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Survey Study of Acute and Long Term Effects of Female Genital Mutilation among Women in Sharkia Governorate

Open Journal of Obstetrics and Gynecology 2014年第14期4卷 874-880页

作者： Essa M. Arafa Amany M. Abdelghany Nadia M. Madkour wael S. Nossair Ekramy A. mohamed Department of Obstetrics and Gynecology Zagazig University Hospitals Zagazig Egypt

Objective: The aim of this study is to evaluate the acute and long-term effects of female genital mutilation (FGM) among women in Sharkia Governorate. Method: This was a cross-sectional descriptive study carried out in Zagazic University Hospital (ZUH) over a two years period from January 2012 to January 2014. The overall sample consisted of 1500 women. An interview was utilized to collect the necessary data. The questionnaires were administered face to face, in Arabic language. Four open and 25 close-ended questions were used to collect socio-demographic data of the sample: women’s experience about the circumcision, occurrence of health hazards after circumcision, and sexual effects on married women. Intention of all women (circumcised or not) to circumcise?their daughters was also documented. Results: This study revealed that the prevalence of FGM in?Sharkia Governorate was about 85.5%. The majority of circumcised women were Muslims (94.4%), married (87.9%), housewife (81.4%), illiterate or with low education level (45.5% and 38.5% respectively) and from rural areas (82.2%). The most common types of FGM were type I (49.2%) and type II (50.8%). The most common motive of FGM was the religious cause (46.6%). The majority of circumcised women (59%) denied the occurrence of any acute complication. The reported acute complications in this study were bleeding (19.6%), urine retention (2.3%), infection (6.3%) and difficult walking (12.8%). The majority of circumcised women (86%) denied the occurrence of any problems at labor related to circumcision. The reported problems at labor in this study were narrowing of introitus (8.4%), laceration (0.7%) and bleeding (4.9%). In this study, 74.6% of circumcised women believed that there was no effect of circumcision on their sexual satisfaction and 92.1% of circumcised women believed that there was no effect of circumcision on their husband’s sexual satisfaction. Approximately 16% of circumcised women complained of dyspareunia and

关键词： Female Genital Mutilation Female Circumcision Sexual Satisfaction

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About a rare cause of intestinal perforation

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Open Journal of Internal Medicine 2011年第2期1卷 14-16页

作者： Mona Mlika Heifa Azouz Inès Chelly Sofiène Ayadi wael Rbai Nidhameddine Kchir Slim Haouet mohamed Moncef Zitouna 不详

Background: Periarteritis nodosa (PAN) is a necrotizing systemic vasculitis involving mediumsized arteries and rarely the smallsized ones. It affects various organs and is generally revealed by different non specific organs. The aim of the authors is to report a rare revealing manifestation of this disease which is the perforation of the small bowel and to highlight the most important histological features. Case report: The authors describe the case of a 48-year-old Caucasian woman, without a particular past medical history, who presented an acute surgical abdomen. A surgical exploration was decided and showed a necrosis of the small bowel and the appendix. A segmental ileectomy was performed. The histological examination of the specimen showed small vasculitis-affected with fibroid necrosis dealing to the diagnosis of intestinal perforation caused by a PAN was retained. Post-operatively, the patient was put on immunosuppressive therapy and presented a prolonged healing process and was discharged from the hospital 20 days after her admission. Conclusion: Although it is rare for PAN to be revealed by small bowel perforation, it should be kept in mind when facing ischemic change of the small bowel.

