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e.pla.na.le.Conforme. Ne.work for De.e.tion of COVID-19 Pne.monia.from Che.t CT sca.: From Conce.ts towa.d Clinica. e.pla.na.ility

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Compute.s, Ma.e.ia.s & Continua 2024年第1期78卷 1171-1187页

作者： mohamed a.de.-Ba.se. Hossa. Ha.a.h mohamed a.ouha.wa.h s.s.a.ka. a.sha.ma. a.Ta.ta.y Fa.ulty of Compute.s a.d Informa.ics Zagazig UniversityZagazig44519Egypt De.a.tme.t of Computa.iona. Ma.he.a.ics Scienceand Engineering(CMSE)Michigan State UniversityEast LansingMI48824USA De.a.tme.t of Ma.he.a.ics Faculty of ScienceMansoura UniversityMansoura35516Egypt De.a.tme.t of sta.istics a.d Ope.a.ions Re.e.0}ch College of ScienceKing Saud UniversityP.O.Box 2455Riyadh11451Saudi Arabia

The.e.0}ly impleme.ta.ion of tre.0}me.t the.a.ie. ne.e.sita.e. the.swift a.d pre.ise.ide.tifica.ion of COVID-19 pne.monia.by the.a.a.ysis of che.t CT *** study a.ms to inve.tiga.e.the.indispe.sa.le.ne.d for pre.ise.a.d inte.pre.a.le.dia.nostic tools for improving clinica. de.ision-ma.ing for COVID-19 *** pa.e. propose. a.nove. de.p le.0}ning a.proa.h,ca.le. Conforme. Ne.work,for e.pla.na.le.discrimina.ion of vira. pne.monia.de.e.ding on the.lung Re.ion of Infe.tions(ROI)within a.single.moda.ity ra.iogra.hic CT ***,a. e.ficie.t U-sha.e. tra.sforme. ne.work is inte.ra.e. for lung ima.e.***,a.robust tra.sfe. le.0}ning te.hnique.is introduce. to de.ign a.robust fe.0}ure.e.tra.tor ba.e. on pre.tra.ne. lightwe.ght Big Tra.sfe.(BiT-L)a.d fine.une. on me.ica. da.a.to e.fe.tive.y le.0}n the.pa.te.ns of infe.tion in the.input ***,this work pre.e.ts a.visua. e.pla.a.ion me.hod to gua.a.te. clinica. e.pla.na.ility for de.isions ma.e.by Conforme. *** e.a.ua.ion of re.0}-world CT da.a.de.onstra.e. tha. the.dia.nostic a.cura.y of ourmode. outpe.forms cutting-e.ge.studie. with sta.istica. *** Conforme. Ne.work a.hie.e. 97.40% of de.e.tion a.cura.y unde. cross-va.ida.ion *** mode. not only a.hie.e. high se.sitivity a.d spe.ificity but a.so a.fords visua.iza.ions of sa.ie.t fe.0}ure. contributing to e.0}h cla.sifica.ion de.ision,e.ha.cing the.ove.a.l tra.spa.e.cy a.d trustworthine.s of our *** findings provide.obvious implica.ions for the.a.ility of our mode. to e.powe. clinica. sta.f by ge.e.a.ing tra.spa.e.t intuitions a.out the.fe.0}ure. driving dia.nostic de.isions.

关键词： De.p le.0}ning COVID-19 multi-moda. me.ica. ima.e.fusion dia.nostic ima.e.fusion

e.ha.cing Re.e.a.le.e.e.gy Inte.ra.ion:a.Ga.ssia.-Ba.e.Bone. Le.y Che.ta. Optimiza.ion a.proa.h to Optima. Powe. Flow in e.e.trica. Ne.works

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Compute. Mode.ing in e.gine.ring & scie.ce. 2024年第8期140卷 1339-1370页

