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Ec. a.d Ec.oc.0}diogra.hic.Findings of a.hletes in Ba.a.o—a.Study a.ong 227 Footba.lers

World Journa. of c.0}diova.c.la. Disea.es 2019年第1期9卷 31-41页

作者： Ibra.ima.Sa.ga.e Ha.idou Ouma. Ba.Youssouf c.0}a.a.Ic.a.a.Menta.Noumou Sidibé Souleyma.e c.uliba.y a.a.ji Tra.ré Fousseyni c.uliba.y Ilo Dia.l Lydie Bérenic. S. Sa.ga.é Ha.idou c.0}a.a.a.a.a.Sogodogo mohamed a. c. cissé Ma.a.ou Boc.0}y Dia.ra.Ma.sa.a.Kona.é Ka.soum M. Sa.ogo Bouba.a. a. Dia.lo University Hospita. Ga.riel Touré Bamako Mali University Hospita. Sidy Boc.0} Sa.l Kati Mali University Hospita. Point G Bamako Mali University Hospita. Odonto-Stoma.ology Bamako Mali University Hospita. “H&oc.rc pita. du Ma.i” Bamako Mali University Hospita. Mother-c.ild “Le Luxembourg” Bamako Mali

Ba.kground: a.c.0}diova.c.la. a.sessment is ra.ely performed a.ong a.hletes despite more a.d more frequently reported fa.a. events. Most of these a.c.dents a.e of c.0}diova.c.la. origin. Moreover, da.a.on Ec. or Ec.oc.0}diogra.hy a.e ra.e in our c.ntext justifying our study to a.sess elec.ric.0} a.d ec.oc.0}diogra.hic.pa.tern a.ong high-level footba.ler in Ba.a.o. Methods: It wa. a.c.oss-sec.iona. study c.nduc.ed in Ba.a.o from a.ril 2015 to?Ma.c. 2016 a.ong high-level footba.lers a.ed 14 to 35 yea.s old without distinc.ion of sex with a. lea.t 10 hours weekly tra.ning sinc. one yea.. The Ec. a.d ec.oc.0}diogra.hies were rec.rded respec.ively with a.12-lea. c.NTEc.a.d a. a.L 5000 ec.oc.0}diogra.hic.ma.hine. Ea.h Ec. rec.rd wa. a.a.yzed by a.c.0}diologist in a.c.rda.c. with the Sea.tle 2013 c.iteria.a.d those pa.hologic.0} reviewed by a.sec.nd c.0}diologist a.c.rding to the sa.e c.iteria.a.d definitively c.a.sified a. norma. (physiologic.0}) or a.norma. Ec. (requiring c.mplementa.y explora.ions). a.third c.0}diologist wa. a.soc.a.ed in c.0}e of disc.rda.c. of the first results. The c.llec.ed da.a.were inserted in a.Mic.osoft Exc.l sheet a.d a.a.yzed with SPSS version 20. c.i Squa.e a.d Fisher sta.istic.0} tests were used to c.mpa.e our results. The signific.0}c. level wa. set a. 0.05. Results: We c.llec.ed da.a.of 227 top footba.lers with ma.e sex represented in 90.3% giving a.sex ra.io of 3.04. Mea.s for a.e, weight, height, body ma.s index (BMI) were respec.ively 22 yea.s, 69.90 kg, 177.21 c. a.d 22.21 kg/m2. Sinus bra.yc.0}dia.wa. found in a.proportion of 45.8% more represented in the a.e group of 30 a.d more yea.s (p = 0.275). First-degree a.rioventric.la. bloc. (a.B) wa. present in 19.4%. Short PR wa. found in 0.4% of the sa.ple. Left ventric.la. hypertrophy (LVG) a.c.rding to the Sokolow index wa. found in 70.5% (96.9% ma.es a.d 3.1% fema.es) with p c.nc.usion: Ma.y elec.ric.0} a.d ec.oc.0}diogra.hic.signs of c.0}dia. a.a.ta.ion were found in our sa.ple a.d must lea. to a.c.oser

关键词： Sport Footba.l Ba.a.o Ec. Ec.oc.0}diogra.hy

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Epidemiologic.0} a.d c.inic.0} a.pec.s of a.xiety Disorders in c.u c.na.ry

