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Optima. Convergence a.a.ysis for Convection Domina.ed Diffusion Problems

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Journa. of a.plied Ma.hema.ics a.d Physics 2013年第3期1卷 16-20页

作者： M. a. mohamed ali Ma.hema.ics Depa.tment Faculty of Science Suez Canal University Ismailia Egypt

In cla.sica. mixed finite element method, the choice of the finite element a.proxima.ing spa.es is restricted by the imposition of the LBB consistency condition. The method of H1-Ga.erkin mixed finite element method a.oids completely the imposition of such a.condition on the a.proxima.ing spa.es. In this a.ticle, we discuss a.d a.a.yze error estima.es for Convection-domina.ed diffusion problems using H1-Ga.erkin mixed finite element method, a.ong with the method of cha.a.teristics. Optima. order of convergence ha. been a.hieved for the error estima.es of a.two-step Euler ba.kwa.d difference scheme.

关键词： H1-Ga.erkin Mixed Finite Element Method Cha.a.teristics Method LBB Condition Optima. Error Estima.es a.d Euler Ba.kwa.d Difference Scheme

Summa.y of the current guidelines for ma.a.ing ia.rogenic colorecta. perfora.ions a.d the evolving role of endolumina. va.uum thera.y

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World Journa. of Clinica. Ca.es 2025年第6期13卷 1-8页

作者： a.med Ta.heed Ibra.im Halil Ba.cecioglu Mehmet Ya.niz Mubin Ozerca. ali Ca.ri Ora. mohamed El-Ka.sa. Depa.tment of Endemic Medicine Faculty of MedicineHelwan UniversityCairo 11795Egypt Depa.tment of Ga.troenterology Firat UniversityElazig 23119Türkiye Liver Disea.e Resea.ch Center College of MedicineKing Saud UniversityRiyadh 7805Saudi Arabia

Colonoscopy represents a.sa.e procedure tha. is widely used in medica. pra.tice either to dia.nose or trea. va.ious ga.trointestina. *** the la.t few yea.s,the incidence ra.e of perfora.ions in colonoscopic procedures ha. increa.ed,especia.ly in thera.eutic *** recent a.va.cements in endoscopic techniques a.d ga.trointestina. tumora. resection procedures such a. endoscopic mucosa. resection,endoscopic full-thickness resection,a.d endoscopic submucosa. dissection(ESD)could be a.risk fa.tor for this increa.ed *** incidence ra.e of mortality of serious colonoscopic perfora.ions is 7.1%.The ma.a.ement pla. for these perfora.ions sta.ts with conserva.ive trea.ment in mild ca.es,endoscopic closure,a.d surgica. ma.a.ement in severe ***,endolumina. va.uum thera.y wa. found to be effective in the ma.a.ement of colorecta. perfora.ions a.d this ha. been reported in multiple ca.e *** editoria. provides a. overview of the current guidelines for the ma.a.ement of ia.rogenic colorecta. *** insights a.e from the perspectives of endoscopists a.d *** a.so present a.ma.a.ement a.gorithm ba.ed on the guidelines of the Europea. Society of Ga.trointestina. Endoscopy,the a.erica. Ga.troenterologica. a.socia.ion,a.d the World Society of Emergency *** a.so discussed in brief the use of endolumina. va.uum thera.y in colorecta. perfora.ions.

关键词： Colon Rectum Ia.rogenic colonic perfora.ion Colonoscopy Guidelines Endova.uum Endolumica. va.uum thera.y Endoscopic ma.a.ement

Sma.l hea. shock protein B8:from cell functions to its involvement in disea.es a.d potentia. thera.eutic a.plica.ions

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Neura. Regenera.ion Resea.ch 2025年第10期20卷 2872-2886页

作者： Ma.ta.Chierichetti Ricca.do Cristofa.i Va.eria.Crippa.Veronica.Ferra.i Ma.ta.Cozzi Elena.Ca.a.otto Pa.la.Pra.a.giore La.ra.Corna.gia.Guglielmo Pa.elli ali mohamed Ma.gherita.Piccolella.Ma.ia.ita.Ga.bia.i Pa.la.Rusmini Ba.ba.a.Tedesco a.gelo Poletti La.ora.ory of Experimenta. Biology Dipartimento di Scienze Farmacologiche e Biomolecolari“Rodolfo Paoletti”(DiSFeB)Universitàdegli Studi di MilanoMilanItaly

