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Hepatocellular carcinoma in Lebanon: Etiology and prognostic factors associated with short-term survival

World Journal of Gastroenterology 2006年第22期12卷 3575-3580页

作者： César Yaghi Ala I Sharara Paul Rassam Rami Moucari Khalil Honein Joseph BouJaoude Rita Slim Roger Noun Heitham Abdul-Baki mohamad khalifeh Sami Ramia Raymond Sayegh Service de Gastroenterologie Hotel Dieu de France University Hospital BeirutLebanon Service de Gastroenterologie Hotel Dieu de France University Hospital.Beirut.Lebanon Departments of Internal Medicine and Surgery American University of Beirut Medical CenterBeirutLebanon Service de Gastroenterologie Hotel Dieu de France University Hospital BeirutLebanon Service de GastroenterologieHopital Saint GeorgesBeirutLebanon Departments of Internal Medicine and Surgery American University of Beirut Medical Center BeirutLebanon

AIM： To study the epidemiology of HCC in Lebanon and prognostic factors predictive of early mortality. METHODS： An observational follow-up cohort study of HCC cases diagnosed over a five-year period was carried out. Multivariate analysis was conducted to identify prognostic factors in comparison to Cancer of the Liver italian Program （CUP） score. Multiple variables including the etiology of underlying liver disease, the demographic characteristics of patients, and the severity of liver disease evaluated by the Child-Pugh score were studied. Tumor parameters included the time of diagnosis of HCC, alpha-fetoprotein level, number and size of nodules, presence of portal vein thrombosis, and treatment modalities. Death or loss of follow-up was considered as an end-point event. RESULTS： Ninety-two patients （mean 60.5 ± 22.3 years） were included. Etiology of underlying disease was hepatitis B, C, and alcohol in 67%, 20%, and 23.5% respectively. Child-Pugh class at diagnosis was A, B, and C in 34.8%, 39.3% and 25.8% respectively. Overall survival was 44.8%, 32.8% and 17.6% at 1, 2 and 3 years respectively （mean F/U 40.2 ± 23.5 mo）. Multivariate analysis identified three predictors of early mortality （〈 6 mo）： bilirubin 〉 3.2 mg/dL （P 〈 0.01）, HCC as first presentation of liver disease （P = 0.035）, and creatinine 〉 1 mg/dL （P = 0.017）. A score based on these variables outperformed the CLIP score by Cox proportional hazard. ROC curve showed both models to be equivalent and moderately accurate.CONCLUSION： HBV is the leading cause of HCC in Lebanon. Independent predictors of early mortality are elevated bilirubin, creatinine and HCC as first manifestation of disease. Prospective validation of a score based on these clinical parameters in predicting short-term survival is needed.

关键词： Liver Epidemiology Hepatitis Neoplasm Cancer Cirrhosis

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Acta Metallurgica Sinica(English Letters) 2013年第6期26卷 721-727页

作者： A.R.khalifeh A.Dehghan E.Hajjari Department of Materials Science and Engineering School of EngineeringShiraz University Department of Materials Science and Engineering Faculty of EngineeringShahid Chamran University

In present work the weldings of an austenitic stainless steel （AISI 304L） and a ferritic carbon steel （St37） were conducted by tungsten inert gas （TIG） welding process using four different austenitic filler metals, namely ER308L, ER309L, ER316L and ER310. Microstructure characteristics and mechanical properties of the weldments were studied using optical and scanning electron microscopy, ferrit-ometry, hardness, tensile and impact tests. The ferrite number （_N-~） of the weldments made by different electrodes varies between 0.5 and 9.5. It was found that the increase in amount of delta ferrite in the microstructure of the weld metals, causes the decrease of the impact toughness of the weldments. It seems that using ER309L and ER316L electrodes can provide a good combination between the mechanical and metallurgical properties of the joint in AISI 304L/St37 dissimilar welding.

