检索结果-南通市图书馆

Updates in the pathophysiological mechanisms of Parkinson's disease: Emerging role of bone marrow mesenchymal stem cells

引用

World Journal of Stem Cells 2016年第3期8卷 106-117页

作者： Hanaa H Ahmed Ahmed M Salem Hazem M Atta Emad F Eskandar Abdel Razik H Farrag mohamed a ghazy Neveen A Salem Hadeer A Aglan Department Medical Research Division National Research Centre Biochemistry Department Faculty of Science Ain Shams University Clinical Biochemistry Department Faculty of Medicine King Abdulaziz University Medical Biochemistry and Molecular Biology Department Faculty of Medicine Cairo University Pathology Department Medical Research Division National Research Centre Narcotics Ergogenic aids and Poisons Department Medical Research Division National Research Centre

AIM: To explore the approaches exerted by mesenchymal stem cells (MSCs) to improve Parkinson’s disease (PD) ***: MSCs were harvested from bone marrow of femoral bones of male rats, grown and propagated in culture. Twenty four ovariectomized animals were classified into 3 groups: Group (1) was control, Groups (2) and (3) were subcutaneously administered with rotenone for 14 d after one month of ovariectomy for induction of PD. Then, Group (2) was left untreated, while Group (3) was treated with single intravenous dose of bone marrow derived MSCs (BM-MSCs). SRY gene was assessed by PCR in brain tissue of the female rats. Serum transforming growth factor beta-1 (TGF-β1), monocyte chemoattractant protein-1 (MCP-1) and brain derived neurotrophic factor (BDNF) levels were assayed by ELISA. Brain dopamine DA level was assayed fluorometrically, while brain tyrosine hydroxylase (TH) and nestin gene expression were detected by semi-quantitative real time PCR. Brain survivin expression was determined by immunohistochemical procedure. Histopathological investigation of brain tissues was also ***: BM-MSCs were able to home at the injured brains and elicited significant decrease in serum TGF-β1 (489.7 ± 13.0 vs 691.2 ± 8.0, P 0.05) expression. Finally, the brain sections showed intact histologica

关键词： Parkinson’s disease Pathophysiology Bone marrow derived mesenchymal stem cells Rotenone Anti-inflammatory action Ovariectomy Anti-apoptotic effect Neurogenic potential

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Determinants of Schistosoma mansoni transmission in hotspots at the late stage of elimination in Egypt

引用

Infectious Diseases of Poverty 2022年第5期11卷 95-96页

作者： Ramy mohamed ghazy Walid Ismail Ellakany Mai M.Badr Nehad E.M.Taktak Heba Elhadad Sarah MAbdo Ayat Hagag Abdel Rahman Hussein mohamed Mostafa Tahoun 不详 Department of Tropical Medicine Faculty of MedicineAlexandria UniversityAlexandriaEgypt

Background In certain settings,the prevalence and severity of schistosoma infection do not lessen despite repeated rounds of preventative chemotherapy;these areas are known as *** study aimed to investigate the role of human practices,besides environmental and malacological factors,in the maintenance of the Schistosoma mansoni infection transmission chain in hotspot areas in *** This cross-sectional study was conducted between July and November 2019 in Kafr El-Sheikh Governorate,Egypt.A pre-designed structured interviewing questionnaire was used to collect humanitarian *** samples were collected from children aged 6–15 years on three successive days and examined using the Kato-Katz ***,water and snail samples were taken from watercourses surrounding *** were identified based on their shell morphology and structure and tested for cercaria *** samples were analyzed for their physicochemical and biological *** A total of 2259 fecal samples(1113 in summer and 1146 in fall)were collected from 861 *** 46.9%of the participants were males,and 31.8%were aged 6–10 *** prevalence of *** infection was higher during the summer than during the fall(19.1%vs 7.2%,respectively,P<0.01).The intensity of infection(light,moderate,and heavy)during summer versus fall was(93.55 vs 89.38%,6.45 vs 8.85%,and 0.00%vs 1.77%),respectively(P<0.05).A higher prevalence of human infection was observed among males than females[OR=1.63,95%confidence interval(CI):1.10–2.40,P=0.015],children aged 11–15 years than among their counterparts aged 6–10 years(OR=2.96,95%CI:1.72–5.06,P<0.001),and mothers with a low level of education(OR=3.33,95%CI:1.70–6.52,P<0.001).The main identified risk factors were contacting the main body of water-canal for washing clothes(OR=1.81,95%CI:1.12–2.49,P=0.015),land irrigation(OR=2.56,95%CI:1.32–4.96,P=0.004),water collection(OR=2.94,95%CI:1.82–4.73,P<0.001),bathing(

