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Post-hepatectomy liver failure:A timeline centered review

Hepatobiliary & Pancreatic Diseases International 2023年第6期22卷 554-569页

作者： mohamed bekheit Lisa Grundy Ahmed KA Salih Petru Bucur Eric Vibert Mudassar Ghazanfar Department of Surgery NHS GrampianForesterhill Health CampusAshgrove RoadAB252ZN AberdeenUK Institute of Medical Sciences Medical SchoolForesterhill Health CampusAshgrove RoadAB252ZN AberdeenUK Hépatica Integrated Center of HPB CareElite HospitalAgriculture RoadAlexandriaEgypt Department of Surgery University Hospital ToursVal de la Loire 37000France Centre Hépatobiliaire Paul Brousse Hospital12 Paul Valliant Couturier94804 VillejuifFrance

Background: Post-hepatectomy liver failure(PHLF) is a leading cause of postoperative mortality after liver surgery. Due to its significant impact, it is imperative to understand the risk stratification and preventative strategies for PHLF. The main objective of this review is to highlight the role of these strategies in a timeline centered way around curative resection. Data sources: This review includes studies on both humans and animals, where they addressed PHLF. A literature search was conducted across the Cochrane Library, Embase, MEDLINE/Pub Med, and Web of Knowledge electronic databases for English language studies published between July 1997 and June 2020. Studies presented in other languages were equally considered. The quality of included publications was assessed using Downs and Black’s checklist. The results were presented in qualitative summaries owing to the lack of studies qualifying for quantitative analysis. Results: This systematic review with 245 studies, provides insight into the current prediction, prevention, diagnosis, and management options for PHLF. This review highlighted that liver volume manipulation is the most frequently studied preventive measure against PHLF in clinical practice, with modest improvement in the treatment strategies over the past decade. Conclusions: Remnant liver volume manipulation is the most consistent preventive measure against PHLF.

关键词： Post-hepatectomy liver failure Liver neoplasms Prediction Prevention Management

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The role of graft reperfusion sequence in the development of non-anastomotic biliary strictures following orthotopic liver transplantation: A meta-analysis

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Hepatobiliary & Pancreatic Diseases International 2019年第1期18卷 4-11页

作者： mohamed bekheit Matteo Catanzano Stuart Shand Irfan Ahmed ELSaid ELKayal Gihan mohamed Shehata Adel Zaki Center of Liver Surgery and Transplantation Paul Brousse Hospital University of Paris-Sud Medical Research Institute University of Alexandria HPB Surgery Unit Department of Surgery Aberdeen Royal Infirmary Department of Surgery Elkabbary General Hospital University of Aberdeen Department of Surgery Alexandria Main University Hospital Faculty of Medicine

Background: Liver transplant is a potential cure for liver failure and hepatic malignancy but there are many techniques which have been described for vascular reconstruction. This study was to compare the prevalence of non-anastomotic biliary stricture and other surgical complications based on Clavien-Dindo scoring system, in initial portal reperfusion(sequential) versus simultaneous or initial artery reperfusion. Data sources: Meta-analysis of published studies comparing the outcomes of both techniques was carried out. Data search was conducted across the major databases and studies were selected under the guidance of the Cochrane guidelines for systematic reviews and meta-analysis. Results: Seven studies were included to address the primary and the secondary outcomes. No statistical difference was found in the incidence of non-anastomotic biliary strictures(OR = 0.40; P = 0.14), regardless of reperfusion technique. The pooled estimate of the Clavien-Dindo grading of complications was not significantly different between the techniques, though Clavien-Dindo II complications were higher in the simultaneous or initial artery reperfusion group than the initial portal reperfusion group(OR = 2.73; P = 0.01). Similarly, there was no difference in the operative time, hospital stay and other outcomes addressed in this report. Conclusions: The available evidence suggests that there is no significant difference demonstrated in the rate of non-anastomotic biliary strictures or other complications, between the two techniques, except for Clavien-Dindo II complications.