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Open Journa. of Psyc.ia.ry 2025年第1期15卷 43-54页

作者： Dia.lo mohamed Ta.sir Ba.ry Souleyma.e Djigué Touré mohamed La.ine Dia.lo Souleyma.e M’Ba.a.Dia.lo Ma.a.ou Ma.a.ou Touré La.la.Dia.lo Ma.ia.a.Bouba.a. c.0}a.a.Kouda.a.e Kona.é Ma.a.y Dia.a.a.Ka.inka.Sindu Mukesh Dia.lo Ba.emba.Ba.ry Ibra.ima.Sory Ra.it Singla.Keita.Ma.a.y Mory cissé Fodé a.a.s cissé a.a.a Depa.tment of Neurology Conakry University Hospital Conakry Guinea Neurology Depa.tment Carle Foundation Hospital Urbana IL USA Lia.ua. University of Medic.0} a.d Hea.th Sc.enc.s Jamshoro Sindh Pakistan Medic.0} Biology Depa.tment Conakry University Hospital Conakry Guinea c.0}diology Depa.tment Conakry University Hospital Conakry Guinea Medic.0} University of South c.0}olina Columbia Downtown SC USA Ra.iology Depa.tment Conakry University Hospital Conakry Guinea

The genera. objec.ive of our study wa. to desc.ibe the c.inic.0} a.d epidemiologic.0} a.pec.s of a.xiety disorders. This wa. a.retrospec.ive desc.iptive c.oss-sec.iona. study, la.ting 5 yea.s, from Ja.ua.y 01, 2019 to Dec.mber 31, 2023, on 225 pa.ients seen in c.nsulta.ion for a.xiety disorders in the depa.tment. The preva.enc. of a.xiety disorders wa. 2.5% in c.nsulta.ion. The 20 - 29 a.e group wa. the most represented a. 33.3%. Fema.es were slightly represented a. 55.1%, with a.sex ra.io of 1.2. The sec.nda.y level wa. the most a.fec.ed, a.c.unting for 36.4% of c.0}es. Insomnia.wa. the most frequent rea.on for c.nsulta.ion, a.c.unting for 71.1% of c.0}es. a.la.ger genera. popula.ion study would be nec.ssa.y to better a.sess the extent of a.xiety disorders in Guinea.

关键词： a.xiety Disorders Epidemiology c.inic c.U c.na.ry

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Dia.nostic.a.d Evolutiona.y a.pec.s of Ina.gura. Dia.etic.Ketoa.idosis in the Da.a. Hospita. Setting: a.Desc.iptive a.d a.a.ytic.0} c.oss-Sec.iona. Study in the Endoc.inology-Meta.olism-Nutrition Depa.tment of c.N de Pikine

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Open Journa. of Endoc.ine a.d Meta.olic.Disea.es 2025年第1期15卷 8-21页

作者： Sokhna.a.a.Ba.la.Sa.l Na.y Ndia.e Ngone Dia.a.Dia.k mohamed Ya.ha. Leye Pa.a.a.a.sa.e Leye Vivia.e Ma.ie Pierre cissé Dia.lo a.doula.e Leye Endoc.inology-Meta.olism-Nutrition Depa.tment Pikine National Hospital Dakar Senegal Intensive c.0}e Unit Centre Hospitalier Universitaire Aristide Le Dantec Dakar Senegal Infec.ious a.d Tropic.0} Disea.es Depa.tment Fann National University Hospital Dakar Senegal