作者： a.i s.a.gha.di mohamed a.Zohdy sa.d a.doihi De.a.tme.t of e.e.trica. e.gine.ring College of EngineeringMajmaah UniversityAl-Majmaah11952Saudi Arabia e.e.trica. a.d Compute. e.gine.ring De.a.tme.t Oakland UniversityRochesterMI48309USA Institute.of e.0}th a.d spa.e.scie.ce King Abdulaziz City for Science and Technology(KACST)Riyadh11442Saudi Arabia Compute. scie.ce.a.d syste.s e.gine.ring Institute Polytechnique de ParisPalaiseau CedexFrance

In the.conte.pora.y e.a.the.globa. e.pa.sion of e.e.trica. grids is prope.le. by va.ious re.e.a.le.e.e.gy source.(Re.s).e.ficie.t inte.ra.ion of stocha.tic Re.s a.d optima. powe. flow(OPF)ma.a.e.e.t a.e.critica. for ne.work *** study introduce. a. innova.ive.solution,the.Ga.ssia. Ba.e.Bone. Le.y Che.ta. Optimize.(GBBLCO),a.dre.sing OPF cha.le.ge. in powe. ge.e.a.ion syste.s with stocha.tic *** prima.y obje.tive.is to minimize.the.tota. ope.a.ing costs of Re.s,conside.ing four functions:ove.a.l ope.a.ing costs,volta.e.de.ia.ion ma.a.e.e.t,e.issions re.uction,volta.e.sta.ility inde.(VsI)a.d powe. loss ***,a.ca.bon ta. is include. in the.obje.tive.function to re.uce.ca.bon *** scrutiny,using modifie. Ie.e.30-bus a.d Ie.e.118-bus syste.s,va.ida.e. GBBLCO’s supe.ior pe.forma.ce.in a.hie.ing optima. *** re.ults de.onstra.e.GBBLCO’s e.fica.y in six optimiza.ion sce.a.ios:tota. cost with va.ve.point e.fe.ts,tota. cost with e.ission a.d ca.bon ta.,tota. cost with prohibite. ope.a.ing zone.,a.tive.powe. loss optimiza.ion,volta.e.de.ia.ion optimiza.ion a.d e.ha.cing volta.e.sta.ility inde.(VsI).GBBLCO outpe.forms conve.tiona. te.hnique. in e.0}h sce.a.io,showca.ing ra.id conve.ge.ce.a.d supe.ior solution ***,GBBLCO na.iga.e. comple.itie. introduce. by va.ve.point e.fe.ts,a.a.ts to e.vironme.ta. constra.nts,optimize. costs while.conside.ing prohibite. ope.a.ing zone.,minimize. a.tive.powe. losse.,a.d optimize. volta.e.de.ia.ion by e.ha.cing the.volta.e.sta.ility inde.(VsI)*** re.e.0}ch significa.tly contribute. to a.va.cing OPF,e.pha.izing GBBLCO’s improve. globa. se.0}ch ca.a.ilitie. a.d a.ility to a.dre.s cha.le.ge. re.a.e. to loca. *** e.e.ge. a. a.ve.sa.ile.a.d robust optimiza.ion tool for dive.se.cha.le.ge. in powe. syste.s,offe.ing a.promising solution for the.e.olving ne.ds of re.e.a.le.e.e.gy-inte.ra.e. powe. grids.

关键词： Re.e.a.le.e.e.gy inte.ra.ion optima. powe. flow stocha.tic re.e.a.le.e.e.gy source. ga.ssia.-ba.e.bone. le.y che.ta. optimize. e.e.trica. ne.work optimiza.ion ca.bon ta. optimiza.ion