关键词： Schistosoma mansoni Praziquantel Biomphalaria alexandrina Community engagement Transmission cycle Neglected tropical diseases

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Uniphyline-Induced Hypophosphatemia: A Rare Etiology of Severe Respiratory Failure

引用

Health 2023年第7期15卷 810-813页

作者： Hassan Mohammed Ismael Mohammed Farooq Ahmad mohamed Abdalrahman ghazy mohamed Gastroenterology/Medicine Department United Lincolnshire Hospitals NHS Trust Grantham Hospital Grantham UK Diabetes and Endocrinology Department United Lincolnshire Hospitals NHS Trust Grantham Hospital Grantham UK Acute Medicine Department United Lincolnshire Hospitals NHS Trust Grantham Hospital Grantham UK University Hospital Coventry NHS Trust Coventry UK

Hypophosphataemia is defined as low level of phosphate in the blood (normal range 0.8 - 1.4 mmol/l), which can be drug-induced such as uniphyline. We present a case of elderly female patient with known chronic obstructive pulmonary disease, admitted with acute respiratory failure and low serum phosphate level, her clinical signs and serum phosphate level did not improve with conventional therapy and intravenous phosphate replacement, until her recently commenced uniphyline was discontinued. This highlights the importance of awareness amongst the clinicians about this rare but potential side effect of uniphyline. We suggest monitoring phosphate levels in patients admitted with acute respiratory failure especially those on extended bronchodilator therapy.

关键词： Hypophosphatemia Acute Respiratory Failure Chronic Obstructive Pulmonary Disease Uniphyline Theophyline Bronchodilator Therapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Immediate and delayed micro-tensile bond strength of different luting resin cements to different regional dentin

引用

The Journal of Biomedical Research 2013年第2期27卷 151-158页

作者： Abdelraheem mohamed Ali Ibrahim mohamed Hamouda mohamed Hamed ghazy Manal mohamed Abo-Madina Department of Conservative Dentistry Faculty of Dentistry Mansoura University Department of Dental Biomaterials Faculty of Dentistry Mansoura University Department of Conservative Dentistry Faculty of Dentistry Umm Al Qura University Crown & Bridge Department of Conservative Dentistry Faculty of Dentistry Mansoura University

We sought to evaluate immediate and delayed micro-tensile bond strength of Panavia F2.0 and Multilink Sprint resin cement to superficial, deep and cervical dentin. Thirty-six freshly extracted non-carious human molars were sectioned in the mesiodistal direction to expose three different dentin regions including superficial dentin （1 mm below the dentine-enamel junction）, deep dentin （1 mm above the highest pulp horn） and cervical dentin （0.5 mm above the cemento-enamel junction and 0.5 mm below the dentine-enamel junction）. Resin cements were applied on dentin surfaces and composite blocks were luted under constant seating pressure. Each group was divided into three subgroups according to time intervals. Specimens were sectioned to obtain sticks of 1 mm2 in diameter and subjected to microtensile bond strength testing at a cross head speed of 1 mrn/min. Both resin cements showed higher micro-tensile bond strength to superficial dentin than that to deep or cervical dentin （P 〈 0.001）. Micro-ten- sile bond strengths of Panavia F2.0 were higher than those of Multilink Sprint at different dentin regions （P 〈 0.001）. Immediate ＂micro-tensile bond strengths were higher than those of delayed micro-tensile bond strengths for both resin cements （P 〈 0.001）. It was concluded that resin cements with different chemical formulations and applications yield significantly different micro-tensile bond strengths to different dentin regions.

