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Hepatobiliary Surgery and Nutrition 2024年第5期13卷 861-864页

作者： mohamed bouattour Julie Devictor Clemence Hollande AP-HP Hôpital BeaujonLiver Cancer and Innovative Therapy UnitClichyFrance UniversitéParis Cité Centre de Recherche sur l’Inflammation(CRI)INSERMU1149ParisFrance UniversitéParis Cité ECEVEINSERM UMR 1123ParisFrance

The collaboration among various Italian scientific societies to establish recommendations for the surgical management of hepatocellular carcinoma(HCC),recently published in Digestive and Liver Disease(1),is a worthy *** multidisciplinary approach,which includes input from different disciplines such as surgery,hepatology,gastroenterology,oncology,pathology,radiology,and patient associations,underscores the commitment to placing patients at the center of *** a holistic and inclusive approach enhances the relevance and applicability of these guidelines in clinical *** several scientific associations have previously issued guidelines for managing HCC,the Italian colleagues have adopted a comprehensive methodology.

关键词： Multidisciplinary patient-centered surgery recommendation

Adjuvant chemotherapy with gemcitabine plus erlotinib *** alone for patients with resected pancreatic ductal adenocarcinoma:is there a role for erlotinib?—review of the open label phase III trial CONKO 005

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Hepatobiliary Surgery and Nutrition 2018年第5期7卷 399-402页

作者： Mathilde Wisniewski Pierre-Alain Placide Sandra Granier Yacoub Al Shatti Shuaib Al Qalaf mohamed bouattour Michele Lamuraglia Pascal Hammel Department of Digestive and Medical Oncology Hopital Beaujon(AP-HP)University Denis Diderot-ParisⅦClichyFrance

Sinn et al. (1) report the results of a multicenter trial comparing the combination of gemcitabine and erlotinib with gemcitabine alone for adjuvant therapy in 436 patients who underwent R0 resection for pancreatic du... 详细信息

关键词： gemcitabine patients ductal

Disease control with sunitinib in advanced intrahepatic cholangiocarcinoma resistant to gemcitabine-oxaliplatin chemotherapy

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World Journal of Hepatology 2015年第6期7卷 910-915页

作者： Chantal Dreyer Marie-Paule Sablin mohamed bouattour Cindy Neuzillet Maxime Ronot Safi Dokmak Jacques Belghiti Nathalie Guedj Valérie Paradis Eric Raymond Sandrine Faivre Department of Medical Oncology Beaujon University Hospital (AP-HP-PRES Paris 7 Diderot) Department of Hepatology Beaujon University Hospital (AP-HP - PRES Paris 7 Diderot) Department of Imaging Beaujon University Hospital (AP-HP - PRES Paris 7 Diderot) Department of Biliary and Pancreatic Surgery Beaujon University Hospital (AP-HP - PRES Paris 7 Diderot) Department of Pathology Beaujon University Hospital (AP-HP - PRES Paris 7 Diderot)

Advanced cholangiocarcinoma is associated with poor prognostic survival and has limited therapeutic options available at present. The importance of angiogenesis and expression of pro-angiogenic factors in intrahepatic forms of cholangiocarcinoma suggest that therapies targeting angiogenesis might be useful for the treatment of this disease. Here we report three cases of patients with advanced intrahepatic cholangiocarcinoma progressive after standard chemotherapy and treated with sunitinib 50 mg/d in 6-wk cycles of 4 wk on treatment followed by 2 wk off treatment(Schedule 4/2). In all three patients, sunitinib treatment was associated with a sustained disease control superior to 4 mo, patients achieving either a partial response or stable disease. A reduction in tumor size and density was observed in all cases, suggesting tumor necrosis as a result of sunitinib treatment in these patients. In addition, sunitinib was generally well tolerated and the occurrence of side effects was managed with standard medical interventions, as required. Our results suggest that sunitinib therapy maybe associated with favorable outcomes and tolerability in patients with advanced cholangiocarcinoma. Those observations contributed to launch a prospective phase Ⅱ multicenter trial investigating sunitinib in advanced intrahepatic cholangiocarcinoma(SUN-CK study; NCT01718327).