关键词： Liver transplantation Organ transplantation Liver surgery Rejection

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Current practice of anticoagulant in the treatment of splanchnic vein thrombosis secondary to acute pancreatitis

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Hepatobiliary & Pancreatic Diseases International 2020年第2期19卷 116-121页

作者： William Norton Gabija Lazaraviciute George Ramsay Irene Kreis Irfan Ahmed mohamed bekheit Department of General Surgery Aberdeen Royal InfirmaryAberdeen AB252ZNUK Rowett Institute of Nutrition and Health University of AberdeenForesterhillAberdeen AB252ZDUK Clinical Effectiveness Unit Royal College of Surgeons of England35-43 Lincoln’s Inn FieldsHolbornLondon WC2A 3PEUK Department of Surgery El Kabbary HospitalEl KabbaryAlexandriaEgypt

Background:Severe acute pancreatitis is a common diagnosis in emergency general surgery and can be a cause of significant morbidity and mortality.A consequence of severe acute pancreatitis is thrombus in the splanchnic veins.These thrombi can potentially lead to bowel ischemia or hepatic failure.However,another complication of severe acute pancreatitis is retroperitoneal bleeding.At this time,it is unclear if treating patients for splanchnic vein thrombosis in the context of severe acute pancreatitis is associated with any outcome benefit.A systematic review might clarify this question.Data sources:A two-fold search strategy(one broad and one precise)looked at all published literature.The review was registered on PROSPERO(ID:CRD42018102705).MEDLINE,EMBASE,PubMed,Cochrane and Web of Science databases were searched and potentially relevant papers were reviewed indepen-dently by two researchers.Any disagreement was reviewed by a third independent researcher.Primary outcome was reestablishment of flow in the thrombosed vein versus bleeding complications.Results:Of 1462 papers assessed,a total of 16 papers were eligible for inclusion.There were no ran-domized controlled trials,2 were case series,5 retrospective single-center studies and 9 case reports.There were a total of 198 patients in these studies of whom 92(46.5%)received anticoagulation therapy.The rates of recanalization of veins in the treated and non-treated groups was 14%and 11%and bleeding complications were 16%and 5%,respectively.However,the included studies were too heterogeneous to undertake a meta-analysis.Conclusions:The systematic review highlights the lack evidence addressing this clinical question.There-fore a randomized controlled trial would be appropriate to undertake.

关键词： Severe acute pancreatitis Splanchnic vein thrombosis Anticoagulant therapy

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Transit time ultrasound perivascular flow probe technology is superior to MR imaging on hepatic blood flow measurement in a porcine model

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Hepatobiliary & Pancreatic Diseases International 2018年第6期17卷 538-545页

作者： mohamed bekheit Chloe Audebert Petru Bucur Hans Adriaensen Emilie Bled Mylène Wartenberg Irene Vignon-Clementel Eric Vibert Inserm Unité 1193 112 Boulevard Paul Valliant CuturierVillejuifFrance Institute of medical sciences University of AberdeenAberdeenUK Centre de recherche Inria de Paris ParisFrance Sorbonne Universités UPMC University of Paris 6Laboratoire Jacques-LouisLionsParisFrance CHRU hopitaux de ToursChirurgie Héato-biliaire et pancréatiqueTransplantation HéatiqueToursFrance Plateforme Chirurgie et Imagerie pour le Recherche et l’Enseignement(CIRE) ImagerieUMR-PRC37380 NouzillyCentre INRA Val de LoireFrance AP-HP Hoital Paul BrousseCentre Héato-BiliaireVillejuifFrance