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On B(5,20) 2-Groups

a.Ge.Ra.COLLOQUIUM 2024年第3期31卷 429-440页

作者： a.ha.sa., e. a. Ta., Y. L. Li, Y. Jia.gsu Univ Sch Math Sci Zhenjiang 212013 Jiangsu Peoples R China Brock Univ Dept Math St Catharines ON L2S 3A1 Canada

a.finite.group G is sa.d to be.a.B( n, k) group if for a.y n-e.4}e.t subse. { a.1) , & mldr; , a.n) } of G, | { a.i) a.j )| 1 <= i, j <= n } | <= k . It is of inte.e.t to cha.a.te.ize.the.structure.of B( n, k) groups ... 详细信息

a.finite.group G is sa.d to be.a.B( n, k) group if for a.y n-e.4}e.t subse. { a.1) , & mldr; , a.n) } of G, | { a.i) a.j )| 1 s of inte.e.t to cha.a.te.ize.the.structure.of B( n, k) groups for n( n+1 ) /2 e.B( 5, k) groups for 15 a.e.be.n inve.tiga.e. by se.e.a. a.thors. In this pa.e., we.give.a.comple.e.cha.a.te.iza.ion of B( 5, 20) 2-groups by showing the.e.a.e.five.cla.se. of such groups which a.e.nontrivia. a.d nona.e.ia..

关键词： B(n, k) groups sma.l squa.ing prope.ty ce.tra. e.te.sion Ga.

Compa.a.ive.study be.we.n thre. ca.bona.e.us na.obla.e. a.d na.oda.ts for a.timicrobia. a.plica.ions

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Journa. of e.vironme.ta. scie.ce. 2024年第2期136卷 594-605页

作者： mohamed s.se.im a.me. M.a.za. mohamed a.she.a.he. shima. a.Higa.y Ba.a.my B.Mosta.a.she.if a.e.-sa.ty Na.iona. Institute.for Ma.e.ia.s scie.ce.NIMs) 1-2-1 SengenTsukuba-ShiIbaraki-Ken 305-0047Japan Pe.role.m a.plica.ion De.a.tme.t Egyptian Petroleum Research InstituteNasr City 11727Egypt De.a.tme.t of e.vironme.ta. Re.e.0}ch Theodor Bilharz Research InstituteGizaEgypt

The.de.ign of na.ostructure. ma.e.ia.s occupie. a.privile.e. position in the.de.e.opme.t a.d ma.a.e.e.t of a.forda.le.a.d e.fe.tive.te.hnology in the.a.tiba.te.ia. ***,we.discuss the.a.timicrobia. prope.tie. of thre. ca.bona.e.us na.obla.e. a.d na.oda.ts ma.e.ia.s of gra.he.e.oxide.GO),re.uce. gra.he.e.oxide.RGO),a.d single.wa.l ca.bon na.otube.(sWCNTs)tha. ha.e.a.me.ha.o-ba.te.icida. e.fe.t,a.d the.a.ility to pie.cing or slicing ba.te.ia. *** de.onstra.e.the.significa.ce.of size.morphology a.d composition on the.a.tiba.te.ia. a.tivity me.ha.ism,the.de.igne. na.oma.e.ia.s ha.e.be.n *** minimum inhibitory conce.tra.ion(MIC),sta.da.d a.a. we.l diffusion,a.d tra.smission e.e.tron microscopy we.e.utilize. to e.a.ua.e.the.a.tiba.te.ia. a.tivity of GO,RGO,a.d *** on the.e.ide.ce.obta.ne.,the.thre. ca.bona.e.us ma.e.ia.s e.hibit a.tivity a.a.nst a.l microbia. stra.ns te.te. by comple.e.y e.ca.sula.ing ba.te.ia. ce.ls a.d ca.sing morphologica. disruption by de.ra.ing the.microbia. ce.l me.bra.e.in the.orde. of RGO>GO>*** of the.e.te.na. ce.l wa.l structure.a.d oute. me.bra.e.prote.ns,the.synthe.ize. ca.bona.e.us na.oma.e.ia.s e.hibite. highe. a.tiba.te.ia. a.tivity a.a.nst Gra.-positive.ba.te.ia. stra.ns tha. Gra.-ne.a.ive.a.d funga. *** ha. the.lowe.t MIC va.ue.(0.062,0.125,a.d 0.25 mg/mL a.a.nst ***,***,a.d ***,re.pe.tive.y),a. we.l a. minimum funga. conce.tra.ions(0.5 mg/mL for both *** a.d ***).a. 12 hr,the.ce.l via.ility va.ue. a.a.nst te.te. microbia. stra.ns we.e.comple.e.y *** lysis a.d de.0}h occurre. a. a.re.ult of se.e.e.me.bra.e.da.a.e.ca.se. by microorga.isms pe.che. on RGO *** work give. a. insight into the.de.ign of e.fe.tive.gra.he.e.ba.e. a.timicrobia. ma.e.ia.s for wa.e. tre.0}me.t a.d re.e.ia.ion.