关键词： Periarteritis Nodosa Intestinal Perforation Vasculitis

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Correlation between Perifollicular Vascularity and Outcome in Stimulated Intrauterine Insemination Treatment Cycles: A Study Using Two-Dimensional Transvaginal Power Doppler Ultrasound

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Open Journal of Obstetrics and Gynecology 2014年第15期4卷 973-980页

作者： Nadia M. Madkour wael S. Nossair Essa M. Arafa Amany M. Abdelghany Ekramy A. mohamed Walid A. Abdelsalam Obstetrics & Gynecology Department Faculty of Medicine Zagazig University Zagazig Egypt

Objective:?The aim of this study is to assess any potential relationship between perifollicular vascularity and occurrence of pregnancy in cases of stimulated IUI cycles using the subjective grading system by 2D transvaginal power Doppler ultrasonography.?Design: A prospective cross sectional cohort study. Method: This is a prospective cross-sectional cohort study of 90 stimulated IUI treatment cycles. Selected women were prescribed clomiphene citrate combined with highly purified urinary follicle stimulating hormone. All patients underwent serial transvaginal ultrasound scans starting from day 6 to 7 of the cycle. Perifollicular Doppler blood flows were assessed in dominant follicles ≥18 mm. The patients then were categorized into 3 groups (high vascularity group {G3 & G4}, low vascularity group {G1 & G2} and mixed grades group). Other parameters measured included number of follicles ≥ 18 mm in both ovaries, endometrial thickness and estradiol (E2) level . Human chorionic gonadotropin (hCG) injection 10,000 IU IM was given to the patient when the dominant follicle reached 18 mm in diameter. At that time, the endometrium was evaluated as regards endometrial thickness. IUI was carried out using prepared/“washed” semen (husband). All patients received luteal support in the form of progesterone from day of IUI for 14 days. Serum Β-hCG was estimated 2 weeks after insemination. Results: In this study, from all 90 cases only 8 cases got pregnant with pregnancy rate of 8.88% (6 cases got pregnant in high grade vascularity group;2 cases in mixed grades group and no cases got pregnant?in low grade group). There was statistically significant difference among the 3 groups as regarding?the pregnancy rate (P value = 0.02). There is statistically significant difference in perifollicular resistance index (RI) and pulsatility index (PI) between pregnant and non pregnant cases (P value = 0.016 and 0.047 respectively). In this study, there is no statistically significant difference b

关键词： Perifollicular Vascularity IUI 2D Power Doppler Ultrasound

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Comparative Study between Intraoperative Frozen Section and Scrape Smear Cytology in the Diagnosis of Ovarian Neoplasm

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Open Journal of Obstetrics and Gynecology 2015年第1期5卷 28-35页

作者： Amany M. Abdelghany Essa M. Arafa Nadia M. Madkour wael S. Nossair Ekramy A. mohamed Walid A. Abdelsalam Amira A. Salem Obstetrics & Gynecology Department Faculty of Medicine Zagazig University Zagazig Egypt

Objective: The aim of this work is to compare between intraoperative frozen section and scrape smear cytology in the diagnosis of ovarian neoplasm. Method: This study was performed between March 2011 and March 2012, on 50 patients presented with ovarian mass. Gross examination of the tumor removed was done by inspection and palpation. The specimen was then cut with a sharp knife into two halves. The area was scraped with a sharp scalpel or the end of a glass slide, depending upon the type of tissue. A semifluid drop thus obtained was spread over a glass slide. One to four slides per case were taken from different representative areas. The slides were labelled and immediately put into 95% ethyl alcohol and stained with hematoxylin-eosin. The specimens were then fixed in formalin. Paraffin blocks of the sections were processed in the routine way and sections were stained with hematoxylin and eosin (H and E). Assessment of the overall accuracy of the intraoperative diagnosis was classified as concordant or discordant. Results: The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of scraping technique in the diagnosis of benign ovarian masses were 100%, 95.2%, 96.7%, 100% and 98% respectively. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of scraping technique in the diagnosis of border line ovarian masses were 100%, 93.4%, 25%, 100% and 94% respectively. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of scraping technique in the diagnosis of malignant ovarian masses were 80%, 100%, 100%, 88.2% and 92% respectively. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of frozen section in the diagnosis of benign ovarian masses were 100%, 100%, 100%, 100% and 100% respectively. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of frozen section