关键词： immediate and delayed micro-tensile bond strength luting resin cements regional dentin

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Gastrointestinal Symptoms—A Rare Complication of Untreated CPA Tumor

引用

Health 2023年第8期15卷 839-844页

作者： Hassan Mohammed Ismael Mohammed Farooq Ahmad mohamed Abdalrahman Raoof Hagag ghazy mohamed Abdelgani Abdlegani Ngwira Joseph Gastroenterology/Medicine Department United Lincolnshire Hospitals NHS Trust Grantham Hospital Grantham UK Internal Medicine Department United Lincolnshire Hospitals NHS Trust Grantham Hospital Grantham UK Acute medicine Department United Lincolnshire Hospitals NHS Trust Grantham Hospital Grantham UK Intensive Care Department Medicine University Hospital Coventry NHS Trust Coventry UK Cardiology Department Scarborough General Hospital Scarborough UK Bank Consultant Internal Medicine Department United Lincolnshire Hospitals NHS Trust Grantham Hospital Grantham UK

Cerebellopontine angle (CPA) lesions account for up to 10% of all intracranial tumors. Most CPA tumors are benign, but can cause nerve damage or compress the surrounding structures if left untreated. The typical presentation is with adult-onset sensorineural hearing loss or non-pulsatile tinnitus. In some patients, this goes unnoticed, and presentation is delayed until the lesion is much larger and presents with symptoms related to mass effect. We present the case study of 63 years old gentleman, who had suspected left CPA lesion on CT head done few years ago for dizziness and left-sided facial numbness. MRI could not be done at that time due to his MRI incompatible pacemaker leading to delay in his management eventually causing loss of patient to the follow up. He later developed progressive difficulty in walking which was initially attributed to as secondary to vasovagal syncope and postural hypotension. He eventually presented to us with intractable nausea and vomiting, worsening headache and ataxia. He had an urgent CT head which showed significant growth in the lesion with compression of the surrounding structures and obstructive hydrocephalus. He was given steroids which improved his nausea and vomiting, followed by undergoing surgery in regional center leading to significant improvement in his gait within few days of surgery. He unfortunately continued to have a degree of ataxia and facial numbness. This case illustrates a rare presentation of CPA tumor with symptoms of nausea and vomiting as a result of mass effect of the growing tumor. In addition, this review also shows the importance of regularly following up the patients with suspected CPA lesions on initial scans which will help with identifying the increase in size of lesion promptly and potentially preventing advanced complications of CPA tumors. We suggest regular monitoring of these patients to timely manage the lesion and avoid the potential life-threatening complications.

关键词： Cerebellopontine Angle (CPA) Vestibulocohlear Nerve (CNV111) Vestibular Schwannoma (VS) Sensorineural Hearing Loss Facial Nerve (CN VII) Vagus Nerve Microsurgery Gamma Knife Surgery (GKS Hydrocephalus)

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Electrodeposition and Surface Characterization of Sulfur on Polycrystalline Platinum from Sulfide Polluted Brine

引用

Journal of Chemistry and Chemical Engineering 2010年第2期4卷 15-21页

作者： Faiza mohamed AI Kharafi Aiman Yehia Saad Badr ghazy Ateya Ibrahim mohamed Ghayad Chemistry Department Faculty of Science Kuwait University Kuwait Safat 13060 Kuwait

This paper investigated the electrodeposition of sulfur on polycrystalline platinum from sulfide polluted brine. Anodic polarization, potentiostatic and electrochemical impedance spectroscopy （EIS） techniques were performed. The slope of Warburg straight line in Nyquiest plot of the EIS spectra performed at 0.0 V indicates diffusion control mechanism of the electrodeposition process. At 0.5 V the Rp （determined from EIS measurements） increased rapidly with time indicating more sulfur deposition and more passivation of platinum surface. Samples subjected to potentiostatic experiments at 0.4, 0.9 and 1.0 V were investigated under Scanning Electron Microscope （SEM）. SEM images reveal the deposition of sulfur on the sample surfaces. The degree of sulfur deposit coverage and its morphology depend on both the potential and time of deposition.