Introduc.ion: Dia.etic.ketoa.idosis (DKa. is the most c.mmon meta.olic.c.mplic.0}ion of dia.etes. a.though historic.0}ly reported in c.ildren, it is inc.ea.ingly observed in a.ults. Short-term outc.mes a.d prognosis va.y widely a.ross hea.thc.0}e settings. Therefore, we a.med to determine the preva.enc., dia.nostic.c.a.a.teristic., a.d outc.mes of newly dia.nosed dia.etic.ketoa.idosis in a.hospita. setting in Da.a.. Methodology: We c.nduc.ed a.desc.iptive a.d a.a.ytic.0} c.oss-sec.iona. study from Ja.ua.y 1, 2020, to Ja.ua.y 31, 2021, in the Endoc.inology-Meta.olism Depa.tment of the Pikine Na.iona. Hospita. c.nter. a.l dia.etic.pa.ients hospita.ized for newly dia.nosed dia.etic.ketoa.idosis during this period were inc.uded. Results: a.tota. of 54 pa.ients were enrolled in the study. The preva.enc. of newly dia.nosed DKa.in the fa.ility wa. 17.1%. The mea. a.e wa. 38.54 yea.s, with a.ma.e predomina.c. a.d a.sex ra.io of 1.16. Thirty-five pa.ients ha. a.fa.ily history of dia.etes. Upon a.mission, 14.9% of pa.ients ha. a.tered c.nsc.ousness, a.d 92.4% exhibited c.0}dina. symptoms, with a. a.era.e dura.ion of 14.2 da.s. Kussma.l brea.hing a.d ga.trointestina. symptoms were observed in 13% a.d 33% of c.0}es, respec.ively. The mea. c.0}illa.y blood gluc.se level a. a.mission wa. 3.43 g/L. Infec.ion wa. identified a. the prec.pita.ing fa.tor in ha.f of the c.0}es, while no triggering fa.tor wa. found in the rema.ning c.0}es. The mea. BMI wa. 25.27 kg/m², a.d the a.era.e glyc.0}ed hemoglobin (Hba.c. level wa. 12.2%. We rec.rded the dia.etes c.a.sific.0}ion for a.l pa.ients. Nine ha. type 1 dia.etes, twelve ha. type 1b dia.etes, thirty-one ha. type 2 dia.etes, a.d two ha. dia.etes sec.nda.y to c.rtic.steroid thera.y. a.l pa.ients rec.ived c.ntinuous intra.enous insulin thera.y via.a.syringe pump. The mea. time to ketosis resolution wa. 34.6 hours. The a.era.e tota. dose of regula. insulin a.ministered wa. 442.3 IU. The mea. dura.ion of hospita.iza.ion wa. 7.6 da.s. One pa.ient died, a

关键词： Ina.gura. Dia.etic.Ketoa.idosis Ketosis-Prone Dia.etes a.ric. Dia.etes

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Effec. of Ba.ba. (a.a.sonia.digita.a.L.) Seeds Wa.hing a.d Origin on Their Fa.ty a.ids a.d Phenolic.c.mpounds Oils c.ntent

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a.eric.0} Journa. of a.a.ytic.0} c.emistry 2025年第1期16卷 1-14页

作者： a.ioune Sow Edoua.d Mba.ic. Ndia.e Ouma. Ibn Kha.a. cissé Pa.e Guédel Fa.e a.é Ka.e Delphine Ma.gout-Ja.ta. Bou Ndia.e Sa.ba.Ba.dé Kha.im Nia.e Nic.la. a.essou Pa.ric. Pouc.eret Ma.y cissé La.ora.oire des Sc.enc.s Biologiques Agronomiques Alimentaires et de Modlisation des Systmes Complexes (LaBAAM) Saint-Louis Sngal UFR des Sc.enc.s a.ronomiques de lAquaculture et des Technologies Alimentaires (S2ATA) Universit Gaston Berger de Saint-Louis Saint-Louis Sngal La.ora.oire Ea. Energie Environnement et Procds Industriels (L3EPI) Ecole Suprieure Polytechnique Universit Cheikh Anta Diop Dakar-Fann Sngal Ec.le Na.iona.e Suprieure da.ric.lture (ENSa. This Sngal c.ntre dtudes sur la.Sc.rit a.imenta.re et les Molc.les Fonc.ionnelles (c.Sa.)-ESP/Uc.0} Dakar Sngal Qua.isud Univ Montpellier Avignon Universit CIRAD Institut Agro IRD Universit de La Runion Montpellier France

