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Pyronaridine combined with diminazene aceturate inhibits Babesia in vitro and in vivo

Asian Pacific Journal of Tropical Biomedicine 2024年第3期14卷 93-99页

作者： Shimaa Abd El-Salam El-Sayed mohamed Z.Sayed-Ahmed Shaimaa Ahmed Awad Ali Nourah Alsadaan Nawazish Alam Mahmoud S.Alkhoudary Ikuo Igarashi mohamed abdo rizk National Research Center for Protozoan Diseases Obihiro University of Agriculture and Veterinary MedicineInada-ChoObihiroHokkaido 080-8555Japan Department of Biochemistry and Chemistry of Nutrition Faculty of Veterinary MedicineMansoura UniversityMansoura 35516Egypt Department of Clinical Pharmacy College of PharmacyJazan UniversityJazan 45142Saudi Arabia Medical-Surgical Department College of NursingJouf UniversitySakaka 72388Saudi Arabia Critical Care and Emergency Nursing Faculty of NursingMansoura UniversityEgypt College of Nursing Jouf UniversitySakaka 72388Saudi Arabia Faculty of Pharmacy Mansoura UniversityMansoura 35516DakahliaEgypt Department of Internal Medicine and Infectious Diseases Faculty of Veterinary MedicineMansoura UniversityMansoura 35516Egypt

Objective:To evaluate the combination therapy of pyronaridine tetraphosphate and diminazene aceturate against Babesia in vitro and in ***:Bioinformatic analysis was performed using atom pair *** in vitro combination test was performed against Babesia bovis and Theileria ***,the in vivo chemotherapeutic efficacy of pyronaridine tetraphosphate in combination with diminazene aceturate was investigated against the growth of Babesia microti in mice using a fluorescence inhibitory ***:Pyronaridine tetraphosphate and diminazene aceturate exhibited nearly similar molecular *** in vitro combination of pyronaridine tetraphosphate and diminazene aceturate was synergistic on Babesia bovis and additive on Theileria *** addition,5 mg/kg pyronaridine tetraphosphate combined with 10 mg/kg diminazene aceturate inhibited Babesia microti growth significantly compared with those observed after treatment with 25 mg/kg diminazene aceturate alone from day 6 post treatment to day 12 post *** combination therapy also normalized the hematological parameters of infected ***:An oral dose of pyronaridine tetraphosphate combined with a subcutaneous dose of diminazene aceturate inhibits Babesia in vitro and in mice,suggesting it might be a new paradigm for the treatment of babesiosis.

关键词： Babesia Pyronaridine tetraphosphate Diminazene aceturate Babesiosis Theileria

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Cocktail of Theileria equi antigens for detecting infection in equines

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亚太热带生物医学杂志：英文版 2015年第12期5卷 977-981页

作者： Shimaa Abd El-Salam El-Sayed mohamed abdo rizk mohamed Alaa Terkawi Ahmed Mousa El Said El Shirbini El Said Gehad Elsayed mohamed Fouda Naoaki Yokoyama Ikuo Igarashi National Research Center for Protozoan Diseases Obihiro University of Agriculture and Veterinary Medicine Department of Biochemistry and Chemistry of Nutrition Faculty of Veterinary Medicine Mansoura University Department of Internal Medicine and Infectious Diseases Faculty of Veterinary Medicine Mansoura University Department of Biochemistry and Chemistry of Nutrition Faculty of Veterinary Medicine Sadat City University

Objective:To use two diagnostic antigens belonging to the frequently associated in Theileria domain,Theileria equi(***)protein 82(Te 82)and *** 104 k Da microneme-rhoptry antigen precursor(Te 43),to diagnose *** infection in horses as compared with equi merozoite antigen-2(EMA-2).Methods:In the current study,we applied a cocktail-ELISA containing two antigens(EMA-2+Te 82)to diagnose *** infection either in experimentally infected horses or in field ***:Our findings have revealed that a cocktail formula of EMA-2+Te 82 provided a more practical and sensitive diagnostic candidate for diagnosing *** infection in horses as compared with Te 82 or Te 43 ***:The ELISA technique using a cocktail formula of EMA-2+Te 82 offers a practical and sensitive diagnostic tool for diagnosing *** infection in horses and using of this promising cocktail formula will be applicable for epidemiological surveys and will help control the infection in horses.

