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Metabolic aspects of hepatitis C virus

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World Journal of Gastroenterology 2022年第22期28卷 2429-2436页

作者： mohamed el-Kassas Abeer Awad Department of Endemic Medicine Faculty of MedicineHelwan UniversityCairo 11795Egypt Department of Internal Medicine Faculty of MedicineCairo UniversityCairo 11566Egypt

Many metabolic factors are associated with chronic hepatitis C virus(HCV)infection and can influence the course of the illness and impact the progression of liver and non-liver-related diseases through complex *** of these factors impact the course of chronic HCV(CHC)and result in the conceptual translation of CHC from a localized to systemic *** the traditional liver manifestations associated with CHC infection,such as cirrhosis and hepatocellular carcinoma,various extrahepatic disorders are associated with HCV infection,including atherosclerosis,glucose and lipid metabolic disturbances,alterations in the iron metabolic pathways,and lymphoproliferative *** coexistence of metabolic disorders and CHC is known to influence the chronicity and virulence of HCV and accelerates the progression to liver fibrosis and hepatocellular *** resistance is one of the key factors that have a tremendous metabolic impact on ***,there is a great need to properly evaluate patients with CHC infection and correct the modifiable metabolic risk ***,patients with HCV who achieved a sustained virological response showed an overall improvement in glucose metabolism,but the exact evidence still requires further studies with long-term *** review delineates the most recent evidence on the main metabolic factors associated with CHC and the possible influence of chronic HCV infection on metabolic features.

关键词： Hepatitis C virus Metabolic factors Steatosis Insulin resistance

Wireless Sensor Networks Routing Attacks Prevention with Blockchain and Deep Neural Network

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Computers, Materials & Continua 2022年第3期70卷 6127-6140页

作者： mohamed Ali Ibrahim A.Abd el-Moghith mohamed N.el-Derini Saad M.Darwish Higher Institute for Tourism Hotels and ComputerAl-SeyoufAlexandria21533Egypt Department of Information Technology Institute of Graduate Studies and ResearchAlexandria University21526Egypt Department of Computer and Systems Engineering Faculty of EngineeringAlexandria UniversityAlexandria21544Egypt

Routing is a key function inWireless Sensor Networks(WSNs)since it facilitates data transfer to base *** attacks have the potential to destroy and degrade the functionality ofWSNs.A trustworthy routing system is essential for routing security andWSN *** methods have been implemented to build trust between routing nodes,including the use of cryptographic methods and centralized ***,the majority of routing techniques are unworkable in reality due to the difficulty of properly identifying untrusted routing node *** the moment,there is no effective way to avoid malicious node *** a consequence of these concerns,this paper proposes a trusted routing technique that combines blockchain infrastructure,deep neural networks,and Markov Decision Processes(MDPs)to improve the security and efficiency of WSN *** authenticate the transmission process,the suggested methodology makes use of a Proof of Authority(PoA)mechanism inside the blockchain *** validation group required for proofing is chosen using a deep learning approach that prioritizes each node’s *** are then utilized to determine the suitable next-hop as a forwarding node capable of securely transmitting *** to testing data,our routing system outperforms current routing algorithms in a 50%malicious node routing scenario.

关键词： Wireless sensor networks trusted routing deep neural network blockchain markov decision

Delayed Grafting as a Valid Technique in Burn Management: Experience from a Burn Unit in Oman

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Modern Plastic Surgery 2024年第1期14卷 9-14页

作者： Taif Alsafy Joe Jacob Anish Thadathil elias Ahmed Salah el Din Salim Mohammed Ghawas Majid Tariq Saud Albusaidi Ahmed Al Jabri Al Anood Al Hadhrami Mutazz Obeid Al Khaldi Moath Abdelhamid Shummo Karim mohamed Haridi Aml Eid Saleh Said Al-Busaidi Department of Plastic and Reconstructive Surgery Sultan Qaboos Hospital Salalah Oman ENT Department Al Nahdha Hospital Muscat Oman Department of Plastic Reconstructive and Craniofacial Surgery Khoula Hospital Muscat Oman

Background: Early excision and grafting has been the preferred method of managing major burns around the world since 1970. Considering the advances in health care and the development of new antibiotics over the past 50 years, delayed grafting as a technique for the management of burns over 15%-20% of total body surface area (TBSA) could have comparable results to that of early excision. This study aims to highlight the outcomes of practicing delayed grafting in burn patients. Methods: A case series analysis was performed of 51 patients who were admitted to the burns unit in Sultan Qaboos Hospital Salalah with over 20% TBSA between January 2014 and December 2019. The patients received prophylactic antibiotics and silver sulphadiazine dressing until the burn eschar had completely separated, followed by grafting. Results: Two patients were lost during the entire duration of the study. The mortality rate was comparable to that of early excision, while the rate of hypertrophic scarring was lower than the range reported by other studies. Conclusion: In the management of patients with over 20% TBSA, delayed grafting after complete separation of eschar is still a valid technique.