关键词： a.timicrobia. prope.tie. Na.obla.e. Me.ha.o-ba.te.icida. e.fe.t RGO na.oshe.ts Gra.-positive.ba.te.ia Ce.l via.ility

Ge.e.ic Va.ia.ility a.d Phe.otypic Corre.a.ions study a.ong Gra.n Qua.ity Tra.ts a.d Mine.a. e.10}e.ts Conce.tra.ions in Colore. a.d Non-Colore. Rice.(Oryza.sa.iva.L.)

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Phyton-Inte.na.iona. Journa. of e.pe.ime.ta. Bota.y 2024年第7期93卷 1733-1748页

作者： a.e. a.Re.k mohamed M.e.-Ma.ky He.a.I.mohamed Hossa. s.e.-Be.ta.i a.ricultura. Biote.hnology De.a.tme.t College of Agricultural and Food ScienceKing Faisal UniversityAl-Ahsa31982Saudi Arabia Pla.t Pa.hology Re.e.0}ch Institute Agriculture Research CenterGiza12619Egypt Rice.Re.e.0}ch a.d Tra.ning Ce.te. Field Crop Research InstituteAgriculture Research Center33717Egypt Biologica. a.d Ge.logica. scie.ce. De.a.tme.t Faculty of EducationAin Shams UniversityCairo11511Egypt Bioche.istry De.a.tme.t Faculty of AgricultureCairo UniversityGiza12613Egypt

Twe.ty-four rice.ge.otype. we.e.e.a.ine. to a.se.s ge.e.ic va.ia.ility,he.ita.ility,a.d corre.a.ions for se.e.-gra.n qua.ity tra.ts,e.ght nutritiona. e.11}e.ts,a.d *** re.e.0}e. signiﬁca.t diffe.e.ce. for the.qua.ity tra.ts *** e.e.y tra.t unde. study,the.phe.otypic coe.ﬁcie.t of va.ia.ion wa. highe. tha. the.corre.pon-de.ce.ge.otypic coe.ﬁcie.t of *** in a.broa. se.se.va.ie. from 29.75%for gra.n le.gth to 98.31%for the.e.onga.ion *** pe.ce.ta.e.re.ove.y ha. a.highly signiﬁca.t positive.corre.a.ion with milling a.d he.0} rice.***,milling pe.ce.ta.e.ha. a.highly positive.corre.a.ion with he.0} rice.*** a.ylose.pe.ce.ta.e.a.l the.ge.otype. be.onge. to low a.ylose.e.ce.t the.Ha.sa.i-1 va.ie.y,which ha. inte.me.ia.e.a.ylose.*** nutrition conte.ts of ma.ne.ium(Mg),sodium(Na.,pota.-sium(K),ca.cium(Ca.,coppe.(Cu),ma.ga.e.e.Mn),zinc(Zn),iron(Fe.,or prote.n pe.ce.ta.e.ga.e.diffe.e.t va.ia.ions for 24 rice.ge.otype. unde. a.l the.nutritiona. *** the.24 ge.otype.,te. rice.ge.otype.–HighNutrie.t-1,HighNutrie.t-2,HighNutrie.t-9,HighNutrie.t-8,HighNutrie.t-3,Ha.sa.i-2,HighNutrie.t-7,HighNutrie.t-6,Ha.sa.i-1,a.d HighNutrie.t-4–ha. the.highe.t he.st va.ue.for a.l nutritiona. a.d prote.n con-te.ts,a.d could be.use. a. a.donor to improving ne. *** wa. a.positive.a.d signiﬁca.t corre.a.ion be.we.n ma.ne.ium Mg,K,Zn a.d ***,K ha. a.positive.corre.a.ion with zinc Zn,Fe.a.d prote.n *** a.a.ysis wa. divide. into two groups:the.rst group include. a.l ge.otype. rich in nutri-e.ts,while.the.re.a.ning ge.otype. with low nutritiona. conte.t we.e.include. in the.se.ond group.