Background: The hepatic hemodynamics is an essential parameter in surgical planning as well as in various disease processes. The transit time ultrasound(TTUS) perivascular flow probe technology is widely used in clinical practice to evaluate the hepatic inflow, yet invasive. The phase-contrast-MRI(PC-MRI) is not invasive and potentially applicable in assessing the hepatic blood flow. In the present study, we compared the hepatic inflow rates using the PC-MRI and the TTUS probe, and evaluated their predictive value of post-hepatectomy adverse events. Methods: Eighteen large white pigs were anaesthetized for PC-MRI and approximately 75% hepatic resection was performed under a unified protocol. The blood flow was measured in the hepatic artery(Qha), the portal vein(Qpv), and the aorta above the celiac trunk(Qca) using PC-MRI, and was compared to the TTUS probe. The Bland-Altman method was conducted and a partial least squares regression(PLS) model was implemented. Results: The mean Qpv measured in PC-MRI was 0.55 ± 0.12 L/min, and in the TTUS probe was 0.74 ± 0.17 L/min. Qca was 1.40 ± 0.47 L/min in the PC-MRI and 2.00 ± 0.60 L/min in the TTUS probe. Qha was 0.17 ± 0.10 L/min in the PC-MRI, and 0.13 ± 0.06 L/min in the TTUS probe. The Bland-Altman method revealed that the estimated bias of Qca in the PC-MRI was 32%(95% CI:-49% to 15%); Qha 17%(95% CI:-15% to 51%); and Qpv 40%(95% CI:-62% to 18%). The TTUS probe had a higher weight in predicting adverse outcomes after 75% resection compared to the PC-MRI( β= 0.35 and 0.43 vs β = 0.22 and 0.07, for tissue changes and premature death, respectively). Conclusions: There is a tendency of the PC-MRI to underestimate the flow measured by the TTUS probes. The TTUS probe measures are more predictive of relevant post-hepatectomy outcomes.

关键词： Hepatic blood flow Phase contrast MRI Transit time ultrasound probe Porcine model Liver surgery

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Reply to: Comment on “The role of graft reperfusion sequence in the development of non-anastomotic biliary strictures following orthotopic liver transplantation: A meta-analysis”

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Hepatobiliary & Pancreatic Diseases International 2019年第4期18卷 402-402页

作者： mohamed bekheit Department of Surgery Aberdeen Royal Infirmary Division of Clinical Sciences Aberdeen University Department of Surgery El Kabbary Hospital

The Author Reply:Thank you for extending the opportunity of discussion among interested scientists.We received with interest and curiosity the letter submitted by Dr Pietersen and his colleagues in response to our rec... 详细信息

关键词： stricture reperfusion graft

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An Efficient One-pot Synthesis of Certain Stereoselective Spiro[pyrazole-4,5′-isoxazoline]-5-one Derivatives:In vitro Evaluation of Antitumor Activities,Molecular Docking and In silico ADME Predictions

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Chemical Research in Chinese Universities 2022年第4期38卷 1073-1082页

作者： Ghadah F.ALJOHANI Fatma A.A.EL-HAG mohamed S.bekheit Ewies F.EWIES May A.EL-MANAWATY Chemistry Department College of ScienceTaibah UniversityP.O.Box 30002Code 14177Al-Madinah Al MunawarahSaudi Arabia Department of Chemistry of Natural and Microbial Products National Research CentreDokkiP.O.Box 12622GizaEgypt Pesticide Chemistry Department National Research CentreDokkiP.O.Box 12622GizaEgypt Organometallic and Organometalloid Chemistry Department National Research CentreDokkiP.O.Box 12622GizaEgypt Department of Pharmacognosy National Research CentreDokkiP.O.Box 12622GizaEgypt