关键词： Theileria equi Equi merozoite antigen-2 Theileria

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Insights into the anorexic mechanism of Khat:an integrated in vivo,ex vivo,and in silico investigations

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Traditional Medicine Research 2024年第10期9卷 36-51页

作者： Ahmed Ali Jerah Manal mohamed Elhassan Taha Abdullah Farasani Sivakumar Sivagurunathan Moni Emad Sayed Shaheen Andleeb Khan Ibrahim abdo Khardali Magbool Oraiby Heyam mohamed Ali Sidahmed Siddig Ibrahim Abdelwahab Department of Medical Laboratory Technology College of Applied Medical SciencesJazan UniversityJazan 45142Saudi Arabia Health Research Centre Jazan UniversityJazan 45142Saudi Arabia Department of Pharmaceutics College of PharmacyJazan UniversityJazan 45142Saudi Arabia Department of Biosciences Faculty of ScienceIntegral UniversityLucknow 226026India Poison Control and Medical Forensic Chemistry Center General Directorate of Health AffairsJazan 45142Saudi Arabia Department of Pharmaceutical Chemistry Faculty of PharmacyAl-Neelain UniversityKhartoum 16458Sudan

Background:Chewing Khat(Catha edulis)releases cathine and cathinone,which may reduce appetite via an unknown *** study investigated the peripheral and central effects of fresh leaves and buds of Catha edulis water extract(CEWE)on appetite biomarkers,gene expression,and body weight,using in vivo,ex vivo,and in silico ***:Rats of both sexes were orally administered CEWE at different doses and durations in three different *** chromatography-mass spectroscopy(LC-MS)-MS was used to detect cathinone and cathine in the murine *** effect of Khat on serotonin receptors was studied in isolated rat fundus *** of the two Khat ligands was performed on G(The 5-hydroxytryptamine-type 2C receptor(5-HT2C)in an agonist-bound active conformation)and H(5-HT2C in an antagonist-bound inactive conformation)proteins to determine which ligands are most likely to act as agonists or ***:Significant differences(P0.05).The expression of the ghrelin and leptin genes was also unaffected,but the expression of the 5-hydroxytryptamine(5-HT)gene decreased(P<0.05)with CEWE *** antagonizes 5-HT receptors in isolated rat fundus *** findings indicated that the khat ligands bound to 5-HT2C *** and cathinone levels in rat plasma were ***:Khat extract may suppress appetite by antagonizing the 5-HT *** research is required to understand its mechanism and potential applications.

关键词： Catha edulis appetite leptin ghrelin 5-hydroxytryptamine molecular docking

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Spectrally adapted red flare tracers with superior spectral performance

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Defence Technology（防务技术） 2017年第6期13卷 406-412页

作者： Ramy Sadek mohamed Kassem mohamed abdo Sherif Elbasuney School of Chemical Engineering Military Technical CollegeKobry ElkobaCairoEgypt

The production of bright light, with vivid color, is the primary purpose of signaling, illuminating devices,and fire control purposes. This study, reports on the development of red flame compositions with enhanced performance in terms of luminous intensity, and color quality. The light intensity and the imprint spectra of developed red flame compositions to standard NATO red tracer(R-284 NATO) were measured using digital luxmeter, and UV-Vis. spectrometer. The main giving of this study is that the light intensity of standard NATO red tracer was increased by 72%, the color quality was also improved by60%(over the red band from 650 to 780 nm). This enhanced spectral performance was achieved by means of deriving the combustion process to maximize the formation of red color emitting species in the combustion flame. Thanks to the optimum ratio of color source to color intensifier using aluminum metal fuel; this approach offered the highest intensity and color quality. Upon combustion, aluminum was found to maximize the formation SrCL(the main reactive red color emitting species) and to minimize the interfering incandescent emission resulted from MgO and SrO. Quantification of active red color emitting species in the combustion flame was conducted using chemical equilibrium thermodynamic code named ICT. The improvement in red flare performance, established the rule that the color intensifier should be in the range from 10 to 15 Wt % of the total composition.