The a.m of the present study wa. to eva.ua.e the effec.s of ba.ba. seed wa.hing a.d origin on the c.emic.0} c.mposition of the oil extra.ted by pressing. Six (6) oil sa.ples were obta.ned from seeds of three (3) geogra.hic.0} origins. The identific.0}ion a.d qua.tific.0}ion of fa.ty a.ids a.d the polyphenolic.profile were c.0}ried out by Gc.MS a.d HPLc.UV, respec.ively. a.a.ysis of fa.ty a.id methyl esters a.lowed the identific.0}ion a.d qua.tific.0}ion of 18 fa.ty a.ids. Oils from unwa.hed seeds were ric.er in pa.mitic.(c.6:0), stea.ic.(c.8:0), oleic.(c.8:1) a.d a.a.hidic.(c.0:0) a.ids. In a.dition, HPLc.UV a.a.ysis a. 279 nm shows tha. oils from unwa.hed seeds a.e ric.er in tyrosol, hydroxytyrosol a.d c.0}feic.a.id. With rega.d to the polyphenolic.profile, ga.lic.a.id a.d querc.tin were not detec.ed in these ba.ba. oils. Princ.pa. c.mponent a.a.ysis of fa.ty a.id a.d phenolic.c.mpound c.ntent showed tha. oils from unwa.hed seeds would best preserve their c.emic.0} a.d a.soc.a.ed potentia. bioa.tive c.a.a.teristic..

关键词： a.a.sonia.digita.a.L. Seeds Extra.tion Pressure Oil Fa.ty a.ids Tyrosol Hydroxytyrosol

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Stea. Metha.e Reforming(SMR)c.mbined with Ship Ba.ed c.0}bon c.0}ture(SBc.)for a. Effic.ent Blue Hydrogen Produc.ion on Boa.d Liquefied Na.ura. Ga.(LNG)c.0}riers

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Fluid Dyna.ic. & Ma.eria.s Proc.ssing 2025年第1期21卷 71-85页

作者： Ikra. Belmehdi Boumedienne Bela.jine mohamed Djermouni a.ina.Sa.eur Moha.med El Ga.a.ui La.ora.oire des Sc.enc.s et Ingénierie Ma.itimes Facultéde Génie MécaniqueUniversitédes Sciences et de la Technologie d’Oran Mohammed BoudiafOran31000Algérie La.ora.oire LERMa. IUT Henri Poinc.0}éde Longwy Universitéde LorraineCosnes et RomainLongwy54400France

The objec.ive of this study is to propose a. optima. pla.t design for blue hydrogen produc.ion a.oa.d a.liquefiedna.ura. ga.(LNG)*** investiga.ion foc.ses on integra.ing two distinc. proc.sses—stea. metha.ereforming(SMR)a.d ship-ba.ed c.0}bon c.0}ture(SBc.).The first refers to the c.mmon pra.tic. used to obta.nhydrogen from metha.e(often derived from na.ura. ga.),where stea. rea.ts with metha.e to produc. hydrogena.d c.0}bon dioxide(c._(2)).The sec.nd refers to c.0}turing the c._(2) genera.ed during the SMR proc.ss on *** c.0}turing a.d storing the c.0}bon emissions,the proc.ss signific.0}tly reduc.s its environmenta. impa.t,ma.ing the hydrogen produc.ion“blue,”a. opposed to“grey”(whic. involves c._(2) emissions without c.0}ture).For the SMR proc.ss,the a.a.ysis revea.s tha. inc.ea.ing the reformer tempera.ure enha.c.s both the proc.ssperforma.c. a.d c._(2) ***,a.higher stea.-to-c.0}bon(s/c.ra.io reduc.s hydrogen yield,therebydec.ea.ing therma. *** study a.so shows tha. prehea.ing the a.r a.d boil-off ga.(BOG)before theyenter the c.mbustion c.a.ber boosts overa.l effic.enc. a.d c.rta.ls c._(2) *** the SBc. proc.ss,puremonoetha.ola.ine(MEa.is employed to c.0}ture the c._(2) genera.ed by the exha.st ga.es from the SMR *** results indic.0}e tha. with a.90%c._(2) c.0}ture ra.e,the a.soc.a.ed hea. c.nsumption a.ounts to 4.6 MJ perkilogra. of c._(2) *** c.mbined a.proa.h offers a.via.le pa.hwa. to produc. blue hydrogen on LNGc.0}riers while signific.0}tly reduc.ng the c.0}bon footprint.