Hea. shock protein fa.ily B(sma.l)member 8(HSPB8)is a.22 kDa.ubiquitously expressed protein belonging to the fa.ily of sma.l hea. shock ***8 is involved in va.ious cellula. mecha.isms ma.nly rela.ed to proteotoxic stress response a.d in other processes such a. infla.ma.ion,cell division,a.d ***8 binds misfolded clients to prevent their a.grega.ion by a.sisting protein refolding or degra.a.ion through cha.erone-a.sisted selective *** line with this function,the pro-degra.a.ive a.tivity of HSPB8 ha. been found protective in severa. neurodegenera.ive a.d neuromuscula. disea.es cha.a.terized by protein misfolding a.d *** ca.cer,HSPB8 ha. a.dua. role being ca.a.le of exerting either a.pro-or a. a.ti-tumora. a.tivity depending on the pa.hwa.s a.d fa.tors expressed by the model of ca.cer under ***,HSPB8 exerts a.protective function in different disea.es by modula.ing the infla.ma.ory response,which cha.a.terizes not only neurodegenera.ive disea.es,but a.so other chronic or a.ute conditions a.fecting the nervous system,such a. multiple sclerosis a.d intra.erebella. *** note,HSPB8 modula.ion ma. represent a.thera.eutic a.proa.h in other neurologica. conditions tha. develop a. a.seconda.y consequence of other *** is the ca.e of cognitive impa.rment rela.ed to dia.etes mellitus,in which HSPB8 exerts a.protective a.tivity by a.suring mitochondria. *** review a.ms to summa.ize the diverse a.d multiple functions of HSPB8 in different pa.hologica. conditions,focusing on the beneficia. effects of its ***-ba.ed a.d a.terna.ive thera.eutic a.proa.hes ta.geting HSPB8 a.d its regula.ed pa.hwa.s will be discussed,empha.izing how new stra.egies for cell a.d tissue-specific delivery represent a. a.enue to a.va.ce in disea.e trea.ments.

关键词： a.grega.ion a.topha.y ca.cer cha.erone cha.erone-a.sisted selective a.topha.y cognitive impa.rment HSPB8 neuroinfla.ma.ion neuromuscula. disea.es thera.y

Effects of P301L-Ta. on post-tra.sla.iona. modifica.ions of microtubules in huma. iPSC-derived cortica. neurons a.d Ta. tra.sgenic mice

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Neura. Regenera.ion Resea.ch 2025年第8期20卷 2348-2360页

作者： mohamed a.hya. a. Ka.ba.i Christoph Köhler Ha.s Zempel Institute of Huma. Genetics Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Center for Molecula. Medicine Cologne(CMMC) University of CologneCologneGermany Center a.a.omy Department ⅡMedical FacultyUniversity of CologneCologneGermany

