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Treatment-induced neuroendocrine prostate cancer and de novo neuroendocrine prostate cancer:Identification,prognosis and survival,genetic and epigenetic factors

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World Journal of Clinical Cases 2024年第13期12卷 2143-2146页

作者： mohamed Wishahi Department of Urology Theodor Bilharz Research InstituteCairo 12411Egypt

Neuroendocrine prostate cancer(NEPC)shows an aggressive behavior compared to prostate cancer(PCa),also known as prostate *** foci in PCa can harbor genetic alternation that can arise in a heterogeneity of prostate *** may arise de novo or develop following androgen deprivation therapy(ADT).NEPC that arise following ADT has the nomenclature“treatmentemerging/induced NEPC(t-NEPC)”.t-NEPC would be anticipated in castration resistant prostate cancer(CRPC)and metastatic PCa.t-NEPC is characterized by low or absent androgen receptor(AR)expression,independence of AR signaling,and gain of neuroendocrine phenotype.t-NEPC is an aggressive metastatic tumor,develops from PCa in response to drug induced ADT,and shows very short response to conventional therapy.t-NEPC occurs in 10%-17%of patients with *** novo NEPC is rare and is accounting for less than 2%of all *** molecular mechanisms underlying the trans-differentiation from CRPC to t-NEPC are not fully *** kinase 1 plays a significant role in t-NEPC *** neuroendocrine markers:Synaptophysin,chromogranin A,and insulinoma associated protein 1(INSM1)are expressed in t-NEPC,they are non-specific for diagnosis,prognosis,and follow-up of therapy.t-NEPC shows enriched genomic alteration in tumor protein P53(TP53)and retinoblastoma 1(RB1).There are evidences suggest that t-NEPC might develop through epigenetic *** are genomic,epigenetic,and transcriptional alterations that are reported to be involved in development of ***-outs of TP53 and RB1 were found to contribute in development of *** is resistant to immunotherapy,and at present there are running trials to approach immunotherapy for PCa,CRPC,and t-NEPC.

关键词： Prostate cancer Neuroendocrine carcinoma Treatment induced neuroendocrine prostate cancer Androgen deprivation therapy Genetic and epigenetic factors Castration resistant prostate cancer De novo neuroendocrine prostate cancer

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Primary gastroduodenal tuberculosis presenting as gastric outlet obstruction:A case report and review of literature

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World Journal of Clinical Cases 2024年第8期12卷 1536-1543页

作者： Abdihamid mohamed Ali Yahye Garad mohamed Abdirahman Ahmed Mohamud Abdulkadir Nor mohamed mohamed Rage Ahmed Ismail Mohamud Abdullahi Tuba Saydam Department of General Surgery Mogadishu Somali Turkey Recep Tayyip Erdogan Training and Research HospitalMogadishu 2526Somalia Department of Radiology Mogadishu Somali TurkeyTraining and Research HospitalMogadishu 2526Somalia Department of Pathology Mogadishu Somali Turkey Recep Tayyip Erdogan Training and Research HospitalMogadishu 2526Somalia

BACKGROUND Mycobacterium tuberculosis(TB)is the causative agent of TB,a chronic granulo-matous *** disease is prevalent in low-income countries,posing a significant global health *** TB is one of the three *** disease can mimic other intra-abdominal conditions,leading to delayed diagnosis owing to the absence of specific *** gastric outlet obs-truction(GOO)remains a frequent complication,its incidence has declined with the advent of proton pump inhibitors and Helicobacter pylori eradication *** TB can cause upper gastrointestinal hemorrhage,obstruction,and malignancy-like *** SUMMARY A 23-year-old male presented with recurrent epigastric pain,distension,nausea,vomiting,and weight loss,prompting a referral to a gastroenterologist *** examination revealed distorted gastric mucosa and signs of chronic ***,treatment was interrupted,possibly owing to vomiting or comorbidities such as human immunodeficiency virus infection or *** surgical intervention revealed a dilated stomach and diffuse thickening of the duodenal *** revealed gastric wall effacement with *** Primary gastric TB is rare,frequently leading to *** its rarity,suspicions should be promptly raised when encountering relevant symptoms,often requiring surgical intervention for diagnosis and treatment.