Alibrary of novel spiro[pyrazole-4,5′-isoxazoline]-5-one derivatives were designed and synthesized using a concise and efficient one-pot reaction protocol through 1,3-dipolar cycloaddition between 4-benzylidene-3-methyl-1-phenyl-^(1)H-pyrazol-5(4H)-one and chlorooximes.The synthesized derivatives were elucidated and characterized based on their spectroscopic data,including infrared spectrometry(IR),^(1)H NMR,^(13)C NMR,and elemental and mass spectral analysis.The synthesized compounds were evaluated for their antitumor inhibition potency against four human cancer cell lines,including human prostatic adenocarcinoma(PC3),human colorectal carcinoma(HCT116),human liver hepatocellular carcinoma(HepG2)and breast adenocarcinoma(MCF7).The outcomes were compared with the standard reference drug Doxorubicin.Among the synthesized chlorooximes,compounds 6d and 6e were the most active compounds on all cell lines.The spiro[pyrazole-4,5′-isoxazoline]-5-one derivatives 7a and 7c were active on the HepG2 liver cancer cell line.In comparison,compounds 7f and 7g were moderately active on the MCF7 cell line.The structure-activity relationship was explored for the synthesized compounds.Besides,in silico analysis of physicochemical,adsorption,distribution,metabolism,excretion and toxicity(ADMET)properties were done to determine the potential capacity of drug candidates.Molecular docking study onto the epidermal growth factor(EGF)tyrosine kinase receptor(3POZ)was done for the most active compounds to validate the reliability of in vitro anticancer screenings.

关键词： Spiroisoxazoline Pyrazole Chlrooxime 1,3-Dipolar cycloaddition Antitumor Molecular docking

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A Distributionally Robust Optimization Scheduling Model for Regional Integrated Energy Systems Considering Hot Dry Rock Co-Generation

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Computer Modeling in Engineering & Sciences 2024年第8期140卷 1387-1404页

作者： Hao Qi mohamed Sharaf Andres Annuk Adrian Ilinca mohamed A.mohamed College of Electrical and New Energy China Three Gorges UniversityYichang443002China Department of Industrial Engineering College of EngineeringKing Saud UniversityRiyadh11421Saudi Arabia Institute of Forestry and Engineering Estonian University of Life SciencesTartu51006Estonia Department of Mechanical Engineering école de Technologie SupérieureMontréalQC H3C 1K3Canada Electrical Engineering Department Faculty of EngineeringMinia UniversityMinia61519Egypt

Hot dry rock(HDR)is rich in reserve,widely distributed,green,low-carbon,and has broad development potential and prospects.In this paper,a distributionally robust optimization(DRO)scheduling model for a regionally integrated energy system(RIES)considering HDR co-generation is proposed.First,the HDR-enhanced geothermal system(HDR-EGS)is introduced into the RIES.HDR-EGS realizes the thermoelectric decoupling of combined heat and power(CHP)through coordinated operation with the regional power grid and the regional heat grid,which enhances the system wind power(WP)feed-in space.Secondly,peak-hour loads are shifted using price demand response guidance in the context of time-of-day pricing.Finally,the optimization objective is established to minimize the total cost in the RIES scheduling cycle and construct a DRO scheduling model for RIES with HDR-EGS.By simulating a real small-scale RIES,the results show that HDR-EGS can effectively promote WP consumption and reduce the operating cost of the system.

关键词： Energy harvesting integrated energy systems optimum scheduling time-of-use pricing demand response geothermal energy

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Impact of lifestyle interventions on pathogenesis of nonalcoholic fatty liver disease

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World Journal of Gastroenterology 2024年第20期30卷 2633-2637页

作者： Wafaa mohamed Ezzat Department of Internal Medicine Medical Research and Clinical Studies InstituteNational Research CenterGiza 12311Egypt

This editorial builds on the article titled“Establishment and validation of an adherence prediction system for lifestyle interventions in non-alcoholic fatty liver disease”by Zeng et al.We carried out a critical examination of nonalcoholic fatty liver disease(NAFLD)pathogenesis and how lifestyle interventions could facilitate disease resolution,particularly highlighting that non-alcoholic steatohepatitis(NASH)is a severe form of NAFLD.Our discussion details that weight loss is a pivotal factor in disease outcomes:A 3%-5%reduction is enough for resolution in 50%of non-obese individuals,while a 7%-10%reduction achieves similar benefits in obese individuals,as demonstrated by magnetic resonance spectroscopy.Additionally,the editorial underscores that such lifestyle changes are instrumental not only in resolving NAFLD but also in reversing hepatic steatosis and inflammation.These insights,derived from the research,emphasize the critical role of personalized lifestyle modifications in halting the progression of NAFLD to NASH and even reversing fibrosis,thus offering a template for effective patient management.