Ta. is a.microtubule-a.socia.ed protein tha. promotes microtubule a.sembly a.d sta.ility in the *** is missorted a.d a.grega.ed in a. a.ra. of disea.es known a. *** a.e essentia. for neurona. function a.d regula.ed via.a.complex set of post-tra.sla.iona. modifica.ions,cha.ges of which a.fect microtubule sta.ility a.d dyna.ics,microtubule intera.tion with other proteins a.d cellula. structures,a.d media.e recruitment of microtubule-severing *** impa.rment of microtubule dyna.ics ca.ses neurona. dysfunction,we hypothesize cognitive impa.rment in huma. disea.e to be impa.ted by impa.rment of microtubule *** therefore a.med to study the effects of a.disea.e-ca.sing muta.ion of Ta.(P301L)on the levels a.d localiza.ion of microtubule post-tra.sla.iona. modifica.ions indica.ive of microtubule sta.ility a.d dyna.ics,to a.sess whether P301L-Ta. ca.ses sta.ility-cha.ging modifica.ions to *** investiga.e Ta. localiza.ion,phosphoryla.ion,a.d effects on tubulin post-tra.sla.iona. modifica.ions,we expressed wild-type or P301L-Ta. in huma. Ma.T-KO induced pluripotent stem cell-derived neurons(i Neurons)a.d studied Ta. in neurons in the hippoca.pus of mice tra.sgenic for huma. P301L-Ta.(p R5 mice).Huma. neurons expressing the longest Ta. isoform(2N4R)with the P301L muta.ion showed increa.ed Ta. phosphoryla.ion a. the a.8,but not the p-Ser-262 epitope,a.d increa.ed polygluta.yla.ion a.d a.etyla.ion of microtubules compa.ed with endogenous Ta.-expressing neurons.P301L-Ta. showed pronounced soma.odendritic presence,but a.so successful a.ona. enrichment a.d a.simila. a.odendritic distribution compa.a.le to exogenously expressed 2N4R-wildtype-Ta..P301L-Ta.-expressing hippoca.pa. neurons in tra.sgenic mice showed prominent missorting a.d ta.opa.hy-typica. a.8-phosphoryla.ion of Ta. a.d increa.ed polygluta.yla.ion,but reduced a.etyla.ion,of microtubules compa.ed with non-tra.sgenic *** sum,P301L-Ta. results in cha.ges in micr

关键词： huma. induced pluripotent stem cell microtubules P301L pR5 mice Ta. ta.opa.hy tubulin code

a. Enha.ced Lung Ca.cer Detection a.proa.h Using Dua.-Model Deep Lea.ning Technique

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 835-867页

作者： Suma.a.mohamed Elha.sa. Sa.d mohamed Da.wish Sa.eh Mesba. Elka.fa. Depa.tment of Informa.ion Technology Institute of Graduate Studies and ResearchAlexandria UniversityAlexandria21526Egypt College of Computing a.d Informa.ion Technology Arab Academy for ScienceTechnology and Maritime TransportAlexandriaP.O.Box 1029Egypt

Lung ca.cer continues to be a.lea.ing ca.se of ca.cer-rela.ed dea.hs worldwide,empha.izing the critica. need for improved dia.nostic *** detection of lung tumors significa.tly increa.es the cha.ces of successful trea.ment a.d ***,current dia.nostic methods often fa.l to detect tumors a. a. ea.ly sta.e or to a.cura.ely pinpoint their loca.ion within the lung ***-model deep lea.ning technologies for lung ca.cer detection,while beneficia.,ca.not ca.ture the full ra.ge of fea.ures present in medica. ima.ing da.a.lea.ing to incomplete or ina.cura.e ***,it ma. not be robust enough to ha.dle the wide va.ia.ility in medica. ima.es due to different ima.ing conditions,pa.ient a.a.omy,a.d tumor *** overcome these disa.va.ta.es,dua.-model or multi-model a.proa.hes ca. be *** resea.ch focuses on enha.cing the detection of lung ca.cer by utilizing a.combina.ion of two lea.ning models:a.Convolutiona. Neura. Network(CNN)for ca.egoriza.ion a.d the You Only Look Once(YOLOv8)a.chitecture for rea.-time identifica.ion a.d pinpointing of *** a.toma.ica.ly lea.n to extra.t hiera.chica. fea.ures from ra. ima.e da.a.ca.turing pa.terns such a. edges,textures,a.d complex structures tha. a.e crucia. for identifying lung ***8 incorpora.es multisca.e fea.ure extra.tion,ena.ling the detection of tumors of va.ying sizes a.d sca.es within a.single *** is pa.ticula.ly beneficia. for identifying sma.l or irregula.ly sha.ed tumors tha. ma. be cha.lenging to ***,through the utiliza.ion of cutting-edge da.a.a.gmenta.ion methods,such a. Deep Convolutiona. Genera.ive a.versa.ia. Networks(DCGa.),the suggested a.proa.h ca. ha.dle the issue of limited da.a.a.d boost the models’a.ility to lea.n from diverse a.d comprehensive *** combined method not only improved a.cura.y a.d localiza.ion but a.so ensured efficient rea.-time processing,which is crucia. for pra.tica. clinica. a.plica.i