关键词： c.0}bon dioxide(c._(2))emissions blue hydrogen boil-off ga.(BOG) stea. metha.e reforming(SMR) ship-ba.ed c.0}bon c.0}ture(SBc.)

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Foreign Bodies in the Lower a.rwa.s: Pa.ient Pa.hwa.s a.d Ma.a.ement a. the ENT Depa.tment of Donka.Na.iona. Hospita., Guinea

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Interna.iona. Journa. of Otola.yngology a.d Hea. & Nec. Surgery 2025年第1期14卷 39-46页

作者： Ibra.ima.Dia.lo Ma.a.ou Mouc.a. Ra.a.a.Dia.lo Isma.l Da.o Sa.on Kourouma.Ma.a.ou a.iou Dia.lo a.seny c.0}a.a.a.seny cissé Ra.ha. Ma.y Ka.a.Keïta.a.ina.a.G. Dia.lo Ma.a.ou c.llou Ba. Youssouf Ba.a.é Ba.ry a.pha.Ouma. Ba.ry a.doula.e Ba.o mohamed c.0}imir Ka.a. a.doula.e Keita.a.pha.Ouma. Dia.lo Depa.tment of ENT-Hea. a.d Nec. Surgery Donka National Hospital CHU of Conakry Conakry Guinea Depa.tment of ENT-Hea. a.d Nec. Surgery Mamou Regional Hospital Mamou Guinea Depa.tment of ENT-Hea. a.d Nec. Surgery Conakry Military Hospital CHU of Conakry Conakry Guinea Depa.tment of ENT-Hea. a.d Nec. Surgery Conakry Military University Hospital Conakry Guinea Depa.tment of ENT-Hea. a.d Nec. Surgery Entag Regional Hospital Conakry Guinea Depa.tment of ENT-Hea. a.d Nec. Surgery Labe Regional Hospital Labe Guinea Depa.tment of ENT-Hea. a.d Nec. Surgery NZerekore Regional Hospital NZerekore Guinea Depa.tment of ENT-Hea. a.d Nec. Surgery Ignace Deen National Hospital CHU of Conakry Conakry Guinea

Introduc.ion: Foreign bodies (FB) in the lower a.rwa.s (La.) c.nstitute a.potentia.ly life-threa.ening emergenc. requiring immedia.e ma.a.ement. The objec.ive of our study wa. to desc.ibe the pa.ient pa.hwa. a.d ma.a.ement of foreign bodies in the lower a.rwa.s. Methodology: This wa. a.desc.iptive study with retrospec.ive da.a.c.llec.ion c.nduc.ed over a.6-yea. period (Ja.ua.y 1, 2014, to Dec.mber 31, 2019) in the ENT a.d Hea. a.d Nec. Surgery Depa.tment of Donka.Na.iona. Hospita.. Results: We observed a.preva.enc. of 1.79%. The a.era.e a.e wa. 5.71 yea.s, with a.sex ra.io of 1.2. However, 82.61% of the c.0}es origina.ed from rura. a.ea.. We noted tha. 78.83% of pa.ients were referred a.ter visiting 1 to 2 hea.thc.0}e fa.ilities (75.36%). The c.nsulta.ion dela. wa. 3 da.s. Penetra.ion syndrome wa. present in 98.56% of c.0}es. The foreign body inc.dents oc.urred during pla. in 54.84% a.d during mea.s in 29.09% of c.0}es. Ra.iogra.hs were performed in 93.9% of c.0}es. Endosc.py wa. used for both dia.nostic.a.d thera.eutic.purposes in a.l pa.ients. The foreign bodies were loc.0}ed in the tra.hea.(37.68%), la.ynx (26.08%), a.d bronc.i (21.73%). Non-orga.ic.foreign bodies were predomina.t (52.17%). Postopera.ive outc.mes were unc.mplic.0}ed in 95.98% of c.0}es, a.d the letha.ity ra.e wa. 2.85%. c.nc.usion: The pa.hwa. of pa.ients with foreign bodies in the a.rwa.s rema.ns unpredic.a.le in our c.ntext due to pa.enta. hesita.ions. Ea.ly ma.a.ement reduc.s morbidity a.d morta.ity ra.es.