关键词： Ferrous alloys Joining Microstructure Mechanical properties Electrode

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Super-hydrophobic stearic acid layer formed on anodized high purified magnesium for improving corrosion resistance of bioabsorbable implants

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Journal of Magnesium and Alloys 2018年第4期6卷 327-336页

作者： Sohrab khalifeh T.David Burleigh Materials&Metallurgical Engineering Department New Mexico Institute of Mining&TechnologySocorroNM 87123USA

Magnesium and its alloys are ideal candidates for bioabsorbable ***,they can dissolve too rapidly in the human body for most *** this research,high purified magnesium(HP-Mg)was coated with stearic acid(SA)to slow the corrosion rate of magnesium in simulated body fluid at 37±1°***-Mg was anodized(AC and DC voltages)to form an oxide/hydroxide layer,and then it was immersed in a SA *** SA coated layer surface,anodized layer,and the thickness of the oxide/hydroxide layer were investigated with Scanning Electron Microscopy(SEM).Electrochemical impedance spectroscopy(EIS)and potentiodynamic polarization(PDP)were used to estimate the corrosion rate of HP-Mg *** results confirm that the hydrophobic coating can decrease the corrosion rate of HP-Mg by more than *** protectiveness of coated layer for anodized specimens with AC voltage continue for 2 and 3 *** the HP-Mg coated anodized with DC voltage,the coated layer could improve the corrosion resistance for only a few days.

关键词： Magnesium Biomaterials Hydrophobic layer Stearic acid Simulated body fluid Electrochemical impedance spectroscopy

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Melamine-formaldehyde resin supported H^+:A mild and inexpensive reagent for synthesis of coumarins under mild conditions

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Chinese Chemical Letters 2011年第11期22卷 1313-1316页

作者： Ramin Rezaei Leila Dorosty Maryam Rajabzadeh Reza khalifeh Department of Chemistry Firoozabad Branch Islamic Azad UniversityP.O.Box 74715-117 FiroozabadIran Department of Chemistry Faculty of Basic Sciences ShirazUniversity of TechnologyShiraz71555-313Iran

Melamine-formaldehyde resin supported H~＋ is used as an efficient catalyst in the Pechmann condensation reaction of phenols withβ-ketoesters,in solvent-free media leading to the formation of coumarin derivatives usi... 详细信息

关键词： Coumarins Phenols β-Ketoesters Melamine-formaldehyde resin Pechmann condensation Solvent-free

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Therapeutic potential of trehalose in neurodegenerative diseases:the knowns and unknowns

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Neural Regeneration Research 2021年第10期16卷 2026-2027页

作者： Masoomeh khalifeh George E.Barreto Amirhossein Sahebkar Department of Medical Biotechnology and Nanotechnology Faculty of MedicineMashhad University of Medical SciencesMashhadIran Department of Biological Sciences Health Research InstituteUniversity of LimerickLimerickIreland Applied Biomedical Research Center Biotechnology Research CenterPharmaceutical Technology InstituteMashhad University of Medical SciencesMashhadIran Polish Mother’s Memorial Hospital Research Institute(PMMHRI) LodzPoland School of Pharmacy Mashhad University of Medical Sciences MashhadIra

Neurodegenerative diseases(NDs)are a growing health problem associated with a high burden due to destructive and longterm clinical *** aggregations of misfolded proteins are the most common pathological hallmark of many late-onset NDs called proteinopathies including Parkinson’s disease(PD),Alzheimer’s disease(AD),tauopathies,amyotrophic lateral sclerosis(ALS),and polyglutamine(polyQ)expansion diseases such as Huntington’s disease(HD)and various spinocerebellar ataxias(SCA)such as SCA3(Renna et al.,2010).Misfolded proteins can be generated by posttranslational conjugation(e.g.,hyperphosphorylated tau in AD),or endoproteolytic cleavage(e.g.,amyloidβpeptides)or genetic mutations in specific proteins(such as HTT in HD,α-synuclein in PD,PrPC in prion disease and SOD1 and TDP-43 in ALS)leading to the formation of oligomers.