关键词： Tuberculosis Gastrointestinal tuberculosis Gastric outlet obstruction Gastroduodenal tuberculosis Case report

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Shear Let Transform Residual Learning Approach for Single-Image Super-Resolution

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Computers, Materials & Continua 2024年第5期79卷 3193-3209页

作者： Israa Ismail Ghada Eltaweel mohamed Meselhy Eltoukhy Department of Computer Science Faculty of Computers and InformaticsSuez Canal UniversityIsmailia51422Egypt Department of Information Technology College of Computing and Information Technology at KhulaisUniversity of JeddahJeddahSaudi Arabia

Super-resolution techniques are employed to enhance image resolution by reconstructing high-resolution images from one or more low-resolution ***-resolution is of paramount importance in the context of remote sensing,satellite,aerial,security and surveillance ***-resolution remote sensing imagery is essential for surveillance and security purposes,enabling authorities to monitor remote or sensitive areas with greater *** study introduces a single-image super-resolution approach for remote sensing images,utilizing deep shearlet residual learning in the shearlet transform domain,and incorporating the Enhanced Deep Super-Resolution network(EDSR).Unlike conventional approaches that estimate residuals between high and low-resolution images,the proposed approach calculates the shearlet coefficients for the desired high-resolution image using the provided low-resolution image instead of estimating a residual image between the high-and low-resolution *** shearlet transform is chosen for its excellent sparse approximation ***,remote sensing images are transformed into the shearlet domain,which divides the input image into low and high *** shearlet coefficients are fed into the EDSR *** high-resolution image is subsequently reconstructed using the inverse shearlet *** incorporation of the EDSR network enhances training stability,leading to improved generated *** experimental results from the Deep Shearlet Residual Learning approach demonstrate its superior performance in remote sensing image recovery,effectively restoring both global topology and local edge detail information,thereby enhancing image *** to other networks,our proposed approach outperforms the state-of-the-art in terms of image quality,achieving an average peak signal-to-noise ratio of 35 and a structural similarity index measure of approximately 0.9.

关键词： Super-resolution shearlet transform shearlet coefficients enhanced deep super-resolution network

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Comparative study between three carbonaceous nanoblades and nanodarts for antimicrobial applications

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Journal of Environmental Sciences 2024年第2期136卷 594-605页

作者： mohamed S.Selim Ahmed M.Azzam mohamed A.Shenashen Shimaa A.Higazy Bayaumy B.Mostafa Sherif A.El-Safty National Institute for Materials Science(NIMS) 1-2-1 SengenTsukuba-ShiIbaraki-Ken 305-0047Japan Petroleum Application Department Egyptian Petroleum Research InstituteNasr City 11727Egypt Department of Environmental Research Theodor Bilharz Research InstituteGizaEgypt

The design of nanostructured materials occupies a privileged position in the development and management of affordable and effective technology in the antibacterial ***,we discuss the antimicrobial properties of three carbonaceous nanoblades and nanodarts materials of graphene oxide(GO),reduced graphene oxide(RGO),and single-wall carbon nanotubes(SWCNTs)that have a mechano-bactericidal effect,and the ability to piercing or slicing bacterial *** demonstrate the significance of size,morphology and composition on the antibacterial activity mechanism,the designed nanomaterials have been *** minimum inhibitory concentration(MIC),standard agar well diffusion,and transmission electron microscopy were utilized to evaluate the antibacterial activity of GO,RGO,and *** on the evidence obtained,the three carbonaceous materials exhibit activity against all microbial strains tested by completely encapsulating bacterial cells and causing morphological disruption by degrading the microbial cell membrane in the order of RGO>GO>*** of the external cell wall structure and outer membrane proteins,the synthesized carbonaceous nanomaterials exhibited higher antibacterial activity against Gram-positive bacterial strains than Gram-negative and fungal *** had the lowest MIC values(0.062,0.125,and 0.25 mg/mL against ***,***,and ***,respectively),as well as minimum fungal concentrations(0.5 mg/mL for both *** and ***).At 12 hr,the cell viability values against tested microbial strains were completely *** lysis and death occurred as a result of severe membrane damage caused by microorganisms perched on RGO *** work gives an insight into the design of effective graphene-based antimicrobial materials for water treatment and remediation.

关键词： Antimicrobial properties Nanoblades Mechano-bactericidal effect RGO nanosheets Gram-positive bacteria Cell viability

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Insulin resistance as the molecular link between diabetes and Alzheimer's disease

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World Journal of Diabetes 2024年第7期15卷 1430-1447页

作者： Mona mohamed Ibrahim Abdalla Department of Human Biology School of MedicineInternational Medical UniversityBukit Jalil 57000Kuala LumpurMalaysia

Diabetes mellitus(DM)and Alzheimer's disease(AD)are two major health concerns that have seen a rising prevalence *** studies have indicated a possible link between DM and an increased risk of developing ***,while primarily known for its role in regulating blood sugar,also plays a vital role in protecting brain *** resistance(IR),especially prevalent in type 2 diabetes,is believed to play a significant role in AD's *** insulin signalling becomes dysfunctional,it can negatively affect various brain functions,making individuals more susceptible to AD's defining features,such as the buildup of beta-amyloid plaques and tau protein *** research suggests that addressing insulin-related issues might help reduce or even reverse the brain changes linked to *** review aims to explore the relationship between DM and AD,with a focus on the role of *** also explores the molecular mechanisms by which IR might lead to brain changes and assesses current treatments that target *** IR's role in the connection between DM and AD offers new possibilities for treatments and highlights the importance of continued research in this interdisciplinary field.