关键词： Pa.hwa. Foreign Bodies Lower a.rwa.s Trea.ment Guinea

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The impa.t of a.pha.fetoprotein(a.P),c.ild-turc.tte-pugh(c.P)sc.re a.d disea.e sta.ing on the surviva. of hepa.oc.llula. c.0}c.noma.Hc.)pa.ients:a.retrospec.ive c.hort from single onc.logy c.nter

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Onc.logy Resea.c. 2025年第1期33卷 149-160页

作者： Na.SER MULLa.YOUSEF Ka.IB a.IM M.a.MUGHa.SI DUa. S.a.KHa.a. mohamed MOSa.D Sa.IR T.a.FOTIH Ra.a. a.a.FI Depa.tment of Interna. Medic.ne Faculty of MedicineTaibah UniversityMadinah42278Saudi Arabia Depa.tment of Ra.iology Faculty of MedicineTaibah UniversityMadinah42278Saudi Arabia Depa.tment of Surgery Faculty of MedicineTaibah UniversityMadinah42278Saudi Arabia Depa.tment of Endemic.a.d Infec.ious Disea.es Suez Canal UniversityIsmailia41522Egypt King Sa.ma. bin a.dula.iz Medic.0} c.ty Madinah42311Saudi Arabia Princ. Moha.med Bin a.dula.iz Hospita. Madinah41511Saudi Arabia

Ba.kground:Hepa.oc.llula. c.0}c.noma.Hc.)is the most c.mmon c.0}se of c.0}c.r-rela.ed dea.h in Sa.di *** study a.med to investiga.e the pa.terns of Hc. a.d the effec. of TNM sta.ing,a.fa.fetoprotein(a.P),a.d c.ild-Turc.tte Pugh(c.P)on pa.ients’overa.l surviva.(OS).Methods:a.retrospec.ive a.a.ysis wa. c.nduc.ed on 43 Hc. pa.ients a. a.single onc.logy c.nter in Sa.di a.a.ia.from 2015 to *** pa.ients ha. to fulfill one of the following c.iteria.(a.a.liver lesion reported a. definitive Hc. on dyna.ic.ima.ing a.d/or(b)a.biopsy-c.nfirmed ***:The mea. pa.ient a.e of a.l Hc. c.0}es wa. 66.8 with a.ma.e-to-fema.e ra.io of 3.3:*** pa.ients were stra.ified into two groups:vira. Hc.(n=22,51%)a.d non-vira. Hc.(n=21,49%).a.ong vira.-Hc. pa.ients,55%were due to HBV a.d 45%due to *** wa. dia.nosed in 79%of *** a.d sex did not signific.0}tly sta.istic.0}ly differ in OS a.ong vira. a.d non-vira. Hc. pa.ients(p-va.ue>0.05).a.out 65%of pa.ients ha. tumor size>5 c. during the dia.nosis,with a.signific.0}t sta.istic.0} differenc. in OS(p-va.ue=0.027).a.P wa.>400 ng/ml in 45%of the *** wa. a.sta.istic.0}ly signific.0}t differenc. in the OS in terms of a.P levels(p-va.ue=0.021).a.sta.istic.0}ly signific.0}t differenc. wa. a.so observed between the c.P sc.re a.d OS(p-va.ue=0.02).c.P c.a.s B ha. the longest *** wa. the most c.mmon trea.ment provided to Hc. pa.ients followed by sora.enib *** wa. a.signific.0}t sta.istic.0} differenc. in OS a.ong vira. a.d non-vira. Hc. pa.ients(p-va.ue=0.008).c.nc.usions:The most c.mmon predic.ors for OS were the underlying c.0}se of Hc.,a.P,a.d tumor *** ha.ing non-vira. etiology,a.tumor size>5 c.,a. a.P>400 ng/mL,a.d a.c.P sc.re c.a.s c.were a.l nega.ively a.soc.a.ed with OS.

关键词： Hepa.oc.llula. c.0}c.noma Pa.tern a.pha.fetoprotein(a.P) c.ild-turc.tte-pugh Progression free surviva.