关键词： Biliary tract tumors Antiangiogenic therapy Hypodensity Tumor response Vascular endothelialgrowth factor receptor inhibitors Chemoresistance

Evaluation of antiangiogenic efficacy in advanced hepatocellular carcinoma: Biomarkers and functional imaging

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World Journal of Hepatology 2015年第20期7卷 2245-2263页

作者： mohamed bouattour Audrey Payancé Johanna Wassermann Department of Hepatology Beaujon University Hospital (AP-HP - Paris 7 Diderot) Department of Medical Oncology La Pitié-Salpêtrière University Hospital (AP-HP - Paris 6 Pierre et Marie Curie)

Many years after therapeutic wilderness, sorafenib finally showed a clinical benefit in patients with advanced hepatocellular carcinoma. After the primary general enthusiasm worldwide, some disappointments emerged particularly since no new treatment could exceed or at least match sorafenib in this setting. Without these new drugs, research focused on optimi-zing care of patients treated with sorafenib. One challenging research approach deals with identifying prognostic and predictive biomarkers of sorafenib in this population. The task still seems difficult; however appropriate investigations could resolve this dilemma, as observed for some malignancies where other drugs were used.

关键词： Hepatocellular carcinoma Antiangiogenic therapies

A New Speed Limit Recognition Methodology Based on Ensemble Learning:Hardware Validation

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Computers, Materials & Continua 2024年第7期80卷 119-138页

作者： mohamed Karray Nesrine Triki mohamed Ksantini ESME ESME Research LabIvry Sur Seine94200France CEM Lab ENISUniversity of SfaxSfax3038Tunisia

Advanced DriverAssistance Systems(ADAS)technologies can assist drivers or be part of automatic driving systems to support the driving process and improve the level of safety and comfort on the *** Sign Recognition System(TSRS)is one of themost important components *** the challengeswith TSRS is being able to recognize road signs with the highest accuracy and the shortest processing ***,this paper introduces a new real time methodology recognizing Speed Limit Signs based on a trio of developed ***,the Speed Limit Detection(SLD)module uses the Haar Cascade technique to generate a new SL detector in order to localize SL signs within captured ***,the Speed Limit Classification(SLC)module,featuring machine learning classifiers alongside a newly developed model called DeepSL,harnesses the power of a CNN architecture to extract intricate features from speed limit sign images,ensuring efficient and precise *** addition,a new Speed Limit Classifiers Fusion(SLCF)module has been developed by combining trained ML classifiers and the DeepSL model by using the Dempster-Shafer theory of belief functions and ensemble learning’s voting *** rigorous software and hardware validation processes,the proposedmethodology has achieved highly significant F1 scores of 99.98%and 99.96%for DS theory and the votingmethod,***,a prototype encompassing all components demonstrates outstanding reliability and efficacy,with processing times of 150 ms for the Raspberry Pi board and 81.5 ms for the Nano Jetson board,marking a significant advancement in TSRS technology.

关键词： Driving automation advanced driver assistance systems(ADAS) traffic sign recognition(TSR) artificial intelligence ensemble learning belief functions voting method

A Distributionally Robust Optimization Scheduling Model for Regional Integrated Energy Systems Considering Hot Dry Rock Co-Generation

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Computer Modeling in Engineering & Sciences 2024年第8期140卷 1387-1404页

作者： Hao Qi mohamed Sharaf Andres Annuk Adrian Ilinca mohamed A.mohamed College of Electrical and New Energy China Three Gorges UniversityYichang443002China Department of Industrial Engineering College of EngineeringKing Saud UniversityRiyadh11421Saudi Arabia Institute of Forestry and Engineering Estonian University of Life SciencesTartu51006Estonia Department of Mechanical Engineering école de Technologie SupérieureMontréalQC H3C 1K3Canada Electrical Engineering Department Faculty of EngineeringMinia UniversityMinia61519Egypt

Hot dry rock(HDR)is rich in reserve,widely distributed,green,low-carbon,and has broad development potential and *** this paper,a distributionally robust optimization(DRO)scheduling model for a regionally integrated energy system(RIES)considering HDR co-generation is ***,the HDR-enhanced geothermal system(HDR-EGS)is introduced into the ***-EGS realizes the thermoelectric decoupling of combined heat and power(CHP)through coordinated operation with the regional power grid and the regional heat grid,which enhances the system wind power(WP)feed-in ***,peak-hour loads are shifted using price demand response guidance in the context of time-of-day ***,the optimization objective is established to minimize the total cost in the RIES scheduling cycle and construct a DRO scheduling model for RIES with *** simulating a real small-scale RIES,the results show that HDR-EGS can effectively promote WP consumption and reduce the operating cost of the system.

