study is that it compensates for the measurement noise using a filtered high-gain observer(FHGO)to ensure EHB state *** proposed FHGO provides an estimate of the master cylinder pressure,motor current,and rotor speed from measurements of the rotor *** second novelty is the design of an extremum-seeking(ES)optimization loop to adjust the FHGO gains *** performance of the developed FHGO with ES-based online gain optimization was highlighted in the presence of model uncertainties and output measurement noise using a Matlab/Simulink *** superiority of the FHGO(even with a fixed gain)over a standard high gain observer(SHGO)was also demonstrated.

关键词： electrohydraulic brake filtered HGO measurement noise optimization extremum-seeking Lyapunov theory