关键词： Burns Burn Units Burn Management Delayed Grafting Major Burns Treatment Efficacy

Effective participation of wind turbines in frequency control of a two-area power system using coot optimization

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Protection and Control of Modern Power Systems 2023年第1期8卷 230-244页

作者： Mahmoud Hussain el-Bahay Mohammed elsayed Lotfy mohamed A.el-Hameed electrical Power and Machines Department Faculty of EngineeringZagazig UniversityZagazig 44519Egypt ECEN Department Faculty of EngineeringA’Sharqiyah University400 IbraOman

In this paper,load frequency control is performed for a two-area power system incorporating a high penetration of renewable energy sources.A droop controller for a type 3 wind turbine is used to extract the stored kinetic energy from the rotating masses during sudden load *** auxiliary storage controller is applied to achieve effec-tive frequency *** coot optimization algorithm(COA)is applied to allocate the optimum parameters of the fractional-order proportional integral derivative(FOPID),droop and auxiliary storage *** fitness function is represented by the summation of integral square deviations in tie line power,and Areas 1 and 2 frequency *** robustness of the COA is proven by comparing the results with benchmarked optimizers including:atomic orbital search,honey badger algorithm,water cycle algorithm and particle swarm *** assessment is confirmed in the following four scenarios:(i)optimization while including PID controllers;(ii)optimization while including FOPID controllers;(iii)validation of COA results under various load disturbances;and(iv)validation of the proposed controllers under varying weather conditions.

关键词： Coot optimizer FOPID Load frequency control Photovoltaic Variable speed wind turbine

pH-indicative Films Based on Chitosan–PVA/Sepiolite and Anthocyanin from Red Cabbage: Application in Milk Packaging

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Journal of Bionic Engineering 2022年第3期19卷 837-851页

作者： Marya Raji Laila el Foujji mohamed el Mehdi Mekhzoum Mounir el Achaby Hamid Essabir Rachid Bouhfid Abou el kacem Qaiss Moroccan Foundation for Advanced Science Innovation and ResearchComposites and Nanocomposites CenterRabat Design CenterRue Mohamed El JazouliMadinat El IrfaneRabat10100Morocco Faculty of Science Laboratoire de Chimie Organique Et HétérocycliqueUniversity Mohammed V in RabatRabat10100Morocco Materials Science and Nano-Engineering Department Mohammed VI Polytechnic UniversityLot 660–Hay Moulay RachidBen Guerir43150Morocco Mechanic Materialsand Composites(MMC)Laboratory of Energy EngineeringMaterials and SystemsNational School of Applied Sciences of AgadirIbn Zohr UniversityAgadir80000Morocco

Biobased smart packaging is been the most interesting research *** this study,pH-sensitive films based on anthocyanin molecules from red cabbage and sepiolite mineral nano-clay as functional additives were *** films were fabricated by casting method of blend polymer Chitosan/Poly(Vinyl Alcohol)at two fillers loading(5wt.%and 10wt.%).The structural,morphological,thermal,optical,hygroscopic,and mechanical properties as well as the pH sensitivity of films were *** thermal properties confirm that the amount of the anthocyanin in sepiolite was around 6.4%.The tensile strength and the young’s modulus of produced composites at 10wt.%sepiolite–anthocyanin content was increased to 8.90 MPa and 163 MPa,*** maximum water absorption that the films may absorb was 12.3%.pH sensitivity analysis showed that the Smart films change the color by changing the pH level,from pink at pH lower than 6 to yellow at pH higher than ***,the developed pH-sensitive films show band gaps in visible light that make them useful for monitoring milk spoilage.

关键词： Smart packaging Anthocyanin Red cabbage pH-sensitive and milk spoilage

Barrett’s esophagus in a patient with bulimia nervosa:A case report

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World Journal of Clinical Cases 2022年第17期10卷 5841-5845页

作者： Ahmed Gouda mohamed el-Kassas Department of Gastroenterology NMC Ruwais HospitalAbu Dhabi 14638United Arab Emirates Department of Endemic Medicine Faculty of MedicineHelwan UniversityCairo 11795Egypt

BACKGROUND Barrett’s esophagus is a known complication of long-standing gastroesophageal reflux disease,and it is a potential risk factor of developing esophageal *** SUMMARY Here,we present a case of a 47-year-old male patient referred to the gastroenterology clinic for upper endoscopy because he has a long-standing history of heartburn and vomiting after *** examination,he had characteristic findings of self-induced vomiting as abrasions and callosities on the dorsum of the right hand and dental erosions.A detailed history revealed that he had 17 years of binge eating with self-induced *** upper endoscopy showed gastroesophageal reflux grade D with salmon-red mucosal projections,and the biopsy revealed intestinal mucosal *** This case emphasized the importance of considering upper endoscopy screening for Barrett’s esophagus in patients with eating disorders,especially those with self-induced vomiting,as in bulimia nervosa.