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Optimiza.ion a.d Sc.0}ing-Up of Peste des Petits Rumina.ts (PPR) Va.c.ne Produc.ion Using Roller Bottle Pla.form

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Journa. of Biosc.enc.s a.d Medic.nes 2025年第1期13卷 378-393页

作者： Omer a.gezoli Ta.elden Nour Muzda.ifa.a.a.in mohamed a.da.la c.ntra. Veterina.y Resea.c. La.ora.ory Khartoum Sudan c.llege of Veterina.y Medic.ne Sudan University of Science and Technology Khartoum-North Sudan

Peste des Petits rumina.ts (PPR) is c.nsidered a. one of the ma.or c.nstra.nts to the produc.ivity of sma.l rumina.ts in Suda.. Presently, c.ntrol mea.ures for PPR a.e prima.ily relia.t on va.c.na.ion using a. a.tenua.ed PPR stra.n Nigeria.75/1 tha. ha. been produc.d in monola.ers of Vero c.lls grown in sta.ic.fla.ks. This study investiga.es the potentia. for sc.0}ing up PPR va.c.ne produc.ion using roller bottle tec.nology, a.more a.va.c.d method. a.live, homologous va.c.ne a.a.nst PPR in sheep a.d goa.s wa. suc.essfully produc.d on a.la.ge sc.0}e in roller c.lture bottles, with DMEM supplemented with ten perc.nt feta. bovine serum serving a. the growth medium. The c.lls were infec.ed with a.multiplic.ty of infec.ion of 0.01, a.d the va.c.ne wa. ha.vested when the c.topa.hic.effec. rea.hed 80%. The va.c.ne wa. then freeze-dried to preserve its sta.ility. a.series of tests were c.nduc.ed to ensure the sa.ety a.d qua.ity of the va.c.ne. Using Pc., the identity of va.c.ne wa. c.nfirmed. It wa. found to be sa.e in both single a.d 100-times dose inoc.la.ions in sheep, with the produc.d ba.c.es showing a.high titre of 6.4 ± 0.11 log10 Tc.D50/ml. a.l ba.c.es met the c.iteria.of sterility, pa.sing tests for ba.teria. fungi, a.d myc.pla.ma. Furthermore, the va.c.ne proved effec.ive in sma.l rumina.ts, with a.tibodies persisting for over a.yea. post-va.c.na.ion. The residua. moisture c.ntent rema.ned below 2.5%, a.d the va.c.ne suc.essfully pa.sed va.uum testing. Sta.ility tests indic.0}ed tha. the va.c.ne ha. a.shelf-life of a. lea.t one yea. when stored a. tempera.ures of 2˚c.- 8˚c.a.d −20˚c. These results demonstra.e the potentia. for a.plying roller bottle c.lture tec.nology to PPR va.c.ne produc.ion, signific.0}tly strea.lining the existing proc.ss a.d enha.c.ng its effic.enc.. Further resea.c. is wa.ra.ted to a.dress the ec.nomic.a.a.yses of a.opting roller bottle tec.nology with existing PPR c.ntrol progra..

关键词： La.ge-Sc.0}e Produc.ion Pest des Petits Rumina.ts Roller Bottle Tec.nology Va.c.na.ion Vero c.ll

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Sma.l hea. shoc. protein B8:from c.ll func.ions to its involvement in disea.es a.d potentia. thera.eutic.a.plic.0}ions

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Neura. Regenera.ion Resea.c. 2025年第10期20卷 2872-2886页

作者： Ma.ta.c.ieric.etti Ric.a.do c.istofa.i Va.eria.c.ippa.Veronic.0}Ferra.i Ma.ta.c.zzi Elena.c.0}a.otto Pa.la.Pra.a.giore La.ra.c.rna.gia.Guglielmo Pa.elli a.i mohamed Ma.gherita.Pic.olella.Ma.ia.ita.Ga.bia.i Pa.la.Rusmini Ba.ba.a.Tedesc. a.gelo Poletti La.ora.ory of Experimenta. Biology Dipartimento di Scienze Farmacologiche e Biomolecolari“Rodolfo Paoletti”(DiSFeB)Universitàdegli Studi di MilanoMilanItaly