关键词： Huntington tau Alzheimer

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Seclusion Room in Psychiatric Setting (National Center for Mental Health): Policy Analysis

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Open Journal of Nursing 2018年第9期8卷 697-707页

作者： Anas H. khalifeh Malek M. Khalil Department of Nursing Prince Hamzah Hospital Ministry of Health Amman Jordan School of Nursing The University of Jordan Amman Jordan Faculty of Nursing Zarqa University Zarqa Jordan

Background: Improving the quality of care in psychiatric settings is the most important goal of policy through the delivery of a comprehensive care, treatment, control, protection, and rehabilitation of patients with mental disorders. The main concern in mental health care is the continuing use of seclusion and the slow pace of change. Purpose: Analyze the seclusion room policy in National Center for Mental Health (NCMH) in Jordan to recognize the issue and present alternative solutions in order to modify and improve the current seclusion room policy. Method: The authors got seclusion room policy from NCMH;the method in this analysis will be used six-step model;and then searched the database for alternatives using EBSCO, PUBMED, MEDLINE, CINAHL, and Ovid. Result: The authors discuss use medications, training program, manipulate environment, de-escalation technique, and status quo alternatives that helps in minimizing use of seclusion, decreasing the incidence of aggressive behaviors occurrences, and decreasing unsafe behaviors against health care providers in the psychiatric settings. Conclusion: Manipulates environment is the best alternative after evaluated alternatives according to criteria.

关键词： Seclusion Policy Analysis Psychiatric Psychiatric Settings

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利用生物表面活性剂净化含油污水:菌浓度影响的评估

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中国洗涤用品工业 2016年第1期 46-50页

作者： A.khalifeh B.Roozbehani A.M.Moradi S.Imani M.Mirdrikvand 伊斯兰科学与研究大学石油和技术大学研究中心

生物表面活性剂是由微生物产生的可降低界面张力的两亲性化合物。因此,生物表面活性剂可以增加溶质溶解度、生物活性以及有机物的分解速率。本研究采用海洋假单胞菌类分析了生物表面活性剂对原油回收和隔离的作用。生物表面活性剂的制... 详细信息

生物表面活性剂是由微生物产生的可降低界面张力的两亲性化合物。因此,生物表面活性剂可以增加溶质溶解度、生物活性以及有机物的分解速率。本研究采用海洋假单胞菌类分析了生物表面活性剂对原油回收和隔离的作用。生物表面活性剂的制备是在玻璃烧瓶内和实验室条件下完成的。本研究试验了两个pH值范围的四种不同浓度的盐溶液,以期获得打破油包水或水包油乳液将油与水隔离开来的最佳生物表面活性剂浓度。当生物表面活性剂浓度为0.1%时可以达到最好的效果。

关键词：环境分解生物分离生物表面活性剂假单胞菌浓度

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儿童胆石性胰腺炎的非典型临床表现及文献回顾

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世界核心医学期刊文摘（儿科学分册） 2006年第1期2卷 17-17页

作者： Akel S. khalifeh M. Makhlouf Akel M. 贺莉 Department of Surgery American University of Beirut Medical Centre 113-6044/A10Beirut Lebanon

Pancreatitis in children is less common than in adults and is mostly related t o trauma, infection and anatomical anomalies. Gallstone pancreatitis is an even rarer entity in infants and children. We present an unusual case of gallstone pa ncreatitis in a 17-month-old girl who presented with jaundice of 1 month durat ion. The laboratory studies showed conjugated hyperbilirubinaemia with associate d acute pancreatitis and pseudo-hyponatraemia secondary to the markedly elevate d lipid profile. Further evaluations revealed obstruction at the Ampulla of Vate r with no evidence of a choledochal cyst and no mass lesion seen in the pancreas . The patient initially underwent urgent decompressive cholecystostomy with intr aoperative cholecystography. When the biochemical parameters improved, the patie nt underwent formal cholecystectomy with common bile duct exploration, extractio n of multiple impacted stones in the ampullary region and Fogarty balloon sphinc terotomy. The post-operative course was uneventful. Conclusion:Acute gallstone pancreatitis in children may present as jaundice or abdominal pain. Recognition, early diagnosis and surgical intervention are the mainstay for a good outcome.

关键词：文献回顾胆总管探查术括约肌切开术胆囊切除术壶腹部胆囊造影术结合胆红素罕见病例造口术

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