关键词： Frozen Section Intraoperative Assessment Scrape Smear Cytology Ovarian

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Accuracy of Intraoperative Frozen Section in the Diagnosis of Ovarian Neoplasms

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Open Journal of Obstetrics and Gynecology 2015年第1期5卷 14-22页

Objective: The aim of the work is to evaluate the accuracy of intraoperative frozen section in the diagnosis of ovarian neoplasms in Zagazig University. Design: A prospective cross sectional cohort study. Method: This study was performed between March 2011 and March 2012, on 50 patients presented with ovarian mass. Gross examination of the tumor removed was done by inspection and palpation. The specimen was then cut with a sharp knife into two halves. The most appropriate area thought to be representative of lesion was chosen. The number of sections frozen was depended on the type and size of the tumor. Seven to eight μm sections were obtained and stained with hematoxylin-eosin. The specimens were then fixed in formalin. Paraffin blocks of the sections were processed in the routine way and sections were stained with hematoxylin and eosin (H and E). The diagnosis obtained by intraoperative frozen section based on cellularity and cell morphology was compared with final histopathological diagnosis in terms of diagnostic sensitivity, to differentiate between benign and malignant lesions. Assessment of the overall accuracy of the intraoperative diagnosis was classified as concordant or discordant. Results: There was no statisticaly significant differencre in the studied patients as regard the clinical data, macroscopic and intraoperative picture, while there was statisticaly significat association as regard the laterality of the ovarian masses. The validity of frozen section in the diagnosis of benign tumour was 100% with 100% accuracy, specificity, positive predictive value, negative predictive value, while sensitivity & negative prediction for borderline tumour and specificity & positive prediction of malignant tumour were 100%, specifecity for borderline tumours was 95% while the positive predictive value was 33.3% with 96% accuracy for both malignant and borderline tumours. Conclusion: Intraoperative frozen section is accurate for rapid diagnosis of ovarian tumors. I

关键词： Intraoperative Frozen Section Ovarian Neoplasms

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Noninvasive Fibrosis Scores as Prognostic Markers for Varices Needing Treatment in Advanced Compensated Liver Cirrhosis

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Open Journal of Gastroenterology 2017年第8期7卷 230-242页

作者： Elham Ahmed Hassan Abeer Sharaf El-Din Abd El-Rehim Zain El-Abdeen Ahmed Sayed Ahmed Mohmmed Ashmawy Emad Farah mohamed Kholef Abeer Sabry wael Abd-Elgwad Elsewify Department of Tropical Medicine and Gastroenterology Faculty of Medicine Assiut University Assiut Egypt Department of Internal Medicine Faculty of Medicine Assiut University Assiut Egypt Department of Clinical pathology Faculty of Medicine Aswan University Aswan Egypt Department of Internal Medicine Faculty of Medicine Helwan University Cairo Egypt Department of Internal Medicine Faculty of Medicine Aswan University Aswan Egypt

Background/purpose: Noninvasive assessment of esophageal varices (EVs), their size and bleeding stigmata may reduce endoscopic burden, cost and drawbacks. We aimed to evaluate the diagnostic performance of noninvasive fibrosis scores (AAR, APRI, FIB-4, King and VITRO scores) in predicting the presence of EVs and high risk varices needing treatment (VNT) in HCV-related cirrhosis of Egyptian patients. Methods: This prospective study included 154 HCV-related advanced compensated cirrhotic patients with no history of bleeding who underwent screening endoscopy for EVs. AAR, APRI, FIB-4, King and VITRO scores were assessed. Results: Esophageal varices were found in 120 patients (77.9%) and VNT in 92 patients (59.7%). Apart from AAR, all scores demonstrated statistically significant correlations with the presence and the size of EVs. Using area under receiver operating characteristic curve (AUC), these scores were good predictors for the presence of EVs and VNT, where VITRO score had the highest AUC (0.920 and 0.900) and accuracy (97.1% and 87%), sensitivity (75, 82.6%), specificity (100, 93.5%), PPV (100, 95%) and NPV (53.2, 78.4%) with cutoffs >1.3 and >1.8 respectively. Conclusion: Noninvasive fibrosis scores can predict the presence of EVs and VNT. VITRO score was the best predictor with higher accuracy for clinical applicability than studied scores.