关键词： a.ylose cluste. a.a.ysis ge.otype. gra.n qua.ity mine.a. nutrition rice

a.Ne. spe.d Limit Re.ognition Me.hodology Ba.e. on e.se.ble.Le.0}ning:Ha.dwa.e.Va.ida.ion

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Compute.s, Ma.e.ia.s & Continua 2024年第7期80卷 119-138页

作者： mohamed Ka.ra. Ne.rine.Triki mohamed Ksa.tini e.Me ESME Research LabIvry Sur Seine94200France Ce. Lab ENISUniversity of SfaxSfax3038Tunisia

a.va.ce. Drive.a.sista.ce.syste.s(a.a.)te.hnologie. ca. a.sist drive.s or be.pa.t of a.toma.ic driving syste.s to support the.driving proce.s a.d improve.the.le.e. of sa.e.y a.d comfort on the.*** sign Re.ognition syste.(TsRs)is one.of the.ost importa.t compone.ts *** the.cha.le.ge.with TsRs is be.ng a.le.to re.ognize.roa. signs with the.highe.t a.cura.y a.d the.shorte.t proce.sing ***,this pa.e. introduce. a.ne. re.0} time.me.hodology re.ognizing spe.d Limit signs ba.e. on a.trio of de.e.ope. ***,the.spe.d Limit De.e.tion(sLD)module.use. the.Ha.r Ca.ca.e.te.hnique.to ge.e.a.e.a.ne. sL de.e.tor in orde. to loca.ize.sL signs within ca.ture. ***,the.spe.d Limit Cla.sifica.ion(sLC)module.fe.0}uring ma.hine.le.0}ning cla.sifie.s a.ongside.a.ne.ly de.e.ope. mode. ca.le. De.psL,ha.ne.se. the.powe. of a.CNN a.chite.ture.to e.tra.t intrica.e.fe.0}ure. from spe.d limit sign ima.e.,e.suring e.ficie.t a.d pre.ise.*** a.dition,a.ne. spe.d Limit Cla.sifie.s Fusion(sLCF)module.ha. be.n de.e.ope. by combining tra.ne. ML cla.sifie.s a.d the.De.psL mode. by using the.De.pste.-sha.e. the.ry of be.ie. functions a.d e.se.ble.le.0}ning’s voting *** rigorous softwa.e.a.d ha.dwa.e.va.ida.ion proce.se.,the.propose.me.hodology ha. a.hie.e. highly significa.t F1 score. of 99.98%a.d 99.96%for Ds the.ry a.d the.votingme.hod,***,a.prototype.e.compa.sing a.l compone.ts de.onstra.e. outsta.ding re.ia.ility a.d e.fica.y,with proce.sing time. of 150 ms for the.Ra.pbe.ry Pi boa.d a.d 81.5 ms for the.Na.o Je.son boa.d,ma.king a.significa.t a.va.ce.e.t in TsRs te.hnology.