关键词： Energy harvesting integrated energy systems optimum scheduling time-of-use pricing demand response geothermal energy

Calculus bovis in hepatocellular carcinoma:Tumor molecular basis,Wnt/β-catenin pathway role,and protective mechanism

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World Journal of Gastroenterology 2024年第35期30卷 3959-3964页

作者： Khaled mohamed mohamed Koriem Department of Medical Physiology Medical Research and Clinical Studies InstituteNational Research CentreGiza 12622Egypt

In this editorial,we comment on the recent article by Huang et *** editorial focuses specifically on the molecular mechanisms of hepatocellular carcinoma(HCC),mechanism of Wnt/β-catenin pathway in HCC,and protective mechanism of Calculus bovis(CB)in *** cancer is the fourth most common cause of cancer-related deaths *** most prevalent kind of primary liver cancer,HCC,is typically brought on by long-term viral infections(hepatitis B and C),non-alcoholic steatohepatitis,excessive alcohol consumption,and other conditions that can cause the liver to become chronically inflamed and *** is a wellknown traditional remedy in China and Japan and has been used extensively to treat a variety of diseases,such as high fever,convulsions,and *** in lipid metabolism,cholesterol metabolism,bile acid metabolism,alcohol metabolism,and xenobiotic detoxification lead to fatty liver disease and liver ***,which is a tricarboxylic acid cycle intermediate,is vital to energy production and mitochondrial *** is also thought to be a signaling molecule in metabolism and in the development and spread of liver *** Wnt/β-catenin pathway is made up of a group of proteins that are essential for both adult tissue homeostasis and embryonic *** is frequently caused by the dysregulation of the Wnt/β-catenin signaling *** HCC liver carcinogenesis,Wnt/β-catenin signaling is activated by the expression of downstream target *** between the liver and the gut exists via the portal vein,biliary tract,and systemic ***"gutliver axis"controls intestinal *** of the main factors contributing to the development,progression,and treatment resistance of HCC is the abnormal activation of the Wnt/β-Catenin signaling ***,understanding this pathway is essential to treating *** ingredients of CB,particularly oleanolic acid,ergosterol,and ursolic acid,have anti-p

关键词： Hepatocellular carcinoma MicroRNAs Wnt/β-catenin pathway Calculus bovis Apoptosis

3D static modeling and sequence stratigraphy using well logs and seismic data:An example of Abu Roash G member in Bahga oilfield

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Energy Geoscience

Energy Geoscience 2024年第3期5卷 362-377页

作者： mohamed Reda mohamed Fathy mohamed Mosaad Fahad Alshehri mohamed S.Ahmed Geology Department Faculty of ScienceAl-Azhar UniversityP.O.Box 11884Nasr CityCairoEgypt Abdullah Alrushaid Chair for Earth Science Remote Sensing Research Geology and Geophysics DepartmentCollege of ScienceKing Saud UniversityRiyadh11451Saudi Arabia

This research uses both three-dimensional(3D)modeling and geologic well control to piece back together the architectural parts of the Late Cretaceous *** goal is to figure out the sizes,directions,locations,and controls of the layers of the fluvial sandstone *** stratigraphy is essential for 3D reservoir modeling and petroleum geology understanding in the Bahga *** purpose of this work is to create a static model that shows the layers and facies distribution in the reservoir *** will use data from nine well logs and 22 seismic lines calibrated by the Abu Roash G Member reservoir core intervals to accomplish *** petrophysical study discovered three parts in the Abu Roash G Member reservoir rock:channel fill that is affected by tides,channel fill that is dominated by tides(intertidal sands),and channel top with lenticular bedded *** model's findings point to the existence of an NNW-oriented sand body,which could be a prime location to produce *** original oil in place(OOIP)is about 3,438,279 Stock Tank Barrels(STB),and the oil reserve reaches up to 1,031,484(STB).Sequence stratigraphic analysis using seismic and well log information(SB)reveals that the Upper Cretaceous AR/G reservoir of the Bahga field is characterized by third-and fourth-order stratigraphic sequences,which are constrained by three Maximum Flooding Surfaces(MFS)and two Sequence *** integration of the derived geological model and sequence stratigraphic results can lower future extraction risk by identifying the locations and trends of the geologic facies with the necessary petrophysical properties for the hydrocarbon accumulations.

