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In vivo printing of growth factor-eluting adhesive scaffolds improves wound healing

Bioactive Materials 2022年第2期7卷 296-308页

作者： Kristo Nuutila mohamadmahdi samandari Yori Endo Yuteng Zhang Jacob Quint Tannin ASchmidt b Ali Tamayol Indranil Sinha Division of Plastic Surgery Brigham and Women’s HospitalHarvard Medical SchoolBostonMA02115USA Department of Biomedical Engineering University of ConnecticutFarmingtonCT06030USA Department of Mechanical and Materials Engineering University of Nebraska-LincolnLincolnNE68588USA

Acute and chronic wounds affect millions of people around the world,imposing a growing financial burden on patients and *** the application of current wound management strategies,the physiological healing process is disrupted in many cases,resulting in impaired wound ***,more efficient and easy-to-use treatment modalities are *** this study,we demonstrate the benefit of in vivo printed,growth factor-eluting adhesive scaffolds for the treatment of full-thickness wounds in a porcine model.A custom-made handheld printer is implemented to finely print gelatin-methacryloyl(GelMA)hydrogel containing vascular endothelial growth factor(VEGF)into the *** vitro and in vivo results show that the in situ GelMA crosslinking induces a strong scaffold adhesion and enables printing on curved surfaces of wet tissues,without the need for any *** scaffold is further shown to offer a sustained release of VEGF,enhancing the migration of endothelial cells in *** analyses demonstrate that the administration of the VEGF-eluting GelMA scaffolds that remain adherent to the wound bed significantly improves the quality of healing in porcine *** introduced in vivo printing strategy for wound healing applications is translational and convenient to use in any place,such as an operating room,and does not require expensive bioprinters or imaging modalities.

关键词： In vivo printing Handheld bioprinter Adhesive scaffolds GelMA VEGF Wound healing

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