关键词： Driving a.toma.ion a.va.ce. drive. a.sista.ce.syste.s(a.a.) tra.fic sign re.ognition(TsR) a.tificia. inte.lige.ce e.se.ble.le.0}ning be.ie. functions voting me.hod

Influe.ce.of Formula.ion a.d Hot-Pre.sing Conditions on the.Pe.forma.ce.of Bio-Ba.e. Mola.se. a.he.ive.for Plywood

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Journa. of Re.e.a.le.Ma.e.ia.s 2024年第8期12卷 1383-1397页

作者： sutia.a. J. sya.fitri a. Kusuma. s.s. He.ma.a. D. sa.i R.K. Ha.im L. Ma.da.a.i e. Lubis M.a.R. Re.e.0}ch Ce.te. for Bioma.s a.d Bioproducts National Research and Innovation Agency Cibinong 16911 Indonesia Fore.t Product De.a.tme.t Faculty of Forestry and Environment IPB University Bogor 16680 Indonesia De.a.tme.t of Fore.t Products Faculty of Forestry Universitas Sumatera Utara Medan 20155 Indonesia Re.e.0}ch Colla.ora.ion Ce.te. for Bioma.s a.d Biore.ine.y BRIN and Universitas Padjadjaran Bandung 40600 Indonesia De.a.tme.t of a.ro-Industria. Te.hnology Universitas Padjadjaran Bandung 40600 Indonesia

Mola.se. ca. se.ve.a. a.na.ura. a.he.ive.for plywood a.d pa.ticle.oa.d. Howe.e., se.e.a. disa.va.ta.e. re.a.n, including lowe. dime.siona. sta.ility a.d low bonding stre.gth compa.e. to othe. a.he.ive.. The.e.ore. modifica.ions a.e.ne.de. to use.mola.se. a. a. a.he.ive.for plywood. This re.e.0}ch a.ms to improve.bio-ba.e. mola.se. (MO) a.he.ive.for plywood using citric a.id (Ca. a.he.ive. In a.dition, this re.e.0}ch a.ms to a.a.yze.the.e.fe.t of a.ding citric a.id a.d to inve.tiga.e.the.optimum hot-pre.sing te.pe.a.ure.to produce.the.be.t qua.ity plywood. In the.first sta.e. the.mola.se. a.d citric a.id we.e.combine. in a.ra.io of 100:0, 75:25, 50:50, 25:75, 0:100 w/w%. The., the.se.ond sta.e.focuse. on a.a.yzing the.influe.ce. of pre.sing te.pe.a.ure.ba.e. on a. optimum first sta.e. The.re.e.0}ch de.onstra.e. tha. the.a.dition of Ca.a.te.e. the.ge.a.ion time. solid conte.t, visc-osity, a.d pH of the.mola.se. a.he.ive.. In a.dition, the.the.ma. prope.tie. of mola.se. a.he.ive. we.e.cha.ge. a.te. mixing with citric a.id. The.e.phe.ome.a.indica.e.cha.ge. in cha.a.te.istics, such a. the.curing of a.he.ive. Ove.a.l, the.cha.a.te.istics of plywood showe. a.ste.0}y improve.e.t a. the.Ca.ra.io incre.0}e. but re.e.0}e. a.significa.t de.line.for the.25:75 MO-Ca.ra.io. By ra.sing the.pre.sing te.pe.a.ure.from 180°C to 200°C, the.qua.ity of plywood wa. e.fe.tive.y improve.. The.plywood tha. wa. bonde. using a.he.ive. with a.50:50 MO-Ca.ra.io e.hibite. supe.ior me.ha.ica. prope.tie. a.d improve. dime.siona. sta.ility compa.e. to the.plywood bonde. sole.y with MO. Furthe.more. the.optima. me.ha.ica. a.d physica. prope.tie. re.ulte. in plywood bonde. with a.50:50 MO-Ca.ra.io whe. subje.te. to a.pre.sing te.pe.a.ure.of 200°C. The.The.ma. a.d FTIR me.0}ure.e.ts re.e.0}e. tha. Ca.e.ta.lishe. e.te. bonds with both the.MO a.d wood ve.e.rs. In conclusion, the.me.ha.ica. cha.a.te.istics of plywood we.e.improve., while.ma.nta.ning its e.ce.le.t dime.siona. sta.ility. © 2024 The.a.thors.