关键词： Esophageal Varices Hepatitis C Liver Cirrhosis VITRO Score

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How to Return the Death Programs of Cancer Cells to Work again and Cure Cancer within a Short Time?

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CellBio 2019年第2期8卷 17-39页

作者： Mahmoud Saad mohamed El-Khodary Sahar Ezeldien Hasan wael A. Hassan Maather M. El-Lamie Ismail A. M. Eissa Waleed F. Khalil Salah M. Aly Suez Canal University Ismailia Egypt General Organization for Export and Import Control Suez Egypt Pharmacology Department Faculty of Vet. Medicine Suez Canal University Ismailia Egypt Pathology Department Faculty of Medicine Suez Canal University Ismailia Egypt Department of Basic Sciences Suliman Al-Rajhi Collage of Medicine Al Bukayriyah KSA Department of Fish Diseases & Management Faculty of Vet. Medicine Suez Canal Univ. Ismailia Egypt Pathology Department Faculty of Vet. Medicine Suez Canal University Ismailia Egypt

Cancer is cell fleeing from death by blocking the intrinsic and extrinsic pathways of cell death programs. In the present work, the experimental formula was designed to remove these blockers. It was applied on 120 Swiss albino mice which were inoculated intraperitoneally and subcutaneously with Ehrlich Ascites Carcinoma cells;1 × (106) cell/mouse. The activity of the cell death programs of the tumor was detected by measuring the volume of Ascites fluid, counting the number of dead cancer cells, measuring the size of the tumor, detecting the positive reaction of caspase enzyme in cancer cells and presence of macrophages and apoptotic bodies in tumor tissue. The experimental formula succeeded in removing the blockers of the cell death program in cancer cells returning the cell death program to work again.

关键词： Cancer Therapeutic Strategy Accumulation Detoxification Enzymes Free Radicals Antioxidants H2O2 Glutathione NF-kB Sulforaphane Flavonoid Cur Cumin

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The Effect of （x-Radiation Dose on CR-39 Polymer Track Detectors Using Positron Annihilation Lifetime and UV-Spectroscopy

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材料科学与工程（中英文版） 2010年第11期4卷 48-52页

作者： Mostafa Fawzy Eissa Esmat mohamed Hassan Emad A. badawi Physics Department Faculty of Science Beni-Suef University Beni-Suef 62511 Egypt Physics Department Faculty of Science Aswan South rally University Aswan 81528 Egypt Physics Department Faculty of Science EI-Minia University EI-Minia 61519 Egypt

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Role of endoscopic ultrasound and cyst fluid tumor markers in diagnosis of pancreatic cystic lesions

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World Journal of Gastrointestinal Endoscopy 2022年第6期14卷 402-415页

