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Celiac disease in Middle Eastern and North African countries:A new burden?

World Journal of Gastroenterology 2010年第12期16卷 1449-1457页

作者： Kassem Barada Abbas Bitar mohamad abdul-razak mokadem Jana Ghazi Hashash Peter Green Division of Gastroenterology Department of Internal MedicineAmerican University of Beirut Medical Center Department of Internal Medicine American University of Beirut Medical Center Department of Internal Medicine Indiana University School of Medicine Department of Internal Medicine University of Pittsburgh Medical Center Division of Gastroenterology Department of Internal MedicineColumbia University College of Physicians and Surgeons

Celiac disease(CD) is now recognized as a common disorder among Middle Eastern(ME) and North African(NA) *** aim of this review is to assess the available data regarding CD in the ME and NA and to compare this information with that of Western countries.A literature review was performed using the electronic databases PubMed and Medline(1950-2008) as search engines,and "celiac disease" was used as a Mesh *** search was limited to ME and NA *** prevalence of CD in ME and NA countries among low risk populations is similar to that of Western countries,but is higher in high risk populations such as those with type 1 *** is underestimated because of lack of clinical suspicion and lack of patient *** presentations in term of gastrointestinal,hematologic,skeletal,and liver manifestations are similar between both populations except for a high prevalence of short stature in some ME and NA *** studies have addressed atypical or silent *** in the West,diagnosis is initially made by serological tests and is confirmed by small intestinal ***-free diet is the main mode of treatment with a higher apparent adherence rate than in the *** disease complications result from *** disease is strongly associated with HLA DQ2 and to a lesser extent with HLA DQ8 *** conclusion,CD prevalence is underestimated,with little data available about its malignant *** parameters in the ME and NA are otherwise similar to those in Western countries.

关键词： Celiac disease Gluten-free diet Insulin dependent diabetes mellitus Iron defi ciency anemia Middle East

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Total pancreatectomy with islet cell transplantation vs intrathecal narcotic pump infusion for pain control in chronic pancreatitis

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World Journal of Gastroenterology 2016年第16期22卷 4160-4167页

作者： mohamad mokadem Lama Noureddine Thomas Howard Lee Mc Henry Stuart Sherman Evan L Fogel James L Watkins Glen A Lehman Division of Gastroenterology and Hepatology Roy J. and Lucille A. Carver College of Medicine University of Iowa Iowa IA 52242 United States Division of Nephrology and Hypertension Roy J. and Lucille A. Carver College of Medicine University of Iowa Iowa IA 52242 United States Community Health Network Indianapolis IN 46219 United States Division of Gastroenterology and Hepatology Indiana University Medical Center Indianapolis IN 46202 United States

AIM: To evaluate pain control in chronic pancreatitis patients who underwent total pancreatectomy with islet cell transplantation or intrathecal narcotic pump ***: We recognized 13 patients who underwent intrathecal narcotic pump(ITNP) infusion and 57 patients who underwent total pancreatectomy with autologous islet cell transplantation(TP + ICT) for chronic pancreatitis(CP) pain control between 1998 and 2008 at Indiana University Hospital. All patients had already failed multiple other modalities for pain control and the decision to proceed with either intervention was made at the discretion of the patients and their treating physicians. All patients were evaluated retrospectively using a questionnaire inquiring about their pain control(using a 0-10 pain scale), daily narcotic dose usage, and hospital admission days for pain control before each intervention and during their last follow-up. RESULTS: All 13 ITNP patients and 30 available TP + ICT patients were evaluated. The mean age was approximately 40 years in both groups. The median duration of pain before intervention was 6 years and 7 years in the ITNP and TP + ICT groups, respectively. The median pain score dropped from 8 to 2.5(on a scale of 0-10) in both groups on their last follow up. The median daily dose of narcotics also decreased from 393 mg equivalent of morphine sulfate to 8 mg in the ITNP group and from 300 mg to 40 mg in the TP + ICT group. No patient had diabetes mellitus(DM) before either procedure whereas 85% of those who underwent pancreatectomy were insulin dependent on their last evaluation despite ICT. CONCLUSION: ITNP and TP + ICT are comparable for pain control in patients with CP however with high incidence of DM among those who underwent TP + ICT. Prospective comparative studies and longer follow up are needed to better define treatment outcomes.

关键词： Chronic pancreatitis Intractable pain Total pancreatectomy Islet cell transplantation Intrathecal narcotic pump infusion

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Improving outdoor air quality based on building morphology:Numerical investigation

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Frontiers of Architectural Research 2020年第2期9卷 319-334页

作者： Asmaa Mohammed Hassan Ashraf Abdel Fatah El mokadem Naglaa Ali Megahed Osama Mahmoud Abo Eleinen Architecture and Urban Planning DepartmentFaculty of EngineeringPort Said UniversityPort SaidEgypt

Due to rapid urbanization around the world,high concentrations of vehicular pollutants have deteriorated the outdoor air quality,which can affect the physical and psychological well-being of *** strategies have been proposed to overcome these harmful impacts by improving the dispersion of air ***,a question arises regarding the potential effects of building morphology on the dispersion of ***,transient three-dimensional Computational Fluid Dynamics(CFD)simulations are performed to examine the effect of building morphology on PM10 *** cases with various prototypes and morphological methods are compared with a simple building form to identify the patterns of PM10 dispersion within a given time sequence under a prevailing inflow *** results indicate that the different designs of building morphology with varying Relative compactness(RC)indicator highlight the importance of considering morphological factors to improve outdoor air *** addition,the proposed prototypes can reduce PM10 concentrations by approximately 30%e90%at specific points in the studied time *** particular,the vertical,horizontal,and grid folded prototypes can be considered more effective as an approximate decrease between 70%and 90%in PM10 concentrations is observed,which reflects the influence of building morphology on improving outdoor air quality.

关键词： Building morphology Morphological methods Outdoor air quality PM10 dispersion CFD simulation

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