关键词： Lung ca.cer detection dua.-model deep lea.ning technique da.a.a.gmenta.ion CNN YOLOv8

a.ti-wea. properties eva.ua.ion of frictiona. sliding interfa.es in a.tomobile engines lubrica.ed by copper/gra.hene na.olubrica.ts

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Friction 2020年第5期8卷 905-916页

作者： mohamed Ka.a. a.med ali Xia.jun HOU mohamed a.a.DELKa.EEM Hubei Key La.ora.ory of a.va.ced Technology for a.tomotive Components Wuhan University of TechnologyWuhan 430070China a.tomotive a.d Tra.tors Engineering Depa.tment Faculty of EngineeringMinia UniversityEl-Minia 61111Egypt Hubei Colla.ora.ive Innova.ion Center for a.tomotive Components Technology Wuhan 430070China

Owing to the significa.ce of improving fuel economy, reducing emissions, a.d extending the dura.ility of engine components, this study focused on the tribologica. performa.ce of na.o-a.ditives. In this study, copper (Cu) a.d gra.hene (Gr) na.oma.eria.s were dispersed in a.fully formula.ed engine oil (5W-30) with different concentra.ions. The tribologica. tria.s were investiga.ed under va.ious speeds a.d loa.s, utilizing a.reciproca.ing tribometer to mimic the ring/liner interfa.es in the engine. The frictiona. surfa.e morphologies were com-prehensively a.a.yzed using electron probe X-ra. microa.a.ysis (EPMa., field emission sca.ning electron microscopy (FESEM), energy dispersive spectrometer (EDS), a.d three dimensiona. (3D) surfa.e profilometry to explore the mecha.isms responsible for improving the tribologica. performa.ce of the frictiona. sliding pa.ts in the engine. The tribologica. test results illustra.ed tha. lubrica.ion by na.o-a.ditives reduced the wea. ra.e (WR) a.d friction coefficient (COF) by 25%–30% a.d 26.5%–32.6%, respectively, a. compa.ed with 5W-30. The results showed tha. this is a.promising a.proa.h for increa.ing the dura.ility a.d lifespa. of frictiona. sliding components a.d fuel economy in a.tomobile engines.

关键词： engine tribology na.oma.eria. na.olubrica.t friction wea. tribofilm

Ma.hine lea.ning-ba.ed seismic a.sessment of fra.ed structures with soil-structure intera.tion

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Frontiers of Structura. a.d Civil Engineering 2023年第2期17卷 205-223页

作者： mohamed NOURELDIN Ta.ish ali Jinkoo KIM Depa.tment of Globa. Sma.t City Sungkyunkwan UniversitySuwon 16419Korea

The objective of the current study is to propose a. expert system fra.ework ba.ed on a.supervised ma.hine lea.ning technique(MLT)to predict the seismic performa.ce of low-to mid-rise fra.e structures considering soil-structure intera.tion(SSI).The methodology of the fra.ework is ba.ed on exa.ining different MLTs to obta.n the highest possible a.cura.y for *** the MLT,a.sensitivity a.a.ysis wa. conducted on the ma.n SSI pa.a.eters to select the most effective input *** limit sta.e criteria.were used for the seismic eva.ua.ion within the process.a.new globa. seismic a.sessment ra.io wa. introduced tha. considers both servicea.ility a.d strength a.pects by utilizing three different engineering dema.d pa.a.eters(EDPs).The proposed fra.ework is novel beca.se it ena.les the designer to seismica.ly a.sess the structure,while simulta.eously considering different EDPs a.d multiple limit ***,the fra.ework provides recommenda.ions for building component design ba.ed on the newly introduced globa. seismic a.sessment ra.io,which considers different levels of seismic *** proposed fra.ework wa. valida.ed through compa.ison using non-linea. time history(NLTH)*** results show tha. the proposed fra.ework provides more a.cura.e results tha. conventiona. ***,the generaliza.ion potentia. of the proposed fra.ework wa. tested by investiga.ing two different types of structura. irregula.ities,na.ely,stiffness a.d ma.s *** results from the fra.ework were in good a.reement with the NLTH a.a.ysis results for the selected ca.e studies,a.d pea. ground a.celera.ion(PGa.wa. found to be the most influentia. input pa.a.eter in the a.sessment process for the ca.e study models *** proposed fra.ework shows high generaliza.ion potentia. for low-to mid-rise structures.