作者： Hussein Hassan Okasha Abeer Abdellatef Shaimaa Elkholy Mohamad-Sherif Mogawer Ayman Yosry Magdy Elserafy Eman Medhat Hanaa Khalaf Magdy Fouad Tamer Elbaz Ahmed Ramadan Mervat E Behiry Kerolis Y William Ghada Habib Mona Kaddah Haitham Abdel-Hamid Amr Abou-Elmagd Ahmed Galal wael A Abbas Ahmed Youssef Altonbary Mahmoud El-Ansary Aml E Abdou Hani Haggag Tarek Ali Abdellah mohamed A Elfeki Heba Ahmed Faheem Hani M Khattab Mervat El-Ansary Safia Beshir mohamed El-Nady Department of Internal Medicine and Hepatogastroenterology Kasr Al-Aini HospitalsCairo UniversityKasr Al-Aini HospitalsCairo UniversityCairo 11451Egypt Department of Endemic Diseases Cairo UniversityCairo 11451Egypt Department of Tropical Medicine and Gastroenterology Minia UniversityMinia 61511Egypt Department of Internal Medicine Kasr Al-Aini HospitalsCairo UniversityCairo 11562Egypt Department of Gastroenterology Armed forces College of MedicineCairo 11451Egypt Endoscopy and Internal Medicine Consultant at Dr/Ahmed Galal Endoscopy Center Alexandria 35516Egypt Department of Internal Medicine Faculty of MedicineAssuit UniversityAssuit 71111Egypt Department of Gastroenterology and Hepatology Mansoura UniversityMansoura 35511Egypt Department of Gastroenterology and Hepatology Theodor Bilharz Research InstituteCairo 11451Egypt Department of Microbiology and Immunology Faculty of Medicine for girls Al-Azhar UniversityCairo 11451Egypt Department of Internal Medicine Faculty of MedicineAin shams UniversityCairo 11451Egypt Department of Internal Medicine Bani-suef UniversityBani-suefBani-suef 62511Egypt Department of Pathology Faculty of MedicineCairo UniversityCairo 11451Egypt Department of Clinical Pathology Faculty of MedicineCairo UniversityCairo 11451Egypt Department of Environmental Medicine&Clinical Pathology National Research CentreCairo 11451Egypt

BACKGROUND Pancreatic cystic lesions(PCLs) are common in clinical practice. The accurate classification and diagnosis of these lesions are crucial to avoid unnecessary treatment of benign lesions and missed opportunities for early treatment of potentially malignant *** To evaluate the role of cyst fluid analysis of different tumor markers such as cancer antigens [e.g., cancer antigen(CA)19-9, CA72-4], carcinoembryonic antigen(CEA), serine protease inhibitor Kazal-type 1(SPINK1), interleukin 1 beta(IL1-β), vascular endothelial growth factor A(VEGF-A), and prostaglandin E2(PGE2)], amylase, and mucin stain in diagnosing pancreatic cysts and differentiating malignant from benign *** This study included 76 patients diagnosed with PCLs using different imaging modalities. All patients underwent endoscopic ultrasound(EUS) and EUS-fine needle aspiration(EUS-FNA) for characterization and sampling of different *** The mean age of studied patients was 47.4 ± 11.4 years, with a slight female predominance(59.2%). Mucin stain showed high statistical significance in predicting malignancy with a sensitivity of 87.1% and specificity of 95.56%. It also showed a positive predictive value and negative predictive value of 93.1% and 91.49%, respectively(P < 0.001). We found that positive mucin stain, cyst fluid glucose, SPINK1, amylase, and CEA levels had high statistical significance(P < 0.0001). In contrast, IL-1β, CA 72-4, VEGF-A, VEGFR2, and PGE2 did not show any statistical significance. Univariate regression analysis for prediction of malignancy in PCLs showed a statistically significant positive correlation with mural nodules, lymph nodes, cyst diameter, mucin stain, and cyst fluid CEA. Meanwhile, logistic multivariable regression analysis proved that mural nodules, mucin stain, and SPINK1 were independent predictors of malignancy in cystic pancreatic *** EUS examination of cyst morphology with cytopathological analysis and cyst fluid ana

关键词： Pancreatic cystic neoplasm Mucinous cystic neoplasm Intraductal papillary mucinous neoplasm Mucin stain Amylase

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Determination of Full Energy Peak Efficiency of NaI(Tl) Detector Depending on Efficiency Transfer Principle for Conversion Form Experimental Values

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World Journal of Nuclear Science and Technology（核科学与技术国际期刊） 2012年第3期

作者： mohamed Abd-Elzaher mohamed Salem badawi Ahmed El-Khatib Abouzeid Ahmed Thabet

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