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Perspectives on immunotherapy utilization for hepatobiliary cancers in the United States

Hepatobiliary Surgery and Nutrition 2020年第4期9卷 501-504页

作者： Pedro Luiz Serrano Usón Junior Daniel Ahn mohamad bassam sonbol Tanios Bekaii-Saab Mitesh J.Borad Hospital Israelita Albert Einstein São PauloBrazil Mayo Clinic Cancer Center Mayo ClinicPhoenixAZUSA

Strategies involving immunotherapy and targeted therapies are emerging in the last years as valuable options for patients with hepatobiliary cancer(HBC)including hepatocellular carcinoma(HCC),gallbladder cancer(GBC),i... 详细信息

关键词： immunotherapy hepato biliary

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Targeting KRAS in pancreatic adenocarcinoma:Progress in demystifying the holy grail

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世界临床肿瘤学杂志:英文版 2023年第8期14卷 285-296页

作者： Ahmed Elhariri Ahmed Alhaj Daniel Ahn mohamad bassam sonbol Tanios Bekaii-Saab Christina Wu Michael Scott Rutenberg John Stauffer Jason Starr Umair Majeed Jeremy Jones Mitesh Borad Hani Babiker Division of Hematology-Oncology Department of MedicineMayo Clinic FloridaMayo Clinic Cancer CenterJacksonvilleFL 32224United States Division of Hematology-Oncology Department of MedicineMayo Clinic ArizonaMayo Clinic Cancer CenterPhoenixAZ 85054United States Department of Radiation-Oncology Mayo Clinic FloridaMayo Clinic Cancer CenterJacksonvilleFL 32224United States Department of Surgical Oncology Hepatopancreatobiliary SurgeryMayo Clinic FloridaJacksonvilleFL 32224United States

Pancreatic cancer(PC)remains one of the most challenging diseases,with a very poor 5-year overall survival of around 11.5%.Kirsten rat sarcoma virus(KRAS)mutation is seen in 90%-95%of PC patients and plays an important role in cancer cell proliferation,differentiation,metabolism,and survival,making it an essential mutation for targeted *** extensive efforts in studying this oncogene,there has been little success in finding a drug to target this pathway,labelling it for decades as“undruggable”.In this article we summarize some of the efforts made to target the KRAS pathway in PC,discuss the challenges,and shed light on promising clinical trials.

关键词： Kirsten rat sarcoma virus Targeted therapy Pancreatic cancer Drug resistance Next generation sequencing Clustered regularly interspaced short palindromic repeats

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Chemical composition and antioxidant activity of a Lebanese plant Euphorbia macroclada schyzoceras

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Asian Pacific Journal of Tropical Biomedicine 2013年第7期3卷 542-548页

作者： Hussein Farhan Hassan Rammal Akram Hijazi Ahmad Daher mohamad Reda Hussein Annan Ali Chokr Ali Bassal bassam Badran Doctoral School of Science and Technology Research Platform for Environmental Science Lebanese UniversityLebanon Faculty of Agricultural and Veterinary Sciences Lebanese UniversityLebanon Faculty of Sciences-1- Lebanese UniversityLebanon

Objective:To determine the chemical composition,total phenolic and total flavonoid contents ofthe crude extracts from leaves and stems of a Lebanese plantEuphorbia macroclada schyzoceras(***),and to evaluate their antioxidant potential using DPPH,H2O2,and chelating offerrous ions ***:Quantification of the total phenolic and total flavonoid contents ofthe crude extracts from leaves and stems and the antioxidant activities were evaluated usingspectrophotometric *** chemical composition has been estimated using differenttechniques such as IR,LC/MS and ***:Ethanolic extract from leaves *** was better than aqueous extract and showed higher content in total phenolic and total flavonoidthan found in the *** the other hand,using DPPH and H2O2tests,this extract from leavesshowed higher antioxidant capacity than aqueous ***,using the chelating of ferrousions test,the antioxidant activity of the aqueous extract of both stems and leaves was strongerthan that of ethanolic *** chemical composition of the whole plant showed the presence ofsome aromatic compounds and fatty ***:Both ethanolic and water extracts fromboth parts of this plant are effective and have good antioxidant ***,this plant can be usedin the prevention of a number of diseases related to oxidative stress.

关键词： Euphorbia macroclada schyzoceras Total phenolic Total flavonoid Antioxidant potential Chemical composition

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Gait-Ground Reaction Force Sensors Selection Based on ROC Curve Evaluation

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Journal of Computer and Communications 2015年第3期3卷 13-19页

作者： Rami Alkhatib mohamad Diab bassam Moslem Christophe Corbier Mohamed El Badaoui Laboratoire LASPI Université Jean-Monnet Roanne France Electrical and Computer Engineering Department College of Engineering Rafik Hariri University Damour Lebanon

Classification of normal gait from pathological gait as then can be used as indicator of falling among subjects requires the correct choice of sensor location in the insole. Such a flexi force- sensor can be used underneath foot to measure vertical ground reaction force. To start with, the most relevant information (parameters) that can characterize the recorded signals are extracted from the vertical ground reaction force signals. Then Receiver Operating Characteristic curve is used to evaluate the features upon 8 sensors underneath each foot located at different locations. To confirm results obtained, features are passed upon a chosen classifier, in this paper K-nearest neighbors algorithm is chosen. Results show that the sensor located at the inner arch of the sole of the foot (i.e. at the mid foot) holds the most relevant information needed for better classification compared to other sensors.

关键词： Gait Analysis ROC Analysis Sensor Selection Gait Ground Reaction Force (GRF)

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