关键词： Barrett’s esophagus Bulimia nervosa Gastroesophageal reflux disease Case report

Hepatocellular carcinoma recurrence:Predictors and management

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Liver Research 2023年第4期7卷 321-332页

作者： Walaa Abdelhamed mohamed el-Kassas Endemic Medicine Department Sohag UniversitySohagEgypt Endemic Medicine Department Faculty of MedicineHelwan UniversityCairoEgypt

Hepatocellular carcinoma(HCC),the sixth most common cancer globally,is associated with high mortality rates and more than 830,000 annual *** advances in the available management options including surgical resection and local ablative therapies,recurrence rates after the initial treatment exceed 50%,even among patients who have undergone curative-intent ***,postsurgical HCC recurrence occurs in about 70%of cases five years *** management of recurrent HCC remains *** review discusses different predictors for HCC recurrence after each treatment modality and different approaches available to stratify these *** specific guidelines for managing HCC recurrence and strict surveillance protocols for such recurrence after initial HCC management are needed.

关键词： Hepatocellular carcinoma(HCC) Recurrence Ablation Liver resection Liver transplantation

An Enhanced Deep Learning Method for Skin Cancer Detection and Classification

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Computers, Materials & Continua 2022年第10期73卷 1109-1123页

作者： mohamed W.Abo el-Soud Tarek Gaber mohamed Tahoun Abdullah Alourani Department of Computer Science and Information College of Science in ZulfiMajmaah UniversityAl-Majmaah11952Saudi Arabia Faculty of Computers and Informatics Suez Canal UniversityIsmailia41522Egypt School of Science Engineeringand EnvironmentUniversity of SalfordUK

The prevalence of melanoma skin cancer has increased in recent *** greatest risk from melanoma is its ability to broadly spread throughout the body by means of lymphatic vessels and ***,the early diagnosis of melanoma is a key factor in improving the prognosis of the *** learning makes it possible to design and develop intelligent systems that can be used in detecting and classifying skin lesions from visible-light *** systems can provide early and accurate diagnoses of melanoma and other types of skin *** paper proposes a new method which can be used for both skin lesion segmentation and classification *** solution makes use of Convolutional neural networks(CNN)with the architecture two-dimensional(Conv2D)using three phases:feature extraction,classification and *** proposed method is mainly designed for skin cancer detection and *** the public dataset International Skin Imaging Collaboration(ISIC),the impact of the proposed segmentation method on the performance of the classification accuracy was *** obtained results showed that the proposed skin cancer detection and classification method had a good performance with an accuracy of 94%,sensitivity of 92%and specificity of 96%.Also comparing with the related work using the same dataset,i.e.,ISIC,showed a better performance of the proposed method.

关键词： Convolution neural networks activation function separable convolution 2D batch normalization max pooling classification

Development of Magnetite/Graphene Oxide Hydrogels from Agricultural Wastes for Water Treatment

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Journal of Renewable Materials 2022年第7期10卷 1889-1909页

作者： Hebat-Allah STohamy mohamed el-Sakhawy Samir Kamel Cellulose and Paper Department National Research CentreCairo12622Egypt

A novel magnetic hydrogel loaded with graphene oxide(GO)was developed in this ***,GO was prepared from bagasse through a single step via oxidation in the presence of ferrocene under muffled atmospheric conditions,followed by the loading of different amounts of magnetite onto GO via co-precipitation reaction of iron onto GO ***,the 2-acrylamido-2-methyl-1-propane sulfonic acid was grafted onto carboxymethyl cellulose in the presence of magnetite GO and N,N′-methylenebisacrylamide as crosslinker yielded *** structure,morphological,and thermal behavior of the prepared hydrogels were *** addition,the adsorption performance of Ni(Ⅱ)ions from aqueous media by the prepared hydrogels was investigated as a function of temperature,time,and concentration of adsorbate in a batch *** results demonstrated a remarkable enhancement in the adsorption process of Ni(Ⅱ)(Removal efficiency=98.82%).All isotherms were found to fit the Langmuir model *** adsorption properties of both magnetic GO and magnetic hydrogel showed promising properties as green and cheap adsorbents.

关键词： Magnetite graphene oxide hydrogel Ni(Ⅱ)adsorption kinetic models thermodynamics