关键词： Pyrotechnics Colored flames Tracers Luminous intensity Molecular spectroscopy

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Novel yellow colored flame compositions with superior spectral performance

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Defence Technology（防务技术） 2017年第1期13卷 33-39页

作者： Ramy Sadek mohamed Kassem mohamed abdo Sherif Elbasuney School of Chemical Engineering Military Technical CollegeKobry El-KobbaCairoEgypt

The production of colored flames is the primary purpose of military signaling, projectile tracing, and illuminating devices. Certain elements and compounds when heated to high temperature have the unique property of emitting lines or narrow bands in the visible region(380-780 nm). This study, reports on the development of novel yellow colored flame compositions with enhanced spectral performance in terms of luminous intensity, and color quality to standard Russian yellow tracer. The light intensity and the imprint spectra of developed yellow flares were measured using digital luxmeter and UV e Vis. spectrometer respectively. The main giving of this study is that the light intensity, and color quality of Russian yellow tracer were improved by 287%, and 170% respectively. This was accomplished by means of optimizing the ratio of novel binder to color source using aluminum metal fuel. Aluminumbased formulations were found to maximize the formation of yellow reactive emitting specimens, and to eliminate any interfering incandescent emission resulted from Mg O. Quantification of yellow color emitting specimens in the combustion gaseous products was achieved using chemical equilibrium thermodynamic code named ICT(Institute of Chemical Technology in Germany, Virgin 2008); in an attempt to judge the light quality. This improvement in yellow flare performance established the rule that the emission intensity increases as the reaction temperature increases. In the meantime upper limit of temperature was avoided to maximize the color quality.

关键词： Pyrotechnics Colored flames Yellow tracer Atomic spectroscopy Color quality

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Development of new potentiometric sensors for the determination of proguanil hydrochloride in serum and urine

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Chinese Chemical Letters 2016年第6期27卷 857-863页

作者： Fatehy M.Abdel-Haleem mohamed Saad mohamed S.rizk Chemistry Department Faculty of Science Cairo University

Potentiometric electrodes were developed for the rapid determination of proguanil hydrochloride in pure samples, pharmaceutical preparations and spiked serum and urine samples using PVC membrane,screen printed（SPE）, coated wired（CWE）, carbon paste（CPE） and modified carbon paste（MCPE）electrodes based on the ion-exchanger of proguanil with phosphotungestic acid（Pr-PT） as a chemical modifier. The prepared electrodes showed Nernestian slopes of 59.7, 58.1, 58.5, 58.5 and 57.0 for the PVC,SPE, CWE, CPE and MCPE for the proguanil ions in a wide concentration range of 1.0 ＊ 10^-5–1.0 ＊ 10^-2mol L^-1 at 25°C with detection limits of 7.94 ＊ 10^-6, 1.0 ＊ 10^-5, 1.0 ＊ 10^-6, 7.07 ＊ 10^-6 and 2.5 ＊ 10^-6 mol L^-1, respectively. The prepared electrodes exhibited high proguanil selectivity in relation to several inorganic ions and sugars and they could be successfully utilized for its determination in pure solutions, pharmaceutical preparations and serum and urine samples using the direct potentiometry and standard addition methods with very good recovery values.

关键词： Proguanil hydrochloride PVC membrane electrode Carbon paste electrode Screen printed electrode MWCNTs Coated wire electrode

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Novel colored flames via chromaticity of essential colors

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Defence Technology（防务技术） 2019年第2期15卷 210-215页

作者： Ramy Sadek mohamed Kassem mohamed abdo Ahmed Fahd Hesham Tantawy Amir Elsaidy Sherif Elbasuney School of Chemical Engineering Military Technical College

Colored flame compositions have distinctive variety of applications ranging from military signaling,rocket tracking, and illuminating devices. Certain elements and compounds when heated to high temperature are able to emit unique wavelengths in the visible region. This study, reports on the development of novel colored flames that cannot be generated by emitting atomic/molecular species. This was achieved by using chromaticity of basic colored flames. Mixing of high quality primary colored flames including Blue, Yellow, and Red in proper ratio was conducted; any interfering incandescent emission resulted from MgO was eliminated using Al metal fuel. The spectral characteristics in terms of luminous intensity, and color quality were evaluated using digital luxmeter and UV-Vis. spectrometer *** quality mixed colored flames include violet, sweet pink, and marigold were developed. This study shaded the light on the state of the art for the real development of novel colored flame compositions and chromaticity of basic colored flames.