关键词： Alzheimer's disease Insulin resistance Obesity Dementia Diabetes Metabolic syndrome

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An inverse method for characterization of dynamic response of 2D structures under stochastic conditions

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Chinese Journal of Aeronautics 2024年第3期37卷 440-455页

作者： Xuefeng LI Abdelmalek ZINE mohamed ICHCHOU Noureddine BOUHADDI Pascal FOSSAT Laboratory of Tribology and Systems Dynamic Central School of LyonEcully 69134France Institut Camille Jordan Central School of LyonEcully 69134France Department of Applied Mechanics University of Burgundy Franche-ComtéBesancon 25000France

The reliable estimation of the wavenumber space(k-space)of the plates remains a longterm concern for acoustic modeling and structural dynamic behavior *** current analyses of wavenumber identification methods are based on the deterministic *** this end,an inverse method is proposed for identifying wave propagation characteristics of twodimensional structures under stochastic conditions,such as wavenumber space,dispersion curves,and band *** proposed method is developed based on an algebraic identification scheme in the polar coordinate system framework,thus named Algebraic K-Space Identification(AKSI)***,a model order estimation strategy and a wavenumber filter are proposed to ensure that AKSI is successfully *** main benefit of AKSI is that it is a reliable and fast method under four stochastic conditions:(A)High level of signal noise;(B)Small perturbation caused by uncertainties in measurement points’coordinates;(C)Non-periodic sampling;(D)Unknown structural *** validate the proposed method,we numerically benchmark AKSI and three other inverse methods to extract dispersion curves on three plates under stochastic *** experiment is then performed on an isotropic steel *** investigations demonstrate that AKSI is a good in-situ k-space estimator under stochastic conditions.

关键词： Inverse method Dispersion relation Wavenumber space Periodic plates Stochastic conditions Wave propagation characterization

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Classified VPN Network Traffic Flow Using Time Related to Artificial Neural Network

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Computers, Materials & Continua 2024年第7期80卷 819-841页

作者： Saad Abdalla Agaili mohamed Sefer Kurnaz Department of Electrical and Computer Engineering Altinbas UniversityIstanbul34000Turkey

VPNs are vital for safeguarding communication routes in the continually changing cybersecurity ***,increasing network attack complexity and variety require increasingly advanced algorithms to recognize and categorizeVPNnetwork *** present a novelVPNnetwork traffic flowclassificationmethod utilizing Artificial Neural Networks(ANN).This paper aims to provide a reliable system that can identify a virtual private network(VPN)traffic fromintrusion attempts,data exfiltration,and denial-of-service *** compile a broad dataset of labeled VPN traffic flows from various apps and usage ***,we create an ANN architecture that can handle encrypted communication and distinguish benign from dangerous *** effectively process and categorize encrypted packets,the neural network model has input,hidden,and output *** use advanced feature extraction approaches to improve the ANN’s classification accuracy by leveraging network traffic’s statistical and behavioral *** also use cutting-edge optimizationmethods to optimize network characteristics and *** suggested ANN-based categorization method is extensively tested and *** show the model effectively classifies VPN traffic *** also show that our ANN-based technique outperforms other approaches in precision,recall,and F1-score with 98.79%*** study improves VPN security and protects against new *** VPNtraffic flows effectively helps enterprises protect sensitive data,maintain network integrity,and respond quickly to security *** study advances network security and lays the groundwork for ANN-based cybersecurity solutions.

关键词： VPN network traffic flow ANN classification intrusion detection data exfiltration encrypted traffic feature extraction network security

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Combined CNN-LSTM Deep Learning Algorithms for Recognizing Human Physical Activities in Large and Distributed Manners:A Recommendation System

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Computers, Materials & Continua 2024年第4期79卷 351-372页

作者： Ameni Ellouze Nesrine Kadri Alaa Alaerjan mohamed Ksantini Control and Energy Management Laboratory National Engineering SchoolPreparatory Institute for Engineering StudiesUniversity of SfaxSfax3029Tunisia Higher Institute of Computer Science and Communication Technologies University of SousseSousseBN19RHTunisia College of Computer and Information Sciences Jouf UniversityPO Box 2014SakakahSaudi Arabia