关键词： Electrodeposition sulfur platinum sulfide pollution.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Efficacy and safety of botulinum toxin in treatment of anismus: A systematic review

引用

World Journal of Gastrointestinal Pharmacology and Therapeutics 2016年第3期7卷 453-462页

作者： Sameh Hany Emile Hossam Ayman Elfeki Hosam ghazy Elbanna mohamed Youssef Waleed Thabet Tito M Abd El-Hamed Basem Said Ahmed Lotfy General Surgery Department Colorectal Surgery Unit Mansoura Faculty of Medicine Mansoura University

AIM: To evaluate the efficacy and safety of botulinum toxin type A(BTX-A) in the management of patients with anismus. METHODS: An organized search of published literature was conducted using electronic databases including: Pub Med/MEDLINE, and Cochrane Central Register of Control ed Trials, also an internet-based search using "Google Scholar" service was conducted. Both comparative and observational studies were included. We excluded irrelevant articles, editorials, case reports, reviews, and meta-analyses. The studies that followed the patients less than 6 mo were excluded. Variables collected were demographic data of the patients, technique of BTX-A injection and number of sessions, short-term and longterm clinical improvement, post-injection changes in electromyography(EMG), defecography, manometry, and balloon expulsion test, and complications recorded after BTX-A ***: Seven studies comprising 189 patients were included in the review. The median age of the patients was 41.2 years and female-to-male ratio was 1.3:1. The median dose of BTX-A injected per procedure was 100 IU(range, 20-100 IU). Lateral injection was done in five trails and combined lateral and posterior injections in two trials. Three studies used endorectal ultrasonographyguided technique, one study used EMG-guided technique,whereas the remaining three studies used manual palpation with the index finger. The median percentage of patients who reported initial improvement of symptoms was 77.4%(range 37.5%-86.7%), this percentage declined to a median of 46%(range 25%-100%) at 4 mo after injection of BTX-A. Rates of improvement evaluated by balloon expulsion test, EMG, and defecography ranged between(37.5%-80%),(54%-86.7%), and(25%-86.6%), respectively. Fourteen(7.4%) patients developed complications after injection of BTX-A. Complication rates across the studies ranged from 0% to 22.6%. CONCLUSION: Initial satisfactory improvement of symptoms after BTX-A injection remarkably deteriorate

关键词： Botulinum toxin Botulinum toxin type A Botox Anismus Puborectalis syndrome Efficacy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rubber band ligation for 750 cases of symptomatic hemorrhoids out of 2200 cases

引用

World Journal of Gastroenterology 2008年第42期14卷 6525-6530页

作者： Ayman M El Nakeeb Amir A Fikry Waleed H Omar Elyamani M Fouda Tito A El Metwally Hosam E ghazy Sabry A Badr Mohmed Y Abu Elkhar Salih M Elawady Hisham H Abd Elmoniam Waiel W Khafagy Mosaad M Morshed Ramadan E El Lithy mohamed E Farid Department of General Surgery Colorectal unit Mansoura University Hospital Mansoura 335111 Egypt

AIM: To study the results for the treatment of symptomatic hemorrhoids using rubber band ligation (RBL) method. METHODS: A retrospective study for 750 patients who came to the colorectal unit from June, 1998 to September, 2006, data was retrieved from archived fi les. RBL was performed using the Mc Gown applicator on an outpatient basis. The patients were asked to return to out-patient clinic for follow up at 2 wk, 1 mo, 6 mo and through telephone call every 6 mo for 2 years). RESULTS: After RBL, 696 patients (92.8%) were cured with no difference in outcome for second or third degree hemorrhoids (P = 0.31). Symptomatic recurrence was detected in 11.04% after 2 years. A total of 52 patients (6.93%) had 77 complications from RBL which required no hospitalization. Complications were pain, rectal bleeding and vaso-vagal symptoms(4.13%, 4.13% and 1.33% of patients, respectively). At 1 mo there were a significant improvement in mean SF-36 scores over baseline in five items, while after 2 years there were improvement in all items over baseline, but not significant. No significant manometeric changes after band ligation. CONCLUSION: RBL is a simple, safe and effective method for treating symptomatic second and third degree hemorrhoids as an out patient procedure with signifi cant improvement in quality of life. RBL doesn't alter ano-rectal functions.

关键词： Piles Rectal bleeding Barron banding Hemorrhoidectomy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：