关键词： Pyrotechnics Colored flame Atomic spectroscopy Molecular spectroscopy Luminous intensity Color quality Chromaticity

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Health problems among street children seeking care in the Center for Social and Preventive Medicine in Egypt

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World Journal of Pediatrics 2017年第5期13卷 503-507页

作者： Hoda Ibrahim rizk Nihal mohamed El Rifai Hana mohamed Aboulghar Public Health and Community Medicine Department Faculty of MedicineCairo UniversityCairoEgypt Pediatrics Department Faculty of MedicineCairo UniversityCairoEgypt

Background:In Egypt,around 1 million children are on the *** children's health is an issue that is not well *** objective of the current study was to determine the health problems of a targeted group of street children seeking medical care and to generate a hypothesis about the positive/negative role of street children care ***:A cross-sectional study was done on 2169 street children who sought medical care at El-Basma clinic at the Center for Social and Preventive Medicine in Cairo University Children Hospital from January 2011 to July ***:Respiratory illnesses and skin problems were the most prevalent conditions,affecting 485 (22.4%) and 359 (16.6%) of the patients,*** issues and trauma were significantly higher among the adolescent *** and gastrointestinal problems were significantly higher among children aged less than 2 *** and cardiac problems were significantly higher among those referred from organizations whereas trauma was significantly higher among those coming directly from the streets.A significant proportion of children at the extremes of the studied age spectrum were coming directly from the *** transmitted infections were rare ***:Respiratory and skin diseases were the major morbidity problems among street children,especially adolescent *** afforded opportunities for access to different health care services.

关键词： Egypt health problems street children

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Chlorine as an integrated approach for environmental health and hygiene:A case study on evaluation of the performance of waste stabilization ponds located at 11 governorates in Egypt

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Emerging Contaminants 2022年第1期8卷 243-253页

作者： Sayeda M.abdo mohamed Azab El-Liethy Hala S.Doma Gamila E.El Taweel Gamila H.Ali Water Pollution Research Department National Research Centre12662DokkiGizaEgypt

The current study summarizes the current status of wastewater stabilization ponds(WSPs)treatment plants that have already been built in 11 governorates throughout ***,this study aims to determine the most appropriate chlorine dose for waste stabilization ponds(WSPs)effluents to ensure the treated effluents are suitable for reuse in unrestricted irrigation and to comply with the current legislation on direct discharge onto water *** to the findings,the chlorine doses used as a disinfectant in the treated effluents of the majority of WSP treatment plants ranged from 3 to 13 mg/***,two of the WSPs treatment plants effluents,the Qus WSPs treatment plant in Qena governorate and the Al Zarabii WSPs treatment plant in Asyut governorate used high chlorine doses reached to 17 and 19 mg/L,*** is due to the fact that both the Qus and Al Zarabii WSPs treatment plants have a high organic load,which necessitated the use of more chlorine to achieve the optimum chlorine dose at 13 mg/L for Qus and 11mg/L for Al *** findings demonstrated that chlorine has a powerful effect in completely removing ***,in most chlorine-treated wastewater final effluents,as the chlorine doses increased,the chlorophyll-a reading *** amount of trihalomethanes(THMs)produced as disinfectant byproduct was *** results proved that the water can be used in unrestricted irrigation,and after adding chlorine,it can be dumped on water bodies without health risks.

关键词： Waste stabilization ponds Microbial pathogens Chlorine doses Trihalomethanes(THMs)

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Maximizing the Benefit of Rate Transient Analysis for Gas Condensate Reservoirs

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Energy Engineering 2021年第5期118卷 1411-1423页

作者： Mahmoud abdo Tantawy Ahmed A.M.Elgibaly Ahmed mohamed Farag Faculty of Petroleum and Mining Engineering Suez UniversitySuezEgypt Abu Qir Petroleum Company AlexandriaEgypt

In recent years,many trials have been made to use the Rate Transient Analysis(RTA)techniques as a method to describe the gas condensate *** problem with using these techniques is the multi-phase behavior of the gas condensate ***,the Pressure Transient Analysis(PTA)is commonly used in this case to analyze the reservoir *** this paper,we are going to compare the results of both PTA and RTA of three wells in gas condensate *** comparison showed a great match between the results of the two mentioned techniques for the first time using a reference GOR of 75,000 SCF/***,we concluded that we could depend on RTA instead of PTA to spare the cost associated with the PTA in the gas condensate reservoirs.

关键词： Rate transient analysis production data analysis well testing permeability skin factor gas condensate

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