Recognizing human activity(HAR)from data in a smartphone sensor plays an important role in the field of health to prevent chronic *** and weekly physical activities are recorded on the smartphone and tell the user whether he is moving well or ***,smartphones and their associated sensing devices operate in distributed and unstable ***,collecting their data and extracting useful information is a significant *** this context,the aimof this paper is twofold:The first is to analyze human behavior based on the recognition of physical *** the results of physical activity detection and classification,the second part aims to develop a health recommendation system to notify smartphone users about their healthy physical behavior related to their physical *** system is based on the calculation of calories burned by each user during physical *** this way,conclusions can be drawn about a person’s physical behavior by estimating the number of calories burned after evaluating data collected daily or even weekly following a series of physical *** identify and classify human behavior our methodology is based on artificial intelligence models specifically deep learning techniques like Long Short-Term Memory(LSTM),stacked LSTM,and bidirectional *** human activity data contains both spatial and temporal information,we proposed,in this paper,to use of an architecture allowing the extraction of the two types of information *** Convolutional Neural Networks(CNN)has an architecture designed for spatial information,our idea is to combine CNN with LSTM to increase classification accuracy by taking into consideration the extraction of both spatial and temporal *** results obtained achieved an accuracy of 96%.On the other side,the data learned by these algorithms is prone to error and *** overcome this constraint and improve performance(96%),we proposed to use the

关键词： Human physical activities smartphone sensors deep learning distributed monitoring recommendation system uncertainty healthy calories

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Erdafitinib and checkpoint inhibitors for first-line and second-line immunotherapy of hepatic,gastrointestinal,and urinary bladder carcinomas:Recent concept

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World Journal of Hepatology 2024年第4期16卷 490-493页

作者： mohamed Wishahi Department of Urology Theodor Bilharz Research InstituteCairo 12411Egypt

Cancer immunotherapy is administered for first-line,second-line,neoadjuvant,or adjuvant treatment of advanced,metastatic,and recurrent cancer in the liver,gastrointestinal tract,and genitourinary tract,and other solid *** is a fibroblast growth factor receptor(FGFR)inhibitor,and it is an adenosine triphosphate competitive inhibitor of FGFR1,FGFR2,FGFR3,and *** checkpoint inhibitors are monoclonal antibodies that block programmed cell death protein 1(PD-1)and its ligand that exert intrinsic antitumor *** promising results of first-line treatment of advanced and metastatic urothelial carcinoma with PD-1 blockades with single or combined agents,indicate a new concept in the treatment of advanced,metastatic,and recurrent hepatic and gastrointestinal *** immunotherapy as first-line treatment will improve overall survival and provide better quality of *** is arising as to whether to apply the cancer immunotherapy as first-line treatment in invasive carcinomas,or as second-line treatment in recurrent or metastatic carcinoma following the standard *** literature in the field is not definite,and so far,there has been no consensus on the best approach in this *** present,as it is described in this editorial,the decision is applied on a case-by-case basis.

关键词： Programmed cell death protein-ligand 1 Erdafitinib Liver cancer Fibroblast growth factor receptor inhibitors Checkpoint inhibitors Bladder cancer Metastases

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Exploring impedance spectrum for lithium-ion batteries diagnosis and prognosis:A comprehensive review

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Journal of Energy Chemistry 2024年第8期95卷 464-483,I0010页

作者： Xinghao Du Jinhao Meng Yassine Amirat Fei Gao mohamed Benbouzid University of Brest UMR CNRS 6027 IRDL29238 BrestFrance School of Electrical Engineering Xi'an Jiaotong UniversityXi'an 710049ShaanxiChina ISEN Yncréa Ouest L@bISEN29200 BrestFrance Universitéde Technolgie de Belfort-Montbéliard UMR CNRS 6174 FEMTO-ST90000 BelfortFrance

Lithium-ion batteries have extensive usage in various energy storage needs,owing to their notable benefits of high energy density and long *** monitoring of battery states and failure identification are indispensable for guaranteeing the secure and optimal functionality of the *** impedance spectrum has garnered growing interest due to its ability to provide a valuable understanding of material characteristics and electrochemical *** inspire further progress in the investigation and application of the battery impedance spectrum,this paper provides a comprehensive review of the determination and utilization of the impedance *** sources of impedance inaccuracies are systematically analyzed in terms of frequency response *** applicability of utilizing diverse impedance features for the diagnosis and prognosis of batteries is further ***,challenges and prospects for future research are discussed.

关键词： Lithium-ion battery Impedance spectrum Temperature monitoring Failure diagnosis Health prognosis

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