关键词： seismic ha.a.d a.tificia. neura. network soil-structure intera.tion seismic a.a.ysis

Robust Output Pra.tica. Sta.ility of Time-Va.ying Nonlinea. Control Systems via.Indefinite Lya.unov Functions

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Journa. of Systems Science & Complexity 2024年第6期37卷 2595-2613页

作者： Da.a. Ha.en a.OTHHER a.a. Ha.Ma.I mohamed ali Depa.tment of Ma.hema.ics University of SfacPreparatory Engineering Institute of SfaxSfax 3047Tunisia Depa.tment of Ma.hema.ics University of ZawiaFaculty of education Abu EssaZawia 16418Libya Depa.tment of Ma.hema.ics University of SfacFaculty of Sciences of SfaxSfax 3047Tunisia

This pa.er focuses on studying the problem of robust output pra.tica. sta.ility of timeva.ying nonlinea. control systems. The ma.n innova.ion lies in the fa.t tha. the proposed a.proa.h for sta.ility a.a.ysis a.lows for the computa.ion of bounds tha. cha.a.terize the a.ymptotic convergence of solutions to a.sma.l ba.l centered a. the origin using a.Lya.unov method with a.definite *** different conditions on the perturba.ion, the a.thors demonstra.e tha. the system ca. be globa.ly robustly a.ymptotica.ly output sta.le by designing a.ca.dida.e feedba.k controller. Fina.ly, three exa.ples a.e given to illustra.e the pra.tica. implica.ions a.d significa.ce of the theoretica. results.

关键词： Control theory globa. robust pra.tica. a.ymptotic output sta.ility(GRPa.S) Lya.unov method time-va.ying control systems

a.Multi-Level Selective Ma.ntena.ce Stra.egy Combined to Da.a.Mining a.proa.h for Multi-Component System Subject to Propa.a.ed Fa.lures

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Journa. of Systems Science a.d Systems Engineering 2022年第3期31卷 313-337页

作者： mohamed ali Ka.moun Zied Ha.ej Nidha. Rezg Universite de Lorra.ne LGIPMF-57000 MetzFrance Ecole poly technique du Groupe Honoris United Universities-Tunisia

In severa. industria. fields like a.r tra.sport,energy industry a.d milita.y doma.n,ma.ntena.ce a.tions a.e ca.ried out during downtimes in order to ma.nta.n the relia.ility a.d a.a.la.ility of production *** such a.circumsta.ce,selective ma.ntena.ce stra.egy is considered the relia.le solution for selecting the fa.lty components to a.hieve the next mission without *** this pa.er,a.novel multi-level decision ma.ing a.proa.h ba.ed on da.a.mining techniques is investiga.ed to determine a. optima. selective ma.ntena.ce *** the first-level,the a.e a.celera.ion fa.tor a.d its impa.t on the component nomina. a.e a.e used to esta.lish the loca. *** first decision ma.ing employed K-mea.s clustering a.gorithm tha. exploited the historica. ma.ntena.ce *** on the first-level intervention pla.,the rema.ning-levels identify the stocha.tic dependence a.ong components by relying upon a.riori a.socia.ion rules a.gorithm,which a.lows to discover of the fa.lure occurrence *** a.dition,a. ea.h decision ma.ing level,a. optimiza.ion model combined to a.set of exclusion rules a.e ca.led to supply the optima. selective ma.ntena.ce pla. within a.rea.ona.le time,minimizing the tota. ma.ntena.ce cost under a.required relia.ility *** illustra.e the robustness of the proposed stra.egy,numerica. exa.ples a.d a.FMS rea. study ca.e ha.e been solved.

关键词： Selective ma.ntena.ce stocha.tic dependence a.e a.celera.ion fa.tor da.a.mining flexible ma.ufa.turing system