关键词： Citric a.id composite mola.se. plywood pre.sing te.pe.a.ure

Mitiga.ing dia.e.e.-re.a.e. complica.ions:e.powe.ing me.formin with chole.a.cife.ol a.d ta.rine.suppleme.ta.ion in type.2 dia.e.ic ra.s

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World Journa. of Dia.e.e. 2024年第8期15卷 1778-1792页

作者： Ma. s a.tia.Fa.wa.a.ma. mohamed s a.tia.Ga.a. Ya.ya.Ma.sour H Za.ra.Ma.di mohamed Ibra.im Kha.il a.de. a.iz a.Dia. De.a.tme.t of Zoology Faculty of ScienceZagazig 44519Egypt De.a.tme.t of Pha.ma.e.tics Faculty of PharmacyZagazig 44519Egypt De.a.tme.t of Microbiology a.d Immunology Faculty of PharmacyZagazig UniversityZagazig 44519Egypt De.a.tme.t of Bioche.istry Faculty of MedicineZagazig 44519Egypt

Ba.KGROUND Type.2 dia.e.e. is one.of the.most pre.a.e.t chronic dise.0}e. worldwide.significa.tly impa.ting pa.ie.ts'qua.ity of *** tre.0}me.t options like.me.formin(Me.)e.fe.tive.y counte.a.t hype.glyce.ia.but fa.l to a.le.ia.e.dia.e.e.-a.socia.e. complica.ions such a. re.inopa.hy,ne.ropa.hy,ne.hropa.hy,he.a.opa.hy,a.d ca.diova.cula. *** To propose.the.suppleme.ta.ion of chole.a.cife.ol(CHO)a.d ta.rine.Ta.)to e.ha.ce.Me. e.fica.y in controlling dia.e.e. while.minimizing the.risk of a.socia.e. *** The.study involve. sixty ra.s,including te. non-dia.e.ic control ra.s a.d fifty e.pe.ime.ta. ra.s with type.2 dia.e.e. induce. by *** e.pe.ime.ta. ra.s we.e.furthe. subdivide. into positive.control a.d tre.0}me.t *** four tre.0}me.t groups we.e.ra.domly a.loca.e. to a.single.Me. tre.0}me.t or Me. combine. with suppleme.ts e.the. CHO,Ta.,or *** Dia.e.ic ra.s e.hibite. e.e.a.e. le.e.s of glucose.insulin,Home.sta.is Mode. a.se.sme.t of Insulin Re.ista.ce.HOMa.IR),glyca.e. he.oglobin pe.ce.ta.e.lipid ma.ke.s,a.pa.ta.e.a.inotra.sfe.a.e.a.d ma.ondia.de.yde.a.ong with re.uce. le.e.s of a.tioxida.t e.zyme.(ca.a.a.e.a.d supe.oxide.dismuta.e..The.a.ministra.ion of CHO a.d Ta. suppleme.ts a.ongside.Me. in dia.e.ic ra.s le. to a.notice.0}le.re.ove.y of isle. *** a.tioxida.ive.a.ti-infla.ma.ory,a.d a.ti-a.optotic prope.tie. of the.propose. combina.ion the.a.y significa.tly a.e.iora.e. the.a.ore.e.tione. *** The.suppleme.ta.ion of CHO a.d Ta. with Me. showe. the.pote.tia. to significa.tly improve.me.a.olic pa.a.e.e.s a.d prote.t a.a.nst dia.e.ic complica.ions through its a.tioxida.ive.a.ti-infla.ma.ory,a.d a.tia.optotic e.fe.ts.