关键词： Three-dimensional reservoir modeling Sequence stratigraphy Reservoir characterization Abu Roash reservoir Abu Gharadig Basin

Privacy-preserved learning from non-i.i.d data in fog-assisted IoT:A federated learning approach

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Digital Communications and Networks 2024年第2期10卷 404-415页

作者： mohamed Abdel-Basset Hossam Hawash Nour Moustafa Imran Razzak mohamed Abd Elfattah Faculty of Computers and Informatics Zagazig UniversityZagazigSharqiyah44519Egypt School of Engineering and Information Technology University of New South Wales@ADFACanberraACT2600Australia Deakin University Geelong Waurn Ponds CampusAustralia Computer Science Department Misr Higher Institute for Commerce and ComputersMansoura35511Egypt

With the prevalence of the Internet of Things(IoT)systems,smart cities comprise complex networks,including sensors,actuators,appliances,and cyber *** complexity and heterogeneity of smart cities have become vulnerable to sophisticated cyber-attacks,especially privacy-related attacks such as inference and data poisoning *** Learning(FL)has been regarded as a hopeful method to enable distributed learning with privacypreserved intelligence in IoT *** though the significance of developing privacy-preserving FL has drawn as a great research interest,the current research only concentrates on FL with independent identically distributed(i.i.d)data and few studies have addressed the non-i.i.d *** is known to be vulnerable to Generative Adversarial Network(GAN)attacks,where an adversary can presume to act as a contributor participating in the training process to acquire the private data of other *** paper proposes an innovative Privacy Protection-based Federated Deep Learning(PP-FDL)framework,which accomplishes data protection against privacy-related GAN attacks,along with high classification rates from non-i.i.d ***-FDL is designed to enable fog nodes to cooperate to train the FDL model in a way that ensures contributors have no access to the data of each other,where class probabilities are protected utilizing a private identifier generated for each *** PP-FDL framework is evaluated for image classification using simple convolutional networks which are trained using MNIST and CIFAR-10 *** empirical results have revealed that PF-DFL can achieve data protection and the framework outperforms the other three state-of-the-art models with 3%–8%as accuracy improvements.

关键词： Privacy preservation Federated learning Deep learning Fog computing Smart cities

Comparison between seismic analysis of twisting and regular 52-story towers considering soil-structure interaction

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Earthquake Engineering and Engineering Vibration 2024年第3期23卷 663-675页

作者： mohamed Naguib Abouelsaad Mohammed Shaaban Salah El Bagalaty mohamed E.El Madawy Structural Engineering Department Faculty of EngineeringMansura UniversityMansoura 35511Egypt Faculty of Engineering Delta University for Science and TechnologyGamasa 35712Egypt

A dynamic analysis of both twisting and regular towers is carried out to determine the results of considering soil-structure interaction(SSI)on high-rise *** addition,the difference between the seismic performance of using twisting towers over regular ones is *** twisting tower is a simulation of the Evolution Tower(Moscow).The towers’skeletons consist of RC elements and rest on a reinforced concrete piled-raft *** soil model is considered as multi-layered with the same soil properties as the zone chosen for the analysis(New Mansoura City,Egypt).The only difference between both towers is their shape in *** whole system is modelled and analyzed in a single step as one full 3D model,which is known as the direct approach in *** analyses are carried out using finite-element software(Midas GTS NX).Dynamic output responses due to three records of seismic loads are proposed and presented in some *** on the results,it is concluded that SSI has a considerable effect on the dynamic response of tall buildings mainly because of the foundation flexibility,as it leads to lengthening the vibration period,increasing the story drift and the base shear for both cases.

关键词： soil-structure interaction seismic analysis twisting towers base shear story drift finite element method Midas GTS NX