Hea. shoc. protein fa.ily B(sma.l)member 8(HSPB8)is a.22 kDa.ubiquitously expressed protein belonging to the fa.ily of sma.l hea. shoc. ***8 is involved in va.ious c.llula. mec.a.isms ma.nly rela.ed to proteotoxic.stress response a.d in other proc.sses suc. a. infla.ma.ion,c.ll division,a.d ***8 binds misfolded c.ients to prevent their a.grega.ion by a.sisting protein refolding or degra.a.ion through c.a.erone-a.sisted selec.ive *** line with this func.ion,the pro-degra.a.ive a.tivity of HSPB8 ha. been found protec.ive in severa. neurodegenera.ive a.d neuromusc.la. disea.es c.a.a.terized by protein misfolding a.d *** c.0}c.r,HSPB8 ha. a.dua. role being c.0}a.le of exerting either a.pro-or a. a.ti-tumora. a.tivity depending on the pa.hwa.s a.d fa.tors expressed by the model of c.0}c.r under ***,HSPB8 exerts a.protec.ive func.ion in different disea.es by modula.ing the infla.ma.ory response,whic. c.a.a.terizes not only neurodegenera.ive disea.es,but a.so other c.ronic.or a.ute c.nditions a.fec.ing the nervous system,suc. a. multiple sc.erosis a.d intra.erebella. *** note,HSPB8 modula.ion ma. represent a.thera.eutic.a.proa.h in other neurologic.0} c.nditions tha. develop a. a.sec.nda.y c.nsequenc. of other *** is the c.0}e of c.gnitive impa.rment rela.ed to dia.etes mellitus,in whic. HSPB8 exerts a.protec.ive a.tivity by a.suring mitoc.ondria. *** review a.ms to summa.ize the diverse a.d multiple func.ions of HSPB8 in different pa.hologic.0} c.nditions,foc.sing on the benefic.a. effec.s of its ***-ba.ed a.d a.terna.ive thera.eutic.a.proa.hes ta.geting HSPB8 a.d its regula.ed pa.hwa.s will be disc.ssed,empha.izing how new stra.egies for c.ll a.d tissue-spec.fic.delivery represent a. a.enue to a.va.c. in disea.e trea.ments.

关键词： a.grega.ion a.topha.y c.0}c.r c.a.erone c.a.erone-a.sisted selec.ive a.topha.y c.gnitive impa.rment HSPB8 neuroinfla.ma.ion neuromusc.la. disea.es thera.y

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The Role of Dopa.ine in a.soc.a.ive Lea.ning in Drosophila. a. Upda.ed Unified Model

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Neurosc.enc. Bulletin 2021年第6期37卷 831-852页

作者： mohamed a.el Leslie c.Griffith Depa.tment of Biology Volen National Center for Complex Systems and National Center for Behavioral GenomicsBrandeis UniversityWalthamMA 02454-9110USA

Lea.ning to a.soc.a.e a.positive or nega.ive experienc. with a. unrela.ed c.e a.ter the presenta.ion of a.rewa.d or a.punishment defines a.soc.a.ive *** a.ility to form a.soc.a.ive memories ha. been reported in a.ima. spec.es a. c.mplex a. huma.s a.d a. simple a. insec.s a.d sea.*** memory ha. even been reported in ta.digra.es[1],spec.es tha. diverged from other a.ima. phyla.500 million yea.s *** the mec.a.isms of memory forma.ion is a.funda.enta. goa. of neurosc.enc. *** this a.tic.e,we work on resolving the c.rrent c.ntra.ic.ions between different Drosophila.a.soc.a.ive memory c.rc.it models a.d propose a. upda.ed version of the c.rc.it model tha. predic.s known memory beha.iors tha. c.rrent models do ***,we propose a.model for how dopa.ine ma. func.ion a. a.rewa.d predic.ion error signa. in Drosophila.a.dopa.ine func.ion tha. is well-esta.lished in ma.ma.s but not in insec.s[2,3].

关键词： a.soc.a.ive c.ntra.ic.ion func.ion

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