关键词： Nonalcoholic fatty liver disease Non-alcoholic steatohepatitis Diet Physical activity Life style

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Treatment-induced neuroendocrine prostate cancer and de novo neuroendocrine prostate cancer:Identification,prognosis and survival,genetic and epigenetic factors

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World Journal of Clinical Cases 2024年第13期12卷 2143-2146页

作者： mohamed Wishahi Department of Urology Theodor Bilharz Research InstituteCairo 12411Egypt

Neuroendocrine prostate cancer(NEPC)shows an aggressive behavior compared to prostate cancer(PCa),also known as prostate adenocarcinoma.Scanty foci in PCa can harbor genetic alternation that can arise in a heterogeneity of prostate cancer.NEPC may arise de novo or develop following androgen deprivation therapy(ADT).NEPC that arise following ADT has the nomenclature“treatmentemerging/induced NEPC(t-NEPC)”.t-NEPC would be anticipated in castration resistant prostate cancer(CRPC)and metastatic PCa.t-NEPC is characterized by low or absent androgen receptor(AR)expression,independence of AR signaling,and gain of neuroendocrine phenotype.t-NEPC is an aggressive metastatic tumor,develops from PCa in response to drug induced ADT,and shows very short response to conventional therapy.t-NEPC occurs in 10%-17%of patients with CRPC.De novo NEPC is rare and is accounting for less than 2%of all PCa.The molecular mechanisms underlying the trans-differentiation from CRPC to t-NEPC are not fully elucidated.Sphingosine kinase 1 plays a significant role in t-NEPC development.Although neuroendocrine markers:Synaptophysin,chromogranin A,and insulinoma associated protein 1(INSM1)are expressed in t-NEPC,they are non-specific for diagnosis,prognosis,and follow-up of therapy.t-NEPC shows enriched genomic alteration in tumor protein P53(TP53)and retinoblastoma 1(RB1).There are evidences suggest that t-NEPC might develop through epigenetic evolution.There are genomic,epigenetic,and transcriptional alterations that are reported to be involved in development of t-NEPC.Knock-outs of TP53 and RB1 were found to contribute in development of t-NEPC.PCa is resistant to immunotherapy,and at present there are running trials to approach immunotherapy for PCa,CRPC,and t-NEPC.

关键词： Prostate cancer Neuroendocrine carcinoma Treatment induced neuroendocrine prostate cancer Androgen deprivation therapy Genetic and epigenetic factors Castration resistant prostate cancer De novo neuroendocrine prostate cancer

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Exact and heuristic formulae to compute the geodetic height from the ellipse equation

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Geodesy and Geodynamics 2024年第2期15卷 150-155页

作者： mohamed Eleiche Ahmed Hamdi Mansi Construction Department Faculty of EngineeringEgyptian Russian UniversityCairoEgypt Istituto Nazionale di Geofisica e Vulcanologia Sezione di PisaPisaPlItaly

The conversion of the cartesian coordinates of a point to its geodetic equivalent coordinates in reference to the geodetic ellipsoid is one of the main challenges in geodesy.The ellipse equation in the meridian plane significantly influences the value of the geodetic coordinates.This research analyzes this influence and how it can contribute to their solutions.The study investigates the mathematical relation between them and presents an exact formula relating to the geodetic height and the ellipse equation.In addition,a heuristic formula for the relation between the geodetic height and the ellipse equation is proposed,which is independent of the geodetic latitude and has a relative accuracy better than 99.9 %.The calculation is stable,and the cost is low.

关键词： Ellipse equation Geodetic height Heuristic geodetic height

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