关键词： Dia.e.e. complica.ions Me.formin Chole.a.cife.ol Ta.rine Glyca.e. he.oglobin% a.tioxida.t

Cha.coa. Na.opa.ticle. a. a.De.ive.y syste. for Doxorubicin a.d sora.e.ib in Tre.0}me.t of He.a.oce.lula. Ca.cinoma

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a.va.ce. in Na.opa.ticle. 2024年第3期13卷 45-60页

作者： a.sha.e.gura.hi a.dulla.Toga.Kha.id mohamed Ga.e. Ma.vit Osma. Widda.a.la. Ome. a.dulla. e. Gouda.sa.a. Ma.douh mohamed a. she.is De.a.tme.t of Clinica. Pha.ma.y Faculty of Pharmacy University of Medical Sciences and Technology Khartoum Sudan De.a.tme.t of Pha.ma.ology Faculty of Pharmacy University of Medical Sciences and Technology Khartoum Sudan De.a.tme.t of Bioche.istry a.d Mole.ula. Biology Theodor Bilharz Research Institute Giza Egypt

Ba.kground: He.a.oce.lula. ca.cinoma.(HCC) is the.most common type.of live. ca.ce. a.d one.of the.le.0}ing ca.se. of ca.ce.-re.a.e. de.0}h worldwide. a.va.ce. HCC displa.s strong re.ista.ce.to che.othe.a.y, a.d tra.itiona. che.othe.a.y drugs do not a.hie.e.sa.isfa.tory the.a.e.tic e.fica.y. The.de.ive.y of the.a.e.tic compounds to the.ta.ge. site.is a.ma.or cha.le.ge.in the.tre.0}me.t of ma.y dise.0}e.. Obje.tive. This study a.ms to e.a.ua.e.a.tiva.e. cha.coa. na.opa.ticle. a. a.drug de.ive.y syste. for a.tica.ce. a.e.ts (sora.e.ib a.d Doxorubicin) in He.a.oce.lula. Ca.ce. ste. Ce.ls. Me.hod: The.pe.ce.t e.ficie.cy of e.tra.me.t (% e.) of the.doxorubicin a.d sora.e.ib e.tra.pe. onto the.a.tiva.e. cha.coa. wa. obta.ne. by de.e.mining the.fre. doxorubicin a.d sora.e.ib conce.tra.ion in the.supe.na.a.t-pre.a.e. solutions. The. the.cha.a.te.iza.ions of na.opa.ticle. we.e.forme. by de.e.mina.ion of the.pa.ticle.size.distribution, ze.a.pote.tia., a.d polydispe.sity inde. (PDI). The.a.tica.ce. a.tivity of a.tiva.e. Cha.coa., Doxorubicin-a.NP, sora.e.ib-a.NP, fre. doxorubicin, a.d fre. sora.e.ib solutions wa. me.0}ure. ba.e. on ce.l via.ility pe.ce.ta.e.in He.G2 ce.l line. (a.CC-CCL 75). In vitro RBC’s toxicity of Doxorubicin/sora.e.ib loa.e. cha.coa. wa. e.tima.e. by he.olysis pe.ce.ta.e. Re.ults: The.synthe.ize. Doxorubicin-a.NP a.d sora.e.ib-a.NP we.e.e.a.ua.e. a.d the.r physioche.ica. prope.tie. we.e.a.so e.a.ine.. e.se.tia.ly, the.pe.ce.t e.ficie.cy of e.tra.me.t (e. %) wa. found to be.87.5% a.d 82.66% for Doxorubicin-a.NP a.d sora.e.ib-a.NP, re.pe.tive.y. The.loa.ing ca.a.ity wa. 34.78% a.d 24.31% for Doxorubicin-a.NP a.d sora.e.ib-a.NP. Using the.Dyna.ic Light sca.te.ing [DLs] for the.de.e.mina.ion of the.hydrodyna.ic size.a.d surfa.e.ze.a.pote.tia., a.na.row sa.ple.size.distribution wa. obta.ne. of (18, 68, a.d 190 nm for cha.coa., 105, 255, a.d 712 nm for doxorubicin, a.d 91, 295, a.d 955 nm for sora.e.ib), re.pe.tive.y. a.surfa.e.cha.ge.of −13.2, −15.6 a.d −17 wa. obta

关键词： a.tiva.e. Cha.coa. Na.opa.ticle. (a.NP) Drug De.ive.y syste. sora.e.ib a.d Doxorubicin He.a.oce.lula. Ca.ce. ste. Ce.ls